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O08841 (QSOX1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified October 19, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sulfhydryl oxidase 1
EC=1.8.3.2
Alternative name(s):
FAD-dependent sulfhydryl oxidase-3
Short name=SOx-3
Glandular epithelial cells protein 3
Quiescin Q6
Gene names
Name:QSOX1
Synonyms:GEC3, QSCN6, SOX3
OrganismCavia porcellus (Guinea pig)
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length613 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity. Ref.1

Catalytic activity

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2.

Cofactor

Binds 1 FAD per subunit By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted. Note: Found in the extracellular medium. Ref.1

Tissue specificity

Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells. Ref.1

Sequence similarities

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.

Contains 1 ERV/ALR sulfhydryl oxidase domain.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 613583Sulfhydryl oxidase 1
PRO_0000249536

Regions

Domain37 – 157121Thioredoxin
Domain397 – 504108ERV/ALR sulfhydryl oxidase
Nucleotide binding479 – 4868FAD By similarity

Sites

Active site711Nucleophile By similarity
Active site741Nucleophile By similarity
Binding site4021FAD By similarity
Binding site4091FAD By similarity
Binding site4131FAD By similarity
Binding site4521FAD By similarity
Binding site4561FAD By similarity
Binding site5011FAD By similarity
Binding site5041FAD By similarity

Amino acid modifications

Glycosylation1311N-linked (GlcNAc...) Potential
Glycosylation2441N-linked (GlcNAc...) Potential
Disulfide bond71 ↔ 74Redox-active By similarity
Disulfide bond394 ↔ 406 By similarity
Disulfide bond450 ↔ 453 By similarity
Disulfide bond510 ↔ 513 By similarity

Sequences

Sequence LengthMass (Da)Tools
O08841 [UniParc].

Last modified March 1, 2001. Version 2.
Checksum: 34105EF608CA7B55

FASTA61368,595
        10         20         30         40         50         60 
MTGCGRRSGW LPPLRLLLLP LLLGGPGVGA AQLAALYSAS DPLTLLQADT VRSTVLNSPS 

        70         80         90        100        110        120 
AWAVEFFASW CGHCIAFAPT WKALAKDIKD WRPALNLAAL NCADETNNAV CRDFNIAGFP 

       130        140        150        160        170        180 
SVRFFKAFSK NSTGTTLPVA GANVQMLRER LIDALESHHD TWPSACPPLE PVKPKEIDTF 

       190        200        210        220        230        240 
FARNNQEYLV LIFEQENSYL GREVTLDLSQ HHDLVVRRVL STEANVVRKF GVADFPSCYL 

       250        260        270        280        290        300 
LFRNGSVSRV PVLVESRRFY TAYLQRLSEV TREGTPTPAV PTISDQIAPT VWKFADRSKI 

       310        320        330        340        350        360 
YMADLESALH YILRVEVGRF SVLEGQRLMA LKKFVTVLTK YFPGQPLVRN FLQSTNEWLK 

       370        380        390        400        410        420 
RQHKKKMPYS FFKTAMDSRN EEAVITKEVN WVGCQGSESH FRGFPCSLWI LFHFLTVQAS 

       430        440        450        460        470        480 
QKNAESSQKP ANGQEVLQAI RNYVRFFFGC RDCANHFEQM AAGSMHRVKS PNDAVLWLWT 

       490        500        510        520        530        540 
SHNRVNARLA GAPSEDPQFP KVQWPPPELC SACHNELSGE PVWDVDATLR FLKTHFSPSN 

       550        560        570        580        590        600 
IVLNFPPAEP ASRSSVHSWG ATPHLELDAL GLVTRNSALA LERAEISESP GSNAMPNIPA 

       610 
ERPELFEALS HSR

« Hide

References

[1]"Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells."
Musard J.-F., Sallot M., Dulieu P., Fraichard A., Ordener C., Remy-Martin J.-P., Jouvenot M., Adami P.
Biochem. Biophys. Res. Commun. 287:83-91(2001) [PubMed: 11549257] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U82982 mRNA. Translation: AAB58401.2.
PIRJC7762.
RefSeqNP_001166479.1. NM_001173008.1.

3D structure databases

HSSPHSSP built from PDB template 1X5D based on UniProtKB Q15084.
ProteinModelPortalO08841.
ModBaseSearch...

Protein-protein interaction databases

STRINGO08841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000002220; ENSCPOP00000001987; ENSCPOG00000002191.
GeneID100135609.

Organism-specific databases

CTD5768.

Phylogenomic databases

eggNOGroNOG14722.
GeneTreeENSGT00390000008045.
HOVERGENHBG080360.
InParanoidO08841.
OrthoDBEOG4JT05B.

Enzyme and pathway databases

BRENDA1.8.3.2. 1225.

Family and domain databases

InterProIPR017905. ERV/ALR_sulphydryl_oxidase.
IPR006863. Evr1_Alr.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
Gene3DG3DSA:1.20.120.310. Evr1_Alr. 1 hit.
G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF04777. Evr1_Alr. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF69000. Evr1_Alr. 1 hit.
SSF52833. Thiordxn-like_fd. 1 hit.
PROSITEPS51324. ERV_ALR. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQSOX1_CAVPO
AccessionPrimary (citable) accession number: O08841
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: March 1, 2001
Last modified: October 19, 2011
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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