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O08784

- TCOF_MOUSE

UniProt

O08784 - TCOF_MOUSE

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Protein

Treacle protein

Gene

Tcof1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex. May participate in certain stages of ribosome biogenesis.

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: MGI
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Treacle protein
Alternative name(s):
Treacher Collins syndrome protein homolog
Gene namesi
Name:Tcof1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:892003. Tcof1.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320Treacle proteinPRO_0000072460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831PhosphoserineBy similarity
Modified residuei85 – 851PhosphoserineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity
Modified residuei88 – 881PhosphoserineBy similarity
Modified residuei132 – 1321N6-acetyllysine1 Publication
Modified residuei151 – 1511PhosphoserineBy similarity
Modified residuei153 – 1531N6-acetyllysineBy similarity
Modified residuei154 – 1541PhosphoserineBy similarity
Modified residuei169 – 1691Phosphoserine2 Publications
Modified residuei171 – 1711Phosphothreonine2 Publications
Modified residuei301 – 3011N6-acetyllysineBy similarity
Modified residuei318 – 3181N6-acetyllysine1 Publication
Modified residuei327 – 3271N6-acetyllysine1 Publication
Modified residuei386 – 3861PhosphoserineBy similarity
Modified residuei433 – 4331PhosphoserineBy similarity
Modified residuei443 – 4431PhosphoserineBy similarity
Modified residuei521 – 5211N6-acetyllysineBy similarity
Modified residuei593 – 5931Phosphoserine1 Publication
Modified residuei626 – 6261N6-acetyllysine1 Publication
Modified residuei630 – 6301N6-acetyllysine1 Publication
Modified residuei655 – 6551N6-acetyllysineBy similarity
Modified residuei662 – 6621PhosphoserineBy similarity
Modified residuei664 – 6641PhosphoserineBy similarity
Modified residuei669 – 6691PhosphoserineBy similarity
Modified residuei671 – 6711PhosphoserineBy similarity
Modified residuei760 – 7601PhosphoserineBy similarity
Modified residuei761 – 7611PhosphoserineBy similarity
Modified residuei765 – 7651PhosphoserineBy similarity
Modified residuei767 – 7671PhosphoserineBy similarity
Modified residuei794 – 7941PhosphoserineBy similarity
Modified residuei853 – 8531PhosphoserineBy similarity
Modified residuei869 – 8691PhosphothreonineBy similarity
Modified residuei922 – 9221N6-acetyllysine1 Publication
Modified residuei976 – 9761N6-acetyllysine1 Publication
Modified residuei1034 – 10341PhosphoserineBy similarity
Modified residuei1191 – 11911Phosphoserine1 Publication
Modified residuei1216 – 12161Phosphoserine1 Publication
Modified residuei1242 – 12421PhosphoserineBy similarity
Modified residuei1249 – 12491N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO08784.
PaxDbiO08784.
PRIDEiO08784.

PTM databases

PhosphoSiteiO08784.

Miscellaneous databases

PMAP-CutDBO08784.

Expressioni

Tissue specificityi

Ubiquitous in adult and embryonic tissues.

Developmental stagei

Expression elevated at 11 dpc when the branchial arches and facial swellings are present.1 Publication

Gene expression databases

BgeeiO08784.
ExpressionAtlasiO08784. baseline and differential.
GenevestigatoriO08784.

Interactioni

Subunit structurei

Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with NOP56 in an RNA-independent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi204043. 1 interaction.
IntActiO08784. 2 interactions.
MINTiMINT-4137233.

Structurei

3D structure databases

ProteinModelPortaliO08784.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3833LisHPROSITE-ProRule annotationAdd
BLAST
Repeati212 – 295841Add
BLAST
Repeati296 – 366712Add
BLAST
Repeati367 – 436703Add
BLAST
Repeati437 – 505694Add
BLAST
Repeati506 – 550455Add
BLAST
Repeati551 – 624746Add
BLAST
Repeati625 – 680567Add
BLAST
Repeati681 – 714348Add
BLAST
Repeati715 – 774609Add
BLAST
Repeati775 – 8396510Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 83962810 X approximate tandem repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 1984Poly-Ser
Compositional biasi216 – 27257Ala-richAdd
BLAST
Compositional biasi253 – 27220Poly-AlaAdd
BLAST
Compositional biasi880 – 8856Poly-Ser
Compositional biasi1179 – 1314136Lys-richAdd
BLAST
Compositional biasi1200 – 12056Poly-Lys
Compositional biasi1270 – 12778Poly-Lys
Compositional biasi1280 – 12889Poly-Lys
Compositional biasi1307 – 13148Poly-Lys

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111382.
HOGENOMiHOG000154524.
HOVERGENiHBG006664.
InParanoidiO08784.
KOiK14562.
PhylomeDBiO08784.
TreeFamiTF341730.

Family and domain databases

InterProiIPR006594. LisH_dimerisation.
IPR003993. TCS_treacle.
IPR017859. Treacle-like_TCS.
[Graphical view]
PfamiPF03546. Treacle. 2 hits.
[Graphical view]
PRINTSiPR01503. TREACLE.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08784-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEARKRREL LPLIYHHLLQ AGYVRAAREV KEQSGQKSFL TQPVTLLDIY
60 70 80 90 100
THWQQTSELG QKQKAEDDET LQAKKSRVSD PVSSSESSDQ EKEEEAATER
110 120 130 140 150
AKATPRPTPV NSATAALPSK VKEKGKTKTA NKTVNSVSHP GSGKTVVHLL
160 170 180 190 200
SGKSPKKSAE PLANTVLASE TEEEGNAQAL GPTAKSGTVS AGQGSSSSED
210 220 230 240 250
SSISSDETDV EVKSPAKPAQ AKASAAPAKD PPARTAPGPT KLGNVAPTPA
260 270 280 290 300
KPARAAAAAA AAAVAAAAAA AAEESESSEE DSDSEDEAPA GLPSQVKASG
310 320 330 340 350
KGPHVRADSV SAKGISGKGP ILATPGKTGP AATQAKAERP EKDSETSSED
360 370 380 390 400
DSDSEDEMPV TVNTPQARTS GKSPRARGTS APAKESSQKG APAVTPGKAR
410 420 430 440 450
PVAAQAGKPE AKSSEESESD SGETPAAATL TTSPAKVKPL GKSSQVRPVS
460 470 480 490 500
TVTPGSSGKG ANLPCPGKVG SAALRVQMVK KEDVSESSSA ELDSDGPGSP
510 520 530 540 550
AKAKASLALP QKVRPVATQV KTDRGKGHSG SSEESSDSEE EAAPAASAAQ
560 570 580 590 600
AKPALEKQMK ASSRKGTPAS ATGASTSSHC KAGAVTSSAS LSSPALAKGT
610 620 630 640 650
QRSDVDSSSE SESEGAAPST PRVQGKSGGK GLQGKAALGQ GVAPVHTQKT
660 670 680 690 700
GPSVKAMAQE DSESLEEDSS SEEEDETPAQ ATPLGRLPQA KANPPPTKTP
710 720 730 740 750
PASASGKAVA APTKGKPPVP NSTVSARGQR SVPAAGKAGA PATQAQKGPV
760 770 780 790 800
AGTGEDSESS SKEESDSEEE TPAQIKPVGK TSQVRAASAP AKESPKKGAH
810 820 830 840 850
PGTPGKTGSS ATQAQPGKTE DSDSSSEESD SDTEMPSAQA IKSPPVSVNR
860 870 880 890 900
NSSPAVPAPT PEGVQAVNTT KKASGTTAQS SSSESEDGDE DLIPATQPST
910 920 930 940 950
YALRTSVTTP AALSRAASQP SKSEQSSRMP KGKKAKAAAS AQTSSAVETL
960 970 980 990 1000
PMMPPQSAPI QPKATNKLGK SKLPEKQQLA PGYPKAPRSS EDSSDTSSED
1010 1020 1030 1040 1050
EEDAKRPQMP KSAHRLDPDP SQKETVVEET PTESSEDEMV APSQSLLSGY
1060 1070 1080 1090 1100
MTPGLTVANS QASKATPRPD SNSLASSAPA TKDNPDGKQK SKSQHAADTA
1110 1120 1130 1140 1150
LPKTGRKEAS SGSTPQKPKK LKKSTSSSPA PTQTLPNSIT QRLLEQAWPL
1160 1170 1180 1190 1200
SEAQVQASVV KVLTELLEQE RLKATEAIKE SGKKSQKRKL SGDLEAGAPK
1210 1220 1230 1240 1250
NKKKKEQPVP RASAVSPEKA PMTSKAKSKL DKGSAGGKGK GSPGPQGAKE
1260 1270 1280 1290 1300
KPDGELLGIK LESGEQSDPK SKSKKKKSLK KKKDKEKKEK KKGKKSLAKD
1310 1320
SASPIQKKKK KKKKSAEPAV
Length:1,320
Mass (Da):135,001
Last modified:July 1, 1997 - v1
Checksum:i34D87F5F5D300758
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351G → A in AAB60933. (PubMed:9158147)Curated
Sequence conflicti125 – 14218Missing in AAB60933. (PubMed:9158147)CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001794 mRNA. Translation: AAB71347.1.
U81030 mRNA. Translation: AAB60933.1.
BC060105 mRNA. Translation: AAH60105.1.
CCDSiCCDS37836.1.
PIRiJC5630.
RefSeqiNP_035682.1. NM_011552.3.
UniGeneiMm.486251.

