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O08812

- CTR3_RAT

UniProt

O08812 - CTR3_RAT

Protein

Cationic amino acid transporter 3

Gene

Slc7a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner.1 Publication

    GO - Molecular functioni

    1. arginine transmembrane transporter activity Source: RGD
    2. L-lysine transmembrane transporter activity Source: RGD
    3. L-ornithine transmembrane transporter activity Source: RGD

    GO - Biological processi

    1. arginine transport Source: RGD
    2. lysine transport Source: RGD
    3. ornithine transport Source: RGD
    4. regulation of TOR signaling Source: RGD

    Keywords - Biological processi

    Amino-acid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cationic amino acid transporter 3
    Short name:
    CAT-3
    Short name:
    CAT3
    Alternative name(s):
    Cationic amino acid transporter y+
    Solute carrier family 7 member 3
    Gene namesi
    Name:Slc7a3
    Synonyms:Atrc3, Cat3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi68342. Slc7a3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619Cationic amino acid transporter 3PRO_0000054268Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Modified residuei606 – 6061PhosphothreonineBy similarity
    Modified residuei618 – 6181PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Expressioni

    Tissue specificityi

    Highly expressed in brain.1 Publication

    Gene expression databases

    GenevestigatoriO08812.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005580.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 614ExtracellularSequence Analysis
    Topological domaini83 – 10725CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini129 – 16234ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 1918CytoplasmicSequence Analysis
    Topological domaini213 – 24432ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini266 – 28520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini307 – 33529ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini357 – 38226CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini404 – 4063ExtracellularSequence Analysis
    Topological domaini428 – 47548CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini497 – 50711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini529 – 54012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini562 – 5698ExtracellularSequence Analysis
    Topological domaini591 – 61929CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei108 – 12821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei192 – 21221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30621Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei383 – 40321Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei476 – 49621Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei508 – 52821Helical; Name=12Sequence AnalysisAdd
    BLAST
    Transmembranei541 – 56121Helical; Name=13Sequence AnalysisAdd
    BLAST
    Transmembranei570 – 59021Helical; Name=14Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0531.
    HOGENOMiHOG000250623.
    HOVERGENiHBG000280.
    InParanoidiO08812.
    KOiK13865.
    PhylomeDBiO08812.

    Family and domain databases

    InterProiIPR002293. AA/rel_permease1.
    IPR015606. CAT3.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view]
    PANTHERiPTHR11785. PTHR11785. 1 hit.
    PTHR11785:SF209. PTHR11785:SF209. 1 hit.
    PfamiPF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsiTIGR00906. 2A0303. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O08812-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWQALRRFG QKLVRRRLLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV    50
    YVLAGEVAKE KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY 100
    SYVTVGELWA FTTGWNLILS YVIGTASVAR AWSSAFDNLI GNHISQTLKG 150
    TILLNMPHVL AEYPDFFALA LVLLLTGLLV LGANESGLVT KVFTGMNLLV 200
    LGFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM GSGGFMPFGL 250
    EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSICFLAYF 300
    GVSSALTLMM PYYKLQPESP LPEAFTYVGW EPARYLVAIG SLCALSTSLL 350
    GSMFPMPRVI YAMAEDGLLF RVLARVHNGT HTPIVATVVS GVIAAFMAFL 400
    FELTDLVDLM SIGTLLAYSL VSICVLILRY QPDQEMKNGE EEVELQEERT 450
    LEAEKLTVQA LFCQVDSIPT LLSGRIVYVC SSLLAVLLTV LCLVLTWWTT 500
    PLHSGDPVWV TVVVLILGLI LGISGVIWRQ PQNRTPLHFK VPVVPLLPLV 550
    SIFVNVYLMM QMTADTWARF GVWMLIGFAI YFGYGIQHSV EEVKNHQTLP 600
    KTRPQTIDLD LTTSCVHSI 619
    Length:619
    Mass (Da):67,525
    Last modified:July 1, 1997 - v1
    Checksum:i07448958386AB9EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000113 mRNA. Translation: BAA20133.1.
    RefSeqiNP_058913.1. NM_017217.1.
    UniGeneiRn.9804.

    Genome annotation databases

    GeneIDi29485.
    KEGGirno:29485.
    UCSCiRGD:68342. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB000113 mRNA. Translation: BAA20133.1 .
    RefSeqi NP_058913.1. NM_017217.1.
    UniGenei Rn.9804.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005580.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29485.
    KEGGi rno:29485.
    UCSCi RGD:68342. rat.

    Organism-specific databases

    CTDi 84889.
    RGDi 68342. Slc7a3.

    Phylogenomic databases

    eggNOGi COG0531.
    HOGENOMi HOG000250623.
    HOVERGENi HBG000280.
    InParanoidi O08812.
    KOi K13865.
    PhylomeDBi O08812.

    Miscellaneous databases

    NextBioi 609350.

    Gene expression databases

    Genevestigatori O08812.

    Family and domain databases

    InterProi IPR002293. AA/rel_permease1.
    IPR015606. CAT3.
    IPR004755. Cat_AA_permease.
    IPR029485. CAT_C.
    [Graphical view ]
    PANTHERi PTHR11785. PTHR11785. 1 hit.
    PTHR11785:SF209. PTHR11785:SF209. 1 hit.
    Pfami PF13520. AA_permease_2. 1 hit.
    PF13906. AA_permease_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006060. AA_transporter. 1 hit.
    TIGRFAMsi TIGR00906. 2A0303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a brain-specific cationic amino acid transporter."
      Hosokawa H., Sawamura T., Kobayashi S., Ninomiya H., Miwa S., Masaki T.
      J. Biol. Chem. 272:8717-8722(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiCTR3_RAT
    AccessioniPrimary (citable) accession number: O08812
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3