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Protein

Matrilin-2

Gene

Matn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in matrix assembly.By similarity

GO - Molecular functioni

GO - Biological processi

  • axon guidance Source: MGI
  • dendrite regeneration Source: MGI
  • glial cell migration Source: MGI
  • neuron migration Source: MGI
  • neuron projection development Source: MGI
  • response to axon injury Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Matrilin-2
Gene namesi
Name:Matn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109613. Matn2.

Subcellular locationi

GO - Cellular componenti

  • basement membrane Source: MGI
  • extracellular matrix Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000765624 – 956Matrilin-2Add BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi242 ↔ 253By similarity
Disulfide bondi249 ↔ 262By similarity
Disulfide bondi264 ↔ 277By similarity
Disulfide bondi283 ↔ 294By similarity
Disulfide bondi290 ↔ 303By similarity
Disulfide bondi305 ↔ 318By similarity
Disulfide bondi324 ↔ 335By similarity
Disulfide bondi331 ↔ 344By similarity
Disulfide bondi346 ↔ 359By similarity
Disulfide bondi365 ↔ 376By similarity
Disulfide bondi372 ↔ 385By similarity
Disulfide bondi387 ↔ 400By similarity
Disulfide bondi406 ↔ 417By similarity
Disulfide bondi413 ↔ 426By similarity
Disulfide bondi428 ↔ 441By similarity
Disulfide bondi447 ↔ 458By similarity
Disulfide bondi454 ↔ 467By similarity
Disulfide bondi469 ↔ 482By similarity
Disulfide bondi488 ↔ 499By similarity
Disulfide bondi495 ↔ 508By similarity
Disulfide bondi510 ↔ 523By similarity
Disulfide bondi529 ↔ 540By similarity
Disulfide bondi536 ↔ 549By similarity
Disulfide bondi551 ↔ 564By similarity
Disulfide bondi570 ↔ 581By similarity
Disulfide bondi577 ↔ 590By similarity
Disulfide bondi592 ↔ 605By similarity
Disulfide bondi611 ↔ 622By similarity
Disulfide bondi618 ↔ 631By similarity
Disulfide bondi633 ↔ 646By similarity
Glycosylationi890N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO08746.
PaxDbiO08746.
PeptideAtlasiO08746.
PRIDEiO08746.

PTM databases

iPTMnetiO08746.
PhosphoSitePlusiO08746.

Expressioni

Tissue specificityi

Detected in a variety of organs, including calvaria, uterus, heart and brain, as well as fibroblast and osteoblast cell lines.

Gene expression databases

BgeeiENSMUSG00000022324.
CleanExiMM_MATN2.
ExpressionAtlasiO08746. baseline and differential.
GenevisibleiO08746. MM.

Interactioni

Protein-protein interaction databases

BioGridi201321. 1 interactor.
IntActiO08746. 2 interactors.
MINTiMINT-1743947.
STRINGi10090.ENSMUSP00000022947.

Structurei

3D structure databases

ProteinModelPortaliO08746.
SMRiO08746.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 232VWFA 1PROSITE-ProRule annotationAdd BLAST176
Domaini238 – 278EGF-like 1Add BLAST41
Domaini279 – 319EGF-like 2Add BLAST41
Domaini320 – 360EGF-like 3Add BLAST41
Domaini361 – 401EGF-like 4Add BLAST41
Domaini402 – 442EGF-like 5Add BLAST41
Domaini443 – 483EGF-like 6Add BLAST41
Domaini484 – 524EGF-like 7Add BLAST41
Domaini525 – 565EGF-like 8Add BLAST41
Domaini566 – 606EGF-like 9Add BLAST41
Domaini607 – 647EGF-like 10Add BLAST41
Domaini655 – 830VWFA 2PROSITE-ProRule annotationAdd BLAST176

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili917 – 955Sequence analysisAdd BLAST39

