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Protein

Cholecystokinin receptor type A

Gene

Cckar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: MGI
  • cholecystokinin signaling pathway Source: GO_Central
  • digestion Source: GO_Central
  • feeding behavior Source: GO_Central
  • forebrain development Source: MGI
  • neuron migration Source: MGI
  • regulation of hormone secretion Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:Cckar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99478. Cckar.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 67Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 115ExtracellularSequence analysisAdd BLAST11
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 157CytoplasmicSequence analysisAdd BLAST20
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 210ExtracellularSequence analysisAdd BLAST32
Transmembranei211 – 234Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini235 – 321CytoplasmicSequence analysisAdd BLAST87
Transmembranei322 – 342Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini343 – 357ExtracellularSequence analysisAdd BLAST15
Transmembranei358 – 381Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini382 – 436CytoplasmicSequence analysisAdd BLAST55

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2798.
GuidetoPHARMACOLOGYi76.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692241 – 436Cholecystokinin receptor type AAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
Glycosylationi24N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Lipidationi395S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO08786.
PRIDEiO08786.

PTM databases

iPTMnetiO08786.
PhosphoSitePlusiO08786.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029193.
CleanExiMM_CCKAR.
ExpressionAtlasiO08786. baseline and differential.
GenevisibleiO08786. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1534448.
STRINGi10090.ENSMUSP00000031093.

Chemistry databases

BindingDBiO08786.

Structurei

3D structure databases

ProteinModelPortaliO08786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 264Poly-Gly7
Compositional biasi265 – 268Poly-Ser4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiO08786.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG091G084J.
PhylomeDBiO08786.
TreeFamiTF315303.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVDSLLMN GSNITPPCEL GLENETLFCL DQPQPSKEWQ SAVQILLYSF
60 70 80 90 100
IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI
110 120 130 140 150
PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICRPLQSR
160 170 180 190 200
VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL
210 220 230 240 250
PSDAMQQSWQ TFLLLILFLI PGVVMVVAYG LISLELYQGI KFDASQKKSA
260 270 280 290 300
KEKRLSSGGG GGGGSSSSRY EDSDGCYLQK SRPPRKLELQ QLSTSSSGGR
310 320 330 340 350
INRIRSSGSA ANLIAKKRVI RMLIVIVVLF FLCWMPIFSA NAWRAYDTVS
360 370 380 390 400
AEKHLSGTPI SFILLLSYTS SCVNPIIYCF MNKRFRLGFM ATFPCCPNPG
410 420 430
PTGVRGEVGE EEDGRTIRAS LSRYSYSHMS TSAPPH
Length:436
Mass (Da):48,437
Last modified:July 1, 1997 - v1
Checksum:iEBB5D8453B792F79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Q → H in BAB23512 (PubMed:16141072).Curated1
Sequence conflicti59N → D in BAB23512 (PubMed:16141072).Curated1
Sequence conflicti436H → P in AAH20534 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015963
, AF015959, AF015960, AF015961, AF015962 Genomic DNA. Translation: AAC07949.1.
D85605 Genomic DNA. Translation: BAA20068.1.
AK004730 mRNA. Translation: BAB23512.1.
BC020534 mRNA. Translation: AAH20534.1.
CCDSiCCDS19293.1.
PIRiJC5599.
RefSeqiNP_033957.1. NM_009827.2.
UniGeneiMm.3521.

Genome annotation databases

EnsembliENSMUST00000031093; ENSMUSP00000031093; ENSMUSG00000029193.
GeneIDi12425.
KEGGimmu:12425.
UCSCiuc008xlm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015963
, AF015959, AF015960, AF015961, AF015962 Genomic DNA. Translation: AAC07949.1.
D85605 Genomic DNA. Translation: BAA20068.1.
AK004730 mRNA. Translation: BAB23512.1.
BC020534 mRNA. Translation: AAH20534.1.
CCDSiCCDS19293.1.
PIRiJC5599.
RefSeqiNP_033957.1. NM_009827.2.
UniGeneiMm.3521.

3D structure databases

ProteinModelPortaliO08786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534448.
STRINGi10090.ENSMUSP00000031093.

Chemistry databases

BindingDBiO08786.
ChEMBLiCHEMBL2798.
GuidetoPHARMACOLOGYi76.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO08786.
PhosphoSitePlusiO08786.

Proteomic databases

PaxDbiO08786.
PRIDEiO08786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031093; ENSMUSP00000031093; ENSMUSG00000029193.
GeneIDi12425.
KEGGimmu:12425.
UCSCiuc008xlm.2. mouse.

Organism-specific databases

CTDi886.
MGIiMGI:99478. Cckar.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00860000133695.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiO08786.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG091G084J.
PhylomeDBiO08786.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiCckar. mouse.
PROiO08786.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029193.
CleanExiMM_CCKAR.
ExpressionAtlasiO08786. baseline and differential.
GenevisibleiO08786. MM.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCKAR_MOUSE
AccessioniPrimary (citable) accession number: O08786
Secondary accession number(s): Q8VCC7, Q9DBV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.