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Protein
Submitted name:

Protein Serpinb9

Gene

Serpinb9

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: MGI
  2. protease binding Source: MGI
  3. serine-type endopeptidase inhibitor activity Source: MGI

GO - Biological processi

  1. acute inflammatory response to antigenic stimulus Source: MGI
  2. defense response to bacterium Source: MGI
  3. immune response Source: MGI
  4. negative regulation of apoptotic process Source: MGI
  5. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  6. negative regulation of endopeptidase activity Source: MGI
  7. negative regulation of T cell apoptotic process Source: MGI
  8. T cell mediated cytotoxicity Source: MGI
Complete GO annotation...

Protein family/group databases

MEROPSiI04.044.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Serpinb9Imported
Submitted name:
SPI6Imported
Submitted name:
Serine (Or cysteine) peptidase inhibitor, clade B, member 9Imported
Gene namesi
Name:Serpinb9Imported
ORF Names:mCG_17886Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:106603. Serpinb9.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. extracellular space Source: MGI
  4. extracellular vesicular exosome Source: MGI
  5. membrane Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiO08797.
PaxDbiO08797.
PRIDEiO08797.

PTM databases

PhosphoSiteiO08797.

Expressioni

Gene expression databases

BgeeiO08797.
GenevestigatoriO08797.

Interactioni

Protein-protein interaction databases

IntActiO08797. 1 interaction.
MINTiMINT-4104570.
STRINGi10090.ENSMUSP00000099002.

Structurei

3D structure databases

ProteinModelPortaliO08797.
SMRiO08797. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO08797.
KOiK13963.
OMAiLINDWVE.
OrthoDBiEOG7327PB.
PhylomeDBiO08797.
TreeFamiTF352619.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08797-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLSEGNGT FAIHLLKMLC QSNPSKNVCY SPASISSALA MVLLGAKGQT
60 70 80 90 100
AVQISQALGL NKEEGIHQGF QLLLRKLNKP DRKYSLRVAN RLFADKTCEV
110 120 130 140 150
LQTFKESSLH FYDSEMEQLS FAEEAEVSRQ HINTWVSKQT EGKIPELLSG
160 170 180 190 200
GSVDSETRLV LINALYFKGK WHQPFNKEYT MDMPFKINKD EKRPVQMMCR
210 220 230 240 250
EDTYNLAYVK EVQAQVLVMP YEGMELSLVV LLPDEGVDLS KVENNLTFEK
260 270 280 290 300
LTAWMEADFM KSTDVEVFLP KFKLQEDYDM ESLFQRLGVV DVFQEDKADL
310 320 330 340 350
SGMSPERNLC VSKFVHQSVV EINEEGTEAA AASAIIEFCC ASSVPTFCAD
360 370
HPFLFFIRHN KANSILFCGR FSSP
Length:374
Mass (Da):42,259
Last modified:July 1, 1997 - v1
Checksum:i76D9ED10D7875281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589871 Genomic DNA. No translation available.
U96700 mRNA. Translation: AAB57812.1.
BC029900 mRNA. Translation: AAH29900.1.
AK035624 mRNA. Translation: BAC29128.1.
AK161581 mRNA. Translation: BAE36475.1.
CH466561 Genomic DNA. Translation: EDL32351.1.
RefSeqiNP_033282.1. NM_009256.3.
XP_006516688.1. XM_006516625.2.
XP_006516689.1. XM_006516626.2.
XP_006516691.1. XM_006516628.2.
XP_006516692.1. XM_006516629.2.
UniGeneiMm.272569.

Genome annotation databases

EnsembliENSMUST00000006391; ENSMUSP00000006391; ENSMUSG00000045827.
ENSMUST00000063191; ENSMUSP00000099002; ENSMUSG00000045827.
GeneIDi20723.
KEGGimmu:20723.
UCSCiuc007pzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589871 Genomic DNA. No translation available.
U96700 mRNA. Translation: AAB57812.1.
BC029900 mRNA. Translation: AAH29900.1.
AK035624 mRNA. Translation: BAC29128.1.
AK161581 mRNA. Translation: BAE36475.1.
CH466561 Genomic DNA. Translation: EDL32351.1.
RefSeqiNP_033282.1. NM_009256.3.
XP_006516688.1. XM_006516625.2.
XP_006516689.1. XM_006516626.2.
XP_006516691.1. XM_006516628.2.
XP_006516692.1. XM_006516629.2.
UniGeneiMm.272569.

3D structure databases

ProteinModelPortaliO08797.
SMRiO08797. Positions 1-374.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08797. 1 interaction.
MINTiMINT-4104570.
STRINGi10090.ENSMUSP00000099002.

Protein family/group databases

MEROPSiI04.044.

PTM databases

PhosphoSiteiO08797.

Proteomic databases

MaxQBiO08797.
PaxDbiO08797.
PRIDEiO08797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006391; ENSMUSP00000006391; ENSMUSG00000045827.
ENSMUST00000063191; ENSMUSP00000099002; ENSMUSG00000045827.
GeneIDi20723.
KEGGimmu:20723.
UCSCiuc007pzz.1. mouse.

Organism-specific databases

CTDi5272.
MGIiMGI:106603. Serpinb9.

Phylogenomic databases

eggNOGiCOG4826.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiO08797.
KOiK13963.
OMAiLINDWVE.
OrthoDBiEOG7327PB.
PhylomeDBiO08797.
TreeFamiTF352619.

Miscellaneous databases

NextBioi299321.
SOURCEiSearch...

Gene expression databases

BgeeiO08797.
GenevestigatoriO08797.

Family and domain databases

InterProiIPR000240. Serpin_B9/Maspin.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSiPR00676. MASPIN.
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9)."
    Sun J., Ooms L., Bird C.H., Sutton V.R., Trapani J.A., Bird P.I.
    J. Biol. Chem. 272:15434-15441(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "High-efficiency full-length cDNA cloning."
    Carninci P., Hayashizaki Y.
    Methods Enzymol. 303:19-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  3. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
    Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
    Genome Res. 10:1617-1630(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  5. "Functional annotation of a full-length mouse cDNA collection."
    The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
    Nature 409:685-690(2000)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  6. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Urinary bladderImported.
  7. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
    The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
    Nature 420:563-573(2001)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  8. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Salivary glandImported.
  10. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported.
  11. "The Transcriptional Landscape of the Mammalian Genome."
    The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
    Science 309:1559-1563(2004)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  12. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: C57BL/6JImported.
    Tissue: Pituitary glandImported and Urinary bladderImported.
  13. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  15. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiO08797_MOUSE
AccessioniPrimary (citable) accession number: O08797
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: April 1, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.