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O08842

- GFRA2_MOUSE

UniProt

O08842 - GFRA2_MOUSE

Protein

GDNF family receptor alpha-2

Gene

Gfra2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (18 Sep 2013)
      Previous versions | rss
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    Functioni

    Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

    GO - Molecular functioni

    1. glial cell-derived neurotrophic factor receptor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of protein autophosphorylation Source: Ensembl
    2. nervous system development Source: MGI
    3. transmembrane receptor protein tyrosine kinase signaling pathway Source: MGI

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GDNF family receptor alpha-2
    Short name:
    GDNF receptor alpha-2
    Short name:
    GDNFR-alpha-2
    Short name:
    GFR-alpha-2
    Alternative name(s):
    GDNF receptor beta
    Short name:
    GDNFR-beta
    Neurturin receptor alpha
    Short name:
    NRTNR-alpha
    Short name:
    NTNR-alpha
    TGF-beta-related neurotrophic factor receptor 2
    Gene namesi
    Name:Gfra2
    Synonyms:Gdnfrb, Trnr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1195462. Gfra2.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 443422GDNF family receptor alpha-2PRO_0000010787Add
    BLAST
    Propeptidei444 – 46421Removed in mature formSequence AnalysisPRO_0000010788Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis
    Lipidationi443 – 4431GPI-anchor amidated serineSequence Analysis

    Keywords - PTMi

    Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiO08842.
    PRIDEiO08842.

    Expressioni

    Tissue specificityi

    Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the spleen and in the adrenal gland.

    Gene expression databases

    ArrayExpressiO08842.
    BgeeiO08842.
    GenevestigatoriO08842.

    Structurei

    3D structure databases

    ProteinModelPortaliO08842.
    SMRiO08842. Positions 157-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GDNFR family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG78285.
    GeneTreeiENSGT00550000074579.
    HOGENOMiHOG000008695.
    HOVERGENiHBG051725.
    InParanoidiO08842.
    OMAiNSGPCRA.
    OrthoDBiEOG7FBRJ3.
    TreeFamiTF331647.

    Family and domain databases

    InterProiIPR016017. GDNF/GAS1.
    IPR003438. GDNF_rcpt.
    IPR003504. GDNF_rcpt_a2.
    IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
    [Graphical view]
    PfamiPF02351. GDNF. 3 hits.
    [Graphical view]
    PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
    PRINTSiPR01318. GDNFRALPHA2.
    PR01316. GDNFRECEPTOR.
    SMARTiSM00907. GDNF. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O08842-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MILANAFCLF FFLDETLRSL ASPSSPQGSE LHGWRPQVDC VRANELCAAE    50
    SNCSSRYRTL RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK 100
    KELQCLQIYW SIHLGLTEGE EFYEASPYEP VTSRLSDIFR LASIFSGTGA 150
    DPVVSAKSNH CLDAAKACNL NDNCKKLRSS YISICNREIS PTERCNRRKC 200
    HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS CSYEDKEKPN 250
    CLDLRSLCRT DHLCRSRLAD FHANCRASYR TITSCPADNY QACLGSYAGM 300
    IGFDMTPNYV DSNPTGIVVS PWCNCRGSGN MEEECEKFLK DFTENPCLRN 350
    AIQAFGNGTD VNMSPKGPTF SATQAPRVEK TPSLPDDLSD STSLGTSVIT 400
    TCTSIQEQGL KANNSKELSM CFTELTTNIS PGSKKVIKLY SGSCRARLST 450
    ALTALPLLMV TLAQ 464
    Length:464
    Mass (Da):51,727
    Last modified:September 18, 2013 - v2
    Checksum:i3A7FB495FA58C61F
    GO
    Isoform 2 (identifier: O08842-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         14-146: Missing.

    Show »
    Length:331
    Mass (Da):36,634
    Checksum:i63FDA76F5CE275F9
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei14 – 146133Missing in isoform 2. 1 PublicationVSP_001662Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002701 mRNA. Translation: AAC53548.1.
    AK138512 mRNA. Translation: BAE23689.1.
    AC124202 Genomic DNA. No translation available.
    CH466535 Genomic DNA. Translation: EDL35876.1.
    BC138561 mRNA. Translation: AAI38562.1.
    CCDSiCCDS27263.1. [O08842-1]
    RefSeqiNP_032141.2. NM_008115.2. [O08842-1]
    XP_006518621.1. XM_006518558.1. [O08842-2]
    UniGeneiMm.32619.

    Genome annotation databases

    EnsembliENSMUST00000022699; ENSMUSP00000022699; ENSMUSG00000022103. [O08842-1]
    GeneIDi14586.
    KEGGimmu:14586.
    UCSCiuc007uoz.1. mouse.
    uc007upb.1. mouse. [O08842-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF002701 mRNA. Translation: AAC53548.1 .
    AK138512 mRNA. Translation: BAE23689.1 .
    AC124202 Genomic DNA. No translation available.
    CH466535 Genomic DNA. Translation: EDL35876.1 .
    BC138561 mRNA. Translation: AAI38562.1 .
    CCDSi CCDS27263.1. [O08842-1 ]
    RefSeqi NP_032141.2. NM_008115.2. [O08842-1 ]
    XP_006518621.1. XM_006518558.1. [O08842-2 ]
    UniGenei Mm.32619.

    3D structure databases

    ProteinModelPortali O08842.
    SMRi O08842. Positions 157-359.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi O08842.
    PRIDEi O08842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022699 ; ENSMUSP00000022699 ; ENSMUSG00000022103 . [O08842-1 ]
    GeneIDi 14586.
    KEGGi mmu:14586.
    UCSCi uc007uoz.1. mouse.
    uc007upb.1. mouse. [O08842-2 ]

    Organism-specific databases

    CTDi 2675.
    MGIi MGI:1195462. Gfra2.

    Phylogenomic databases

    eggNOGi NOG78285.
    GeneTreei ENSGT00550000074579.
    HOGENOMi HOG000008695.
    HOVERGENi HBG051725.
    InParanoidi O08842.
    OMAi NSGPCRA.
    OrthoDBi EOG7FBRJ3.
    TreeFami TF331647.

    Miscellaneous databases

    NextBioi 286330.
    PROi O08842.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08842.
    Bgeei O08842.
    Genevestigatori O08842.

    Family and domain databases

    InterProi IPR016017. GDNF/GAS1.
    IPR003438. GDNF_rcpt.
    IPR003504. GDNF_rcpt_a2.
    IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
    [Graphical view ]
    Pfami PF02351. GDNF. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF038071. GDNF_family_receptor_alpha. 1 hit.
    PRINTSi PR01318. GDNFRALPHA2.
    PR01316. GDNFRECEPTOR.
    SMARTi SM00907. GDNF. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal cord.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGFRA2_MOUSE
    AccessioniPrimary (citable) accession number: O08842
    Secondary accession number(s): Q3UUD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 18, 2013
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3