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Protein

Cationic amino acid transporter 3

Gene

Slc7a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

GO - Molecular functioni

  • antiporter activity Source: GO_Central
  • arginine transmembrane transporter activity Source: RGD
  • basic amino acid transmembrane transporter activity Source: RGD
  • L-lysine transmembrane transporter activity Source: RGD
  • L-ornithine transmembrane transporter activity Source: RGD

GO - Biological processi

  • arginine transport Source: RGD
  • lysine transport Source: RGD
  • ornithine transport Source: RGD
  • regulation of TOR signaling Source: RGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cationic amino acid transporter 3
Short name:
CAT-3
Short name:
CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene namesi
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68342. Slc7a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 57Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini58 – 61ExtracellularSequence analysis4
Transmembranei62 – 82Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini83 – 107CytoplasmicSequence analysisAdd BLAST25
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 162ExtracellularSequence analysisAdd BLAST34
Transmembranei163 – 183Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini184 – 191CytoplasmicSequence analysis8
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 244ExtracellularSequence analysisAdd BLAST32
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 285CytoplasmicSequence analysisAdd BLAST20
Transmembranei286 – 306Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini307 – 335ExtracellularSequence analysisAdd BLAST29
Transmembranei336 – 356Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini357 – 382CytoplasmicSequence analysisAdd BLAST26
Transmembranei383 – 403Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini404 – 406ExtracellularSequence analysis3
Transmembranei407 – 427Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini428 – 475CytoplasmicSequence analysisAdd BLAST48
Transmembranei476 – 496Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini497 – 507ExtracellularSequence analysisAdd BLAST11
Transmembranei508 – 528Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini529 – 540CytoplasmicSequence analysisAdd BLAST12
Transmembranei541 – 561Helical; Name=13Sequence analysisAdd BLAST21
Topological domaini562 – 569ExtracellularSequence analysis8
Transmembranei570 – 590Helical; Name=14Sequence analysisAdd BLAST21
Topological domaini591 – 619CytoplasmicSequence analysisAdd BLAST29

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000542681 – 619Cationic amino acid transporter 3Add BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Modified residuei606PhosphothreonineBy similarity1
Modified residuei618PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO08812.

Expressioni

Tissue specificityi

Highly expressed in brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005580.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiO08812.
KOiK13865.
PhylomeDBiO08812.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PTHR11785:SF209. PTHR11785:SF209. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.

Sequencei

Sequence statusi: Complete.

O08812-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWQALRRFG QKLVRRRLLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV
60 70 80 90 100
YVLAGEVAKE KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY
110 120 130 140 150
SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISQTLKG
160 170 180 190 200
TILLNMPHVL AEYPDFFALA LVLLLTGLLV LGANESGLVT KVFTGMNLLV
210 220 230 240 250
LGFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL
260 270 280 290 300
EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSICFLAYF
310 320 330 340 350
GVSSALTLMM PYYKLQPESP LPEAFTYVGW EPARYLVAIG SLCALSTSLL
360 370 380 390 400
GSMFPMPRVI YAMAEDGLLF RVLARVHNGT HTPIVATVVS GVIAAFMAFL
410 420 430 440 450
FELTDLVDLM SIGTLLAYSL VSICVLILRY QPDQEMKNGE EEVELQEERT
460 470 480 490 500
LEAEKLTVQA LFCQVDSIPT LLSGRIVYVC SSLLAVLLTV LCLVLTWWTT
510 520 530 540 550
PLHSGDPVWV TVVVLILGLI LGISGVIWRQ PQNRTPLHFK VPVVPLLPLV
560 570 580 590 600
SIFVNVYLMM QMTADTWARF GVWMLIGFAI YFGYGIQHSV EEVKNHQTLP
610
KTRPQTIDLD LTTSCVHSI
Length:619
Mass (Da):67,525
Last modified:July 1, 1997 - v1
Checksum:i07448958386AB9EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000113 mRNA. Translation: BAA20133.1.
RefSeqiNP_058913.1. NM_017217.1.
UniGeneiRn.9804.

Genome annotation databases

GeneIDi29485.
KEGGirno:29485.
UCSCiRGD:68342. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000113 mRNA. Translation: BAA20133.1.
RefSeqiNP_058913.1. NM_017217.1.
UniGeneiRn.9804.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005580.

Proteomic databases

PaxDbiO08812.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29485.
KEGGirno:29485.
UCSCiRGD:68342. rat.

Organism-specific databases

CTDi84889.
RGDi68342. Slc7a3.

Phylogenomic databases

eggNOGiKOG1286. Eukaryota.
COG0531. LUCA.
HOGENOMiHOG000250623.
HOVERGENiHBG000280.
InParanoidiO08812.
KOiK13865.
PhylomeDBiO08812.

Miscellaneous databases

PROiO08812.

Family and domain databases

InterProiIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERiPTHR11785. PTHR11785. 3 hits.
PTHR11785:SF209. PTHR11785:SF209. 3 hits.
PfamiPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00906. 2A0303. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCTR3_RAT
AccessioniPrimary (citable) accession number: O08812
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.