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O08789

- MNT_MOUSE

UniProt

O08789 - MNT_MOUSE

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Protein

Max-binding protein MNT

Gene
Mnt, Rox
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. protein binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell aging Source: MGI
  2. negative regulation of apoptotic signaling pathway Source: MGI
  3. regulation of cell cycle Source: MGI
  4. regulation of transcription, DNA-templated Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Max-binding protein MNT
Alternative name(s):
Myc antagonist MNT
Protein ROX
Gene namesi
Name:Mnt
Synonyms:Rox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:109150. Mnt.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 591590Max-binding protein MNTPRO_0000127282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiO08789.

PTM databases

PhosphoSiteiO08789.

Expressioni

Gene expression databases

ArrayExpressiO08789.
BgeeiO08789.
CleanExiMM_MNT.
GenevestigatoriO08789.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

Protein-protein interaction databases

BioGridi201461. 3 interactions.
IntActiO08789. 1 interaction.
STRINGi10090.ENSMUSP00000000291.

Structurei

3D structure databases

ProteinModelPortaliO08789.
SMRiO08789. Positions 223-298.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini222 – 27352bHLHAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni273 – 30129Leucine-zipperAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG314808.
GeneTreeiENSGT00510000048287.
HOGENOMiHOG000013115.
HOVERGENiHBG006379.
InParanoidiQ6GTJ3.
KOiK09115.
OMAiGPPKLNH.
OrthoDBiEOG74R1QW.
TreeFamiTF315654.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08789-1 [UniParc]FASTAAdd to Basket

« Hide

MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEREREREQ EQKRASNLAR    50
LAHALPVEEP RIEAPPLPLS PPAPPPAPPP PLATPAPLTV IPIPVVTNSP 100
QSLPPPPPLP PAAQPLPLAP RQPALVSTPG LSIKEPVTLP TRPQVPTPAP 150
LLPDAKTTVA PTGSPKPLQP LPAPILTIAP HPGVQPQLAP QQPPPPTLGT 200
LKLAPAEEAK SSEQKKRPGG IGTREVHNKL EKNRRAHLKE CFETLKRNIP 250
NVDDKKTSNL SVLRTALRYI QSLKRKEKEY EHEMERLARE KIATQQRLAE 300
LKHELSQWMD VLEIDRVLRQ TGQPEDDQAS TSTASEGEDN VDEEMEGDRA 350
GLGPPKLNHR PQPELLKSAL PTPSTAPAPL PTHPHPHPHP VALSPAHLPV 400
QQQQPPQQKT PLPAPPPPPA TPTQTLVPAP AHLVATAGGG STVIAHTATT 450
HASVIQTVNH VLQGPGGKHI AHIAPSAPSP AVQLAPATPP IGHITVHPAT 500
LNHVAHLGSQ LPLYPQPVAV SQPVAVSHIA HTLSHQQVNG TAGLGPPATV 550
MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A 591
Length:591
Mass (Da):63,274
Last modified:July 27, 2011 - v2
Checksum:i17C2B830381D2190
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti379 – 3791P → T in AAB38687. 1 Publication
Sequence conflicti392 – 3921A → V in AAB38687. 1 Publication
Sequence conflicti402 – 4032QQ → EE in AAB38687. 1 Publication
Sequence conflicti414 – 4141A → G in AAB38687. 1 Publication
Sequence conflicti431 – 4311A → V in AAB38687. 1 Publication
Sequence conflicti465 – 4651P → A in AAB38687. 1 Publication
Sequence conflicti525 – 5251A → T in AAB38687. 1 Publication
Sequence conflicti558 – 5581A → G in AAB38687. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77356 mRNA. Translation: AAB38687.1.
Y07609 mRNA. Translation: CAA68878.1.
AL604066 Genomic DNA. Translation: CAI24245.1.
CH466596 Genomic DNA. Translation: EDL12780.1.
BC054534 mRNA. Translation: AAH54534.1.
CCDSiCCDS25037.1.
RefSeqiNP_034943.3. NM_010813.3.
UniGeneiMm.3759.

Genome annotation databases

EnsembliENSMUST00000000291; ENSMUSP00000000291; ENSMUSG00000000282.
GeneIDi17428.
KEGGimmu:17428.
UCSCiuc011xzb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U77356 mRNA. Translation: AAB38687.1 .
Y07609 mRNA. Translation: CAA68878.1 .
AL604066 Genomic DNA. Translation: CAI24245.1 .
CH466596 Genomic DNA. Translation: EDL12780.1 .
BC054534 mRNA. Translation: AAH54534.1 .
CCDSi CCDS25037.1.
RefSeqi NP_034943.3. NM_010813.3.
UniGenei Mm.3759.

3D structure databases

ProteinModelPortali O08789.
SMRi O08789. Positions 223-298.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201461. 3 interactions.
IntActi O08789. 1 interaction.
STRINGi 10090.ENSMUSP00000000291.

PTM databases

PhosphoSitei O08789.

Proteomic databases

PRIDEi O08789.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000291 ; ENSMUSP00000000291 ; ENSMUSG00000000282 .
GeneIDi 17428.
KEGGi mmu:17428.
UCSCi uc011xzb.1. mouse.

Organism-specific databases

CTDi 4335.
MGIi MGI:109150. Mnt.

Phylogenomic databases

eggNOGi NOG314808.
GeneTreei ENSGT00510000048287.
HOGENOMi HOG000013115.
HOVERGENi HBG006379.
InParanoidi Q6GTJ3.
KOi K09115.
OMAi GPPKLNH.
OrthoDBi EOG74R1QW.
TreeFami TF315654.

Miscellaneous databases

NextBioi 292056.
PROi O08789.
SOURCEi Search...

Gene expression databases

ArrayExpressi O08789.
Bgeei O08789.
CleanExi MM_MNT.
Genevestigatori O08789.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites."
    Hurlin P.J., Queva C., Eisenman R.N.
    Genes Dev. 11:44-58(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor."
    Meroni G., Reymond A., Alcalay M., Borsani G., Tanigami A., Tonlorenzi R., Lo Nigro C., Messali S., Zollo M., Ledbetter D.H., Brent R., Ballabio A., Carrozzo R.
    EMBO J. 16:2892-2906(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiMNT_MOUSE
AccessioniPrimary (citable) accession number: O08789
Secondary accession number(s): P97349, Q6GTJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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