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O08762 (NETR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotrypsin

EC=3.4.21.-
Alternative name(s):
Brain-specific serine protease 3
Short name=BSSP-3
Motopsin
Serine protease 12
Gene names
Name:Prss12
Synonyms:Bssp3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length761 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.

Subcellular location

Secreted.

Tissue specificity

Most abundant in cerebral cortex, hippocampus and amygdala.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 kringle domain.

Contains 1 peptidase S1 domain.

Contains 3 SRCR domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 761740Neurotrypsin
PRO_0000027670

Regions

Domain85 – 15773Kringle
Domain166 – 267102SRCR 1
Domain273 – 373101SRCR 2
Domain386 – 487102SRCR 3
Domain517 – 760244Peptidase S1
Region505 – 51612Zymogen activation region

Sites

Active site5621Charge relay system
Active site6121Charge relay system
Active site7111Charge relay system
Site516 – 5172Reactive bond homolog Potential

Amino acid modifications

Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation5211N-linked (GlcNAc...) Potential
Glycosylation5691N-linked (GlcNAc...) Potential
Disulfide bond85 ↔ 157 By similarity
Disulfide bond101 ↔ 141 By similarity
Disulfide bond130 ↔ 155 By similarity
Disulfide bond191 ↔ 255 By similarity
Disulfide bond204 ↔ 265 By similarity
Disulfide bond235 ↔ 245 By similarity
Disulfide bond298 ↔ 361 By similarity
Disulfide bond311 ↔ 371 By similarity
Disulfide bond341 ↔ 351 By similarity
Disulfide bond411 ↔ 475 By similarity
Disulfide bond424 ↔ 485 By similarity
Disulfide bond455 ↔ 465 By similarity
Disulfide bond505 ↔ 636 Potential
Disulfide bond547 ↔ 563 By similarity
Disulfide bond651 ↔ 717 By similarity
Disulfide bond680 ↔ 694 By similarity
Disulfide bond707 ↔ 736 By similarity

Sequences

Sequence LengthMass (Da)Tools
O08762 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: DF507B03712164E6

FASTA76184,118
        10         20         30         40         50         60 
MALARCVLAV ILGALSVVAR ADPVSRSPLH RPHPSPPRSQ HAHYLPSSRR PPRTPRFPLP 

        70         80         90        100        110        120 
LRIPAAQRPQ VLSTGHTPPT IPRRCGAGES WGNATNLGVP CLHWDEVPPF LERSPPASWA 

       130        140        150        160        170        180 
ELRGQPHNFC RSPDGSGRPW CFYRNAQGKV DWGYCDCGQG PALPVIRLVG GNSGHEGRVE 

       190        200        210        220        230        240 
LYHAGQWGTI CDDQWDNADA DVICRQLGLS GIAKAWHQAH FGEGSGPILL DEVRCTGNEL 

       250        260        270        280        290        300 
SIEQCPKSSW GEHNCGHKED AGVSCVPLTD GVIRLAGGKS THEGRLEVYY KGQWGTVCDD 

       310        320        330        340        350        360 
GWTEMNTYVA CRLLGFKYGK QSSVNHFDGS NRPIWLDDVS CSGKEVSFIQ CSRRQWGRHD 

       370        380        390        400        410        420 
CSHREDVGLT CYPDSDGHRL SPGFPIRLVD GENKKEGRVE VFVNGQWGTI CDDGWTDKHA 

       430        440        450        460        470        480 
AVICRQLGYK GPARARTMAY FGEGKGPIHM DNVKCTGNEK ALADCVKQDI GRHNCRHSED 

       490        500        510        520        530        540 
AGVICDYLEK KASSSGNKEM LSSGCGLRLL HRRQKRIIGG NNSLRGAWPW QASLRLRSAH 

       550        560        570        580        590        600 
GDGRLLCGAT LLSSCWVLTA AHCFKRYGNN SRSYAVRVGD YHTLVPEEFE QEIGVQQIVI 

       610        620        630        640        650        660 
HRNYRPDRSD YDIALVRLQG PGEQCARLST HVLPACLPLW RERPQKTASN CHITGWGDTG 

       670        680        690        700        710        720 
RAYSRTLQQA AVPLLPKRFC KERYKGLFTG RMLCAGNLQE DNRVDSCQGD SGGPLMCEKP 

       730        740        750        760 
DESWVVYGVT SWGYGCGVKD TPGVYTRVPA FVPWIKSVTS L 

« Hide

References

« Hide 'large scale' references
[1]"Neurotrypsin, a novel multidomain serine protease expressed in the nervous system."
Gschwend T.P., Krueger S.R., Kozlov S.V., Wolfer D.P., Sonderegger P.
Mol. Cell. Neurosci. 9:207-219(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs."
Yamamura Y., Yamashiro K., Tsuruoka N., Nakazato H., Tsujimura A., Yamaguchi N.
Biochem. Biophys. Res. Commun. 239:386-392(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13192 mRNA. Translation: CAA73646.1.
D89871 mRNA. Translation: BAA23986.1.
BC031429 mRNA. Translation: AAH31429.1.
CCDSCCDS17817.1.
PIRJC5759.
RefSeqNP_032965.1. NM_008939.2.
UniGeneMm.9431.

3D structure databases

ProteinModelPortalO08762.
SMRO08762. Positions 84-160, 384-760.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029603.

Protein family/group databases

MEROPSS01.237.

PTM databases

PhosphoSiteO08762.

Proteomic databases

PaxDbO08762.
PRIDEO08762.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029603; ENSMUSP00000029603; ENSMUSG00000027978.
GeneID19142.
KEGGmmu:19142.
UCSCuc008rfl.2. mouse.

Organism-specific databases

CTD8492.
MGIMGI:1100881. Prss12.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00740000115025.
HOGENOMHOG000113767.
HOVERGENHBG006465.
InParanoidO08762.
KOK09624.
OMADDGWTDK.
OrthoDBEOG7RNK07.
PhylomeDBO08762.
TreeFamTF329295.

Gene expression databases

BgeeO08762.
CleanExMM_PRSS12.
GenevestigatorO08762.

Family and domain databases

Gene3D2.40.20.10. 1 hit.
3.10.250.10. 3 hits.
InterProIPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00051. Kringle. 1 hit.
PF00530. SRCR. 3 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
PR00258. SPERACTRCPTR.
SMARTSM00130. KR. 1 hit.
SM00202. SR. 3 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 3 hits.
SSF57440. SSF57440. 1 hit.
PROSITEPS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
PS00420. SRCR_1. 3 hits.
PS50287. SRCR_2. 3 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295774.
PROO08762.
SOURCESearch...

Entry information

Entry nameNETR_MOUSE
AccessionPrimary (citable) accession number: O08762
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot