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Protein

Synaptotagmin-11

Gene

Syt11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Calcium 1By similarity
Metal bindingi187 – 1871Calcium 2By similarity
Metal bindingi194 – 1941Calcium 1By similarity
Metal bindingi248 – 2481Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi249 – 2491Calcium 1By similarity
Metal bindingi249 – 2491Calcium 2By similarity
Metal bindingi249 – 2491Calcium 3By similarity
Metal bindingi252 – 2521Calcium 3By similarity
Metal bindingi255 – 2551Calcium 2By similarity
Metal bindingi255 – 2551Calcium 3By similarity

GO - Molecular functioni

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
  • negative regulation of clathrin-mediated endocytosis Source: ParkinsonsUK-UCL
  • negative regulation of membrane invagination Source: ParkinsonsUK-UCL
  • negative regulation of synaptic vesicle endocytosis Source: ParkinsonsUK-UCL
  • vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-11
Alternative name(s):
Synaptotagmin XI
Short name:
SytXI
Gene namesi
Name:Syt11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi62042. Syt11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515VesicularSequence analysisAdd
BLAST
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Topological domaini37 – 430394CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon Source: ParkinsonsUK-UCL
  • cell body Source: ParkinsonsUK-UCL
  • cell junction Source: UniProtKB-KW
  • dendritic spine Source: ParkinsonsUK-UCL
  • excitatory synapse Source: ParkinsonsUK-UCL
  • inhibitory synapse Source: ParkinsonsUK-UCL
  • integral component of plasma membrane Source: Ensembl
  • plasma membrane Source: GO_Central
  • postsynaptic density Source: ParkinsonsUK-UCL
  • presynapse Source: ParkinsonsUK-UCL
  • presynaptic active zone membrane Source: ParkinsonsUK-UCL
  • synaptic vesicle Source: ParkinsonsUK-UCL
  • synaptic vesicle membrane Source: UniProtKB-SubCell
  • vesicle Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Synaptotagmin-11PRO_0000183971Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei133 – 1331PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated and targeted to the proteasome complex for degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiO08835.
PRIDEiO08835.

PTM databases

iPTMnetiO08835.
PhosphoSiteiO08835.

Expressioni

Tissue specificityi

Highly expressed in brain and at lower levels in other tissues.

Gene expression databases

ExpressionAtlasiO08835. baseline and differential.
GenevisibleiO08835. RN.

Interactioni

Subunit structurei

Homodimer. Can also form heterodimers. Interacts with PARK2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi248858. 1 interaction.
STRINGi10116.ENSRNOP00000027474.

Structurei

3D structure databases

ProteinModelPortaliO08835.
SMRiO08835. Positions 159-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini158 – 261104C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini292 – 396105C2 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated
Contains 2 C2 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiO08835.
PhylomeDBiO08835.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEITNIRPS FDVSPVAAGL IGASVLVVCV SVTVFVWTCC HQQAEKKHKT
60 70 80 90 100
PPYKFIHMLK GISIYPETLS NKKKIIKVRR DKDGSHRESG RGNLLVNAES
110 120 130 140 150
GLLSHDRDPR GPSPASCIDQ LPIKRDYGEE LRSPMTSLTP GESKPTSPSS
160 170 180 190 200
PEEDVMLGSL TFSVDYNFPK KALVVTIQEA HGLPVMDGQT QGSDPYIKMT
210 220 230 240 250
ILPDKRHRVK TRVLRKTLDP VFDETFTFYG IPYSQLQDLV LHFLVLSFDR
260 270 280 290 300
FSRDDVIGEV MVPLAGVDPS TGKVQLTRDI IKRNIQKCIS RGELQVSLSY
310 320 330 340 350
QPVAQRMTVV VLKARHLPKM DITGLSGNPY VKVNVYYGRK RIAKKKTHVK
360 370 380 390 400
KCTLNPIFNE SFIYDIPTDL LPDISIEFLV IDFDRTTKNE VVGRLILGAH
410 420 430
SVTTSGAEHW REVCESPRKP VAKWHSLSEY
Length:430
Mass (Da):48,268
Last modified:July 11, 2003 - v2
Checksum:iFEEB06702BAC2AFB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741K → E in AAB58344 (PubMed:9162066).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000423 mRNA. Translation: AAB58344.1.
AF375465 mRNA. Translation: AAK56960.1.
RefSeqiXP_006232810.1. XM_006232748.1.
UniGeneiRn.9805.

Genome annotation databases

EnsembliENSRNOT00000027474; ENSRNOP00000027474; ENSRNOG00000020279.
GeneIDi60568.
UCSCiRGD:62042. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000423 mRNA. Translation: AAB58344.1.
AF375465 mRNA. Translation: AAK56960.1.
RefSeqiXP_006232810.1. XM_006232748.1.
UniGeneiRn.9805.

3D structure databases

ProteinModelPortaliO08835.
SMRiO08835. Positions 159-281.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248858. 1 interaction.
STRINGi10116.ENSRNOP00000027474.

PTM databases

iPTMnetiO08835.
PhosphoSiteiO08835.

Proteomic databases

PaxDbiO08835.
PRIDEiO08835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027474; ENSRNOP00000027474; ENSRNOG00000020279.
GeneIDi60568.
UCSCiRGD:62042. rat.

Organism-specific databases

CTDi23208.
RGDi62042. Syt11.

Phylogenomic databases

eggNOGiKOG1028. Eukaryota.
ENOG410XRME. LUCA.
GeneTreeiENSGT00760000118973.
HOGENOMiHOG000232126.
HOVERGENiHBG005010.
InParanoidiO08835.
PhylomeDBiO08835.

Miscellaneous databases

PROiO08835.

Gene expression databases

ExpressionAtlasiO08835. baseline and differential.
GenevisibleiO08835. RN.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028699. SYT11.
[Graphical view]
PANTHERiPTHR10024:SF115. PTHR10024:SF115. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
PROSITEiPS50004. C2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding."
    von Poser C., Ichtchenko K., Shao X., Rizo J., Suedhof T.C.
    J. Biol. Chem. 272:14314-14319(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. Shin O.-H., von Poser C., Ichtchenko K., Shao X., Rizo J., Suedhof T.C.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSYT11_RAT
AccessioniPrimary (citable) accession number: O08835
Secondary accession number(s): Q925B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 11, 2003
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.