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Protein

Transcription factor COE3

Gene

Ebf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17020C5-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE3
Alternative name(s):
Early B-cell factor 3
Short name:
EBF-3
Olf-1/EBF-like 2
Short name:
O/E-2
Short name:
OE-2
Gene namesi
Name:Ebf3
Synonyms:Coe3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:894289. Ebf3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 596596Transcription factor COE3PRO_0000107833Add
BLAST

Proteomic databases

MaxQBiO08791.
PaxDbiO08791.
PeptideAtlasiO08791.
PRIDEiO08791.

PTM databases

iPTMnetiO08791.
PhosphoSiteiO08791.

Expressioni

Tissue specificityi

Highly expressed in adult olfactory epithelium. In embryo, expressed in epithalamus, hypothalamus, throughout the brainstem and near the ventricular zones of mesencephalon, in rostral rhombencephalon, in vomeronasal organ, at high level in developing retina, developing spinal cord, at low level in dorsal root ganglia, trigeminal ganglia, glossopharyngeal nerve ganglia. Not expressed in developing inner eat.

Developmental stagei

First detected at 9.5 dpc.

Gene expression databases

BgeeiENSMUSG00000010476.
CleanExiMM_EBF3.
ExpressionAtlasiO08791. baseline and differential.
GenevisibleiO08791. MM.

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei163 – 1631Interaction with DNABy similarity
Sitei172 – 1721Interaction with DNABy similarity

Protein-protein interaction databases

BioGridi199360. 1 interaction.
IntActiO08791. 1 interaction.
STRINGi10090.ENSMUSP00000101724.

Structurei

3D structure databases

ProteinModelPortaliO08791.
SMRiO08791. Positions 35-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini263 – 34684IPT/TIGAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 664Interaction with DNABy similarity
Regioni197 – 2048Interaction with DNABy similarity
Regioni236 – 2394Interaction with DNABy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi464 – 55592Pro/Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Belongs to the COE family.Curated
Contains 1 IPT/TIG domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri151 – 17020C5-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3836. Eukaryota.
ENOG410XQ9Z. LUCA.
GeneTreeiENSGT00390000014051.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiO08791.
KOiK09103.
OMAiASHGGMM.
OrthoDBiEOG091G0A9D.
PhylomeDBiO08791.
TreeFamiTF313391.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: O08791-1) [UniParc]FASTAAdd to basket
Also known as: 9L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFGIQENIPR GGTTMKEEPL GSGMNPVRSW MHTAGVVDAN TAAQSGVGLA
60 70 80 90 100
RAHFEKQPPS NLRKSNFFHF VLALYDRQGQ PVEIERTAFV DFVEKEKEPN
110 120 130 140 150
NEKTNNGIHY KLQLLYSNGV RTEQDLYVRL IDSMTKQAIV YEGQDKNPEM
160 170 180 190 200
CRVLLTHEIM CSRCCDKKSC GNRNETPSDP VIIDRFFLKF FLKCNQNCLK
210 220 230 240 250
NAGNPRDMRR FQVVVSTTVN VDGHVLAVSD NMFVHNNSKH GRRARRLDPS
260 270 280 290 300
EGTAPSYLEN ATPCIKAISP SEGWTTGGAT VIIIGDNFFD GLQVVFGTML
310 320 330 340 350
VWSELITPHA IRVQTPPRHI PGVVEVTLSY KSKQFCKGAP GRFVYTALNE
360 370 380 390 400
PTIDYGFQRL QKVIPRHPGD PERLPKEVLL KRAADLVEAL YGMPHNNQEI
410 420 430 440 450
ILKRAADIAE ALYSVPRNHN QIPTLGNTPA HTGMMGVNSF SSQLAVNVSE
460 470 480 490 500
TSQANDQVGY SRNTSSVSPR GYVPSSTPQQ SNYNTVSTSM NGYGSGAMAN
510 520 530 540 550
LGVPGSPGFL NGSSANSPYG IVPSSPTMAA SSVTLPSNCS STHGIFSFSP
560 570 580 590
ANVISAVKQK SAFAPVVRPQ ASPPPSCTSA NGNGLQAMSG LVVPPM
Length:596
Mass (Da):64,878
Last modified:July 1, 1997 - v1
Checksum:i6934286C500F0ECE
GO
Isoform Short (identifier: O08791-2) [UniParc]FASTAAdd to basket
Also known as: 0S

