O08807 (PRDX4_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 121.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Peroxiredoxin-4 EC=1.11.1.15 Alternative name(s): Antioxidant enzyme AOE372 Peroxiredoxin IV Short name=Prx-IV Thioredoxin peroxidase AO372 Thioredoxin-dependent peroxide reductase A0372 | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus![]() |
Protein attributes
| Sequence length | 274 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Probably involved in redox regulation of the cell. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. |
| Catalytic activity | 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
| Subunit structure | Homodimer or heterodimer with PRDX1; disulfide-linked, upon oxidation. |
| Subcellular location | |
| Miscellaneous | The active site is the redox-active Cys-127 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-248-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin By similarity. Irreversibly inactivated by overoxidation of Cys-127 (to Cys-SO3H) upon oxidative stress By similarity. |
| Sequence similarities | Belongs to the AhpC/TSA family. Contains 1 thioredoxin domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Secreted |
| Domain | Redox-active center Signal |
| Molecular function | Antioxidant Oxidoreductase Peroxidase |
| PTM | Disulfide bond |
| Technical term | Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | reactive oxygen species metabolic process Inferred from direct assay Ref.1. Source: MGI |
| Cellular_component | extracellular space Inferred from electronic annotation. Source: Compara mitochondrionInferred from direct assay PubMed 14651853. Source: MGI |
| Molecular_function | peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 40 | 40 | By similarity | ||||||
| Chain | 41 – 274 | 234 | Peroxiredoxin-4 | PRO_0000135099 | |||||
Regions | |||||||||
| Domain | 82 – 240 | 159 | Thioredoxin | ||||||
Sites | |||||||||
| Active site | 127 | 1 | Cysteine sulfenic acid (-SOH) intermediate By similarity | ||||||
Amino acid modifications | |||||||||
| Disulfide bond | 127 | Interchain (with C-248); in linked form By similarity | |||||||
| Disulfide bond | 248 | Interchain (with C-127); in linked form By similarity | |||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U96746 mRNA. Translation: AAB57846.1. AK005031 mRNA. Translation: BAB23758.1. AK146402 mRNA. Translation: BAE27143.1. AK152255 mRNA. Translation: BAE31074.1. BX005263 Genomic DNA. Translation: CAM23139.1. BC003349 mRNA. Translation: AAH03349.1. BC019578 mRNA. Translation: AAH19578.1. |
| IPI | IPI00116254. |
| RefSeq | NP_058044.1. NM_016764.4. |
| UniGene | Mm.247542. |
3D structure databases | |
| ProteinModelPortal | O08807. |
| SMR | O08807. Positions 77-272. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | O08807. 1 interaction. |
| STRING | 10090.ENSMUSP00000026328. |
Protein family/group databases | |
| PeroxiBase | 4532. Mm2CysPrx04. |
PTM databases | |
| PhosphoSite | O08807. |
2D gel databases | |
| REPRODUCTION-2DPAGE | O08807. |
Proteomic databases | |
| PaxDb | O08807. |
| PRIDE | O08807. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000026328; ENSMUSP00000026328; ENSMUSG00000025289. |
| GeneID | 53381. |
| KEGG | mmu:53381. |
| UCSC | uc009uru.1. mouse. |
Organism-specific databases | |
| CTD | 10549. |
| MGI | MGI:1859815. Prdx4. |
Phylogenomic databases | |
| eggNOG | COG0450. |
| GeneTree | ENSGT00390000004653. |
| HOGENOM | HOG000022343. |
| HOVERGEN | HBG000286. |
| InParanoid | B1AZS7. |
| KO | K03386. |
| OrthoDB | EOG4CC424. |
Gene expression databases | |
| ArrayExpress | O08807. |
| Bgee | O08807. |
| CleanEx | MM_PRDX4. |
| Genevestigator | O08807. |
| GermOnline | ENSMUSG00000025289. Mus musculus. |
Family and domain databases | |
| Gene3D | 3.40.30.10. 1 hit. |
| InterPro | IPR000866. AhpC/TSA. IPR024706. Peroxiredoxin_AhpC-typ. IPR019479. Peroxiredoxin_C. IPR012336. Thioredoxin-like_fold. [Graphical view] |
| Pfam | PF10417. 1-cysPrx_C. 1 hit. PF00578. AhpC-TSA. 1 hit. [Graphical view] |
| PIRSF | PIRSF000239. AHPC. 1 hit. |
| SUPFAM | SSF52833. Thiordxn-like_fd. 1 hit. |
| PROSITE | PS51352. THIOREDOXIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 310209. |
| SOURCE | Search... |
Entry information
| Entry name | PRDX4_MOUSE | ||||||||
| Accession | Primary (citable) accession number: O08807 Secondary accession number(s): B1AZS7, Q3U8E4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
