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O08800

- SPB8_MOUSE

UniProt

O08800 - SPB8_MOUSE

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Protein

Serpin B8

Gene
Serpinb8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei339 – 3402Reactive bond By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. negative regulation of endopeptidase activity Source: RefGenome
  2. regulation of proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin B8
Gene namesi
Name:Serpinb8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:894657. Serpinb8.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytosol Source: Ensembl
  3. extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 374374Serpin B8PRO_0000094112Add
BLAST

Proteomic databases

MaxQBiO08800.
PaxDbiO08800.
PRIDEiO08800.

PTM databases

PhosphoSiteiO08800.

Expressioni

Gene expression databases

ArrayExpressiO08800.
BgeeiO08800.
GenevestigatoriO08800.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000514.

Structurei

3D structure databases

ProteinModelPortaliO08800.
SMRiO08800. Positions 1-374.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00740000114938.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO08800.
KOiK13965.
OMAiRNARCCR.
OrthoDBiEOG7327PB.
PhylomeDBiO08800.
TreeFamiTF352619.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08800-1 [UniParc]FASTAAdd to Basket

« Hide

MDDLSEANGS FAISLLKILS EKDKSRNLFF CPMSVSSALA MVYLGAKGNT    50
ATQMSEVLGL SGNGDVHQSF QTLLAEINKT DTQYLLKSAC RLFGEESCDF 100
LSTFKESCHK FYQAGLEELS FAKDTEGCRK HINDWVSEKT EGKISEVLSP 150
GTVCPLTKLV LVNAMYFKGK WKAQFDRKYT RGMPFKTNQE KKTVQMMFKH 200
AKFKMGHVDE VNMQVLALPY AEEELSMVIL LPDESTDLAV VEKALTYEKL 250
RAWTNPETLT ESQVQVFLPR LKLEESYDLE TVLQNLGMTD AFEETRADFS 300
GMTTKKNVPV SKVAHKCFVE VNEEGTEAAA ATAVIRNARC CRTEPRFCAD 350
HPFLFFIWHH KTSSILFCGR FSSP 374
Length:374
Mass (Da):42,150
Last modified:December 1, 2001 - v2
Checksum:iF8B2ABB47AA47378
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96703 mRNA. Translation: AAB57815.2.
AK036811 mRNA. Translation: BAC29588.1.
BC025121 mRNA. Translation: AAH25121.1.
CCDSiCCDS15220.1.
RefSeqiNP_035589.1. NM_011459.4.
UniGeneiMm.83909.

Genome annotation databases

EnsembliENSMUST00000000514; ENSMUSP00000000514; ENSMUSG00000026315.
ENSMUST00000112706; ENSMUSP00000108326; ENSMUSG00000026315.
GeneIDi20725.
KEGGimmu:20725.
UCSCiuc007chs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U96703 mRNA. Translation: AAB57815.2 .
AK036811 mRNA. Translation: BAC29588.1 .
BC025121 mRNA. Translation: AAH25121.1 .
CCDSi CCDS15220.1.
RefSeqi NP_035589.1. NM_011459.4.
UniGenei Mm.83909.

3D structure databases

ProteinModelPortali O08800.
SMRi O08800. Positions 1-374.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000000514.

Protein family/group databases

MEROPSi I04.013.

PTM databases

PhosphoSitei O08800.

Proteomic databases

MaxQBi O08800.
PaxDbi O08800.
PRIDEi O08800.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000514 ; ENSMUSP00000000514 ; ENSMUSG00000026315 .
ENSMUST00000112706 ; ENSMUSP00000108326 ; ENSMUSG00000026315 .
GeneIDi 20725.
KEGGi mmu:20725.
UCSCi uc007chs.2. mouse.

Organism-specific databases

CTDi 5271.
MGIi MGI:894657. Serpinb8.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00740000114938.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi O08800.
KOi K13965.
OMAi RNARCCR.
OrthoDBi EOG7327PB.
PhylomeDBi O08800.
TreeFami TF352619.

Miscellaneous databases

NextBioi 299329.
PROi O08800.
SOURCEi Search...

Gene expression databases

ArrayExpressi O08800.
Bgeei O08800.
Genevestigatori O08800.

Family and domain databases

InterProi IPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
PRINTSi PR00676. MASPIN.
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse."
    Kaiserman D., Knaggs S., Scarff K.L., Gillard A., Mirza G., Cadman M., McKeone R., Denny P., Cooley J., Benarafa C., Remold-O'Donnell E., Ragoussis J., Bird P.I.
    Genomics 79:349-362(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Vagina.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSPB8_MOUSE
AccessioniPrimary (citable) accession number: O08800
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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