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O08784

- TCOF_MOUSE

UniProt

O08784 - TCOF_MOUSE

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Protein
Treacle protein
Gene
Tcof1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex. May participate in certain stages of ribosome biogenesis.

GO - Biological processi

  1. transcription of nuclear large rRNA transcript from RNA polymerase I promoter Source: MGI
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Treacle protein
Alternative name(s):
Treacher Collins syndrome protein homolog
Gene namesi
Name:Tcof1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:892003. Tcof1.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13201320Treacle protein
PRO_0000072460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831Phosphoserine By similarity
Modified residuei85 – 851Phosphoserine By similarity
Modified residuei87 – 871Phosphoserine By similarity
Modified residuei88 – 881Phosphoserine By similarity
Modified residuei132 – 1321N6-acetyllysine1 Publication
Modified residuei151 – 1511Phosphoserine By similarity
Modified residuei153 – 1531N6-acetyllysine By similarity
Modified residuei154 – 1541Phosphoserine By similarity
Modified residuei169 – 1691Phosphoserine2 Publications
Modified residuei171 – 1711Phosphothreonine2 Publications
Modified residuei301 – 3011N6-acetyllysine By similarity
Modified residuei318 – 3181N6-acetyllysine1 Publication
Modified residuei327 – 3271N6-acetyllysine1 Publication
Modified residuei386 – 3861Phosphoserine By similarity
Modified residuei433 – 4331Phosphoserine By similarity
Modified residuei443 – 4431Phosphoserine By similarity
Modified residuei521 – 5211N6-acetyllysine By similarity
Modified residuei593 – 5931Phosphoserine1 Publication
Modified residuei626 – 6261N6-acetyllysine1 Publication
Modified residuei630 – 6301N6-acetyllysine1 Publication
Modified residuei655 – 6551N6-acetyllysine By similarity
Modified residuei662 – 6621Phosphoserine By similarity
Modified residuei664 – 6641Phosphoserine By similarity
Modified residuei669 – 6691Phosphoserine By similarity
Modified residuei671 – 6711Phosphoserine By similarity
Modified residuei760 – 7601Phosphoserine By similarity
Modified residuei761 – 7611Phosphoserine By similarity
Modified residuei765 – 7651Phosphoserine By similarity
Modified residuei767 – 7671Phosphoserine By similarity
Modified residuei794 – 7941Phosphoserine By similarity
Modified residuei853 – 8531Phosphoserine By similarity
Modified residuei869 – 8691Phosphothreonine By similarity
Modified residuei922 – 9221N6-acetyllysine1 Publication
Modified residuei976 – 9761N6-acetyllysine1 Publication
Modified residuei1034 – 10341Phosphoserine By similarity
Modified residuei1191 – 11911Phosphoserine1 Publication
Modified residuei1216 – 12161Phosphoserine1 Publication
Modified residuei1242 – 12421Phosphoserine By similarity
Modified residuei1249 – 12491N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiO08784.
PaxDbiO08784.
PRIDEiO08784.

PTM databases

PhosphoSiteiO08784.

Miscellaneous databases

PMAP-CutDBO08784.

Expressioni

Tissue specificityi

Ubiquitous in adult and embryonic tissues.

Developmental stagei

Expression elevated at 11 dpc when the branchial arches and facial swellings are present.1 Publication

Gene expression databases

ArrayExpressiO08784.
BgeeiO08784.
GenevestigatoriO08784.

Interactioni

Subunit structurei

Part of a large pre-ribosomal ribonucleoprotein (RNP) complex, that consists of at least 62 ribosomal proteins, 45 nonribosomal proteins and both pre-rRNA and mature rRNA species. Within this complex directly interacts with NOP56 in an RNA-independent manner By similarity.

Protein-protein interaction databases

BioGridi204043. 1 interaction.
IntActiO08784. 2 interactions.
MINTiMINT-4137233.

Structurei

3D structure databases

ProteinModelPortaliO08784.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 3833LisH
Add
BLAST
Repeati212 – 295841
Add
BLAST
Repeati296 – 366712
Add
BLAST
Repeati367 – 436703
Add
BLAST
Repeati437 – 505694
Add
BLAST
Repeati506 – 550455
Add
BLAST
Repeati551 – 624746
Add
BLAST
Repeati625 – 680567
Add
BLAST
Repeati681 – 714348
Add
BLAST
Repeati715 – 774609
Add
BLAST
Repeati775 – 8396510
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni212 – 83962810 X approximate tandem repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi195 – 1984Poly-Ser
Compositional biasi216 – 27257Ala-rich
Add
BLAST
Compositional biasi253 – 27220Poly-Ala
Add
BLAST
Compositional biasi880 – 8856Poly-Ser
Compositional biasi1179 – 1314136Lys-rich
Add
BLAST
Compositional biasi1200 – 12056Poly-Lys
Compositional biasi1270 – 12778Poly-Lys
Compositional biasi1280 – 12889Poly-Lys
Compositional biasi1307 – 13148Poly-Lys

Sequence similaritiesi

Contains 1 LisH domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00730000111382.
HOGENOMiHOG000154524.
HOVERGENiHBG006664.
InParanoidiO08784.
KOiK14562.
PhylomeDBiO08784.
TreeFamiTF341730.

Family and domain databases

InterProiIPR006594. LisH_dimerisation.
IPR003993. TCS_treacle.
IPR017859. Treacle-like_TCS.
[Graphical view]
PfamiPF03546. Treacle. 2 hits.
[Graphical view]
PRINTSiPR01503. TREACLE.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08784-1 [UniParc]FASTAAdd to Basket

« Hide

MAEARKRREL LPLIYHHLLQ AGYVRAAREV KEQSGQKSFL TQPVTLLDIY     50
THWQQTSELG QKQKAEDDET LQAKKSRVSD PVSSSESSDQ EKEEEAATER 100
AKATPRPTPV NSATAALPSK VKEKGKTKTA NKTVNSVSHP GSGKTVVHLL 150
SGKSPKKSAE PLANTVLASE TEEEGNAQAL GPTAKSGTVS AGQGSSSSED 200
SSISSDETDV EVKSPAKPAQ AKASAAPAKD PPARTAPGPT KLGNVAPTPA 250
KPARAAAAAA AAAVAAAAAA AAEESESSEE DSDSEDEAPA GLPSQVKASG 300
KGPHVRADSV SAKGISGKGP ILATPGKTGP AATQAKAERP EKDSETSSED 350
DSDSEDEMPV TVNTPQARTS GKSPRARGTS APAKESSQKG APAVTPGKAR 400
PVAAQAGKPE AKSSEESESD SGETPAAATL TTSPAKVKPL GKSSQVRPVS 450
TVTPGSSGKG ANLPCPGKVG SAALRVQMVK KEDVSESSSA ELDSDGPGSP 500
AKAKASLALP QKVRPVATQV KTDRGKGHSG SSEESSDSEE EAAPAASAAQ 550
AKPALEKQMK ASSRKGTPAS ATGASTSSHC KAGAVTSSAS LSSPALAKGT 600
QRSDVDSSSE SESEGAAPST PRVQGKSGGK GLQGKAALGQ GVAPVHTQKT 650
GPSVKAMAQE DSESLEEDSS SEEEDETPAQ ATPLGRLPQA KANPPPTKTP 700
PASASGKAVA APTKGKPPVP NSTVSARGQR SVPAAGKAGA PATQAQKGPV 750
AGTGEDSESS SKEESDSEEE TPAQIKPVGK TSQVRAASAP AKESPKKGAH 800
PGTPGKTGSS ATQAQPGKTE DSDSSSEESD SDTEMPSAQA IKSPPVSVNR 850
NSSPAVPAPT PEGVQAVNTT KKASGTTAQS SSSESEDGDE DLIPATQPST 900
YALRTSVTTP AALSRAASQP SKSEQSSRMP KGKKAKAAAS AQTSSAVETL 950
PMMPPQSAPI QPKATNKLGK SKLPEKQQLA PGYPKAPRSS EDSSDTSSED 1000
EEDAKRPQMP KSAHRLDPDP SQKETVVEET PTESSEDEMV APSQSLLSGY 1050
MTPGLTVANS QASKATPRPD SNSLASSAPA TKDNPDGKQK SKSQHAADTA 1100
LPKTGRKEAS SGSTPQKPKK LKKSTSSSPA PTQTLPNSIT QRLLEQAWPL 1150
SEAQVQASVV KVLTELLEQE RLKATEAIKE SGKKSQKRKL SGDLEAGAPK 1200
NKKKKEQPVP RASAVSPEKA PMTSKAKSKL DKGSAGGKGK GSPGPQGAKE 1250
KPDGELLGIK LESGEQSDPK SKSKKKKSLK KKKDKEKKEK KKGKKSLAKD 1300
SASPIQKKKK KKKKSAEPAV 1320
Length:1,320
Mass (Da):135,001
Last modified:July 1, 1997 - v1
Checksum:i34D87F5F5D300758
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351G → A in AAB60933. 1 Publication
Sequence conflicti125 – 14218Missing in AAB60933. 1 Publication
Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001794 mRNA. Translation: AAB71347.1.
U81030 mRNA. Translation: AAB60933.1.
BC060105 mRNA. Translation: AAH60105.1.
CCDSiCCDS37836.1.
PIRiJC5630.
RefSeqiNP_035682.1. NM_011552.3.
UniGeneiMm.486251.

