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Protein
Submitted name:

Cyclin dependent kinase inhibitor

Gene

Cdkn1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • chaperone binding Source: RGD
  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: Ensembl
  • cysteine-type endopeptidase activator activity involved in apoptotic process Source: Ensembl
  • Hsp70 protein binding Source: RGD
  • kinase activity Source: UniProtKB-KW
  • protein complex binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

CyclinImported, KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-RNO-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-RNO-198323. AKT phosphorylates targets in the cytosol.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-RNO-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
R-RNO-68949. Orc1 removal from chromatin.
R-RNO-69202. Cyclin E associated events during G1/S transition.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69563. p53-Dependent G1 DNA Damage Response.
R-RNO-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-RNO-8849470. PTK6 Regulates Cell Cycle.

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin dependent kinase inhibitorImported
Submitted name:
Cyclin kinase inhibitorImported
Submitted name:
Cyclin-dependent kinase inhibitor 1BImported
Submitted name:
P27 kip1Imported
Submitted name:
P27kip1Imported
Submitted name:
Protein Cdkn1bImported
Gene namesi
Name:Cdkn1bImported
Synonyms:p27Kip1Imported
ORF Names:rCG_29991Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi69062. Cdkn1b.

Subcellular locationi

GO - Cellular componenti

  • Cul4A-RING E3 ubiquitin ligase complex Source: Ensembl
  • cytoplasm Source: RGD
  • cytosol Source: Ensembl
  • nucleus Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P032552EBI-7796656,EBI-2603114From a different organism.
P032592EBI-7796656,EBI-6947456From a different organism.

GO - Molecular functioni

  • chaperone binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • protein complex binding Source: RGD

Protein-protein interaction databases

DIPiDIP-44911N.
MINTiMINT-1785011.
STRINGi10116.ENSRNOP00000050173.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG4743. Eukaryota.
ENOG410XXN5. LUCA.
GeneTreeiENSGT00530000063588.
HOGENOMiHOG000294081.
HOVERGENiHBG073988.
KOiK06624.
OMAiYPKPSAC.
OrthoDBiEOG7GJ6HD.
TreeFamiTF101038.

Family and domain databases

InterProiIPR003175. CDI.
IPR029843. CDKN1B.
[Graphical view]
PANTHERiPTHR10265. PTHR10265. 1 hit.
PTHR10265:SF9. PTHR10265:SF9. 1 hit.
PfamiPF02234. CDI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVRVSNGS PSLERMDARQ TEHPKPSACR NLFGPVNHEE LTRDLEKHCR
60 70 80 90 100
DMEEASQRKW NFDFQNHKPL EGRYEWQEVE RGSLPEFYYR PPRPPKSACK
110 120 130 140 150
VPAQESLDVS GSRQAVPSIG SQANSEDRHL VDQMPDSSDS PAGLAEQCPG
160 170 180 190
MRKRPAAEDS SSQNKRANRT EENVSDGSPN AGTVEQTPKK PGLRRQT
Length:197
Mass (Da):22,139
Last modified:July 1, 1997 - v1
Checksum:i55738078C2C9847F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136063 Genomic DNA. No translation available.
AF015194 mRNA. Translation: AAB71368.1.
AY623024 mRNA. Translation: AAT46041.1.
AY623040 mRNA. Translation: AAT46051.1.
D86924 mRNA. Translation: BAA19960.1.
CH473964 Genomic DNA. Translation: EDM01643.1.
RefSeqiNP_113950.2. NM_031762.3.
XP_006237601.1. XM_006237539.2.
UniGeneiRn.29897.

Genome annotation databases

EnsembliENSRNOT00000049848; ENSRNOP00000050173; ENSRNOG00000007249.
GeneIDi83571.
KEGGirno:83571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136063 Genomic DNA. No translation available.
AF015194 mRNA. Translation: AAB71368.1.
AY623024 mRNA. Translation: AAT46041.1.
AY623040 mRNA. Translation: AAT46051.1.
D86924 mRNA. Translation: BAA19960.1.
CH473964 Genomic DNA. Translation: EDM01643.1.
RefSeqiNP_113950.2. NM_031762.3.
XP_006237601.1. XM_006237539.2.
UniGeneiRn.29897.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-44911N.
MINTiMINT-1785011.
STRINGi10116.ENSRNOP00000050173.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049848; ENSRNOP00000050173; ENSRNOG00000007249.
GeneIDi83571.
KEGGirno:83571.

Organism-specific databases

CTDi1027.
RGDi69062. Cdkn1b.

Phylogenomic databases

eggNOGiKOG4743. Eukaryota.
ENOG410XXN5. LUCA.
GeneTreeiENSGT00530000063588.
HOGENOMiHOG000294081.
HOVERGENiHBG073988.
KOiK06624.
OMAiYPKPSAC.
OrthoDBiEOG7GJ6HD.
TreeFamiTF101038.

Enzyme and pathway databases

ReactomeiR-RNO-176408. Regulation of APC/C activators between G1/S and early anaphase.
R-RNO-187577. SCF(Skp2)-mediated degradation of p27/p21.
R-RNO-198323. AKT phosphorylates targets in the cytosol.
R-RNO-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-RNO-2559586. DNA Damage/Telomere Stress Induced Senescence.
R-RNO-6804116. TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.
R-RNO-68949. Orc1 removal from chromatin.
R-RNO-69202. Cyclin E associated events during G1/S transition.
R-RNO-69231. Cyclin D associated events in G1.
R-RNO-69563. p53-Dependent G1 DNA Damage Response.
R-RNO-69656. Cyclin A:Cdk2-associated events at S phase entry.
R-RNO-8849470. PTK6 Regulates Cell Cycle.

Family and domain databases

InterProiIPR003175. CDI.
IPR029843. CDKN1B.
[Graphical view]
PANTHERiPTHR10265. PTHR10265. 1 hit.
PTHR10265:SF9. PTHR10265:SF9. 1 hit.
PfamiPF02234. CDI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Uehara Y.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Dastvan F., Reidy M.A.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
  3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Rat Genome Sequencing Project Consortium
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown NorwayImported.
  4. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BNImported.
  6. "Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners."
    Iwanaga R., Komori H., Ishida S., Okamura N., Nakayama K., Nakayama K., Ohtani K.
    Oncogene 25:1786-1798(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Brown NorwayImported.
  9. "Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway."
    Kawada M., Yamagoe S., Murakami Y., Suzuki K., Mizuno S., Uehara Y.
    Oncogene 0:0-0(0)
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO08769_RAT
AccessioniPrimary (citable) accession number: O08769
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.