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O08800

- SPB8_MOUSE

UniProt

O08800 - SPB8_MOUSE

Protein

Serpin B8

Gene

Serpinb8

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei339 – 3402Reactive bondBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. negative regulation of endopeptidase activity Source: RefGenome
    2. regulation of proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Protein family/group databases

    MEROPSiI04.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serpin B8
    Gene namesi
    Name:Serpinb8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:894657. Serpinb8.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: Ensembl
    3. extracellular space Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 374374Serpin B8PRO_0000094112Add
    BLAST

    Proteomic databases

    MaxQBiO08800.
    PaxDbiO08800.
    PRIDEiO08800.

    PTM databases

    PhosphoSiteiO08800.

    Expressioni

    Gene expression databases

    ArrayExpressiO08800.
    BgeeiO08800.
    GenevestigatoriO08800.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000000514.

    Structurei

    3D structure databases

    ProteinModelPortaliO08800.
    SMRiO08800. Positions 1-374.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family. Ov-serpin subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00740000114938.
    HOGENOMiHOG000238519.
    HOVERGENiHBG005957.
    InParanoidiO08800.
    KOiK13965.
    OMAiRNARCCR.
    OrthoDBiEOG7327PB.
    PhylomeDBiO08800.
    TreeFamiTF352619.

    Family and domain databases

    InterProiIPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    PRINTSiPR00676. MASPIN.
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08800-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDLSEANGS FAISLLKILS EKDKSRNLFF CPMSVSSALA MVYLGAKGNT    50
    ATQMSEVLGL SGNGDVHQSF QTLLAEINKT DTQYLLKSAC RLFGEESCDF 100
    LSTFKESCHK FYQAGLEELS FAKDTEGCRK HINDWVSEKT EGKISEVLSP 150
    GTVCPLTKLV LVNAMYFKGK WKAQFDRKYT RGMPFKTNQE KKTVQMMFKH 200
    AKFKMGHVDE VNMQVLALPY AEEELSMVIL LPDESTDLAV VEKALTYEKL 250
    RAWTNPETLT ESQVQVFLPR LKLEESYDLE TVLQNLGMTD AFEETRADFS 300
    GMTTKKNVPV SKVAHKCFVE VNEEGTEAAA ATAVIRNARC CRTEPRFCAD 350
    HPFLFFIWHH KTSSILFCGR FSSP 374
    Length:374
    Mass (Da):42,150
    Last modified:December 1, 2001 - v2
    Checksum:iF8B2ABB47AA47378
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96703 mRNA. Translation: AAB57815.2.
    AK036811 mRNA. Translation: BAC29588.1.
    BC025121 mRNA. Translation: AAH25121.1.
    CCDSiCCDS15220.1.
    RefSeqiNP_035589.1. NM_011459.4.
    UniGeneiMm.83909.

    Genome annotation databases

    EnsembliENSMUST00000000514; ENSMUSP00000000514; ENSMUSG00000026315.
    ENSMUST00000112706; ENSMUSP00000108326; ENSMUSG00000026315.
    GeneIDi20725.
    KEGGimmu:20725.
    UCSCiuc007chs.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U96703 mRNA. Translation: AAB57815.2 .
    AK036811 mRNA. Translation: BAC29588.1 .
    BC025121 mRNA. Translation: AAH25121.1 .
    CCDSi CCDS15220.1.
    RefSeqi NP_035589.1. NM_011459.4.
    UniGenei Mm.83909.

    3D structure databases

    ProteinModelPortali O08800.
    SMRi O08800. Positions 1-374.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000000514.

    Protein family/group databases

    MEROPSi I04.013.

    PTM databases

    PhosphoSitei O08800.

    Proteomic databases

    MaxQBi O08800.
    PaxDbi O08800.
    PRIDEi O08800.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000514 ; ENSMUSP00000000514 ; ENSMUSG00000026315 .
    ENSMUST00000112706 ; ENSMUSP00000108326 ; ENSMUSG00000026315 .
    GeneIDi 20725.
    KEGGi mmu:20725.
    UCSCi uc007chs.2. mouse.

    Organism-specific databases

    CTDi 5271.
    MGIi MGI:894657. Serpinb8.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00740000114938.
    HOGENOMi HOG000238519.
    HOVERGENi HBG005957.
    InParanoidi O08800.
    KOi K13965.
    OMAi RNARCCR.
    OrthoDBi EOG7327PB.
    PhylomeDBi O08800.
    TreeFami TF352619.

    Miscellaneous databases

    NextBioi 299329.
    PROi O08800.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08800.
    Bgeei O08800.
    Genevestigatori O08800.

    Family and domain databases

    InterProi IPR000240. Serpin_B9/Maspin.
    IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    PRINTSi PR00676. MASPIN.
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse."
      Kaiserman D., Knaggs S., Scarff K.L., Gillard A., Mirza G., Cadman M., McKeone R., Denny P., Cooley J., Benarafa C., Remold-O'Donnell E., Ragoussis J., Bird P.I.
      Genomics 79:349-362(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Vagina.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiSPB8_MOUSE
    AccessioniPrimary (citable) accession number: O08800
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3