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O08790 (FPRS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formyl peptide receptor-related sequence 1
Alternative name(s):
FMLP-related receptor I
Short name=FMLP-R-I
Formyl peptide receptor related sequence 1
Formyl peptide receptor-like 1
Lipoxin A4 receptor
Short name=LXA4 receptor
N-formyl peptide receptor 2
N-formyl peptide receptor 3
Gene names
Name:Fpr-s1
Synonyms:Fpr2, Fpr3, Fprl1, Lxa4r
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Low affinity receptor for N-formyl-methionyl peptides. Receptor for lipoxin A4. May have an olfactory function associated with the identification of pathogens or of pathogenic states. Ref.3

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed exclusively in vomeronasal neurons (Ref.3 and Ref.4). Expressed in 0.6 % of a subset of sensory neurons located in the basal layer of the vomeronasal organ. Each neuron appears to express only one receptor gene. Expressed mostly in neutrophils, followed by spleen and lung and expressed at very low levels in heart and liver (Ref.3). Ref.1 Ref.2 Ref.3 Ref.4

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Formyl peptide receptor-related sequence 1
PRO_0000069453

Regions

Topological domain1 – 2727Extracellular Potential
Transmembrane28 – 5023Helical; Name=1; Potential
Topological domain51 – 6111Cytoplasmic Potential
Transmembrane62 – 8322Helical; Name=2; Potential
Topological domain84 – 10017Extracellular Potential
Transmembrane101 – 12121Helical; Name=3; Potential
Topological domain122 – 14019Cytoplasmic Potential
Transmembrane141 – 16222Helical; Name=4; Potential
Topological domain163 – 20543Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 24216Cytoplasmic Potential
Transmembrane243 – 26624Helical; Name=6; Potential
Topological domain267 – 28620Extracellular Potential
Transmembrane287 – 30620Helical; Name=7; Potential
Topological domain307 – 35145Cytoplasmic Potential

Amino acid modifications

Glycosylation41N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 176 Potential

Experimental info

Sequence conflict31T → S in AAC53198. Ref.1
Sequence conflict81P → H in AAC53198. Ref.1
Sequence conflict131D → E in AAC53198. Ref.1
Sequence conflict161I → V in AAC53198. Ref.1
Sequence conflict142 – 1454Missing in AAC34584. Ref.2
Sequence conflict2261T → Y in AAC34584. Ref.2
Sequence conflict2401F → S in AAC34584. Ref.2
Sequence conflict3001I → M in AAC34584. Ref.2
Sequence conflict3221Q → P in AAC34584. Ref.2

Sequences

Sequence LengthMass (Da)Tools
O08790 [UniParc].

Last modified September 1, 2009. Version 2.
Checksum: 295618B0ED0F98D6

FASTA35139,523
        10         20         30         40         50         60 
METNYSIPLN GSDVVIYDST ISRVLWILSM VVVSITFFLG VLGNGLVIWV AGFRMPHTVT 

        70         80         90        100        110        120 
TIWYLNLALA DFSFTATLPF LLVEMAMKEK WPFGWFLCKL VHIAVDVNLF GSVFLIAVIA 

       130        140        150        160        170        180 
LDRCICVLHP VWAQNHRTVS LARNVVVGSW IFALILTLPL FLFLTTVRDA RGDVHCRLSF 

       190        200        210        220        230        240 
VSWGNSVEER LNTAITFVTT RGIIRFIVSF SLPMSFVAIC YGLITTKIHK KAFVNSSRPF 

       250        260        270        280        290        300 
RVLTGVVASF FICWFPFQLV ALLGTVWLKE MQFSGSYKII GRLVNPTSSL AFFNSCLNPI 

       310        320        330        340        350 
LYVFMGQDFQ ERLIHSLSSR LQRALSEDSG HISDTRTNLA SLPEDIEIKA I 

« Hide

References

[1]"Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors."
Takano T., Fiore S., Maddox J.F., Brady H.R., Petasis N.A., Serhan C.N.
J. Exp. Med. 185:1693-1704(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], LIGAND-BINDING, TISSUE SPECIFICITY.
Tissue: Neutrophil and Spleen.
[2]"Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse."
Gao J.-L., Chen H., Filie J.D., Kozak C.A., Murphy P.M.
Genomics 51:270-276(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[3]"Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors."
Riviere S., Challet L., Fluegge D., Spehr M., Rodriguez I.
Nature 459:574-577(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
[4]"Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ."
Liberles S.D., Horowitz L.F., Kuang D., Contos J.J., Wilson K.L., Siltberg-Liberles J., Liberles D.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 106:9842-9847(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Web resources

Protein Spotlight

A sickly smell - Issue 114 of February 2010

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U78299 mRNA. Translation: AAC53198.1.
AF071179 Genomic DNA. Translation: AAC34584.1.
RefSeqNP_032068.2. NM_008042.2.
UniGeneMm.378918.
Mm.491469.

3D structure databases

ProteinModelPortalO08790.
SMRO08790. Positions 32-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000111227.

Chemistry

GuidetoPHARMACOLOGY224.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEO08790.

Protocols and materials databases

DNASU14294.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054871; ENSMUSP00000093316; ENSMUSG00000079700.
ENSMUST00000115565; ENSMUSP00000111227; ENSMUSG00000079700.
GeneID14294.
KEGGmmu:14294.
UCSCuc008apv.1. mouse.

Organism-specific databases

CTD2359.
MGIMGI:1194495. Fpr3.

Phylogenomic databases

eggNOGNOG150376.
GeneTreeENSGT00730000110302.
HOGENOMHOG000234122.
InParanoidO88535.
KOK04173.
OMAANQTERM.
OrthoDBEOG77DJ6B.
PhylomeDBO08790.
TreeFamTF330976.

Gene expression databases

BgeeO08790.
GenevestigatorO08790.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR027346. Formyl_pep_1/2_rcpt.
IPR000826. Formyl_pep_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24225. PTHR24225. 1 hit.
PTHR24225:SF7. PTHR24225:SF7. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00526. FMETLEUPHER.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio285699.
PROO08790.
SOURCESearch...

Entry information

Entry nameFPRS1_MOUSE
AccessionPrimary (citable) accession number: O08790
Secondary accession number(s): O88535
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 1, 2009
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries