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O08812 (CTR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cationic amino acid transporter 3

Short name=CAT-3
Short name=CAT3
Alternative name(s):
Cationic amino acid transporter y+
Solute carrier family 7 member 3
Gene names
Name:Slc7a3
Synonyms:Atrc3, Cat3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Highly expressed in brain. Ref.1

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619Cationic amino acid transporter 3
PRO_0000054268

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Name=1; Potential
Topological domain58 – 614Extracellular Potential
Transmembrane62 – 8221Helical; Name=2; Potential
Topological domain83 – 10725Cytoplasmic Potential
Transmembrane108 – 12821Helical; Name=3; Potential
Topological domain129 – 16234Extracellular Potential
Transmembrane163 – 18321Helical; Name=4; Potential
Topological domain184 – 1918Cytoplasmic Potential
Transmembrane192 – 21221Helical; Name=5; Potential
Topological domain213 – 24432Extracellular Potential
Transmembrane245 – 26521Helical; Name=6; Potential
Topological domain266 – 28520Cytoplasmic Potential
Transmembrane286 – 30621Helical; Name=7; Potential
Topological domain307 – 33529Extracellular Potential
Transmembrane336 – 35621Helical; Name=8; Potential
Topological domain357 – 38226Cytoplasmic Potential
Transmembrane383 – 40321Helical; Name=9; Potential
Topological domain404 – 4063Extracellular Potential
Transmembrane407 – 42721Helical; Name=10; Potential
Topological domain428 – 47548Cytoplasmic Potential
Transmembrane476 – 49621Helical; Name=11; Potential
Topological domain497 – 50711Extracellular Potential
Transmembrane508 – 52821Helical; Name=12; Potential
Topological domain529 – 54012Cytoplasmic Potential
Transmembrane541 – 56121Helical; Name=13; Potential
Topological domain562 – 5698Extracellular Potential
Transmembrane570 – 59021Helical; Name=14; Potential
Topological domain591 – 61929Cytoplasmic Potential

Amino acid modifications

Modified residue6061Phosphothreonine By similarity
Modified residue6181Phosphoserine By similarity
Glycosylation2321N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O08812 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 07448958386AB9EE

FASTA61967,525
        10         20         30         40         50         60 
MLWQALRRFG QKLVRRRLLE LGMGETRLAR CLSTLDLVAL GVGSTLGAGV YVLAGEVAKE 

        70         80         90        100        110        120 
KAGPSIVICF LVAALSSVLA GLCYAEFGAR VPGSGSAYLY SYVTVGELWA FTTGWNLILS 

       130        140        150        160        170        180 
YVIGTASVAR AWSSAFDNLI GNHISQTLKG TILLNMPHVL AEYPDFFALA LVLLLTGLLV 

       190        200        210        220        230        240 
LGANESGLVT KVFTGMNLLV LGFVIISGFI KGELRNWKLT KEDYCLTMSE SNGTCSLDSM 

       250        260        270        280        290        300 
GSGGFMPFGL EGILRGAATC FYAFVGFDCI ATTGEEAQNP QRSIPMGIVI SLSICFLAYF 

       310        320        330        340        350        360 
GVSSALTLMM PYYKLQPESP LPEAFTYVGW EPARYLVAIG SLCALSTSLL GSMFPMPRVI 

       370        380        390        400        410        420 
YAMAEDGLLF RVLARVHNGT HTPIVATVVS GVIAAFMAFL FELTDLVDLM SIGTLLAYSL 

       430        440        450        460        470        480 
VSICVLILRY QPDQEMKNGE EEVELQEERT LEAEKLTVQA LFCQVDSIPT LLSGRIVYVC 

       490        500        510        520        530        540 
SSLLAVLLTV LCLVLTWWTT PLHSGDPVWV TVVVLILGLI LGISGVIWRQ PQNRTPLHFK 

       550        560        570        580        590        600 
VPVVPLLPLV SIFVNVYLMM QMTADTWARF GVWMLIGFAI YFGYGIQHSV EEVKNHQTLP 

       610 
KTRPQTIDLD LTTSCVHSI 

« Hide

References

[1]"Cloning and characterization of a brain-specific cationic amino acid transporter."
Hosokawa H., Sawamura T., Kobayashi S., Ninomiya H., Miwa S., Masaki T.
J. Biol. Chem. 272:8717-8722(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: Wistar.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB000113 mRNA. Translation: BAA20133.1.
RefSeqNP_058913.1. NM_017217.1.
UniGeneRn.9804.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005580.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29485.
KEGGrno:29485.
UCSCRGD:68342. rat.

Organism-specific databases

CTD84889.
RGD68342. Slc7a3.

Phylogenomic databases

eggNOGCOG0531.
HOGENOMHOG000250623.
HOVERGENHBG000280.
InParanoidO08812.
KOK13865.
PhylomeDBO08812.

Gene expression databases

GenevestigatorO08812.

Family and domain databases

InterProIPR002293. AA/rel_permease1.
IPR015606. CAT3.
IPR004755. Cat_AA_permease.
IPR029485. CAT_C.
[Graphical view]
PANTHERPTHR11785. PTHR11785. 1 hit.
PTHR11785:SF209. PTHR11785:SF209. 1 hit.
PfamPF13520. AA_permease_2. 1 hit.
PF13906. AA_permease_C. 1 hit.
[Graphical view]
PIRSFPIRSF006060. AA_transporter. 1 hit.
TIGRFAMsTIGR00906. 2A0303. 1 hit.
ProtoNetSearch...

Other

NextBio609350.

Entry information

Entry nameCTR3_RAT
AccessionPrimary (citable) accession number: O08812
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families