Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hepatocyte nuclear factor 6

Gene

Onecut1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Stimulates the expression of Onecut3 in the developing endoderm.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi283 – 369CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi385 – 444HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: MGI
  • B cell differentiation Source: MGI
  • cell differentiation Source: MGI
  • cell fate commitment Source: MGI
  • cilium assembly Source: MGI
  • endocrine pancreas development Source: MGI
  • endoderm development Source: MGI
  • epithelial cell development Source: MGI
  • glucose metabolic process Source: MGI
  • liver development Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • Notch signaling pathway Source: MGI
  • pancreas development Source: MGI
  • positive regulation of cell migration Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell-matrix adhesion Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • spleen development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 6
Short name:
HNF-6
Alternative name(s):
One cut domain family member 1
One cut homeobox 1
Gene namesi
Name:Onecut1
Synonyms:Hnf6, Hnf6a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1196423. Onecut1.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002024031 – 465Hepatocyte nuclear factor 6Add BLAST465

Proteomic databases

PaxDbiO08755.
PeptideAtlasiO08755.
PRIDEiO08755.

PTM databases

PhosphoSitePlusiO08755.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043013.
CleanExiMM_ONECUT1.
GenevisibleiO08755. MM.

Interactioni

Subunit structurei

Binds DNA as a monomer.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058020.

Structurei

Secondary structure

1465
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi295 – 305Combined sources11
Helixi312 – 318Combined sources7
Beta strandi320 – 322Combined sources3
Helixi326 – 330Combined sources5
Helixi344 – 355Combined sources12
Beta strandi378 – 380Combined sources3
Helixi394 – 403Combined sources10
Helixi412 – 419Combined sources8
Beta strandi424 – 426Combined sources3
Helixi427 – 435Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S7ENMR-A291-437[»]
ProteinModelPortaliO08755.
SMRiO08755.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08755.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi69 – 72Poly-His4
Compositional biasi124 – 138Poly-HisAdd BLAST15
Compositional biasi450 – 460Poly-SerAdd BLAST11

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiO08755.
KOiK08026.
OMAiQMEEVNT.
OrthoDBiEOG091G0E7H.
PhylomeDBiO08755.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08755-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVGH RGSHLPPAHP
60 70 80 90 100
RSMGMASLLD GGSGGSDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP
110 120 130 140 150
TTYTTLTPLQ PLPPISTVSD KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT
160 170 180 190 200
LMRDERGLAS MNNLYTPYHK DVAGMGQSLS PLSGSGLGSI HNSQQGLPHY
210 220 230 240 250
AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG MVPINGLPPH
260 270 280 290 300
HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR
310 320 330 340 350
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM
360 370 380 390 400
WKWLQEPEFQ RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL
410 420 430 440 450
HAIFKENKRP SKELQITISQ QLGLELSTVS NFFMNARRRS LDKWQDEGGS
460
NSGSSSSSSS TCTKA
Length:465
Mass (Da):50,952
Last modified:July 1, 1997 - v1
Checksum:iA770D27DD5AAC896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95945 mRNA. Translation: AAB53863.1.
BC024053 mRNA. Translation: AAH24053.1.
CCDSiCCDS23339.1.
RefSeqiNP_032288.1. NM_008262.3.
UniGeneiMm.303355.

Genome annotation databases

EnsembliENSMUST00000056006; ENSMUSP00000058020; ENSMUSG00000043013.
GeneIDi15379.
KEGGimmu:15379.
UCSCiuc009qrh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95945 mRNA. Translation: AAB53863.1.
BC024053 mRNA. Translation: AAH24053.1.
CCDSiCCDS23339.1.
RefSeqiNP_032288.1. NM_008262.3.
UniGeneiMm.303355.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1S7ENMR-A291-437[»]
ProteinModelPortaliO08755.
SMRiO08755.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058020.

Chemistry databases

ChEMBLiCHEMBL2176818.

PTM databases

PhosphoSitePlusiO08755.

Proteomic databases

PaxDbiO08755.
PeptideAtlasiO08755.
PRIDEiO08755.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056006; ENSMUSP00000058020; ENSMUSG00000043013.
GeneIDi15379.
KEGGimmu:15379.
UCSCiuc009qrh.1. mouse.

Organism-specific databases

CTDi3175.
MGIiMGI:1196423. Onecut1.

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiO08755.
KOiK08026.
OMAiQMEEVNT.
OrthoDBiEOG091G0E7H.
PhylomeDBiO08755.
TreeFamiTF318206.

Enzyme and pathway databases

ReactomeiR-MMU-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.

Miscellaneous databases

EvolutionaryTraceiO08755.
PROiO08755.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043013.
CleanExiMM_ONECUT1.
GenevisibleiO08755. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNF6_MOUSE
AccessioniPrimary (citable) accession number: O08755
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.