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Protein
Submitted name:

Cyclin dependent kinase inhibitor

Gene

Cdkn1b

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCyclinImported, KinaseImported, Transferase

Enzyme and pathway databases

ReactomeiR-RNO-176408 Regulation of APC/C activators between G1/S and early anaphase
R-RNO-187577 SCF(Skp2)-mediated degradation of p27/p21
R-RNO-198323 AKT phosphorylates targets in the cytosol
R-RNO-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-RNO-2559586 DNA Damage/Telomere Stress Induced Senescence
R-RNO-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
R-RNO-68949 Orc1 removal from chromatin
R-RNO-69202 Cyclin E associated events during G1/S transition
R-RNO-69231 Cyclin D associated events in G1
R-RNO-69563 p53-Dependent G1 DNA Damage Response
R-RNO-69656 Cyclin A:Cdk2-associated events at S phase entry
R-RNO-8849470 PTK6 Regulates Cell Cycle

Names & Taxonomyi

Protein namesi
Submitted name:
Cyclin dependent kinase inhibitorImported
Submitted name:
Cyclin kinase inhibitorImported
Submitted name:
Cyclin-dependent kinase inhibitor 1BImported
Submitted name:
p27 kip1Imported
Submitted name:
p27kip1Imported
Gene namesi
Name:Cdkn1bImported
Synonyms:p27Kip1Imported
ORF Names:rCG_29991Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi69062 Cdkn1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000007249

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • chaperone binding Source: RGD
  • cyclin binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • protein kinase binding Source: RGD
  • protein phosphatase binding Source: RGD

Protein-protein interaction databases

DIPiDIP-44911N
IntActiO08769, 4 interactors
STRINGi10116.ENSRNOP00000050173

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili38 – 58Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4743 Eukaryota
ENOG410XXN5 LUCA
GeneTreeiENSGT00530000063588
HOGENOMiHOG000294081
HOVERGENiHBG073988
KOiK06624
OMAiYPKPSAC
OrthoDBiEOG091G19PZ
TreeFamiTF101038

Family and domain databases

InterProiView protein in InterPro
IPR003175 CDI
IPR029843 CDKN1B
PANTHERiPTHR10265 PTHR10265, 1 hit
PTHR10265:SF9 PTHR10265:SF9, 1 hit
PfamiView protein in Pfam
PF02234 CDI, 1 hit

Sequencei

Sequence statusi: Complete.

O08769-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVRVSNGS PSLERMDARQ TEHPKPSACR NLFGPVNHEE LTRDLEKHCR
60 70 80 90 100
DMEEASQRKW NFDFQNHKPL EGRYEWQEVE RGSLPEFYYR PPRPPKSACK
110 120 130 140 150
VPAQESLDVS GSRQAVPSIG SQANSEDRHL VDQMPDSSDS PAGLAEQCPG
160 170 180 190
MRKRPAAEDS SSQNKRANRT EENVSDGSPN AGTVEQTPKK PGLRRQT
Length:197
Mass (Da):22,139
Last modified:July 1, 1997 - v1
Checksum:i55738078C2C9847F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136063 Genomic DNA No translation available.
AF015194 mRNA Translation: AAB71368.1
AY623024 mRNA Translation: AAT46041.1
AY623040 mRNA Translation: AAT46051.1
D86924 mRNA Translation: BAA19960.1
CH473964 Genomic DNA Translation: EDM01643.1
RefSeqiNP_113950.2, NM_031762.3
XP_006237601.1, XM_006237539.3
UniGeneiRn.29897

Genome annotation databases

EnsembliENSRNOT00000049848; ENSRNOP00000050173; ENSRNOG00000007249
GeneIDi83571
KEGGirno:83571

Similar proteinsi

Entry informationi

Entry nameiO08769_RAT
AccessioniPrimary (citable) accession number: O08769
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health