Formyl peptide receptor-related sequence 1

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O08790 (FPRS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Formyl peptide receptor-related sequence 1

Alternative name(s):
FMLP-related receptor I
Short name=FMLP-R-I
Formyl peptide receptor related sequence 1
Formyl peptide receptor-like 1
Lipoxin A4 receptor
Short name=LXA4 receptor
N-formyl peptide receptor 2
N-formyl peptide receptor 3

Gene names

Name:	Fpr-s1
Synonyms:	Fpr2, Fpr3, Fprl1, Lxa4r

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed exclusively in vomeronasal neurons (Ref.3 and Ref.4). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (Ref.3). Ref.1 Ref.2 Ref.3 Ref.4
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from direct assay PubMed 12470609. Source: MGI chemotaxis Traceable author statement PubMed 12470609. Source: MGI inflammatory response Inferred from electronic annotation. Source: InterPro superoxide anion generation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	N-formyl peptide receptor activity Inferred from electronic annotation. Source: InterPro receptor activity Inferred from direct assay PubMed 12218158. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 351

351

Formyl peptide receptor-related sequence 1

PRO_0000069453

Regions

Topological domain

1 – 27

Extracellular Potential

Transmembrane

28 – 50

Helical; Name=1; Potential

Topological domain

51 – 61

Cytoplasmic Potential

Transmembrane

62 – 83

Helical; Name=2; Potential

Topological domain

84 – 100

Extracellular Potential

Transmembrane

101 – 121

Helical; Name=3; Potential

Topological domain

122 – 140

Cytoplasmic Potential

Transmembrane

141 – 162

Helical; Name=4; Potential

Topological domain

163 – 205

Extracellular Potential

Transmembrane

206 – 226

Helical; Name=5; Potential

Topological domain

227 – 242

Cytoplasmic Potential

Transmembrane

243 – 266

Helical; Name=6; Potential

Topological domain

267 – 286

Extracellular Potential

Transmembrane

287 – 306

Helical; Name=7; Potential

Topological domain

307 – 351

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

98 ↔ 176

Potential

Experimental info

Sequence conflict

T → S in AAC53198. Ref.1

Sequence conflict

P → H in AAC53198. Ref.1

Sequence conflict

D → E in AAC53198. Ref.1

Sequence conflict

I → V in AAC53198. Ref.1

Sequence conflict

142 – 145

Missing in AAC34584. Ref.2

Sequence conflict

226

T → Y in AAC34584. Ref.2

Sequence conflict

240

F → S in AAC34584. Ref.2

Sequence conflict

300

I → M in AAC34584. Ref.2

Sequence conflict

322

Q → P in AAC34584. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

O08790 [UniParc].

Last modified September 1, 2009. Version 2.
Checksum: 295618B0ED0F98D6
Show »

FASTA

351

39,523

        10         20         30         40         50         60 
METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV AGFRMPHTVT 

        70         80         90        100        110        120 
TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL VHIAVDVNLF GSVFLIAVIA 

       130        140        150        160        170        180 
LDRCICVLHP VWAQNHRTVS LARNVVVGSW IFALILTLPL FLFLTTVRDA RGDVHCRLSF 

       190        200        210        220        230        240 
VSWGNSVEER LNTAITFVTT RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF 

       250        260        270        280        290        300 
RVLTGVVASF FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI 

       310        320        330        340        350 
LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA I

« Hide

References

[1]	"Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors." Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., Serhan C.N. J. Exp. Med. 185:1693-1704(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], LIGAND-BINDING, TISSUE SPECIFICITY. Tissue: Neutrophil and Spleen.
[2]	"Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse." Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M. Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]	"Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors." Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I. Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION.
[4]	"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ." Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Cross-references

Sequence databases
EMBL GenBank DDBJ	U78299 mRNA. Translation: AAC53198.1. AF071179 Genomic DNA. Translation: AAC34584.1.
IPI	IPI00115675.
RefSeq	NP_032068.2. NM_008042.2.
UniGene	Mm.378918.
3D structure databases
ProteinModelPortal	O08790.
SMR	O08790. Positions 32-319.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000111227.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	O08790.
Protocols and materials databases
DNASU	14294.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700. ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
GeneID	14294.
KEGG	mmu:14294.
UCSC	uc008apv.1. mouse.
Organism-specific databases
CTD	2359.
MGI	MGI:1194495. Fpr3.
Phylogenomic databases
eggNOG	NOG150376.
GeneTree	ENSGT00630000089620.
HOGENOM	HOG000234122.
InParanoid	O88535.
KO	K04173.
OMA	ANQTERM.
OrthoDB	EOG4SQWWZ.
Gene expression databases
Bgee	O08790.
Genevestigator	O08790.
GermOnline	ENSMUSG00000052270. Mus musculus.
Family and domain databases
InterPro	IPR027346. Formyl_pep_2_rcpt. IPR000826. Formyl_pep_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
PANTHER	PTHR24225. PTHR24225. 1 hit. PTHR24225:SF7. PTHR24225:SF7. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	285699.
SOURCE	Search...

Entry information

Entry name

FPRS1_MOUSE

Accession

Primary (citable) accession number: O08790
Secondary accession number(s): O88535

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents