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Protein

Immunoglobulin-binding protein 1

Gene

Igbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein phosphatase 2A binding Source: RGD
  • protein phosphatase type 2A regulator activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

B-cell activation

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin-binding protein 1
Alternative name(s):
Alpha4 phosphoprotein
CD79a-binding protein 1
Protein phosphatase 2/4/6 regulatory subunit
Gene namesi
Name:Igbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi62011. Igbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Immunoglobulin-binding protein 1PRO_0000218620Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylated.
Monoubiquitination by MID1 triggers calpain-mediated cleavage and switches IGBP1 activity from protective to destructive.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei256 – 2572Cleavage; by calpainBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO08836.
PRIDEiO08836.

PTM databases

PhosphoSiteiO08836.

Expressioni

Gene expression databases

GenevisibleiO08836. RN.

Interactioni

Subunit structurei

Interacts with partially folded PPP2CA, but not with the fully active protein. Interacts with PPP2CB, and with PP4 and PP6. Interacts with MID1 and MID2. Interacts with ubiquitin (By similarity).By similarity

GO - Molecular functioni

  • protein complex binding Source: RGD
  • protein phosphatase 2A binding Source: RGD

Protein-protein interaction databases

BioGridi248646. 3 interactions.
STRINGi10116.ENSRNOP00000054708.

Structurei

3D structure databases

ProteinModelPortaliO08836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 6115UIMCuratedAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni99 – 203105Interaction with PPP2CABy similarityAdd
BLAST
Regioni226 – 29166Interaction with MID1By similarityAdd
BLAST

Domaini

The UIM domain is required for protective effect on PP2A.By similarity

Sequence similaritiesi

Belongs to the IGBP1/TAP42 family.Curated

Phylogenomic databases

eggNOGiKOG2830. Eukaryota.
ENOG41110HD. LUCA.
GeneTreeiENSGT00390000002414.
HOVERGENiHBG052090.
InParanoidiO08836.
KOiK17606.
OMAiGKIANYR.
OrthoDBiEOG7992R2.
PhylomeDBiO08836.

Family and domain databases

InterProiIPR007304. TAP42-like.
[Graphical view]
PANTHERiPTHR10933. PTHR10933. 1 hit.
PfamiPF04177. TAP42. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASEEELLL PRLPELFETS KKLLEELEVA TEPTGSRTIQ DKVSKGLELL
60 70 80 90 100
EKAAGMLSQL DLFSRNEDLE EIASIDLKYL MVPALQGALT MKQVNPSKRL
110 120 130 140 150
DHLQRAREHF IHFLTQCHCY HVAEFQLPQT KNNSAENNTA RSSMAYPNLV
160 170 180 190 200
AMASQRQAKI ERYKQKKEVE HRLSALKSAV ESGQADDERV REYYLLHLRR
210 220 230 240 250
WIGISLEEIE SIDQEIKILK DKDSPREESA CQSSLPEKPP MKPFILTRNK
260 270 280 290 300
AQAKVFGTGY PSLATMTVSD WYEQHQKYGA LPDRGIAKPP SADFQRAAQQ
310 320 330 340
QEDQEQKDEE NEEKALHRMR EWDDWKDTHP RGYGNRQNMG
Length:340
Mass (Da):39,135
Last modified:May 1, 2000 - v2
Checksum:i391487769DE8E554
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000577 mRNA. Translation: AAD05364.2.
BC068202 mRNA. Translation: AAH68202.1.
RefSeqiNP_113812.1. NM_031624.3.
UniGeneiRn.7079.

Genome annotation databases

EnsembliENSRNOT00000057900; ENSRNOP00000054708; ENSRNOG00000026267.
GeneIDi58845.
KEGGirno:58845.
UCSCiRGD:62011. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000577 mRNA. Translation: AAD05364.2.
BC068202 mRNA. Translation: AAH68202.1.
RefSeqiNP_113812.1. NM_031624.3.
UniGeneiRn.7079.

3D structure databases

ProteinModelPortaliO08836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248646. 3 interactions.
STRINGi10116.ENSRNOP00000054708.

PTM databases

PhosphoSiteiO08836.

Proteomic databases

PaxDbiO08836.
PRIDEiO08836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000057900; ENSRNOP00000054708; ENSRNOG00000026267.
GeneIDi58845.
KEGGirno:58845.
UCSCiRGD:62011. rat.

Organism-specific databases

CTDi3476.
RGDi62011. Igbp1.

Phylogenomic databases

eggNOGiKOG2830. Eukaryota.
ENOG41110HD. LUCA.
GeneTreeiENSGT00390000002414.
HOVERGENiHBG052090.
InParanoidiO08836.
KOiK17606.
OMAiGKIANYR.
OrthoDBiEOG7992R2.
PhylomeDBiO08836.

Miscellaneous databases

PROiO08836.

Gene expression databases

GenevisibleiO08836. RN.

Family and domain databases

InterProiIPR007304. TAP42-like.
[Graphical view]
PANTHERiPTHR10933. PTHR10933. 1 hit.
PfamiPF04177. TAP42. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of elongation factor-2, alpha4 phosphoprotein and Cdc5-like protein in prolactin-dependent/independent rat lymphoid cells."
    Too C.K.
    Mol. Cell. Endocrinol. 131:221-232(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Noble.
    Tissue: T-cell lymphoma.
  2. Too C.K.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiIGBP1_RAT
AccessioniPrimary (citable) accession number: O08836
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: July 6, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.