Cationic amino acid transporter 3 - Rattus norvegicus (Rat)

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O08812 (CTR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 88. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cationic amino acid transporter 3
Short name=CAT-3
Short name=CAT3

Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3

Gene names

Name:	Slc7a3
Synonyms:	Atrc3, Cat3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	619 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Ref.1
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Highly expressed in brain. Ref.1
Sequence similarities	Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Ontologies

Keywords
Biological process	Amino-acid transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of TOR signaling cascade Inferred from mutant phenotype PubMed 17234578. Source: RGD
Cellular_component	integral to membrane Inferred by curator Ref.1. Source: RGD plasma membrane Inferred from direct assay PubMed 17234578. Source: RGD
Molecular_function	L-lysine transmembrane transporter activity Inferred from direct assay Ref.1. Source: RGD L-ornithine transmembrane transporter activity Inferred from direct assay Ref.1. Source: RGD arginine transmembrane transporter activity Inferred from direct assay PubMed 17234578 Ref.1. Source: RGD cationic amino acid transmembrane transporter activity Inferred from direct assay Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 619

619

Cationic amino acid transporter 3

PRO_0000054268

Regions

Topological domain

1 – 36

Cytoplasmic Potential

Transmembrane

37 – 57

Helical; Name=1; Potential

Topological domain

58 – 61

Extracellular Potential

Transmembrane

62 – 82

Helical; Name=2; Potential

Topological domain

83 – 107

Cytoplasmic Potential

Transmembrane

108 – 128

Helical; Name=3; Potential

Topological domain

129 – 162

Extracellular Potential

Transmembrane

163 – 183

Helical; Name=4; Potential

Topological domain

184 – 191

Cytoplasmic Potential

Transmembrane

192 – 212

Helical; Name=5; Potential

Topological domain

213 – 244

Extracellular Potential

Transmembrane

245 – 265

Helical; Name=6; Potential

Topological domain

266 – 285

Cytoplasmic Potential

Transmembrane

286 – 306

Helical; Name=7; Potential

Topological domain

307 – 335

Extracellular Potential

Transmembrane

336 – 356

Helical; Name=8; Potential

Topological domain

357 – 382

Cytoplasmic Potential

Transmembrane

383 – 403

Helical; Name=9; Potential

Topological domain

404 – 406

Extracellular Potential

Transmembrane

407 – 427

Helical; Name=10; Potential

Topological domain

428 – 475

Cytoplasmic Potential

Transmembrane

476 – 496

Helical; Name=11; Potential

Topological domain

497 – 507

Extracellular Potential

Transmembrane

508 – 528

Helical; Name=12; Potential

Topological domain

529 – 540

Cytoplasmic Potential

Transmembrane

541 – 561

Helical; Name=13; Potential

Topological domain

562 – 569

Extracellular Potential

Transmembrane

570 – 590

Helical; Name=14; Potential

Topological domain

591 – 619

Cytoplasmic Potential

Amino acid modifications

Modified residue

606

Phosphothreonine By similarity

Modified residue

618

Phosphoserine By similarity

Glycosylation

232

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

O08812 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 07448958386AB9EE
Show »

FASTA

619

67,525

        10         20         30         40         50         60 
MLWQALRRFG QKLVRRRLLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKE 

        70         80         90        100        110        120 
KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY SYVTVGELWA FTTGWNLILS 

       130        140        150        160        170        180 
YVIGTASVAR AWSSAFDNLI GNHISQTLKG TILLNMPHVL AEYPDFFALA LVLLLTGLLV 

       190        200        210        220        230        240 
LGANESGLVT KVFTGMNLLV LGFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM 

       250        260        270        280        290        300 
GSGGFMPFGL EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSICFLAYF 

       310        320        330        340        350        360 
GVSSALTLMM PYYKLQPESP LPEAFTYVGW EPARYLVAIG SLCALSTSLL GSMFPMPRVI 

       370        380        390        400        410        420 
YAMAEDGLLF RVLARVHNGT HTPIVATVVS GVIAAFMAFL FELTDLVDLM SIGTLLAYSL 

       430        440        450        460        470        480 
VSICVLILRY QPDQEMKNGE EEVELQEERT LEAEKLTVQA LFCQVDSIPT LLSGRIVYVC 

       490        500        510        520        530        540 
SSLLAVLLTV LCLVLTWWTT PLHSGDPVWV TVVVLILGLI LGISGVIWRQ PQNRTPLHFK 

       550        560        570        580        590        600 
VPVVPLLPLV SIFVNVYLMM QMTADTWARF GVWMLIGFAI YFGYGIQHSV EEVKNHQTLP 

       610 
KTRPQTIDLD LTTSCVHSI

« Hide

References

[1]	"Cloning and characterization of a brain-specific cationic amino acid transporter." Hosokawa H., Sawamura T., Kobayashi S., Ninomiya H., Miwa S., Masaki T. J. Biol. Chem. 272:8717-8722(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Strain: Wistar. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB000113 mRNA. Translation: BAA20133.1.
IPI	IPI00196436.
RefSeq	NP_058913.1. NM_017217.1.
UniGene	Rn.9804.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000005580.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	29485.
KEGG	rno:29485.
UCSC	RGD:68342. rat.
Organism-specific databases
CTD	84889.
RGD	68342. Slc7a3.
Phylogenomic databases
eggNOG	COG0531.
HOGENOM	HOG000250623.
HOVERGEN	HBG000280.
InParanoid	O08812.
KO	K13865.
OrthoDB	EOG45DWP8.
Gene expression databases
Genevestigator	O08812.
GermOnline	ENSRNOG00000004133. Rattus norvegicus.
Family and domain databases
InterPro	IPR002293. AA/rel_permease1. IPR015606. Cat-AATrans. IPR004755. Cat_AA_permease. [Graphical view]
PANTHER	PTHR11785. PTHR11785. 1 hit. PTHR11785:SF53. PTHR11785:SF53. 1 hit.
PIRSF	PIRSF006060. AA_transporter. 1 hit.
TIGRFAMs	TIGR00906. 2A0303. 1 hit.
ProtoNet	Search...
Other
NextBio	609350.

Entry information

Entry name

CTR3_RAT

Accession

Primary (citable) accession number: O08812

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 16, 2004
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents