O08790 (FPRS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formyl peptide receptor-related sequence 1

Alternative name(s):
FMLP-related receptor I
Short name=FMLP-R-I
Formyl peptide receptor related sequence 1
Formyl peptide receptor-like 1
Lipoxin A4 receptor
Short name=LXA4 receptor
N-formyl peptide receptor 2
N-formyl peptide receptor 3

Gene names

Name:	Fpr-s1
Synonyms:	Fpr2, Fpr3, Fprl1, Lxa4r

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. Ref.3
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed exclusively in vomeronasal neurons (Ref.3 and Ref.4). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (Ref.3). Ref.2 Ref.3 Ref.4
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Chemotaxis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chemotaxis Traceable author statement. Source: MGI
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-formyl peptide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Formyl peptide receptor-related sequence 1		PRO_0000069453
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 50	23	Helical; Name=1; Potential
	Topological domain	51 – 61	11	Cytoplasmic Potential
	Transmembrane	62 – 83	22	Helical; Name=2; Potential
	Topological domain	84 – 100	17	Extracellular Potential
	Transmembrane	101 – 121	21	Helical; Name=3; Potential
	Topological domain	122 – 140	19	Cytoplasmic Potential
	Transmembrane	141 – 162	22	Helical; Name=4; Potential
	Topological domain	163 – 205	43	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 242	16	Cytoplasmic Potential
	Transmembrane	243 – 266	24	Helical; Name=6; Potential
	Topological domain	267 – 286	20	Extracellular Potential
	Transmembrane	287 – 306	20	Helical; Name=7; Potential
	Topological domain	307 – 351	45	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential
	Glycosylation	10	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 176		Potential
Experimental info
	Sequence conflict	3	1	T → S in AAC53198. Ref.1
	Sequence conflict	8	1	P → H in AAC53198. Ref.1
	Sequence conflict	13	1	D → E in AAC53198. Ref.1
	Sequence conflict	16	1	I → V in AAC53198. Ref.1
	Sequence conflict	142 – 145	4	Missing in AAC34584. Ref.2
	Sequence conflict	226	1	T → Y in AAC34584. Ref.2
	Sequence conflict	240	1	F → S in AAC34584. Ref.2
	Sequence conflict	300	1	I → M in AAC34584. Ref.2
	Sequence conflict	322	1	Q → P in AAC34584. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	O08790 [UniParc]. Last modified September 1, 2009. Version 2. Checksum: 295618B0ED0F98D6	FASTA	351	39,523
	10 20 30 40 50 60 METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV AGFRMPHTVT 70 80 90 100 110 120 TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL VHIAVDVNLF GSVFLIAVIA 130 140 150 160 170 180 LDRCICVLHP VWAQNHRTVS LARNVVVGSW IFALILTLPL FLFLTTVRDA RGDVHCRLSF 190 200 210 220 230 240 VSWGNSVEER LNTAITFVTT RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF 250 260 270 280 290 300 RVLTGVVASF FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI 310 320 330 340 350 LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA I

References

[1]	"Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors." Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., Serhan C.N. J. Exp. Med. 185:1693-1704(1997) [PubMed: 9151906] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], LIGAND-BINDING, TISSUE SPECFICITY. Tissue: Neutrophil and Spleen.
[2]	"Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse." Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M. Genomics 51:270-276(1998) [PubMed: 9722950] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]	"Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors." Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I. Nature 459:574-577(2009) [PubMed: 19387439] [Abstract] Cited for: TISSUE SPECIFICITY, FUNCTION.
[4]	"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ." Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed: 19497865] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Cross-references

Sequence databases
EMBL GenBank DDBJ	U78299 mRNA. Translation: AAC53198.1. AF071179 Genomic DNA. Translation: AAC34584.1.
IPI	IPI00115675.
RefSeq	NP_032068.2. NM_008042.2.
UniGene	Mm.378918.
3D structure databases
ProteinModelPortal	O08790.
SMR	O08790. Positions 110-141, 286-319.
ModBase	Search...
Protein-protein interaction databases
STRING	O08790.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	O08790.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700. ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
GeneID	14294.
KEGG	mmu:14294.
UCSC	uc008apv.1. mouse.
Organism-specific databases
CTD	2359.
MGI	MGI:1194495. Fpr3.
Phylogenomic databases
GeneTree	ENSGT00560000076935.
InParanoid	O08790.
OMA	FINIVAD.
OrthoDB	EOG4SQWWZ.
Gene expression databases
ArrayExpress	O08790.
Bgee	O08790.
Genevestigator	O08790.
GermOnline	ENSMUSG00000052270. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR000826. Frt_met_rcpt. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
KO	K04173.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00526. FMETLEUPHER. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

FPRS1_MOUSE

Accession

Primary (citable) accession number: O08790
Secondary accession number(s): O88535

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	September 1, 2009
Last modified:	November 16, 2011
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program