Genome annotation databases

EnsembliENSMUST00000176630; ENSMUSP00000135476; ENSMUSG00000024613.
GeneIDi21453.
KEGGimmu:21453.
UCSCiuc008fbb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF001794 mRNA. Translation: AAB71347.1 .
U81030 mRNA. Translation: AAB60933.1 .
BC060105 mRNA. Translation: AAH60105.1 .
CCDSi CCDS37836.1.
PIRi JC5630.
RefSeqi NP_035682.1. NM_011552.3.
UniGenei Mm.486251.

3D structure databases

ProteinModelPortali O08784.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204043. 1 interaction.
IntActi O08784. 2 interactions.
MINTi MINT-4137233.

PTM databases

PhosphoSitei O08784.

Proteomic databases

MaxQBi O08784.
PaxDbi O08784.
PRIDEi O08784.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000176630 ; ENSMUSP00000135476 ; ENSMUSG00000024613 .
GeneIDi 21453.
KEGGi mmu:21453.
UCSCi uc008fbb.2. mouse.

Organism-specific databases

CTDi 6949.
MGIi MGI:892003. Tcof1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00730000111382.
HOGENOMi HOG000154524.
HOVERGENi HBG006664.
InParanoidi O08784.
KOi K14562.
PhylomeDBi O08784.
TreeFami TF341730.

Miscellaneous databases

NextBioi 300816.
PMAP-CutDB O08784.
PROi O08784.
SOURCEi Search...

Gene expression databases

ArrayExpressi O08784.
Bgeei O08784.
Genevestigatori O08784.

Family and domain databases

InterProi IPR006594. LisH_dimerisation.
IPR003993. TCS_treacle.
IPR017859. Treacle-like_TCS.
[Graphical view ]
Pfami PF03546. Treacle. 2 hits.
[Graphical view ]
PRINTSi PR01503. TREACLE.
SMARTi SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar phosphoproteins, and maps to chromosome 18."
    Paznekas W.A., Zhang N., Gridley T., Jabs E.W.
    Biochem. Biophys. Res. Commun. 238:1-6(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Sequence analysis, identification of evolutionary conserved motifs and expression analysis of murine tcof1 provide further evidence for a potential function for the gene and its human homologue, TCOF1."
    Dixon J., Hovanes K., Shiang R., Dixon M.J.
    Hum. Mol. Genet. 6:727-737(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1314.
    Strain: C57BL/6.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169 AND THR-171, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169; THR-171; SER-593 AND SER-1216, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  8. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-132; LYS-318; LYS-327; LYS-626; LYS-630; LYS-922 AND LYS-976, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTCOF_MOUSE
AccessioniPrimary (citable) accession number: O08784
Secondary accession number(s): O08857
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi