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Protein

Ankyrin repeat and BTB/POZ domain-containing protein 2

Gene

Abtb2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the initiation of hepatocyte growth.

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and BTB/POZ domain-containing protein 2
Alternative name(s):
CCA3
Confluent 3Y1 cell-associated protein
Gene namesi
Name:Abtb2
Synonyms:Cca3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620724. Abtb2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10091009Ankyrin repeat and BTB/POZ domain-containing protein 2PRO_0000066889Add
BLAST

Proteomic databases

PaxDbiO08764.
PRIDEiO08764.

Expressioni

Tissue specificityi

Highly expressed in liver, brain and testis with lower expression in the spleen.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038218.

Structurei

3D structure databases

ProteinModelPortaliO08764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati520 – 54930ANK 1Add
BLAST
Repeati566 – 59530ANK 2Add
BLAST
Repeati605 – 63430ANK 3Add
BLAST
Repeati648 – 67730ANK 4Add
BLAST
Domaini843 – 91270BTBPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IESM. Eukaryota.
ENOG410XRDX. LUCA.
HOGENOMiHOG000033776.
HOVERGENiHBG050447.
InParanoidiO08764.
KOiK10521.
PhylomeDBiO08764.

Family and domain databases

Gene3Di1.10.20.10. 2 hits.
1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR009072. Histone-fold.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAPQHR
60 70 80 90 100
GAAWWCYSGS MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT
110 120 130 140 150
EGDVARVLRK SVGGRRLPSF SAEAVRRLAG LLRRALIRVA REAQRLSVLH
160 170 180 190 200
AKCTRFEVQS AVRLVHSWAL AESCALAAVK ALSLYSMSAG DGLRRGKSAR
210 220 230 240 250
CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE EIRARVLASQ
260 270 280 290 300
SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
310 320 330 340 350
AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA
360 370 380 390 400
MHHMQGRHPL CPGTSPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME
410 420 430 440 450
NPNLDPPRMT LNNERPFMLL PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA
460 470 480 490 500
ARLLLPGLDC EPRQLKPECC FSSFRRLDAR AATERFNQDL GFRMLNCGRT
510 520 530 540 550
DLISQPSSPG PDGVNTMDDQ GLTPLMYACA TGDEAMVQML IDAGANLDIQ
560 570 580 590 600
VPSNSPRHPS VHPDSRHWTS LTFAVLHGHI SVVQLLLDAG AHVEGSAVNS
610 620 630 640 650
GEDSYAETPL QLASAAGNYE LVSLLLSRGA DPLLSMLEAN GMASSLHEDM
660 670 680 690 700
NCFSHSAAHG HRNVLRKLLT QPQQAKADVL SLEEILAEGV EESDTSSQGS
710 720 730 740 750
SEGPVRLSRT RTKALQEAMY YSAEHGYVDI TMELRALGVP WKLHIWIESL
760 770 780 790 800
RTSFSQSRYS VVQGLLRDFS SIKEEEYNEE LVTEGLQLMF DILKTSKNDS
810 820 830 840 850
VLQQLATIFT HCYGTSPIPS IPEIRKTLPA RLDPHFLNNK EMSDVTFLVE
860 870 880 890 900
GKLFYAHKVL LVTASNRFKT LMTNKSEQDG DNSKTIEISD IKYHIFQMLM
910 920 930 940 950
QYLYYGGTES MEIPTADILQ LLSAANLFQL DALQRHCEIL CSQTLSVESA
960 970 980 990 1000
VNTYKYAKIH NAPELALFCE GFFLKHMKAL LEQMPSGSSS MAEAAKSRAW

THCRICRAP
Length:1,009
Mass (Da):111,603
Last modified:July 1, 1997 - v1
Checksum:iE25CE5BA846510FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000216 mRNA. Translation: BAA19969.1.
PIRiT31081.
RefSeqiNP_599230.2. NM_134403.2.
UniGeneiRn.11149.

Genome annotation databases

GeneIDi171440.
KEGGirno:171440.
UCSCiRGD:620724. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000216 mRNA. Translation: BAA19969.1.
PIRiT31081.
RefSeqiNP_599230.2. NM_134403.2.
UniGeneiRn.11149.

3D structure databases

ProteinModelPortaliO08764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038218.

Proteomic databases

PaxDbiO08764.
PRIDEiO08764.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171440.
KEGGirno:171440.
UCSCiRGD:620724. rat.

Organism-specific databases

CTDi25841.
RGDi620724. Abtb2.

Phylogenomic databases

eggNOGiENOG410IESM. Eukaryota.
ENOG410XRDX. LUCA.
HOGENOMiHOG000033776.
HOVERGENiHBG050447.
InParanoidiO08764.
KOiK10521.
PhylomeDBiO08764.

Miscellaneous databases

NextBioi622352.
PROiO08764.

Family and domain databases

Gene3Di1.10.20.10. 2 hits.
1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR000210. BTB/POZ_dom.
IPR009072. Histone-fold.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00248. ANK. 5 hits.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF54695. SSF54695. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cca3, the mRNA level of which transiently decreases before initiation of DNA synthesis in regenerating rat liver cells."
    Hayashi Y., Ichinose M., Yuasa H., Tatematsu M., Ishibashi M.
    FEBS Lett. 406:147-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Fibroblast.

Entry informationi

Entry nameiABTB2_RAT
AccessioniPrimary (citable) accession number: O08764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 1, 1997
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.