Sequence similaritiesi

Contains 10 EGF-like domains.Curated
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR7H. Eukaryota.
ENOG410XSTY. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiO08746.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR009030. Growth_fac_rcpt_.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PfamiPF07645. EGF_CA. 6 hits.
PF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00179. EGF_CA. 10 hits.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS01186. EGF_2. 9 hits.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O08746-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKMLVGCLL MLGQLFLVLP VDGRERPQAR FPSRGRHVRM YPQTALLESS
60 70 80 90 100
CENKRADLVF IIDSSRSVNT YDYAKVKEFI LDILQFLDIG PDVTRVGLLQ
110 120 130 140 150
YGSTVKNEFS LKTFKRKSEV ERAVKRMRHL STGTMTGLAI QYALNIAFSE
160 170 180 190 200
AEGARPLREN VPRIIMIVTD GRPQDSVAEV AAKARNTGIL IFAIGVGQVD
210 220 230 240 250
LNTLKAIGSE PHKDHVFLVA NFSQIESLTS VFQNKLCTVH MCSVLEHNCA
260 270 280 290 300
HFCLNTPGSY ICKCKQGYIL STDQKTCRIQ DLCATEDHGC EQLCVNMLGS
310 320 330 340 350
FVCQCYSGYT LAEDGKRCTA VDYCASENHG CEHECVNAES SYLCRCHEGF
360 370 380 390 400
ALNSDKKTCS KIDYCASSNH GCQHECVNAQ TSALCRCLKG FMLNPDRKTC
410 420 430 440 450
RRINYCALNK PGCEHECVNT EEGHYCRCRQ GYNLDPNGKT CSRVDHCAQQ
460 470 480 490 500
DHGCEQLCLN TEESFVCQCS EGFLINDDLK TCSRADYCLL SNHGCEYSCV
510 520 530 540 550
NTDKSFACQC PEGHVLRSDG KTCAKLDSCA LGDHGCEHSC VSSEDSFVCQ
560 570 580 590 600
CFEGYILRDD GKTCRRKDVC QDVNHGCEHL CVNSGESYVC KCLEGFRLAE
610 620 630 640 650
DGKRCRRKNV CKSTQHGCEH MCVNNGNSYL CRCSEGFVLA EDGKHCKRCT
660 670 680 690 700
EGPIDLVFVI DGSKSLGEEN FETVKHFVTG IIDSLAVSPK AARVGLLQYS
710 720 730 740 750
TQVRTEFTLR GFSSAKEMKK AVTHMKYMGK GSMTGLALKH MFERSFTQVE
760 770 780 790 800
GARPPSTQVP RVAIVFTDGR AQDDVSEWAS KAKANGITMY AVGVGKAIEE
810 820 830 840 850
ELQEIASEPI DKHLFYAEDF STMGEISEKL KEGICEALED SGGRQDSAAW
860 870 880 890 900
DLPQQAHQPT EPEPVTIKIK DLLSCSNFAV QHRFLFEEDN LSRSTQKLFH
910 920 930 940 950
STKSSGNPLE ESQDQCKCEN LILFQNVANE EVRKLTQRLE EMTQRMEALE

NRLKYR
Length:956
Mass (Da):106,748
Last modified:September 21, 2011 - v2
Checksum:i3E4A608FF92BDE55
GO
Isoform 2 (identifier: O08746-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     861-879: Missing.

Show »
Length:937
Mass (Da):104,662
Checksum:i6FBBA81D1CF75B50
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321V → M in AAC53163 (PubMed:9083061).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041771861 – 879Missing in isoform 2. CuratedAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69262 mRNA. Translation: AAC53163.1.
AF358844
, AF358831, AF358832, AF358833, AF358834, AF358835, AF358836, AF358837, AF358838, AF358839, AF358840, AF358841, AF358842, AF358843 Genomic DNA. Translation: AAM11539.1.
AC126028 Genomic DNA. No translation available.
AC133101 Genomic DNA. No translation available.
AC144632 Genomic DNA. No translation available.
CCDSiCCDS37056.1. [O08746-2]
RefSeqiXP_006520086.1. XM_006520023.2. [O08746-1]
UniGeneiMm.396856.

Genome annotation databases

EnsembliENSMUST00000022947; ENSMUSP00000022947; ENSMUSG00000022324. [O08746-2]
GeneIDi17181.
UCSCiuc007vln.1. mouse. [O08746-1]
uc007vlo.1. mouse. [O08746-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U69262 mRNA. Translation: AAC53163.1.
AF358844
, AF358831, AF358832, AF358833, AF358834, AF358835, AF358836, AF358837, AF358838, AF358839, AF358840, AF358841, AF358842, AF358843 Genomic DNA. Translation: AAM11539.1.
AC126028 Genomic DNA. No translation available.
AC133101 Genomic DNA. No translation available.
AC144632 Genomic DNA. No translation available.
CCDSiCCDS37056.1. [O08746-2]
RefSeqiXP_006520086.1. XM_006520023.2. [O08746-1]
UniGeneiMm.396856.

3D structure databases

ProteinModelPortaliO08746.
SMRiO08746.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201321. 1 interactor.
IntActiO08746. 2 interactors.
MINTiMINT-1743947.
STRINGi10090.ENSMUSP00000022947.

PTM databases

iPTMnetiO08746.
PhosphoSitePlusiO08746.

Proteomic databases

MaxQBiO08746.
PaxDbiO08746.
PeptideAtlasiO08746.
PRIDEiO08746.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022947; ENSMUSP00000022947; ENSMUSG00000022324. [O08746-2]
GeneIDi17181.
UCSCiuc007vln.1. mouse. [O08746-1]
uc007vlo.1. mouse. [O08746-2]

Organism-specific databases

CTDi4147.
MGIiMGI:109613. Matn2.

Phylogenomic databases

eggNOGiENOG410IR7H. Eukaryota.
ENOG410XSTY. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000263415.
HOVERGENiHBG056906.
InParanoidiO08746.

Miscellaneous databases

ChiTaRSiMatn2. mouse.
PROiO08746.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022324.
CleanExiMM_MATN2.
ExpressionAtlasiO08746. baseline and differential.
GenevisibleiO08746. MM.

Family and domain databases

Gene3Di1.20.5.30. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR009030. Growth_fac_rcpt_.
IPR019466. Matrilin_coiled-coil_trimer.
IPR002035. VWF_A.
[Graphical view]
PfamiPF07645. EGF_CA. 6 hits.
PF10393. Matrilin_ccoil. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00179. EGF_CA. 10 hits.
SM01279. Matrilin_ccoil. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS01186. EGF_2. 9 hits.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMATN2_MOUSE
AccessioniPrimary (citable) accession number: O08746
Secondary accession number(s): E9QPK9, Q8R542
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 21, 2011
Last modified: November 2, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.