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Protein

Platelet glycoprotein V

Gene

Gp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (By similarity).By similarity

GO - Molecular functioni

  • collagen binding Source: MGI

GO - Biological processi

  • axonogenesis Source: GO_Central
  • blood coagulation Source: UniProtKB-KW
  • cell-matrix adhesion Source: MGI
  • negative regulation of platelet activation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein V
Short name:
GPV
Alternative name(s):
Glycoprotein 5
CD_antigen: CD42d
Gene namesi
Name:Gp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1096363. Gp5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini17 – 522ExtracellularSequence analysisAdd BLAST506
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Topological domaini544 – 567CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000002136217 – 567Platelet glycoprotein VAdd BLAST551

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)Sequence analysis1
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiO08742.
PaxDbiO08742.
PeptideAtlasiO08742.
PRIDEiO08742.

PTM databases

PhosphoSitePlusiO08742.

Expressioni

Gene expression databases

CleanExiMM_GP5.

Interactioni

GO - Molecular functioni

  • collagen binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051895.

Structurei

3D structure databases

ProteinModelPortaliO08742.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 50LRRNTAdd BLAST34
Repeati75 – 96LRR 1Add BLAST22
Repeati99 – 120LRR 2Add BLAST22
Repeati123 – 144LRR 3Add BLAST22
Repeati147 – 168LRR 4Add BLAST22
Repeati171 – 193LRR 5Add BLAST23
Repeati195 – 216LRR 6Add BLAST22
Repeati219 – 240LRR 7Add BLAST22
Repeati243 – 264LRR 8Add BLAST22
Repeati267 – 288LRR 9Add BLAST22
Repeati291 – 312LRR 10Add BLAST22
Repeati315 – 337LRR 11Add BLAST23
Repeati340 – 361LRR 12Add BLAST22
Repeati364 – 385LRR 13Add BLAST22
Repeati388 – 409LRR 14Add BLAST22
Domaini421 – 474LRRCTAdd BLAST54

Sequence similaritiesi

Contains 14 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000112798.
HOVERGENiHBG005906.
InParanoidiO08742.
PhylomeDBiO08742.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSALLSAV LPLLRAQPFP CPKTCKCVVR DAAQCSGGSV AHIAELGLPT
60 70 80 90 100
NLTHILLFRM DQGILRNHSF SGMTVLQRQM LSDSHISAID PGTFNDLVKL
110 120 130 140 150
KTLRLTRNKI SRLPRAILDK MVLLEQLFLD HNALRDLDQN LFQQLRNLQE
160 170 180 190 200
LGLNQNQLSF LPANLFSSLR ELKLLDLSRN NLTHLPKGLL GAQVKLEKLL
210 220 230 240 250
LYSNQLTSVD SGLLSNLGAL TELRLERNHL RSVAPGAFDR LGNLSSLTLS
260 270 280 290 300
GNLLESLPPA LFLHVSSVSR LTLFENPLEE LPDVLFGEMA GLRELWLNGT
310 320 330 340 350
HLSTLPAAAF RNLSGLQTLG LTRNPRLSAL PRGVFQGLRE LRVLGLHTNA
360 370 380 390 400
LAELRDDALR GLGHLRQVSL RHNRLRALPR TLFRNLSSLE SVQLEHNQLE
410 420 430 440 450
TLPGDVFAAL PQLTQVLLGH NPWLCDCGLW RFLQWLRHHP DILGRDEPPQ
460 470 480 490 500
CRGPEPRASL SFWELLQGDP WCPDPRSLPL DPPTENALEA PVPSWLPNSW
510 520 530 540 550
QSQTWAQLVA RGESPNNRLY WGLYILLLVA QAIIAAFIVF AMIKIGQLFR
560
TLIREKLLLE AMGKSCN
Length:567
Mass (Da):63,468
Last modified:July 1, 1997 - v1
Checksum:iC48643AA73967A7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69595 Genomic DNA. Translation: CAA93441.1.
CCDSiCCDS28100.1.
UniGeneiMm.3519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69595 Genomic DNA. Translation: CAA93441.1.
CCDSiCCDS28100.1.
UniGeneiMm.3519.

3D structure databases

ProteinModelPortaliO08742.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051895.

PTM databases

PhosphoSitePlusiO08742.

Proteomic databases

MaxQBiO08742.
PaxDbiO08742.
PeptideAtlasiO08742.
PRIDEiO08742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1096363. Gp5.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000112798.
HOVERGENiHBG005906.
InParanoidiO08742.
PhylomeDBiO08742.

Miscellaneous databases

PROiO08742.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GP5.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 4 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPV_MOUSE
AccessioniPrimary (citable) accession number: O08742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.