SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O08841

- QSOX1_CAVPO

UniProt

O08841 - QSOX1_CAVPO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Sulfhydryl oxidase 1
Gene
QSOX1, GEC3, QSCN6, SOX3
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.1 Publication

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

Binds 1 FAD per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711Nucleophile By similarity
Active sitei74 – 741Nucleophile By similarity
Binding sitei402 – 4021FAD By similarity
Binding sitei409 – 4091FAD By similarity
Binding sitei413 – 4131FAD By similarity
Binding sitei452 – 4521FAD By similarity
Binding sitei456 – 4561FAD By similarity
Binding sitei501 – 5011FAD By similarity
Binding sitei504 – 5041FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi479 – 4868FAD By similarity

GO - Molecular functioni

  1. flavin-linked sulfhydryl oxidase activity Source: UniProtKB
  2. protein disulfide isomerase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.8.3.2. 1225.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.2)
Alternative name(s):
FAD-dependent sulfhydryl oxidase-3
Short name:
SOx-3
Glandular epithelial cells protein 3
Quiescin Q6
Gene namesi
Name:QSOX1
Synonyms:GEC3, QSCN6, SOX3
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Secreted
Note: Found in the extracellular medium.1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. integral component of Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030 Reviewed prediction
Add
BLAST
Chaini31 – 613583Sulfhydryl oxidase 1
PRO_0000249536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 74Redox-active By similarity
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi244 – 2441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi394 ↔ 406 By similarity
Disulfide bondi450 ↔ 453 By similarity
Disulfide bondi510 ↔ 513 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells.1 Publication

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001987.

Structurei

3D structure databases

ProteinModelPortaliO08841.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 157121Thioredoxin
Add
BLAST
Domaini397 – 504108ERV/ALR sulfhydryl oxidase
Add
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000231631.
HOVERGENiHBG080360.
InParanoidiO08841.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08841-1 [UniParc]FASTAAdd to Basket

« Hide

MTGCGRRSGW LPPLRLLLLP LLLGGPGVGA AQLAALYSAS DPLTLLQADT    50
VRSTVLNSPS AWAVEFFASW CGHCIAFAPT WKALAKDIKD WRPALNLAAL 100
NCADETNNAV CRDFNIAGFP SVRFFKAFSK NSTGTTLPVA GANVQMLRER 150
LIDALESHHD TWPSACPPLE PVKPKEIDTF FARNNQEYLV LIFEQENSYL 200
GREVTLDLSQ HHDLVVRRVL STEANVVRKF GVADFPSCYL LFRNGSVSRV 250
PVLVESRRFY TAYLQRLSEV TREGTPTPAV PTISDQIAPT VWKFADRSKI 300
YMADLESALH YILRVEVGRF SVLEGQRLMA LKKFVTVLTK YFPGQPLVRN 350
FLQSTNEWLK RQHKKKMPYS FFKTAMDSRN EEAVITKEVN WVGCQGSESH 400
FRGFPCSLWI LFHFLTVQAS QKNAESSQKP ANGQEVLQAI RNYVRFFFGC 450
RDCANHFEQM AAGSMHRVKS PNDAVLWLWT SHNRVNARLA GAPSEDPQFP 500
KVQWPPPELC SACHNELSGE PVWDVDATLR FLKTHFSPSN IVLNFPPAEP 550
ASRSSVHSWG ATPHLELDAL GLVTRNSALA LERAEISESP GSNAMPNIPA 600
ERPELFEALS HSR 613
Length:613
Mass (Da):68,595
Last modified:March 1, 2001 - v2
Checksum:i34105EF608CA7B55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82982 mRNA. Translation: AAB58401.2.
PIRiJC7762.
RefSeqiNP_001166479.1. NM_001173008.2.

Genome annotation databases

GeneIDi100135609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U82982 mRNA. Translation: AAB58401.2 .
PIRi JC7762.
RefSeqi NP_001166479.1. NM_001173008.2.

3D structure databases

ProteinModelPortali O08841.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000001987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100135609.

Organism-specific databases

CTDi 5768.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000231631.
HOVERGENi HBG080360.
InParanoidi O08841.

Enzyme and pathway databases

BRENDAi 1.8.3.2. 1225.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells."
    Musard J.-F., Sallot M., Dulieu P., Fraichard A., Ordener C., Remy-Martin J.-P., Jouvenot M., Adami P.
    Biochem. Biophys. Res. Commun. 287:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiQSOX1_CAVPO
AccessioniPrimary (citable) accession number: O08841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2001
Last modified: March 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi