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Protein

Cholecystokinin receptor type A

Gene

Cckar

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Cholecystokinin receptor type A
Short name:
CCK-A receptor
Short name:
CCK-AR
Alternative name(s):
Cholecystokinin-1 receptor
Short name:
CCK1-R
Gene namesi
Name:Cckar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99478. Cckar.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141ExtracellularSequence analysisAdd
BLAST
Transmembranei42 – 6726Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini68 – 7710CytoplasmicSequence analysis
Transmembranei78 – 10427Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini105 – 11511ExtracellularSequence analysisAdd
BLAST
Transmembranei116 – 13722Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15720CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 21032ExtracellularSequence analysisAdd
BLAST
Transmembranei211 – 23424Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini235 – 32187CytoplasmicSequence analysisAdd
BLAST
Transmembranei322 – 34221Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini343 – 35715ExtracellularSequence analysisAdd
BLAST
Transmembranei358 – 38124Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini382 – 43655CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2111334.
GuidetoPHARMACOLOGYi76.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 436436Cholecystokinin receptor type APRO_0000069224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi18 ↔ 29PROSITE-ProRule annotation
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 196PROSITE-ProRule annotation
Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence analysis
Lipidationi395 – 3951S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiO08786.
PRIDEiO08786.

PTM databases

PhosphoSiteiO08786.

Expressioni

Gene expression databases

BgeeiO08786.
CleanExiMM_CCKAR.
ExpressionAtlasiO08786. baseline and differential.
GenevisibleiO08786. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1534448.
STRINGi10090.ENSMUSP00000031093.

Chemistry

BindingDBiO08786.

Structurei

3D structure databases

ProteinModelPortaliO08786.
SMRiO08786. Positions 1-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi258 – 2647Poly-Gly
Compositional biasi265 – 2684Poly-Ser

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiO08786.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG7QVM36.
PhylomeDBiO08786.
TreeFamiTF315303.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVVDSLLMN GSNITPPCEL GLENETLFCL DQPQPSKEWQ SAVQILLYSF
60 70 80 90 100
IFLLSVLGNT LVITVLIRNK RMRTVTNIFL LSLAVSDLML CLFCMPFNLI
110 120 130 140 150
PNLLKDFIFG SAVCKTTTYF MGTSVSVSTF NLVAISLERY GAICRPLQSR
160 170 180 190 200
VWQTKSHALK VIAATWCLSF TIMTPYPIYS NLVPFTKNNN QTANMCRFLL
210 220 230 240 250
PSDAMQQSWQ TFLLLILFLI PGVVMVVAYG LISLELYQGI KFDASQKKSA
260 270 280 290 300
KEKRLSSGGG GGGGSSSSRY EDSDGCYLQK SRPPRKLELQ QLSTSSSGGR
310 320 330 340 350
INRIRSSGSA ANLIAKKRVI RMLIVIVVLF FLCWMPIFSA NAWRAYDTVS
360 370 380 390 400
AEKHLSGTPI SFILLLSYTS SCVNPIIYCF MNKRFRLGFM ATFPCCPNPG
410 420 430
PTGVRGEVGE EEDGRTIRAS LSRYSYSHMS TSAPPH
Length:436
Mass (Da):48,437
Last modified:July 1, 1997 - v1
Checksum:iEBB5D8453B792F79
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341Q → H in BAB23512 (PubMed:16141072).Curated
Sequence conflicti59 – 591N → D in BAB23512 (PubMed:16141072).Curated
Sequence conflicti436 – 4361H → P in AAH20534 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015963
, AF015959, AF015960, AF015961, AF015962 Genomic DNA. Translation: AAC07949.1.
D85605 Genomic DNA. Translation: BAA20068.1.
AK004730 mRNA. Translation: BAB23512.1.
BC020534 mRNA. Translation: AAH20534.1.
CCDSiCCDS19293.1.
PIRiJC5599.
RefSeqiNP_033957.1. NM_009827.2.
UniGeneiMm.3521.

Genome annotation databases

EnsembliENSMUST00000031093; ENSMUSP00000031093; ENSMUSG00000029193.
GeneIDi12425.
KEGGimmu:12425.
UCSCiuc008xlm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF015963
, AF015959, AF015960, AF015961, AF015962 Genomic DNA. Translation: AAC07949.1.
D85605 Genomic DNA. Translation: BAA20068.1.
AK004730 mRNA. Translation: BAB23512.1.
BC020534 mRNA. Translation: AAH20534.1.
CCDSiCCDS19293.1.
PIRiJC5599.
RefSeqiNP_033957.1. NM_009827.2.
UniGeneiMm.3521.

3D structure databases

ProteinModelPortaliO08786.
SMRiO08786. Positions 1-432.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1534448.
STRINGi10090.ENSMUSP00000031093.

Chemistry

BindingDBiO08786.
ChEMBLiCHEMBL2111334.
GuidetoPHARMACOLOGYi76.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO08786.

Proteomic databases

PaxDbiO08786.
PRIDEiO08786.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031093; ENSMUSP00000031093; ENSMUSG00000029193.
GeneIDi12425.
KEGGimmu:12425.
UCSCiuc008xlm.2. mouse.

Organism-specific databases

CTDi886.
MGIiMGI:99478. Cckar.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000118781.
HOGENOMiHOG000294067.
HOVERGENiHBG036927.
InParanoidiO08786.
KOiK04194.
OMAiYSYSHMS.
OrthoDBiEOG7QVM36.
PhylomeDBiO08786.
TreeFamiTF315303.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiCckar. mouse.
NextBioi281232.
PROiO08786.
SOURCEiSearch...

Gene expression databases

BgeeiO08786.
CleanExiMM_CCKAR.
ExpressionAtlasiO08786. baseline and differential.
GenevisibleiO08786. MM.

Family and domain databases

Gene3Di4.10.670.10. 1 hit.
InterProiIPR009126. Cholcskin_rcpt.
IPR000596. Cholcy_rcpt_A.
IPR015276. CholecystokininA_recpt_N.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF09193. CholecysA-Rec_N. 1 hit.
[Graphical view]
PRINTSiPR01822. CCYSTOKININR.
PR00524. CCYSTOKNINAR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse cholecystokinin type-A receptor gene and its structural analysis."
    Takata Y., Takiguchi S., Takaoka K., Funakoshi A., Miyasaka K., Kono A.
    Gene 187:267-271(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiCCKAR_MOUSE
AccessioniPrimary (citable) accession number: O08786
Secondary accession number(s): Q8VCC7, Q9DBV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.