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Protein

Cholecystokinin receptor type A

Gene

Cckar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: MGI
  • cellular response to hormone stimulus Source: GO_Central
  • cholecystokinin signaling pathway Source: MGI
  • digestion Source: GO_Central
  • feeding behavior Source: GO_Central
  • forebrain development Source: MGI
  • neuron migration Source: MGI
  • regulation of hormone secretion Source: GO_Central
  • response to peptide Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:Cckar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99478 Cckar

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 67Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 104Helical; Name=2Sequence analysisAdd BLAST27
Topological domaini105 – 115ExtracellularSequence analysisAdd BLAST11
Transmembranei116 – 137Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini138 – 157CytoplasmicSequence analysisAdd BLAST20
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 210ExtracellularSequence analysisAdd BLAST32
Transmembranei211 – 234Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini235 – 321CytoplasmicSequence analysisAdd BLAST87
Transmembranei322 – 342Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini343 – 357ExtracellularSequence analysisAdd BLAST15
Transmembranei358 – 381Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini382 – 436CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2798
GuidetoPHARMACOLOGYi76

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692241 – 436Cholecystokinin receptor type AAdd BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi395S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO08786
PRIDEiO08786

PTM databases

iPTMnetiO08786
PhosphoSitePlusiO08786

Expressioni

Gene expression databases

BgeeiENSMUSG00000029193
CleanExiMM_CCKAR
ExpressionAtlasiO08786 baseline and differential
GenevisibleiO08786 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031093

Chemistry databases

BindingDBiO08786

Structurei

3D structure databases

ProteinModelPortaliO08786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 264Poly-Gly7
Compositional biasi265 – 268Poly-Ser4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00860000133695
HOGENOMiHOG000294067
HOVERGENiHBG036927
InParanoidiO08786
KOiK04194
OMAiYSYSHMS
OrthoDBiEOG091G084J
PhylomeDBiO08786
TreeFamiTF315303

Family and domain databases

Gene3Di4.10.670.10, 1 hit
InterProiView protein in InterPro
IPR009126 Cholcskin_rcpt
IPR000596 Cholcy_rcpt_A
IPR015276 CholecystokininA_recpt_N
IPR036472 CholecystokininA_recpt_N_sf
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF09193 CholecysA-Rec_N, 1 hit
PRINTSiPR01822 CCYSTOKININR
PR00524 CCYSTOKNINAR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O08786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVDSLLMN GSNITPPCEL GLENETLFCL DQPQPSKEWQ SAVQILLYSF
60 70 80 90 100
IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI
110 120 130 140 150
PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICRPLQSR
160 170 180 190 200
VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL
210 220 230 240 250
PSDAMQQSWQ TFLLLILFLI PGVVMVVAYG LISLELYQGI KFDASQKKSA
260 270 280 290 300
KEKRLSSGGG GGGGSSSSRY EDSDGCYLQK SRPPRKLELQ QLSTSSSGGR
310 320 330 340 350
INRIRSSGSA ANLIAKKRVI RMLIVIVVLF FLCWMPIFSA NAWRAYDTVS
360 370 380 390 400
AEKHLSGTPI SFILLLSYTS SCVNPIIYCF MNKRFRLGFM ATFPCCPNPG
410 420 430
PTGVRGEVGE EEDGRTIRAS LSRYSYSHMS TSAPPH
Length:436
Mass (Da):48,437
Last modified:July 1, 1997 - v1
Checksum:iEBB5D8453B792F79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34Q → H in BAB23512 (PubMed:16141072).Curated1
Sequence conflicti59N → D in BAB23512 (PubMed:16141072).Curated1
Sequence conflicti436H → P in AAH20534 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015963
, AF015959, AF015960, AF015961, AF015962 Genomic DNA Translation: AAC07949.1
D85605 Genomic DNA Translation: BAA20068.1
AK004730 mRNA Translation: BAB23512.1
BC020534 mRNA Translation: AAH20534.1
CCDSiCCDS19293.1
PIRiJC5599
RefSeqiNP_033957.1, NM_009827.2
UniGeneiMm.3521

Genome annotation databases

EnsembliENSMUST00000031093; ENSMUSP00000031093; ENSMUSG00000029193
GeneIDi12425
KEGGimmu:12425
UCSCiuc008xlm.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCCKAR_MOUSE
AccessioniPrimary (citable) accession number: O08786
Secondary accession number(s): Q8VCC7, Q9DBV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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