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O08797

- O08797_MOUSE

UniProt

O08797 - O08797_MOUSE

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Protein
Submitted name:

Protein Serpinb9

Gene
Serpinb9, mCG_17886
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: MGI
  2. serine-type endopeptidase inhibitor activity Source: MGI

GO - Biological processi

  1. acute inflammatory response to antigenic stimulus Source: MGI
  2. defense response to bacterium Source: MGI
  3. negative regulation of apoptotic process Source: MGI
  4. negative regulation of endopeptidase activity Source: GOC
  5. negative regulation of T cell apoptotic process Source: MGI
  6. regulation of proteolysis Source: RefGenome
  7. T cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiI04.014.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Serpinb9Imported
Submitted name:
SPI6Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade B, member 9Imported
Gene namesi
Name:Serpinb9Imported
ORF Names:mCG_17886Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:106603. Serpinb9.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriO08797.

Interactioni

Protein-protein interaction databases

MINTiMINT-4104570.
STRINGi10090.ENSMUSP00000099002.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00740000114938.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO08797.
KOiK13963.
OMAiFKLAYIE.
OrthoDBiEOG7327PB.
TreeFamiTF352619.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08797-1 [UniParc]FASTAAdd to Basket

« Hide

MNTLSEGNGT FAIHLLKMLC QSNPSKNVCY SPASISSALA MVLLGAKGQT    50
AVQISQALGL NKEEGIHQGF QLLLRKLNKP DRKYSLRVAN RLFADKTCEV 100
LQTFKESSLH FYDSEMEQLS FAEEAEVSRQ HINTWVSKQT EGKIPELLSG 150
GSVDSETRLV LINALYFKGK WHQPFNKEYT MDMPFKINKD EKRPVQMMCR 200
EDTYNLAYVK EVQAQVLVMP YEGMELSLVV LLPDEGVDLS KVENNLTFEK 250
LTAWMEADFM KSTDVEVFLP KFKLQEDYDM ESLFQRLGVV DVFQEDKADL 300
SGMSPERNLC VSKFVHQSVV EINEEGTEAA AASAIIEFCC ASSVPTFCAD 350
HPFLFFIRHN KANSILFCGR FSSP 374
Length:374
Mass (Da):42,259
Last modified:July 1, 1997 - v1
Checksum:i76D9ED10D7875281
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589871 Genomic DNA. No translation available.
U96700 mRNA. Translation: AAB57812.1.
BC029900 mRNA. Translation: AAH29900.1.
AK035624 mRNA. Translation: BAC29128.1.
AK161581 mRNA. Translation: BAE36475.1.
CH466561 Genomic DNA. Translation: EDL32351.1.
RefSeqiNP_033282.1. NM_009256.3.
XP_006516688.1. XM_006516625.1.
XP_006516689.1. XM_006516626.1.
XP_006516690.1. XM_006516627.1.
XP_006516691.1. XM_006516628.1.
XP_006516692.1. XM_006516629.1.
UniGeneiMm.272569.

Genome annotation databases

EnsembliENSMUST00000006391; ENSMUSP00000006391; ENSMUSG00000045827.
ENSMUST00000063191; ENSMUSP00000099002; ENSMUSG00000045827.
GeneIDi20723.
KEGGimmu:20723.
UCSCiuc007pzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL589871 Genomic DNA. No translation available.
U96700 mRNA. Translation: AAB57812.1 .
BC029900 mRNA. Translation: AAH29900.1 .
AK035624 mRNA. Translation: BAC29128.1 .
AK161581 mRNA. Translation: BAE36475.1 .
CH466561 Genomic DNA. Translation: EDL32351.1 .
RefSeqi NP_033282.1. NM_009256.3.
XP_006516688.1. XM_006516625.1.
XP_006516689.1. XM_006516626.1.
XP_006516690.1. XM_006516627.1.
XP_006516691.1. XM_006516628.1.
XP_006516692.1. XM_006516629.1.
UniGenei Mm.272569.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4104570.
STRINGi 10090.ENSMUSP00000099002.

Protein family/group databases

MEROPSi I04.014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000006391 ; ENSMUSP00000006391 ; ENSMUSG00000045827 .
ENSMUST00000063191 ; ENSMUSP00000099002 ; ENSMUSG00000045827 .
GeneIDi 20723.
KEGGi mmu:20723.
UCSCi uc007pzz.1. mouse.

Organism-specific databases

CTDi 5272.
MGIi MGI:106603. Serpinb9.

Phylogenomic databases

eggNOGi COG4826.
GeneTreei ENSGT00740000114938.
HOGENOMi HOG000238519.
HOVERGENi HBG005957.
InParanoidi O08797.
KOi K13963.
OMAi FKLAYIE.
OrthoDBi EOG7327PB.
TreeFami TF352619.

Miscellaneous databases

NextBioi 299321.
SOURCEi Search...

Gene expression databases

Genevestigatori O08797.

Family and domain databases

InterProi IPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
PRINTSi PR00676. MASPIN.
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
PROSITEi PS00284. SERPIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)."
    Sun J., Ooms L., Bird C.H., Sutton V.R., Trapani J.A., Bird P.I.
    J. Biol. Chem. 272:15434-15441(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  3. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  7. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  8. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Salivary glandImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported.
  11. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2005)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  13. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  15. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiO08797_MOUSE
AccessioniPrimary (citable) accession number: O08797
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: June 11, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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