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O08841

- QSOX1_CAVPO

UniProt

O08841 - QSOX1_CAVPO

Protein

Sulfhydryl oxidase 1

Gene

QSOX1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.By similarity

    Catalytic activityi

    2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei71 – 711NucleophileBy similarity
    Active sitei74 – 741NucleophileBy similarity
    Binding sitei402 – 4021FADBy similarity
    Binding sitei409 – 4091FADBy similarity
    Binding sitei413 – 4131FADBy similarity
    Binding sitei452 – 4521FADBy similarity
    Binding sitei456 – 4561FADBy similarity
    Binding sitei501 – 5011FADBy similarity
    Binding sitei504 – 5041FADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi479 – 4868FADBy similarity

    GO - Molecular functioni

    1. flavin-linked sulfhydryl oxidase activity Source: UniProtKB
    2. protein disulfide isomerase activity Source: UniProtKB

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BRENDAi1.8.3.2. 1225.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sulfhydryl oxidase 1 (EC:1.8.3.2)
    Alternative name(s):
    FAD-dependent sulfhydryl oxidase-3
    Short name:
    SOx-3
    Glandular epithelial cells protein 3
    Quiescin Q6
    Gene namesi
    Name:QSOX1
    Synonyms:GEC3, QSCN6, SOX3
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    Secreted 1 Publication
    Note: Found in the extracellular medium.

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB
    2. integral component of Golgi membrane Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3030Sequence AnalysisAdd
    BLAST
    Chaini31 – 613583Sulfhydryl oxidase 1PRO_0000249536Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi71 ↔ 74Redox-activePROSITE-ProRule annotation
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi394 ↔ 406PROSITE-ProRule annotation
    Disulfide bondi450 ↔ 453PROSITE-ProRule annotation
    Disulfide bondi510 ↔ 513PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells.1 Publication

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000001987.

    Structurei

    3D structure databases

    ProteinModelPortaliO08841.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 157121ThioredoxinPROSITE-ProRule annotationAdd
    BLAST
    Domaini397 – 504108ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000231631.
    HOVERGENiHBG080360.
    InParanoidiO08841.

    Family and domain databases

    Gene3Di1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PfamiPF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEiPS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08841-1 [UniParc]FASTAAdd to Basket

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    MTGCGRRSGW LPPLRLLLLP LLLGGPGVGA AQLAALYSAS DPLTLLQADT    50
    VRSTVLNSPS AWAVEFFASW CGHCIAFAPT WKALAKDIKD WRPALNLAAL 100
    NCADETNNAV CRDFNIAGFP SVRFFKAFSK NSTGTTLPVA GANVQMLRER 150
    LIDALESHHD TWPSACPPLE PVKPKEIDTF FARNNQEYLV LIFEQENSYL 200
    GREVTLDLSQ HHDLVVRRVL STEANVVRKF GVADFPSCYL LFRNGSVSRV 250
    PVLVESRRFY TAYLQRLSEV TREGTPTPAV PTISDQIAPT VWKFADRSKI 300
    YMADLESALH YILRVEVGRF SVLEGQRLMA LKKFVTVLTK YFPGQPLVRN 350
    FLQSTNEWLK RQHKKKMPYS FFKTAMDSRN EEAVITKEVN WVGCQGSESH 400
    FRGFPCSLWI LFHFLTVQAS QKNAESSQKP ANGQEVLQAI RNYVRFFFGC 450
    RDCANHFEQM AAGSMHRVKS PNDAVLWLWT SHNRVNARLA GAPSEDPQFP 500
    KVQWPPPELC SACHNELSGE PVWDVDATLR FLKTHFSPSN IVLNFPPAEP 550
    ASRSSVHSWG ATPHLELDAL GLVTRNSALA LERAEISESP GSNAMPNIPA 600
    ERPELFEALS HSR 613
    Length:613
    Mass (Da):68,595
    Last modified:March 1, 2001 - v2
    Checksum:i34105EF608CA7B55
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82982 mRNA. Translation: AAB58401.2.
    PIRiJC7762.
    RefSeqiNP_001166479.1. NM_001173008.2.

    Genome annotation databases

    GeneIDi100135609.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U82982 mRNA. Translation: AAB58401.2 .
    PIRi JC7762.
    RefSeqi NP_001166479.1. NM_001173008.2.

    3D structure databases

    ProteinModelPortali O08841.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000001987.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100135609.

    Organism-specific databases

    CTDi 5768.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000231631.
    HOVERGENi HBG080360.
    InParanoidi O08841.

    Enzyme and pathway databases

    BRENDAi 1.8.3.2. 1225.

    Family and domain databases

    Gene3Di 1.20.120.310. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    Pfami PF04777. Evr1_Alr. 1 hit.
    PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    SSF69000. SSF69000. 1 hit.
    PROSITEi PS51324. ERV_ALR. 1 hit.
    PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells."
      Musard J.-F., Sallot M., Dulieu P., Fraichard A., Ordener C., Remy-Martin J.-P., Jouvenot M., Adami P.
      Biochem. Biophys. Res. Commun. 287:83-91(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiQSOX1_CAVPO
    AccessioniPrimary (citable) accession number: O08841
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2006
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3