Genome annotation databases

EnsembliENSMUST00000176630; ENSMUSP00000135476; ENSMUSG00000024613.
GeneIDi21453.
KEGGimmu:21453.
UCSCiuc008fbb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001794 mRNA. Translation: AAB71347.1 .
U81030 mRNA. Translation: AAB60933.1 .
BC060105 mRNA. Translation: AAH60105.1 .
CCDSi CCDS37836.1.
PIRi JC5630.
RefSeqi NP_035682.1. NM_011552.3.
UniGenei Mm.486251.

3D structure databases

ProteinModelPortali O08784.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204043. 1 interaction.
IntActi O08784. 2 interactions.
MINTi MINT-4137233.

PTM databases

PhosphoSitei O08784.

Proteomic databases

MaxQBi O08784.
PaxDbi O08784.
PRIDEi O08784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000176630 ; ENSMUSP00000135476 ; ENSMUSG00000024613 .
GeneIDi 21453.
KEGGi mmu:21453.
UCSCi uc008fbb.2. mouse.

Organism-specific databases

CTDi 6949.
MGIi MGI:892003. Tcof1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111382.
HOGENOMi HOG000154524.
HOVERGENi HBG006664.
InParanoidi O08784.
KOi K14562.
PhylomeDBi O08784.
TreeFami TF341730.

Miscellaneous databases

NextBioi 300816.
PMAP-CutDB O08784.
PROi O08784.
SOURCEi Search...

Gene expression databases

Bgeei O08784.
ExpressionAtlasi O08784. baseline and differential.
Genevestigatori O08784.

Family and domain databases

InterProi IPR006594. LisH_dimerisation.
IPR003993. TCS_treacle.
IPR017859. Treacle-like_TCS.
[Graphical view ]
Pfami PF03546. Treacle. 2 hits.
[Graphical view ]
PRINTSi PR01503. TREACLE.
SMARTi SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar phosphoproteins, and maps to chromosome 18."
    Paznekas W.A., Zhang N., Gridley T., Jabs E.W.
    Biochem. Biophys. Res. Commun. 238:1-6(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1."
    Dixon J., Hovanes K., Shiang R., Dixon M.J.
    Hum. Mol. Genet. 6:727-737(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1314.
    Strain: C57BL/6.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND THR-171, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; THR-171; SER-593 AND SER-1216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-132; LYS-318; LYS-327; LYS-626; LYS-630; LYS-922 AND LYS-976, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTCOF_MOUSE
AccessioniPrimary (citable) accession number: O08784
Secondary accession number(s): O08857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3