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O08762

- NETR_MOUSE

UniProt

O08762 - NETR_MOUSE

Protein

Neurotrypsin

Gene

Prss12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei516 – 5172Reactive bond homologSequence Analysis
    Active sitei562 – 5621Charge relay system
    Active sitei612 – 6121Charge relay system
    Active sitei711 – 7111Charge relay system

    GO - Molecular functioni

    1. peptidase activity Source: MGI
    2. scavenger receptor activity Source: InterPro
    3. serine-type endopeptidase activity Source: MGI

    GO - Biological processi

    1. exocytosis Source: UniProtKB
    2. proteolysis Source: MGI
    3. zymogen activation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.237.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrypsin (EC:3.4.21.-)
    Alternative name(s):
    Brain-specific serine protease 3
    Short name:
    BSSP-3
    Motopsin
    Serine protease 12
    Gene namesi
    Name:Prss12
    Synonyms:Bssp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1100881. Prss12.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. cytoplasmic vesicle Source: MGI
    3. dendrite Source: MGI
    4. extracellular region Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB
    6. synapse Source: MGI
    7. synaptic cleft Source: MGI
    8. terminal bouton Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 761740NeurotrypsinPRO_0000027670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi85 ↔ 157By similarity
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 141By similarity
    Disulfide bondi130 ↔ 155By similarity
    Disulfide bondi191 ↔ 255By similarity
    Disulfide bondi204 ↔ 265By similarity
    Disulfide bondi235 ↔ 245By similarity
    Disulfide bondi298 ↔ 361By similarity
    Disulfide bondi311 ↔ 371By similarity
    Disulfide bondi341 ↔ 351By similarity
    Disulfide bondi411 ↔ 475By similarity
    Disulfide bondi424 ↔ 485By similarity
    Disulfide bondi455 ↔ 465By similarity
    Disulfide bondi505 ↔ 636Sequence Analysis
    Glycosylationi521 – 5211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi547 ↔ 563By similarity
    Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi651 ↔ 717By similarity
    Disulfide bondi680 ↔ 694By similarity
    Disulfide bondi707 ↔ 736By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO08762.
    PRIDEiO08762.

    PTM databases

    PhosphoSiteiO08762.

    Expressioni

    Tissue specificityi

    Most abundant in cerebral cortex, hippocampus and amygdala.

    Gene expression databases

    BgeeiO08762.
    CleanExiMM_PRSS12.
    GenevestigatoriO08762.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029603.

    Structurei

    3D structure databases

    ProteinModelPortaliO08762.
    SMRiO08762. Positions 84-160, 384-760.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 15773KringlePROSITE-ProRule annotationAdd
    BLAST
    Domaini166 – 267102SRCR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini273 – 373101SRCR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini386 – 487102SRCR 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 760244Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni505 – 51612Zymogen activation regionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 kringle domain.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation
    Contains 3 SRCR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Kringle, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    GeneTreeiENSGT00740000115025.
    HOGENOMiHOG000113767.
    HOVERGENiHBG006465.
    InParanoidiO08762.
    KOiK09624.
    OMAiDDGWTDK.
    OrthoDBiEOG7RNK07.
    PhylomeDBiO08762.
    TreeFamiTF329295.

