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Reviewed, UniProtKB/Swiss-Prot O08756 (HCD2_MOUSE)

Last modified January 19, 2010. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    3-hydroxyacyl-CoA dehydrogenase type-2
    EC=1.1.1.35
Alternative name(s):
    3-hydroxyacyl-CoA dehydrogenase type II
    Type II HADH
    3-hydroxy-2-methylbutyryl-CoA dehydrogenase
    EC=1.1.1.178
    17-beta-hydroxysteroid dehydrogenase 10
    Mitochondrial ribonuclease P protein 2
      Short name=Mitochondrial RNase P protein 2
    Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
Gene names
Name: Hsd17b10
Synonyms: Erab, Hadh2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends By similarity.

Catalytic activity

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ = 2-methylacetoacetyl-CoA + NADH.

Subunit structure

Homotetramer. Interacts with MRPP1/RG9MTD1 and MRPP3/KIAA0391 By similarity.

Subcellular location

Mitochondrion By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 2612603-hydroxyacyl-CoA dehydrogenase type-2
PRO_0000054811

Regions

Nucleotide binding12 – 3726NAD By similarity

Sites

Active site1681Proton acceptor By similarity
Binding site1551Substrate By similarity

Amino acid modifications

Modified residue21N-acetylalanine Ref.2

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Sequences

Sequence LengthMass (Da)Tools
O08756-1 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 61213B13E2839D41

FASTA26127,419
        10         20         30         40         50         60 
MAAAVRSVKG LVAVVTGGAS GPWLATAKRL VGQGATAVLL DVPDSEGESQ AKKLGESCIF 

        70         80         90        100        110        120 
APANVTSEKE IQAALTLAKE KFGRIDVAVN CAGIAVAIKT YHQKKNKIHT LEDFQRVINV 

       130        140        150        160        170        180 
NLIGTFNVIR LVAGEMGQNE PDQGGQRGVI INTASVAAFE GQVGQAAYSA SKGGIDGMTL 

       190        200        210        220        230        240 
PIARDLAPTG IRVVTIAPGL FATPLLTTLP EKVRNFLASQ VPFPSRLGDP AEYAHLVQTI 

       250        260 
IENPFLNGEV IRLDGAIRMQ P

« Hide

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References

[1]Fu J., Chen X., Stern D., Yan S.D.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X CBA.
[2]Bienvenut W.V.
Submitted (JUL-2005) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-6; 193-212 AND 215-226, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Liver.
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 70-79 AND 131-147, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U96116 mRNA. Translation: AAB57689.1. Different initiation.
IPIIPI00320847.
UniGeneMm.6994

3D structure databases

SMRO08756. Positions 7-261.
ModBaseSearch...

Protein-protein interaction databases

STRINGO08756.

2-D gel databases

SWISS-2DPAGEO08756.

Proteomic databases

PRIDEO08756.

Genome annotation databases

EnsemblENSMUST00000026289; ENSMUSP00000026289; ENSMUSG00000025260; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:1333871. Hsd17b10.

Phylogenomic databases

eggNOGroNOG12500.
HOVERGENO08756.

Enzyme and pathway databases

BRENDA1.1.1.178. 244.
1.1.1.35. 244.

Gene expression databases

ArrayExpressO08756.
BgeeO08756.
CleanExMM_HSD17B10.
GenevestigatorO08756.
GermOnlineENSMUSG00000025260. Mus musculus.

Family and domain databases

InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR19410. ADH_short_C2. 1 hit.
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

PMAP-CutDBO08756.
SOURCESearch...

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Entry information

Entry nameHCD2_MOUSE
AccessionPrimary (citable) accession number: O08756
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: January 19, 2010
This is version 89 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents