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Protein

Serpin B8

Gene

Serpinb8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei339 – 3402Reactive bondBy similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: MGI

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B8
Gene namesi
Name:Serpinb8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:894657. Serpinb8.

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. cytosol Source: MGI
  3. extracellular space Source: GO_Central
  4. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Serpin B8PRO_0000094112Add
BLAST

Proteomic databases

MaxQBiO08800.
PaxDbiO08800.
PRIDEiO08800.

PTM databases

PhosphoSiteiO08800.

Expressioni

Gene expression databases

BgeeiO08800.
ExpressionAtlasiO08800. baseline and differential.
GenevestigatoriO08800.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000514.

Structurei

3D structure databases

ProteinModelPortaliO08800.
SMRiO08800. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO08800.
KOiK13965.
OMAiSKISHKC.
OrthoDBiEOG7327PB.
PhylomeDBiO08800.
TreeFamiTF352619.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08800-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDLSEANGS FAISLLKILS EKDKSRNLFF CPMSVSSALA MVYLGAKGNT
60 70 80 90 100
ATQMSEVLGL SGNGDVHQSF QTLLAEINKT DTQYLLKSAC RLFGEESCDF
110 120 130 140 150
LSTFKESCHK FYQAGLEELS FAKDTEGCRK HINDWVSEKT EGKISEVLSP
160 170 180 190 200
GTVCPLTKLV LVNAMYFKGK WKAQFDRKYT RGMPFKTNQE KKTVQMMFKH
210 220 230 240 250
AKFKMGHVDE VNMQVLALPY AEEELSMVIL LPDESTDLAV VEKALTYEKL
260 270 280 290 300
RAWTNPETLT ESQVQVFLPR LKLEESYDLE TVLQNLGMTD AFEETRADFS
310 320 330 340 350
GMTTKKNVPV SKVAHKCFVE VNEEGTEAAA ATAVIRNARC CRTEPRFCAD
360 370
HPFLFFIWHH KTSSILFCGR FSSP
Length:374
Mass (Da):42,150
Last modified:December 1, 2001 - v2
Checksum:iF8B2ABB47AA47378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96703 mRNA. Translation: AAB57815.2.
AK036811 mRNA. Translation: BAC29588.1.
BC025121 mRNA. Translation: AAH25121.1.
CCDSiCCDS15220.1.
RefSeqiNP_035589.1. NM_011459.4.
UniGeneiMm.83909.

Genome annotation databases

EnsembliENSMUST00000000514; ENSMUSP00000000514; ENSMUSG00000026315.
ENSMUST00000112706; ENSMUSP00000108326; ENSMUSG00000026315.
GeneIDi20725.
KEGGimmu:20725.
UCSCiuc007chs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96703 mRNA. Translation: AAB57815.2.
AK036811 mRNA. Translation: BAC29588.1.
BC025121 mRNA. Translation: AAH25121.1.
CCDSiCCDS15220.1.
RefSeqiNP_035589.1. NM_011459.4.
UniGeneiMm.83909.

3D structure databases

ProteinModelPortaliO08800.
SMRiO08800. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000514.

Protein family/group databases

MEROPSiI04.013.

PTM databases

PhosphoSiteiO08800.

Proteomic databases

MaxQBiO08800.
PaxDbiO08800.
PRIDEiO08800.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000514; ENSMUSP00000000514; ENSMUSG00000026315.
ENSMUST00000112706; ENSMUSP00000108326; ENSMUSG00000026315.
GeneIDi20725.
KEGGimmu:20725.
UCSCiuc007chs.2. mouse.

Organism-specific databases

CTDi5271.
MGIiMGI:894657. Serpinb8.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO08800.
KOiK13965.
OMAiSKISHKC.
OrthoDBiEOG7327PB.
PhylomeDBiO08800.
TreeFamiTF352619.

Miscellaneous databases

NextBioi299329.
PROiO08800.
SOURCEiSearch...

Gene expression databases

BgeeiO08800.
ExpressionAtlasiO08800. baseline and differential.
GenevestigatoriO08800.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse."
    Kaiserman D., Knaggs S., Scarff K.L., Gillard A., Mirza G., Cadman M., McKeone R., Denny P., Cooley J., Benarafa C., Remold-O'Donnell E., Ragoussis J., Bird P.I.
    Genomics 79:349-362(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Vagina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSPB8_MOUSE
AccessioniPrimary (citable) accession number: O08800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.