Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O08790

- FPRS1_MOUSE

UniProt

O08790 - FPRS1_MOUSE

Protein

Formyl peptide receptor-related sequence 1

Gene

Fpr-s1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (01 Sep 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. receptor activity Source: MGI

    GO - Biological processi

    1. chemotaxis Source: MGI
    2. G-protein coupled receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Chemotaxis

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formyl peptide receptor-related sequence 1
    Alternative name(s):
    FMLP-related receptor I
    Short name:
    FMLP-R-I
    Formyl peptide receptor related sequence 1
    Formyl peptide receptor-like 1
    Lipoxin A4 receptor
    Short name:
    LXA4 receptor
    N-formyl peptide receptor 2
    N-formyl peptide receptor 3
    Gene namesi
    Name:Fpr-s1
    Synonyms:Fpr2, Fpr3, Fprl1, Lxa4r
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1194495. Fpr3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Formyl peptide receptor-related sequence 1PRO_0000069453Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiO08790.

    Expressioni

    Tissue specificityi

    Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439).4 Publications

    Gene expression databases

    BgeeiO08790.
    GenevestigatoriO08790.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000111227.

    Structurei

    3D structure databases

    ProteinModelPortaliO08790.
    SMRiO08790. Positions 32-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 6111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini84 – 10017ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14019CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 20543ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini267 – 28620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini307 – 35145CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 5023Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei62 – 8322Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12121Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei141 – 16222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei287 – 30620Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150376.
    GeneTreeiENSGT00730000110302.
    HOGENOMiHOG000234122.
    InParanoidiO88535.
    KOiK04173.
    OMAiANQTERM.
    OrthoDBiEOG77DJ6B.
    PhylomeDBiO08790.
    TreeFamiTF330976.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24225. PTHR24225. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08790-1 [UniParc]FASTAAdd to Basket

    « Hide

    METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV    50
    AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL 100
    VHIAVDVNLF GSVFLIAVIA LDRCICVLHP VWAQNHRTVS LARNVVVGSW 150
    IFALILTLPL FLFLTTVRDA RGDVHCRLSF VSWGNSVEER LNTAITFVTT 200
    RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF RVLTGVVASF 250
    FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI 300
    LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA 350
    I 351
    Length:351
    Mass (Da):39,523
    Last modified:September 1, 2009 - v2
    Checksum:i295618B0ED0F98D6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti3 – 31T → S in AAC53198. (PubMed:9151906)Curated
    Sequence conflicti8 – 81P → H in AAC53198. (PubMed:9151906)Curated
    Sequence conflicti13 – 131D → E in AAC53198. (PubMed:9151906)Curated
    Sequence conflicti16 – 161I → V in AAC53198. (PubMed:9151906)Curated
    Sequence conflicti142 – 1454Missing in AAC34584. (PubMed:9722950)Curated
    Sequence conflicti226 – 2261T → Y in AAC34584. (PubMed:9722950)Curated
    Sequence conflicti240 – 2401F → S in AAC34584. (PubMed:9722950)Curated
    Sequence conflicti300 – 3001I → M in AAC34584. (PubMed:9722950)Curated
    Sequence conflicti322 – 3221Q → P in AAC34584. (PubMed:9722950)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78299 mRNA. Translation: AAC53198.1.
    AF071179 Genomic DNA. Translation: AAC34584.1.
    CCDSiCCDS28420.1.
    RefSeqiNP_032068.2. NM_008042.2.
    UniGeneiMm.378918.
    Mm.491469.

    Genome annotation databases

    EnsembliENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700.
    ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
    GeneIDi14294.
    KEGGimmu:14294.
    UCSCiuc008apv.1. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    A sickly smell - Issue 114 of February 2010

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78299 mRNA. Translation: AAC53198.1 .
    AF071179 Genomic DNA. Translation: AAC34584.1 .
    CCDSi CCDS28420.1.
    RefSeqi NP_032068.2. NM_008042.2.
    UniGenei Mm.378918.
    Mm.491469.

    3D structure databases

    ProteinModelPortali O08790.
    SMRi O08790. Positions 32-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000111227.

    Chemistry

    GuidetoPHARMACOLOGYi 224.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi O08790.

    Protocols and materials databases

    DNASUi 14294.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054871 ; ENSMUSP00000093316 ; ENSMUSG00000079700 .
    ENSMUST00000115565 ; ENSMUSP00000111227 ; ENSMUSG00000079700 .
    GeneIDi 14294.
    KEGGi mmu:14294.
    UCSCi uc008apv.1. mouse.

    Organism-specific databases

    CTDi 2359.
    MGIi MGI:1194495. Fpr3.

    Phylogenomic databases

    eggNOGi NOG150376.
    GeneTreei ENSGT00730000110302.
    HOGENOMi HOG000234122.
    InParanoidi O88535.
    KOi K04173.
    OMAi ANQTERM.
    OrthoDBi EOG77DJ6B.
    PhylomeDBi O08790.
    TreeFami TF330976.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 285699.
    PROi O08790.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08790.
    Genevestigatori O08790.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000826. Formyl_rcpt-rel.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24225. PTHR24225. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors."
      Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., Serhan C.N.
      J. Exp. Med. 185:1693-1704(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], LIGAND-BINDING, TISSUE SPECIFICITY.
      Tissue: Neutrophil and Spleen.
    2. "Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
      Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
      Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    3. "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
      Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
      Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    4. Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFPRS1_MOUSE
    AccessioniPrimary (citable) accession number: O08790
    Secondary accession number(s): O88535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3