Reviewed,
UniProtKB/Swiss-Prot O08841 (QSOX1_CAVPO)
Last modified
June 16, 2009.
Version 51.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Sulfhydryl oxidase 1 EC=1.8.3.2 Alternative name(s): Quiescin Q6 FAD-dependent sulfhydryl oxidase-3 Short name=SOx-3 Glandular epithelial cells protein 3 | ||||
| Gene names |
| ||||
| Organism | Cavia porcellus (Guinea pig) | ||||
| Taxonomic identifier | 10141 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia |
Protein attributes
| Sequence length | 613 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity. |
| Catalytic activity | 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O. |
| Cofactor | Binds 1 FAD per subunit By similarity. |
| Subunit structure | Monomer By similarity. |
| Subcellular location | |
| Tissue specificity | Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells. Ref.1 |
| Sequence similarities | Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Contains 1 ERV/ALR sulfhydryl oxidase domain. Contains 1 thioredoxin domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | FAD Flavoprotein |
| Molecular function | Oxidoreductase |
| PTM | Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW protein thiol-disulfide exchangeInferred from sequence or structural similarity. Source: UniProtKB |
| Cellular component | extracellular space Inferred from sequence or structural similarity. Source: UniProtKB integral to Golgi membraneInferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | flavin-linked sulfhydryl oxidase activity Inferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | Potential | ||||||
| Chain | 31 – 613 | 583 | Sulfhydryl oxidase 1 | PRO_0000249536 | |||||
Regions | |||||||||
| Domain | 37 – 157 | 121 | Thioredoxin | ||||||
| Domain | 397 – 504 | 108 | ERV/ALR sulfhydryl oxidase | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 131 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 244 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells." Musard J.-F., Sallot M., Dulieu P., Fraichard A., Ordener C., Remy-Martin J.-P., Jouvenot M., Adami P. Biochem. Biophys. Res. Commun. 287:83-91(2001) [PubMed: 11549257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION. |
Cross-references
Sequence databases | |
|---|---|
| U82982 mRNA. Translation: AAB58401.2. | |
| PIR | JC7762. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSCPOG00000002191. Cavia porcellus. [Contig view] |
Phylogenomic databases | |
| HOVERGEN | O08841. |
Enzyme and pathway databases | |
| BRENDA | 1.8.3.2. 44. |
Family and domain databases | |
| InterPro | IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006863. Evr1_Alr. IPR017936. Thioredoxin-like. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:1.20.120.310. Evr1_Alr. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| Pfam | PF04777. Evr1_Alr. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view] |
| PROSITE | PS51324. ERV_ALR. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | QSOX1_CAVPO | ||||||||
| Accession | Primary (citable) accession number: O08841 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

Clusters with


