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O08789 (MNT_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Max-binding protein MNT
Alternative name(s):
Myc antagonist MNT
Protein ROX
Gene names
Name:Mnt
Synonyms:Rox
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length591 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

Subcellular location

Nucleus.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 591590Max-binding protein MNT
PRO_0000127282

Regions

Domain222 – 27352bHLH
Region273 – 30129Leucine-zipper

Amino acid modifications

Modified residue21N-acetylserine By similarity

Experimental info

Sequence conflict3791P → T in AAB38687. Ref.1
Sequence conflict3921A → V in AAB38687. Ref.1
Sequence conflict402 – 4032QQ → EE in AAB38687. Ref.1
Sequence conflict4141A → G in AAB38687. Ref.1
Sequence conflict4311A → V in AAB38687. Ref.1
Sequence conflict4651P → A in AAB38687. Ref.1
Sequence conflict5251A → T in AAB38687. Ref.1
Sequence conflict5581A → G in AAB38687. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O08789 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 17C2B830381D2190

FASTA59163,274
        10         20         30         40         50         60 
MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEREREREQ EQKRASNLAR LAHALPVEEP 

        70         80         90        100        110        120 
RIEAPPLPLS PPAPPPAPPP PLATPAPLTV IPIPVVTNSP QSLPPPPPLP PAAQPLPLAP 

       130        140        150        160        170        180 
RQPALVSTPG LSIKEPVTLP TRPQVPTPAP LLPDAKTTVA PTGSPKPLQP LPAPILTIAP 

       190        200        210        220        230        240 
HPGVQPQLAP QQPPPPTLGT LKLAPAEEAK SSEQKKRPGG IGTREVHNKL EKNRRAHLKE 

       250        260        270        280        290        300 
CFETLKRNIP NVDDKKTSNL SVLRTALRYI QSLKRKEKEY EHEMERLARE KIATQQRLAE 

       310        320        330        340        350        360 
LKHELSQWMD VLEIDRVLRQ TGQPEDDQAS TSTASEGEDN VDEEMEGDRA GLGPPKLNHR 

       370        380        390        400        410        420 
PQPELLKSAL PTPSTAPAPL PTHPHPHPHP VALSPAHLPV QQQQPPQQKT PLPAPPPPPA 

       430        440        450        460        470        480 
TPTQTLVPAP AHLVATAGGG STVIAHTATT HASVIQTVNH VLQGPGGKHI AHIAPSAPSP 

       490        500        510        520        530        540 
AVQLAPATPP IGHITVHPAT LNHVAHLGSQ LPLYPQPVAV SQPVAVSHIA HTLSHQQVNG 

       550        560        570        580        590 
TAGLGPPATV MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A 

« Hide

References

« Hide 'large scale' references
[1]"Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites."
Hurlin P.J., Queva C., Eisenman R.N.
Genes Dev. 11:44-58(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor."
Meroni G., Reymond A., Alcalay M., Borsani G., Tanigami A., Tonlorenzi R., Lo Nigro C., Messali S., Zollo M., Ledbetter D.H., Brent R., Ballabio A., Carrozzo R.
EMBO J. 16:2892-2906(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U77356 mRNA. Translation: AAB38687.1.
Y07609 mRNA. Translation: CAA68878.1.
AL604066 Genomic DNA. Translation: CAI24245.1.
CH466596 Genomic DNA. Translation: EDL12780.1.
BC054534 mRNA. Translation: AAH54534.1.
CCDSCCDS25037.1.
RefSeqNP_034943.3. NM_010813.3.
UniGeneMm.3759.

3D structure databases

ProteinModelPortalO08789.
SMRO08789. Positions 223-298.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201461. 3 interactions.
IntActO08789. 1 interaction.
STRING10090.ENSMUSP00000000291.

PTM databases

PhosphoSiteO08789.

Proteomic databases

PRIDEO08789.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000291; ENSMUSP00000000291; ENSMUSG00000000282.
GeneID17428.
KEGGmmu:17428.
UCSCuc011xzb.1. mouse.

Organism-specific databases

CTD4335.
MGIMGI:109150. Mnt.

Phylogenomic databases

eggNOGNOG314808.
GeneTreeENSGT00510000048287.
HOGENOMHOG000013115.
HOVERGENHBG006379.
InParanoidQ6GTJ3.
KOK09115.
OMAGPPKLNH.
OrthoDBEOG74R1QW.
TreeFamTF315654.

Gene expression databases

ArrayExpressO08789.
BgeeO08789.
CleanExMM_MNT.
GenevestigatorO08789.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio292056.
PROO08789.
SOURCESearch...

Entry information

Entry nameMNT_MOUSE
AccessionPrimary (citable) accession number: O08789
Secondary accession number(s): P97349, Q6GTJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot