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Protein

Platelet glycoprotein V

Gene

Gp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Cell adhesion, Hemostasis

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet glycoprotein V
Short name:
GPV
Alternative name(s):
Glycoprotein 5
CD_antigen: CD42d
Gene namesi
Name:Gp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1096363. Gp5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 522506ExtracellularSequence AnalysisAdd
BLAST
Transmembranei523 – 54321HelicalSequence AnalysisAdd
BLAST
Topological domaini544 – 56724CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 567551Platelet glycoprotein VPRO_0000021362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO08742.
PRIDEiO08742.

PTM databases

PhosphoSiteiO08742.

Expressioni

Gene expression databases

CleanExiMM_GP5.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051895.

Structurei

3D structure databases

ProteinModelPortaliO08742.
SMRiO08742. Positions 20-457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 5034LRRNTAdd
BLAST
Repeati75 – 9622LRR 1Add
BLAST
Repeati99 – 12022LRR 2Add
BLAST
Repeati123 – 14422LRR 3Add
BLAST
Repeati147 – 16822LRR 4Add
BLAST
Repeati171 – 19323LRR 5Add
BLAST
Repeati195 – 21622LRR 6Add
BLAST
Repeati219 – 24022LRR 7Add
BLAST
Repeati243 – 26422LRR 8Add
BLAST
Repeati267 – 28822LRR 9Add
BLAST
Repeati291 – 31222LRR 10Add
BLAST
Repeati315 – 33723LRR 11Add
BLAST
Repeati340 – 36122LRR 12Add
BLAST
Repeati364 – 38522LRR 13Add
BLAST
Repeati388 – 40922LRR 14Add
BLAST
Domaini421 – 47454LRRCTAdd
BLAST

Sequence similaritiesi

Contains 14 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000112798.
HOVERGENiHBG005906.
InParanoidiO08742.
PhylomeDBiO08742.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRSALLSAV LPLLRAQPFP CPKTCKCVVR DAAQCSGGSV AHIAELGLPT
60 70 80 90 100
NLTHILLFRM DQGILRNHSF SGMTVLQRQM LSDSHISAID PGTFNDLVKL
110 120 130 140 150
KTLRLTRNKI SRLPRAILDK MVLLEQLFLD HNALRDLDQN LFQQLRNLQE
160 170 180 190 200
LGLNQNQLSF LPANLFSSLR ELKLLDLSRN NLTHLPKGLL GAQVKLEKLL
210 220 230 240 250
LYSNQLTSVD SGLLSNLGAL TELRLERNHL RSVAPGAFDR LGNLSSLTLS
260 270 280 290 300
GNLLESLPPA LFLHVSSVSR LTLFENPLEE LPDVLFGEMA GLRELWLNGT
310 320 330 340 350
HLSTLPAAAF RNLSGLQTLG LTRNPRLSAL PRGVFQGLRE LRVLGLHTNA
360 370 380 390 400
LAELRDDALR GLGHLRQVSL RHNRLRALPR TLFRNLSSLE SVQLEHNQLE
410 420 430 440 450
TLPGDVFAAL PQLTQVLLGH NPWLCDCGLW RFLQWLRHHP DILGRDEPPQ
460 470 480 490 500
CRGPEPRASL SFWELLQGDP WCPDPRSLPL DPPTENALEA PVPSWLPNSW
510 520 530 540 550
QSQTWAQLVA RGESPNNRLY WGLYILLLVA QAIIAAFIVF AMIKIGQLFR
560
TLIREKLLLE AMGKSCN
Length:567
Mass (Da):63,468
Last modified:July 1, 1997 - v1
Checksum:iC48643AA73967A7D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69595 Genomic DNA. Translation: CAA93441.1.
CCDSiCCDS28100.1.
UniGeneiMm.3519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z69595 Genomic DNA. Translation: CAA93441.1.
CCDSiCCDS28100.1.
UniGeneiMm.3519.

3D structure databases

ProteinModelPortaliO08742.
SMRiO08742. Positions 20-457.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000051895.

PTM databases

PhosphoSiteiO08742.

Proteomic databases

PaxDbiO08742.
PRIDEiO08742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1096363. Gp5.

Phylogenomic databases

eggNOGiCOG4886.
HOGENOMiHOG000112798.
HOVERGENiHBG005906.
InParanoidiO08742.
PhylomeDBiO08742.

Miscellaneous databases

PROiO08742.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GP5.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 10 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage."
    Ravanat C., Morales M., Azorsa D.O., Moog S., Schuhler S., Grunert P., Loew D., van Dorsselaer A., Cazenave J.-P., Lanza F.
    Blood 89:3253-3262(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
    Tissue: Liver.

Entry informationi

Entry nameiGPV_MOUSE
AccessioniPrimary (citable) accession number: O08742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: June 24, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.