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Protein

Formyl peptide receptor-related sequence 1

Gene

Fpr-s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyl peptide receptor-related sequence 1
Alternative name(s):
FMLP-related receptor I
Short name:
FMLP-R-I
Formyl peptide receptor related sequence 1
Formyl peptide receptor-like 1
Lipoxin A4 receptor
Short name:
LXA4 receptor
N-formyl peptide receptor 2
N-formyl peptide receptor 3
Gene namesi
Name:Fpr-s1
Synonyms:Fpr2, Fpr3, Fprl1, Lxa4r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1194495. Fpr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 50Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini51 – 61CytoplasmicSequence analysisAdd BLAST11
Transmembranei62 – 83Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini84 – 100ExtracellularSequence analysisAdd BLAST17
Transmembranei101 – 121Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini122 – 140CytoplasmicSequence analysisAdd BLAST19
Transmembranei141 – 162Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini163 – 205ExtracellularSequence analysisAdd BLAST43
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 266Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini267 – 286ExtracellularSequence analysisAdd BLAST20
Transmembranei287 – 306Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini307 – 351CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3407315.
GuidetoPHARMACOLOGYi224.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694531 – 351Formyl peptide receptor-related sequence 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi98 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO08790.
PRIDEiO08790.

PTM databases

iPTMnetiO08790.

Expressioni

Tissue specificityi

Expressed exclusively in vomeronasal neurons (PubMed:19387439 and PubMed:19497865). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (PubMed:19387439).4 Publications

Gene expression databases

BgeeiENSMUSG00000079700.
GenevisibleiO08790. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093316.

Chemistry databases

BindingDBiO08790.

Structurei

3D structure databases

ProteinModelPortaliO08790.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiO08790.
KOiK04173.
OMAiMAMNERW.
OrthoDBiEOG091G09ZK.
PhylomeDBiO08790.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08790-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV
60 70 80 90 100
AGFRMPHTVT TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL
110 120 130 140 150
VHIAVDVNLF GSVFLIAVIA LDRCICVLHP VWAQNHRTVS LARNVVVGSW
160 170 180 190 200
IFALILTLPL FLFLTTVRDA RGDVHCRLSF VSWGNSVEER LNTAITFVTT
210 220 230 240 250
RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF RVLTGVVASF
260 270 280 290 300
FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI
310 320 330 340 350
LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA

I
Length:351
Mass (Da):39,523
Last modified:September 1, 2009 - v2
Checksum:i295618B0ED0F98D6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3T → S in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti8P → H in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti13D → E in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti16I → V in AAC53198 (PubMed:9151906).Curated1
Sequence conflicti142 – 145Missing in AAC34584 (PubMed:9722950).Curated4
Sequence conflicti226T → Y in AAC34584 (PubMed:9722950).Curated1
Sequence conflicti240F → S in AAC34584 (PubMed:9722950).Curated1
Sequence conflicti300I → M in AAC34584 (PubMed:9722950).Curated1
Sequence conflicti322Q → P in AAC34584 (PubMed:9722950).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78299 mRNA. Translation: AAC53198.1.
AF071179 Genomic DNA. Translation: AAC34584.1.
CCDSiCCDS28420.1.
RefSeqiNP_032068.2. NM_008042.2.
UniGeneiMm.378918.
Mm.491469.

Genome annotation databases

EnsembliENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700.
ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
GeneIDi14294.
KEGGimmu:14294.
UCSCiuc008apv.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78299 mRNA. Translation: AAC53198.1.
AF071179 Genomic DNA. Translation: AAC34584.1.
CCDSiCCDS28420.1.
RefSeqiNP_032068.2. NM_008042.2.
UniGeneiMm.378918.
Mm.491469.

3D structure databases

ProteinModelPortaliO08790.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093316.

Chemistry databases

BindingDBiO08790.
ChEMBLiCHEMBL3407315.
GuidetoPHARMACOLOGYi224.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO08790.

Proteomic databases

PaxDbiO08790.
PRIDEiO08790.

Protocols and materials databases

DNASUi14294.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700.
ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
GeneIDi14294.
KEGGimmu:14294.
UCSCiuc008apv.1. mouse.

Organism-specific databases

CTDi2359.
MGIiMGI:1194495. Fpr3.

Phylogenomic databases

eggNOGiENOG410II0H. Eukaryota.
ENOG410YB48. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
InParanoidiO08790.
KOiK04173.
OMAiMAMNERW.
OrthoDBiEOG091G09ZK.
PhylomeDBiO08790.
TreeFamiTF330976.

Enzyme and pathway databases

ReactomeiR-MMU-416476. G alpha (q) signalling events.
R-MMU-418594. G alpha (i) signalling events.
R-MMU-444473. Formyl peptide receptors bind formyl peptides and many other ligands.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiO08790.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079700.
GenevisibleiO08790. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPRS1_MOUSE
AccessioniPrimary (citable) accession number: O08790
Secondary accession number(s): O88535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 1, 2009
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.