Reviewed, UniProtKB/Swiss-Prot O08841 (QSOX1_CAVPO)

Names and origin

Protein names

Recommended name:
    Sulfhydryl oxidase 1
    EC=1.8.3.2
Alternative name(s):
    Quiescin Q6
    FAD-dependent sulfhydryl oxidase-3
      Short name=SOx-3
    Glandular epithelial cells protein 3

Gene names

Name:	QSOX1
Synonyms:	GEC3, QSCN6, SOX3

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	613 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins By similarity.
Catalytic activity	4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O.
Cofactor	Binds 1 FAD per subunit By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Secreted. Note: Found in the extracellular medium. Ref.1
Tissue specificity	Expressed in testis, placenta, pancreas, lung, ovary, endometrium, but not in brain, liver and kidney tissues. Higher expression in epithelial cells. Ref.1
Sequence similarities	Belongs to the quiescin-sulfhydryl oxidase (QSOX) family. Contains 1 ERV/ALR sulfhydryl oxidase domain. Contains 1 thioredoxin domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW protein thiol-disulfide exchange Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	extracellular space Inferred from sequence or structural similarity. Source: UniProtKB integral to Golgi membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	flavin-linked sulfhydryl oxidase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 30	30	Potential
	Chain	31 – 613	583	Sulfhydryl oxidase 1		PRO_0000249536
Regions
	Domain	37 – 157	121	Thioredoxin
	Domain	397 – 504	108	ERV/ALR sulfhydryl oxidase
Amino acid modifications
	Glycosylation	131	1	N-linked (GlcNAc...) Potential
	Glycosylation	244	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O08841-1 [UniParc]. Last modified March 1, 2001. Version 2. Checksum: 34105EF608CA7B55	FASTA	613	68,595
	10 20 30 40 50 60 MTGCGRRSGW LPPLRLLLLP LLLGGPGVGA AQLAALYSAS DPLTLLQADT VRSTVLNSPS 70 80 90 100 110 120 AWAVEFFASW CGHCIAFAPT WKALAKDIKD WRPALNLAAL NCADETNNAV CRDFNIAGFP 130 140 150 160 170 180 SVRFFKAFSK NSTGTTLPVA GANVQMLRER LIDALESHHD TWPSACPPLE PVKPKEIDTF 190 200 210 220 230 240 FARNNQEYLV LIFEQENSYL GREVTLDLSQ HHDLVVRRVL STEANVVRKF GVADFPSCYL 250 260 270 280 290 300 LFRNGSVSRV PVLVESRRFY TAYLQRLSEV TREGTPTPAV PTISDQIAPT VWKFADRSKI 310 320 330 340 350 360 YMADLESALH YILRVEVGRF SVLEGQRLMA LKKFVTVLTK YFPGQPLVRN FLQSTNEWLK 370 380 390 400 410 420 RQHKKKMPYS FFKTAMDSRN EEAVITKEVN WVGCQGSESH FRGFPCSLWI LFHFLTVQAS 430 440 450 460 470 480 QKNAESSQKP ANGQEVLQAI RNYVRFFFGC RDCANHFEQM AAGSMHRVKS PNDAVLWLWT 490 500 510 520 530 540 SHNRVNARLA GAPSEDPQFP KVQWPPPELC SACHNELSGE PVWDVDATLR FLKTHFSPSN 550 560 570 580 590 600 IVLNFPPAEP ASRSSVHSWG ATPHLELDAL GLVTRNSALA LERAEISESP GSNAMPNIPA 610 ERPELFEALS HSR

References

[1]

"Identification and expression of a new sulfhydryl oxidase SOx-3 during the cell cycle and the estrus cycle in uterine cells." Musard J.-F., Sallot M., Dulieu P., Fraichard A., Ordener C., Remy-Martin J.-P., Jouvenot M., Adami P. Biochem. Biophys. Res. Commun. 287:83-91(2001) [PubMed: 11549257] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, FUNCTION, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U82982 mRNA. Translation: AAB58401.2.
PIR	JC7762.
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSCPOG00000002191. Cavia porcellus. [Contig view]
Phylogenomic databases
HOVERGEN	O08841.
Enzyme and pathway databases
BRENDA	1.8.3.2. 44.
Family and domain databases
InterPro	IPR017905. ERV/ALR_sulphydryl_oxidase. IPR006863. Evr1_Alr. IPR017936. Thioredoxin-like. IPR013766. Thioredoxin_domain. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:1.20.120.310. Evr1_Alr. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF04777. Evr1_Alr. 1 hit. PF00085. Thioredoxin. 1 hit. [Graphical view]
PROSITE	PS51324. ERV_ALR. 1 hit. PS51352. THIOREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

QSOX1_CAVPO

Accession

Primary (citable) accession number: O08841

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	March 1, 2001
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)