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O08841

- QSOX1_CAVPO

UniProt

O08841 - QSOX1_CAVPO

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Protein

Sulfhydryl oxidase 1

Gene

QSOX1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity).By similarity

Catalytic activityi

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei71 – 711NucleophileBy similarity
Active sitei74 – 741NucleophileBy similarity
Binding sitei402 – 4021FADBy similarity
Binding sitei409 – 4091FADBy similarity
Binding sitei413 – 4131FADBy similarity
Binding sitei452 – 4521FADBy similarity
Binding sitei456 – 4561FADBy similarity
Binding sitei501 – 5011FADBy similarity
Binding sitei504 – 5041FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi479 – 4868FADBy similarity

GO - Molecular functioni

  1. flavin-linked sulfhydryl oxidase activity Source: UniProtKB
  2. protein disulfide isomerase activity Source: UniProtKB

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BRENDAi1.8.3.2. 1225.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.2)
Alternative name(s):
FAD-dependent sulfhydryl oxidase-3
Short name:
SOx-3
Glandular epithelial cells protein 3
Quiescin Q6
Gene namesi
Name:QSOX1
Synonyms:GEC3, QSCN6, SOX3
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Secreted 1 Publication
Note: Found in the extracellular medium.

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of Golgi membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence AnalysisAdd
BLAST
Chaini31 – 613583Sulfhydryl oxidase 1PRO_0000249536Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 74Redox-activePROSITE-ProRule annotation
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi244 – 2441N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi394 ↔ 406PROSITE-ProRule annotation
Disulfide bondi450 ↔ 453PROSITE-ProRule annotation
Disulfide bondi510 ↔ 513PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells.1 Publication

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000001987.

Structurei

3D structure databases

ProteinModelPortaliO08841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 157121ThioredoxinPROSITE-ProRule annotationAdd
BLAST
Domaini397 – 504108ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ERV/ALR sulfhydryl oxidase domain.PROSITE-ProRule annotation
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000231631.
HOVERGENiHBG080360.
InParanoidiO08841.

Family and domain databases

Gene3Di1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEiPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08841-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGCGRRSGW LPPLRLLLLP LLLGGPGVGA AQLAALYSAS DPLTLLQADT
60 70 80 90 100
VRSTVLNSPS AWAVEFFASW CGHCIAFAPT WKALAKDIKD WRPALNLAAL
110 120 130 140 150
NCADETNNAV CRDFNIAGFP SVRFFKAFSK NSTGTTLPVA GANVQMLRER
160 170 180 190 200
LIDALESHHD TWPSACPPLE PVKPKEIDTF FARNNQEYLV LIFEQENSYL
210 220 230 240 250
GREVTLDLSQ HHDLVVRRVL STEANVVRKF GVADFPSCYL LFRNGSVSRV
260 270 280 290 300
PVLVESRRFY TAYLQRLSEV TREGTPTPAV PTISDQIAPT VWKFADRSKI
310 320 330 340 350
YMADLESALH YILRVEVGRF SVLEGQRLMA LKKFVTVLTK YFPGQPLVRN
360 370 380 390 400
FLQSTNEWLK RQHKKKMPYS FFKTAMDSRN EEAVITKEVN WVGCQGSESH
410 420 430 440 450
FRGFPCSLWI LFHFLTVQAS QKNAESSQKP ANGQEVLQAI RNYVRFFFGC
460 470 480 490 500
RDCANHFEQM AAGSMHRVKS PNDAVLWLWT SHNRVNARLA GAPSEDPQFP
510 520 530 540 550
KVQWPPPELC SACHNELSGE PVWDVDATLR FLKTHFSPSN IVLNFPPAEP
560 570 580 590 600
ASRSSVHSWG ATPHLELDAL GLVTRNSALA LERAEISESP GSNAMPNIPA
610
ERPELFEALS HSR
Length:613
Mass (Da):68,595
Last modified:March 1, 2001 - v2
Checksum:i34105EF608CA7B55
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82982 mRNA. Translation: AAB58401.2.
PIRiJC7762.
RefSeqiNP_001166479.1. NM_001173008.2.

Genome annotation databases

GeneIDi100135609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82982 mRNA. Translation: AAB58401.2 .
PIRi JC7762.
RefSeqi NP_001166479.1. NM_001173008.2.

3D structure databases

ProteinModelPortali O08841.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000001987.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100135609.

Organism-specific databases

CTDi 5768.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000231631.
HOVERGENi HBG080360.
InParanoidi O08841.

Enzyme and pathway databases

BRENDAi 1.8.3.2. 1225.

Family and domain databases

Gene3Di 1.20.120.310. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR017905. ERV/ALR_sulphydryl_oxidase.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
SSF69000. SSF69000. 1 hit.
PROSITEi PS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells."
    Musard J.-F., Sallot M., Dulieu P., Fraichard A., Ordener C., Remy-Martin J.-P., Jouvenot M., Adami P.
    Biochem. Biophys. Res. Commun. 287:83-91(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiQSOX1_CAVPO
AccessioniPrimary (citable) accession number: O08841
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2001
Last modified: November 26, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3