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O08742

- GPV_MOUSE

UniProt

O08742 - GPV_MOUSE

Protein

Platelet glycoprotein V

Gene

Gp5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis By similarity.By similarity

    GO - Biological processi

    1. blood coagulation Source: UniProtKB-KW
    2. cell adhesion Source: UniProtKB-KW

    Keywords - Biological processi

    Blood coagulation, Cell adhesion, Hemostasis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet glycoprotein V
    Short name:
    GPV
    Alternative name(s):
    Glycoprotein 5
    CD_antigen: CD42d
    Gene namesi
    Name:Gp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1096363. Gp5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 567551Platelet glycoprotein VPRO_0000021362Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO08742.
    PRIDEiO08742.

    PTM databases

    PhosphoSiteiO08742.

    Expressioni

    Gene expression databases

    CleanExiMM_GP5.
    GenevestigatoriO08742.

    Structurei

    3D structure databases

    ProteinModelPortaliO08742.
    SMRiO08742. Positions 20-485.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 522506ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini544 – 56724CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 5034LRRNTAdd
    BLAST
    Repeati75 – 9622LRR 1Add
    BLAST
    Repeati99 – 12022LRR 2Add
    BLAST
    Repeati123 – 14422LRR 3Add
    BLAST
    Repeati147 – 16822LRR 4Add
    BLAST
    Repeati171 – 19323LRR 5Add
    BLAST
    Repeati195 – 21622LRR 6Add
    BLAST
    Repeati219 – 24022LRR 7Add
    BLAST
    Repeati243 – 26422LRR 8Add
    BLAST
    Repeati267 – 28822LRR 9Add
    BLAST
    Repeati291 – 31222LRR 10Add
    BLAST
    Repeati315 – 33723LRR 11Add
    BLAST
    Repeati340 – 36122LRR 12Add
    BLAST
    Repeati364 – 38522LRR 13Add
    BLAST
    Repeati388 – 40922LRR 14Add
    BLAST
    Domaini421 – 47454LRRCTAdd
    BLAST

    Sequence similaritiesi

    Contains 14 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    HOGENOMiHOG000112798.
    HOVERGENiHBG005906.
    InParanoidiO08742.
    PhylomeDBiO08742.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 10 hits.
    SM00082. LRRCT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 12 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08742-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRSALLSAV LPLLRAQPFP CPKTCKCVVR DAAQCSGGSV AHIAELGLPT    50
    NLTHILLFRM DQGILRNHSF SGMTVLQRQM LSDSHISAID PGTFNDLVKL 100
    KTLRLTRNKI SRLPRAILDK MVLLEQLFLD HNALRDLDQN LFQQLRNLQE 150
    LGLNQNQLSF LPANLFSSLR ELKLLDLSRN NLTHLPKGLL GAQVKLEKLL 200
    LYSNQLTSVD SGLLSNLGAL TELRLERNHL RSVAPGAFDR LGNLSSLTLS 250
    GNLLESLPPA LFLHVSSVSR LTLFENPLEE LPDVLFGEMA GLRELWLNGT 300
    HLSTLPAAAF RNLSGLQTLG LTRNPRLSAL PRGVFQGLRE LRVLGLHTNA 350
    LAELRDDALR GLGHLRQVSL RHNRLRALPR TLFRNLSSLE SVQLEHNQLE 400
    TLPGDVFAAL PQLTQVLLGH NPWLCDCGLW RFLQWLRHHP DILGRDEPPQ 450
    CRGPEPRASL SFWELLQGDP WCPDPRSLPL DPPTENALEA PVPSWLPNSW 500
    QSQTWAQLVA RGESPNNRLY WGLYILLLVA QAIIAAFIVF AMIKIGQLFR 550
    TLIREKLLLE AMGKSCN 567
    Length:567
    Mass (Da):63,468
    Last modified:July 1, 1997 - v1
    Checksum:iC48643AA73967A7D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69595 Genomic DNA. Translation: CAA93441.1.
    CCDSiCCDS28100.1.
    UniGeneiMm.3519.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z69595 Genomic DNA. Translation: CAA93441.1 .
    CCDSi CCDS28100.1.
    UniGenei Mm.3519.

    3D structure databases

    ProteinModelPortali O08742.
    SMRi O08742. Positions 20-485.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei O08742.

    Proteomic databases

    PaxDbi O08742.
    PRIDEi O08742.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1096363. Gp5.

    Phylogenomic databases

    eggNOGi COG4886.
    HOGENOMi HOG000112798.
    HOVERGENi HBG005906.
    InParanoidi O08742.
    PhylomeDBi O08742.

    Miscellaneous databases

    PROi O08742.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GP5.
    Genevestigatori O08742.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 10 hits.
    SM00082. LRRCT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 12 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage."
      Ravanat C., Morales M., Azorsa D.O., Moog S., Schuhler S., Grunert P., Loew D., van Dorsselaer A., Cazenave J.-P., Lanza F.
      Blood 89:3253-3262(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
      Tissue: Liver.

    Entry informationi

    Entry nameiGPV_MOUSE
    AccessioniPrimary (citable) accession number: O08742
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3