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Protein

Max-binding protein MNT

Gene

Mnt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.

GO - Molecular functioni

GO - Biological processi

  • cell aging Source: MGI
  • negative regulation of apoptotic signaling pathway Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • regulation of cell cycle Source: MGI
  • regulation of transcription, DNA-templated Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Max-binding protein MNT
Alternative name(s):
Myc antagonist MNT
Protein ROX
Gene namesi
Name:Mnt
Synonyms:Rox
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109150 Mnt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001272822 – 591Max-binding protein MNTAdd BLAST590

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiO08789
MaxQBiO08789
PaxDbiO08789
PeptideAtlasiO08789
PRIDEiO08789

PTM databases

iPTMnetiO08789
PhosphoSitePlusiO08789

Expressioni

Gene expression databases

BgeeiENSMUSG00000000282
CleanExiMM_MNT
ExpressionAtlasiO08789 baseline and differential
GenevisibleiO08789 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201461, 3 interactors
IntActiO08789, 1 interactor
STRINGi10090.ENSMUSP00000000291

Structurei

3D structure databases

ProteinModelPortaliO08789
SMRiO08789
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 273bHLHPROSITE-ProRule annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni273 – 301Leucine-zipperAdd BLAST29

Phylogenomic databases

eggNOGiKOG2483 Eukaryota
ENOG4111VW9 LUCA
GeneTreeiENSGT00510000048287
HOGENOMiHOG000013115
HOVERGENiHBG006379
InParanoidiO08789
KOiK09115
OMAiAVIPMVP
OrthoDBiEOG091G0PW2
TreeFamiTF315654

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08789-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIETLLEAA RFLEWQAQQQ QRAREEQERL RLEREREREQ EQKRASNLAR
60 70 80 90 100
LAHALPVEEP RIEAPPLPLS PPAPPPAPPP PLATPAPLTV IPIPVVTNSP
110 120 130 140 150
QSLPPPPPLP PAAQPLPLAP RQPALVSTPG LSIKEPVTLP TRPQVPTPAP
160 170 180 190 200
LLPDAKTTVA PTGSPKPLQP LPAPILTIAP HPGVQPQLAP QQPPPPTLGT
210 220 230 240 250
LKLAPAEEAK SSEQKKRPGG IGTREVHNKL EKNRRAHLKE CFETLKRNIP
260 270 280 290 300
NVDDKKTSNL SVLRTALRYI QSLKRKEKEY EHEMERLARE KIATQQRLAE
310 320 330 340 350
LKHELSQWMD VLEIDRVLRQ TGQPEDDQAS TSTASEGEDN VDEEMEGDRA
360 370 380 390 400
GLGPPKLNHR PQPELLKSAL PTPSTAPAPL PTHPHPHPHP VALSPAHLPV
410 420 430 440 450
QQQQPPQQKT PLPAPPPPPA TPTQTLVPAP AHLVATAGGG STVIAHTATT
460 470 480 490 500
HASVIQTVNH VLQGPGGKHI AHIAPSAPSP AVQLAPATPP IGHITVHPAT
510 520 530 540 550
LNHVAHLGSQ LPLYPQPVAV SQPVAVSHIA HTLSHQQVNG TAGLGPPATV
560 570 580 590
MAKPAVGAQV VHHPQLVGQT VLNPVTMVTM PSFPVSTLKL A
Length:591
Mass (Da):63,274
Last modified:July 27, 2011 - v2
Checksum:i17C2B830381D2190
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti379P → T in AAB38687 (PubMed:9000049).Curated1
Sequence conflicti392A → V in AAB38687 (PubMed:9000049).Curated1
Sequence conflicti402 – 403QQ → EE in AAB38687 (PubMed:9000049).Curated2
Sequence conflicti414A → G in AAB38687 (PubMed:9000049).Curated1
Sequence conflicti431A → V in AAB38687 (PubMed:9000049).Curated1
Sequence conflicti465P → A in AAB38687 (PubMed:9000049).Curated1
Sequence conflicti525A → T in AAB38687 (PubMed:9000049).Curated1
Sequence conflicti558A → G in AAB38687 (PubMed:9000049).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U77356 mRNA Translation: AAB38687.1
Y07609 mRNA Translation: CAA68878.1
AL604066 Genomic DNA Translation: CAI24245.1
CH466596 Genomic DNA Translation: EDL12780.1
BC054534 mRNA Translation: AAH54534.1
CCDSiCCDS25037.1
RefSeqiNP_034943.3, NM_010813.3
UniGeneiMm.3759

Genome annotation databases

EnsembliENSMUST00000000291; ENSMUSP00000000291; ENSMUSG00000000282
GeneIDi17428
KEGGimmu:17428
UCSCiuc011xzb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMNT_MOUSE
AccessioniPrimary (citable) accession number: O08789
Secondary accession number(s): P97349, Q6GTJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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