    Family and domain databases

    Gene3Di2.40.20.10. 1 hit.
    3.10.250.10. 3 hits.
    InterProiIPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00051. Kringle. 1 hit.
    PF00530. SRCR. 3 hits.
    PF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    PR00258. SPERACTRCPTR.
    SMARTiSM00130. KR. 1 hit.
    SM00202. SR. 3 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    SSF56487. SSF56487. 3 hits.
    SSF57440. SSF57440. 1 hit.
    PROSITEiPS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS00420. SRCR_1. 3 hits.
    PS50287. SRCR_2. 3 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08762-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALARCVLAV ILGALSVVAR ADPVSRSPLH RPHPSPPRSQ HAHYLPSSRR    50
    PPRTPRFPLP LRIPAAQRPQ VLSTGHTPPT IPRRCGAGES WGNATNLGVP 100
    CLHWDEVPPF LERSPPASWA ELRGQPHNFC RSPDGSGRPW CFYRNAQGKV 150
    DWGYCDCGQG PALPVIRLVG GNSGHEGRVE LYHAGQWGTI CDDQWDNADA 200
    DVICRQLGLS GIAKAWHQAH FGEGSGPILL DEVRCTGNEL SIEQCPKSSW 250
    GEHNCGHKED AGVSCVPLTD GVIRLAGGKS THEGRLEVYY KGQWGTVCDD 300
    GWTEMNTYVA CRLLGFKYGK QSSVNHFDGS NRPIWLDDVS CSGKEVSFIQ 350
    CSRRQWGRHD CSHREDVGLT CYPDSDGHRL SPGFPIRLVD GENKKEGRVE 400
    VFVNGQWGTI CDDGWTDKHA AVICRQLGYK GPARARTMAY FGEGKGPIHM 450
    DNVKCTGNEK ALADCVKQDI GRHNCRHSED AGVICDYLEK KASSSGNKEM 500
    LSSGCGLRLL HRRQKRIIGG NNSLRGAWPW QASLRLRSAH GDGRLLCGAT 550
    LLSSCWVLTA AHCFKRYGNN SRSYAVRVGD YHTLVPEEFE QEIGVQQIVI 600
    HRNYRPDRSD YDIALVRLQG PGEQCARLST HVLPACLPLW RERPQKTASN 650
    CHITGWGDTG RAYSRTLQQA AVPLLPKRFC KERYKGLFTG RMLCAGNLQE 700
    DNRVDSCQGD SGGPLMCEKP DESWVVYGVT SWGYGCGVKD TPGVYTRVPA 750
    FVPWIKSVTS L 761
    Length:761
    Mass (Da):84,118
    Last modified:July 1, 1997 - v1
    Checksum:iDF507B03712164E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13192 mRNA. Translation: CAA73646.1.
    D89871 mRNA. Translation: BAA23986.1.
    BC031429 mRNA. Translation: AAH31429.1.
    CCDSiCCDS17817.1.
    PIRiJC5759.
    RefSeqiNP_032965.1. NM_008939.2.
    UniGeneiMm.9431.

    Genome annotation databases

    EnsembliENSMUST00000029603; ENSMUSP00000029603; ENSMUSG00000027978.
    GeneIDi19142.
    KEGGimmu:19142.
    UCSCiuc008rfl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13192 mRNA. Translation: CAA73646.1 .
    D89871 mRNA. Translation: BAA23986.1 .
    BC031429 mRNA. Translation: AAH31429.1 .
    CCDSi CCDS17817.1.
    PIRi JC5759.
    RefSeqi NP_032965.1. NM_008939.2.
    UniGenei Mm.9431.

    3D structure databases

    ProteinModelPortali O08762.
    SMRi O08762. Positions 84-160, 384-760.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029603.

    Protein family/group databases

    MEROPSi S01.237.

    PTM databases

    PhosphoSitei O08762.

    Proteomic databases

    PaxDbi O08762.
    PRIDEi O08762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029603 ; ENSMUSP00000029603 ; ENSMUSG00000027978 .
    GeneIDi 19142.
    KEGGi mmu:19142.
    UCSCi uc008rfl.2. mouse.

    Organism-specific databases

    CTDi 8492.
    MGIi MGI:1100881. Prss12.

    Phylogenomic databases

    eggNOGi COG5640.
    GeneTreei ENSGT00740000115025.
    HOGENOMi HOG000113767.
    HOVERGENi HBG006465.
    InParanoidi O08762.
    KOi K09624.
    OMAi DDGWTDK.
    OrthoDBi EOG7RNK07.
    PhylomeDBi O08762.
    TreeFami TF329295.

    Miscellaneous databases

    NextBioi 295774.
    PROi O08762.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08762.
    CleanExi MM_PRSS12.
    Genevestigatori O08762.

    Family and domain databases

    Gene3Di 2.40.20.10. 1 hit.
    3.10.250.10. 3 hits.
    InterProi IPR000001. Kringle.
    IPR013806. Kringle-like.
    IPR018056. Kringle_CS.
    IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR001190. SRCR.
    IPR017448. SRCR-like_dom.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00051. Kringle. 1 hit.
    PF00530. SRCR. 3 hits.
    PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    PR00258. SPERACTRCPTR.
    SMARTi SM00130. KR. 1 hit.
    SM00202. SR. 3 hits.
    SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    SSF56487. SSF56487. 3 hits.
    SSF57440. SSF57440. 1 hit.
    PROSITEi PS00021. KRINGLE_1. 1 hit.
    PS50070. KRINGLE_2. 1 hit.
    PS00420. SRCR_1. 3 hits.
    PS50287. SRCR_2. 3 hits.
    PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neurotrypsin, a novel multidomain serine protease expressed in the nervous system."
      Gschwend T.P., Krueger S.R., Kozlov S.V., Wolfer D.P., Sonderegger P.
      Mol. Cell. Neurosci. 9:207-219(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs."
      Yamamura Y., Yamashiro K., Tsuruoka N., Nakazato H., Tsujimura A., Yamaguchi N.
      Biochem. Biophys. Res. Commun. 239:386-392(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiNETR_MOUSE
    AccessioniPrimary (citable) accession number: O08762
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3