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O08742 (GPV_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet glycoprotein V

Short name=GPV
Alternative name(s):
Glycoprotein 5
CD_antigen=CD42d
Gene names
Name:Gp5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 14 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 567551Platelet glycoprotein V
PRO_0000021362

Regions

Topological domain17 – 522506Extracellular Potential
Transmembrane523 – 54321Helical; Potential
Topological domain544 – 56724Cytoplasmic Potential
Domain17 – 5034LRRNT
Repeat75 – 9622LRR 1
Repeat99 – 12022LRR 2
Repeat123 – 14422LRR 3
Repeat147 – 16822LRR 4
Repeat171 – 19323LRR 5
Repeat195 – 21622LRR 6
Repeat219 – 24022LRR 7
Repeat243 – 26422LRR 8
Repeat267 – 28822LRR 9
Repeat291 – 31222LRR 10
Repeat315 – 33723LRR 11
Repeat340 – 36122LRR 12
Repeat364 – 38522LRR 13
Repeat388 – 40922LRR 14
Domain421 – 47454LRRCT

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3851N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O08742 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: C48643AA73967A7D

FASTA56763,468
        10         20         30         40         50         60 
MLRSALLSAV LPLLRAQPFP CPKTCKCVVR DAAQCSGGSV AHIAELGLPT NLTHILLFRM 

        70         80         90        100        110        120 
DQGILRNHSF SGMTVLQRQM LSDSHISAID PGTFNDLVKL KTLRLTRNKI SRLPRAILDK 

       130        140        150        160        170        180 
MVLLEQLFLD HNALRDLDQN LFQQLRNLQE LGLNQNQLSF LPANLFSSLR ELKLLDLSRN 

       190        200        210        220        230        240 
NLTHLPKGLL GAQVKLEKLL LYSNQLTSVD SGLLSNLGAL TELRLERNHL RSVAPGAFDR 

       250        260        270        280        290        300 
LGNLSSLTLS GNLLESLPPA LFLHVSSVSR LTLFENPLEE LPDVLFGEMA GLRELWLNGT 

       310        320        330        340        350        360 
HLSTLPAAAF RNLSGLQTLG LTRNPRLSAL PRGVFQGLRE LRVLGLHTNA LAELRDDALR 

       370        380        390        400        410        420 
GLGHLRQVSL RHNRLRALPR TLFRNLSSLE SVQLEHNQLE TLPGDVFAAL PQLTQVLLGH 

       430        440        450        460        470        480 
NPWLCDCGLW RFLQWLRHHP DILGRDEPPQ CRGPEPRASL SFWELLQGDP WCPDPRSLPL 

       490        500        510        520        530        540 
DPPTENALEA PVPSWLPNSW QSQTWAQLVA RGESPNNRLY WGLYILLLVA QAIIAAFIVF 

       550        560 
AMIKIGQLFR TLIREKLLLE AMGKSCN 

« Hide

References

[1]"Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage."
Ravanat C., Morales M., Azorsa D.O., Moog S., Schuhler S., Grunert P., Loew D., van Dorsselaer A., Cazenave J.-P., Lanza F.
Blood 89:3253-3262(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C57BL/6.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z69595 Genomic DNA. Translation: CAA93441.1.
CCDSCCDS28100.1.
UniGeneMm.3519.

3D structure databases

ProteinModelPortalO08742.
SMRO08742. Positions 20-485.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteO08742.

Proteomic databases

PaxDbO08742.
PRIDEO08742.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1096363. Gp5.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000112798.
HOVERGENHBG005906.
InParanoidO08742.
PhylomeDBO08742.

Gene expression databases

CleanExMM_GP5.
GenevestigatorO08742.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetSearch...

Other

PROO08742.
SOURCESearch...

Entry information

Entry nameGPV_MOUSE
AccessionPrimary (citable) accession number: O08742
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot