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Protein

Formyl peptide receptor-related sequence 1

Gene

Fpr-s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. receptor activity Source: MGI

GO - Biological processi

  1. chemotaxis Source: MGI
  2. G-protein coupled receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_229705. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 1
Alternative name(s):
FMLP-related receptor I
Short name:
FMLP-R-I
Formyl peptide receptor related sequence 1
Formyl peptide receptor-like 1
Lipoxin A4 receptor
Short name:
LXA4 receptor
N-formyl peptide receptor 2
N-formyl peptide receptor 3
Gene namesi
Name:Fpr-s1
Synonyms:Fpr2, Fpr3, Fprl1, Lxa4r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1194495. Fpr3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 5023Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 6111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini84 – 10017ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei141 – 16222Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 20543ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei243 – 26624Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini267 – 28620ExtracellularSequence AnalysisAdd
BLAST
Transmembranei287 – 30620Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini307 – 35145CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Formyl peptide receptor-related sequence 1PRO_0000069453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO08790.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439).4 Publications

Gene expression databases

BgeeiO08790.
GenevestigatoriO08790.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111227.

Structurei

3D structure databases

ProteinModelPortaliO08790.
SMRiO08790. Positions 32-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiO08790.
KOiK04173.
OMAiTELIICH.
OrthoDBiEOG77DJ6B.
PhylomeDBiO08790.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08790-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV
60 70 80 90 100
AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL
110 120 130 140 150
VHIAVDVNLF GSVFLIAVIA LDRCICVLHP VWAQNHRTVS LARNVVVGSW
160 170 180 190 200
IFALILTLPL FLFLTTVRDA RGDVHCRLSF VSWGNSVEER LNTAITFVTT
210 220 230 240 250
RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF RVLTGVVASF
260 270 280 290 300
FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI
310 320 330 340 350
LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA

I
Length:351
Mass (Da):39,523
Last modified:September 1, 2009 - v2
Checksum:i295618B0ED0F98D6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31T → S in AAC53198. (PubMed:9151906)Curated
Sequence conflicti8 – 81P → H in AAC53198. (PubMed:9151906)Curated
Sequence conflicti13 – 131D → E in AAC53198. (PubMed:9151906)Curated
Sequence conflicti16 – 161I → V in AAC53198. (PubMed:9151906)Curated
Sequence conflicti142 – 1454Missing in AAC34584. (PubMed:9722950)Curated
Sequence conflicti226 – 2261T → Y in AAC34584. (PubMed:9722950)Curated
Sequence conflicti240 – 2401F → S in AAC34584. (PubMed:9722950)Curated
Sequence conflicti300 – 3001I → M in AAC34584. (PubMed:9722950)Curated
Sequence conflicti322 – 3221Q → P in AAC34584. (PubMed:9722950)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78299 mRNA. Translation: AAC53198.1.
AF071179 Genomic DNA. Translation: AAC34584.1.
CCDSiCCDS28420.1.
RefSeqiNP_032068.2. NM_008042.2.
UniGeneiMm.378918.
Mm.491469.

Genome annotation databases

EnsembliENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700.
ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
GeneIDi14294.
KEGGimmu:14294.
UCSCiuc008apv.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78299 mRNA. Translation: AAC53198.1.
AF071179 Genomic DNA. Translation: AAC34584.1.
CCDSiCCDS28420.1.
RefSeqiNP_032068.2. NM_008042.2.
UniGeneiMm.378918.
Mm.491469.

3D structure databases

ProteinModelPortaliO08790.
SMRiO08790. Positions 32-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111227.

Chemistry

GuidetoPHARMACOLOGYi224.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiO08790.

Protocols and materials databases

DNASUi14294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700.
ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
GeneIDi14294.
KEGGimmu:14294.
UCSCiuc008apv.1. mouse.

Organism-specific databases

CTDi2359.
MGIiMGI:1194495. Fpr3.

Phylogenomic databases

eggNOGiNOG150376.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiO08790.
KOiK04173.
OMAiTELIICH.
OrthoDBiEOG77DJ6B.
PhylomeDBiO08790.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_229705. Formyl peptide receptors bind formyl peptides and many other ligands.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi285699.
PROiO08790.
SOURCEiSearch...

Gene expression databases

BgeeiO08790.
GenevestigatoriO08790.

Family and domain databases

InterProiIPR000826. Formyl_rcpt-rel.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24225. PTHR24225. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors."
    Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., Serhan C.N.
    J. Exp. Med. 185:1693-1704(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], LIGAND-BINDING, TISSUE SPECIFICITY.
    Tissue: Neutrophil and Spleen.
  2. "Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
    Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
    Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  3. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
    Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
    Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.
  4. Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiFPRS1_MOUSE
AccessioniPrimary (citable) accession number: O08790
Secondary accession number(s): O88535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 1, 2009
Last modified: January 7, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.