The sequence of this isoform differs from the canonical sequence as follows:
     252-260: Missing.
     521-557: IVPSSPTMAASSVTLPSNCSSTHGIFSFSPANVISAV → M

Show »
Length:551
Mass (Da):60,429
Checksum:i19E3A4A70510BEEF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei252 – 2609Missing in isoform Short. CuratedVSP_001115
Alternative sequencei521 – 55737IVPSS…VISAV → M in isoform Short. CuratedVSP_001116Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92702 mRNA. Translation: AAB58322.1.
U92704 mRNA. Translation: AAB58324.1.
U82442 mRNA. Translation: AAC64323.1.
CCDSiCCDS21946.1. [O08791-2]
CCDS52422.1. [O08791-1]
RefSeqiNP_001106886.1. NM_001113415.1. [O08791-1]
NP_034226.1. NM_010096.3. [O08791-2]
UniGeneiMm.258708.

Genome annotation databases

EnsembliENSMUST00000033378; ENSMUSP00000033378; ENSMUSG00000010476. [O08791-2]
ENSMUST00000106118; ENSMUSP00000101724; ENSMUSG00000010476. [O08791-1]
GeneIDi13593.
KEGGimmu:13593.
UCSCiuc009ker.2. mouse. [O08791-2]
uc012fvm.1. mouse. [O08791-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92702 mRNA. Translation: AAB58322.1.
U92704 mRNA. Translation: AAB58324.1.
U82442 mRNA. Translation: AAC64323.1.
CCDSiCCDS21946.1. [O08791-2]
CCDS52422.1. [O08791-1]
RefSeqiNP_001106886.1. NM_001113415.1. [O08791-1]
NP_034226.1. NM_010096.3. [O08791-2]
UniGeneiMm.258708.

3D structure databases

ProteinModelPortaliO08791.
SMRiO08791. Positions 35-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199360. 1 interaction.
IntActiO08791. 1 interaction.
STRINGi10090.ENSMUSP00000101724.

PTM databases

iPTMnetiO08791.
PhosphoSiteiO08791.

Proteomic databases

MaxQBiO08791.
PaxDbiO08791.
PeptideAtlasiO08791.
PRIDEiO08791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033378; ENSMUSP00000033378; ENSMUSG00000010476. [O08791-2]
ENSMUST00000106118; ENSMUSP00000101724; ENSMUSG00000010476. [O08791-1]
GeneIDi13593.
KEGGimmu:13593.
UCSCiuc009ker.2. mouse. [O08791-2]
uc012fvm.1. mouse. [O08791-1]

Organism-specific databases

CTDi253738.
MGIiMGI:894289. Ebf3.

Phylogenomic databases

eggNOGiKOG3836. Eukaryota.
ENOG410XQ9Z. LUCA.
GeneTreeiENSGT00390000014051.
HOGENOMiHOG000092311.
HOVERGENiHBG005108.
InParanoidiO08791.
KOiK09103.
OMAiASHGGMM.
OrthoDBiEOG091G0A9D.
PhylomeDBiO08791.
TreeFamiTF313391.

Miscellaneous databases

ChiTaRSiEbf3. mouse.
PROiO08791.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000010476.
CleanExiMM_EBF3.
ExpressionAtlasiO08791. baseline and differential.
GenevisibleiO08791. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOE3_MOUSE
AccessioniPrimary (citable) accession number: O08791
Secondary accession number(s): O08793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.