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Protein

Neurotrypsin

Gene

Prss12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei516 – 517Reactive bond homologSequence analysis2
Active sitei562Charge relay system1
Active sitei612Charge relay system1
Active sitei711Charge relay system1

GO - Molecular functioni

  • peptidase activity Source: MGI
  • scavenger receptor activity Source: InterPro
  • serine-type endopeptidase activity Source: MGI

GO - Biological processi

  • exocytosis Source: UniProtKB
  • proteolysis Source: MGI
  • zymogen activation Source: MGI

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.237

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrypsin (EC:3.4.21.-)
Alternative name(s):
Brain-specific serine protease 3
Short name:
BSSP-3
Motopsin
Serine protease 12
Gene namesi
Name:Prss12
Synonyms:Bssp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1100881 Prss12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002767022 – 761NeurotrypsinAdd BLAST740

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 157By similarity
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 141By similarity
Disulfide bondi130 ↔ 155By similarity
Disulfide bondi191 ↔ 255By similarity
Disulfide bondi204 ↔ 265By similarity
Disulfide bondi235 ↔ 245By similarity
Disulfide bondi298 ↔ 361By similarity
Disulfide bondi311 ↔ 371By similarity
Disulfide bondi341 ↔ 351By similarity
Disulfide bondi411 ↔ 475By similarity
Disulfide bondi424 ↔ 485By similarity
Disulfide bondi455 ↔ 465By similarity
Disulfide bondi505 ↔ 636Sequence analysis
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi547 ↔ 563By similarity
Glycosylationi569N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi651 ↔ 717By similarity
Disulfide bondi680 ↔ 694By similarity
Disulfide bondi707 ↔ 736By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO08762
PaxDbiO08762
PeptideAtlasiO08762
PRIDEiO08762

PTM databases

PhosphoSitePlusiO08762

Expressioni

Tissue specificityi

Most abundant in cerebral cortex, hippocampus and amygdala.

Gene expression databases

BgeeiENSMUSG00000027978
CleanExiMM_PRSS12
GenevisibleiO08762 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029603

Structurei

3D structure databases

ProteinModelPortaliO08762
SMRiO08762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 157KringlePROSITE-ProRule annotationAdd BLAST73
Domaini166 – 267SRCR 1PROSITE-ProRule annotationAdd BLAST102
Domaini273 – 373SRCR 2PROSITE-ProRule annotationAdd BLAST101
Domaini386 – 487SRCR 3PROSITE-ProRule annotationAdd BLAST102
Domaini517 – 760Peptidase S1PROSITE-ProRule annotationAdd BLAST244

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni505 – 516Zymogen activation regionAdd BLAST12

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00900000140803
HOGENOMiHOG000113767
HOVERGENiHBG006465
InParanoidiO08762
KOiK09624
OMAiCIKQDIG
OrthoDBiEOG091G0DF7
PhylomeDBiO08762
TreeFamiTF329295

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 1 hit
3.10.250.10, 3 hits
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
PF00530 SRCR, 3 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
PR00258 SPERACTRCPTR
SMARTiView protein in SMART
SM00130 KR, 1 hit
SM00202 SR, 3 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF56487 SSF56487, 3 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit
PS00420 SRCR_1, 3 hits
PS50287 SRCR_2, 3 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALARCVLAV ILGALSVVAR ADPVSRSPLH RPHPSPPRSQ HAHYLPSSRR
60 70 80 90 100
PPRTPRFPLP LRIPAAQRPQ VLSTGHTPPT IPRRCGAGES WGNATNLGVP
110 120 130 140 150
CLHWDEVPPF LERSPPASWA ELRGQPHNFC RSPDGSGRPW CFYRNAQGKV
160 170 180 190 200
DWGYCDCGQG PALPVIRLVG GNSGHEGRVE LYHAGQWGTI CDDQWDNADA
210 220 230 240 250
DVICRQLGLS GIAKAWHQAH FGEGSGPILL DEVRCTGNEL SIEQCPKSSW
260 270 280 290 300
GEHNCGHKED AGVSCVPLTD GVIRLAGGKS THEGRLEVYY KGQWGTVCDD
310 320 330 340 350
GWTEMNTYVA CRLLGFKYGK QSSVNHFDGS NRPIWLDDVS CSGKEVSFIQ
360 370 380 390 400
CSRRQWGRHD CSHREDVGLT CYPDSDGHRL SPGFPIRLVD GENKKEGRVE
410 420 430 440 450
VFVNGQWGTI CDDGWTDKHA AVICRQLGYK GPARARTMAY FGEGKGPIHM
460 470 480 490 500
DNVKCTGNEK ALADCVKQDI GRHNCRHSED AGVICDYLEK KASSSGNKEM
510 520 530 540 550
LSSGCGLRLL HRRQKRIIGG NNSLRGAWPW QASLRLRSAH GDGRLLCGAT
560 570 580 590 600
LLSSCWVLTA AHCFKRYGNN SRSYAVRVGD YHTLVPEEFE QEIGVQQIVI
610 620 630 640 650
HRNYRPDRSD YDIALVRLQG PGEQCARLST HVLPACLPLW RERPQKTASN
660 670 680 690 700
CHITGWGDTG RAYSRTLQQA AVPLLPKRFC KERYKGLFTG RMLCAGNLQE
710 720 730 740 750
DNRVDSCQGD SGGPLMCEKP DESWVVYGVT SWGYGCGVKD TPGVYTRVPA
760
FVPWIKSVTS L
Length:761
Mass (Da):84,118
Last modified:July 1, 1997 - v1
Checksum:iDF507B03712164E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13192 mRNA Translation: CAA73646.1
D89871 mRNA Translation: BAA23986.1
BC031429 mRNA Translation: AAH31429.1
CCDSiCCDS17817.1
PIRiJC5759
RefSeqiNP_032965.1, NM_008939.2
UniGeneiMm.9431

Genome annotation databases

EnsembliENSMUST00000029603; ENSMUSP00000029603; ENSMUSG00000027978
GeneIDi19142
KEGGimmu:19142
UCSCiuc008rfl.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNETR_MOUSE
AccessioniPrimary (citable) accession number: O08762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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