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Protein

Cationic amino acid transporter 3

Gene

Slc7a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • arginine transmembrane transporter activity Source: RGD
  • basic amino acid transmembrane transporter activity Source: RGD
  • L-lysine transmembrane transporter activity Source: RGD
  • L-ornithine transmembrane transporter activity Source: RGD

GO - Biological processi

  • arginine transport Source: RGD
  • L-arginine import across plasma membrane Source: GO_Central
  • L-lysine transmembrane transport Source: GOC
  • L-ornithine transmembrane transport Source: GOC
  • lysine transport Source: RGD
  • ornithine transport Source: RGD
  • regulation of TOR signaling Source: RGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68342. Slc7a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini58 – 614ExtracellularSequence Analysis
Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini83 – 10725CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini129 – 16234ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini184 – 1918CytoplasmicSequence Analysis
Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini213 – 24432ExtracellularSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 28520CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini307 – 33529ExtracellularSequence AnalysisAdd
BLAST
Transmembranei336 – 35621Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini357 – 38226CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei383 – 40321Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini404 – 4063ExtracellularSequence Analysis
Transmembranei407 – 42721Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini428 – 47548CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei476 – 49621Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini497 – 50711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei508 – 52821Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini529 – 54012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei541 – 56121Helical; Name=13Sequence AnalysisAdd
BLAST
Topological domaini562 – 5698ExtracellularSequence Analysis
Transmembranei570 – 59021Helical; Name=14Sequence AnalysisAdd
BLAST
Topological domaini591 – 61929CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Cationic amino acid transporter 3PRO_0000054268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
Modified residuei606 – 6061PhosphothreonineBy similarity
Modified residuei618 – 6181PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Gene expression databases

GenevisibleiO08812. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005580.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiO08812.
KOiK13865.
PhylomeDBiO08812.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

O08812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWQALRRFG QKLVRRRLLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKE KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISQTLKG
160 170 180 190 200
TILLNMPHVL AEYPDFFALA LVLLLTGLLV LGANESGLVT KVFTGMNLLV
210 220 230 240 250
LGFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSICFLAYF
310 320 330 340 350
GVSSALTLMM PYYKLQPESP LPEAFTYVGW EPARYLVAIG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVI YAMAEDGLLF RVLARVHNGT HTPIVATVVS GVIAAFMAFL
410 420 430 440 450
FELTDLVDLM SIGTLLAYSL VSICVLILRY QPDQEMKNGE EEVELQEERT
460 470 480 490 500
LEAEKLTVQA LFCQVDSIPT LLSGRIVYVC SSLLAVLLTV LCLVLTWWTT
510 520 530 540 550
PLHSGDPVWV TVVVLILGLI LGISGVIWRQ PQNRTPLHFK VPVVPLLPLV
560 570 580 590 600
SIFVNVYLMM QMTADTWARF GVWMLIGFAI YFGYGIQHSV EEVKNHQTLP
610
KTRPQTIDLD LTTSCVHSI
Length:619
Mass (Da):67,525
Last modified:July 1, 1997 - v1
Checksum:i07448958386AB9EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000113 mRNA. Translation: BAA20133.1.
RefSeqiNP_058913.1. NM_017217.1.
UniGeneiRn.9804.

Genome annotation databases

GeneIDi29485.
KEGGirno:29485.
UCSCiRGD:68342. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000113 mRNA. Translation: BAA20133.1.
RefSeqiNP_058913.1. NM_017217.1.
UniGeneiRn.9804.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005580.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29485.
KEGGirno:29485.
UCSCiRGD:68342. rat.

Organism-specific databases

CTDi84889.
RGDi68342. Slc7a3.

Phylogenomic databases

eggNOGiCOG0531.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiO08812.
KOiK13865.
PhylomeDBiO08812.

Miscellaneous databases

NextBioi609350.
PROiO08812.

Gene expression databases

GenevisibleiO08812. RN.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a brain-specific cationic amino acid transporter."
    Hosokawa H., Sawamura T., Kobayashi S., Ninomiya H., Miwa S., Masaki T.
    J. Biol. Chem. 272:8717-8722(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiCTR3_RAT
AccessioniPrimary (citable) accession number: O08812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: July 1, 1997
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.