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O08738

- CASP6_MOUSE

UniProt

O08738 - CASP6_MOUSE

Protein

Caspase-6

Gene

Casp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death By similarity.By similarity

    Catalytic activityi

    Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.

    Enzyme regulationi

    Activation is suppressed by phosphorylation at Ser-239.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei104 – 1041By similarity
    Active sitei146 – 1461By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome
    2. protein binding Source: MGI

    GO - Biological processi

    1. apoptotic process Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    BRENDAi3.4.22.59. 3474.
    ReactomeiREACT_209025. Breakdown of the nuclear lamina.
    REACT_210562. Caspase-mediated cleavage of cytoskeletal proteins.
    REACT_224460. Apoptotic cleavage of cellular proteins.

    Protein family/group databases

    MEROPSiC14.005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase-6 (EC:3.4.22.59)
    Short name:
    CASP-6
    Alternative name(s):
    Apoptotic protease Mch-2
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Casp6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1312921. Casp6.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. cytosol Source: Ensembl
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 55By similarityPRO_0000004612
    Chaini6 – 162157Caspase-6 subunit p18By similarityPRO_0000004613Add
    BLAST
    Propeptidei163 – 17614By similarityPRO_0000004614Add
    BLAST
    Chaini177 – 276100Caspase-6 subunit p11By similarityPRO_0000004615Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei239 – 2391Phosphoserine; by NUAK1By similarity

    Post-translational modificationi

    Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.By similarity

    Keywords - PTMi

    Phosphoprotein, Zymogen

    Proteomic databases

    MaxQBiO08738.
    PaxDbiO08738.
    PRIDEiO08738.

    PTM databases

    PhosphoSiteiO08738.

    Expressioni

    Tissue specificityi

    Highly expressed in lung, liver, kidney, testis, and heart. Lower levels in spleen, skeletal muscle and brain.

    Gene expression databases

    ArrayExpressiO08738.
    BgeeiO08738.
    CleanExiMM_CASP6.
    GenevestigatoriO08738.

    Interactioni

    Subunit structurei

    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.By similarity

    Protein-protein interaction databases

    BioGridi198498. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO08738.
    SMRiO08738. Positions 7-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated

    Phylogenomic databases

    eggNOGiNOG278720.
    HOGENOMiHOG000231878.
    HOVERGENiHBG050802.
    InParanoidiO08738.
    KOiK04396.
    OMAiDFCKDPS.
    OrthoDBiEOG7TTQ7K.
    PhylomeDBiO08738.
    TreeFamiTF102023.

    Family and domain databases

    Gene3Di3.40.50.1460. 1 hit.
    InterProiIPR029030. Caspase-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00115. CASc. 1 hit.
    [Graphical view]
    PROSITEiPS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08738-1 [UniParc]FASTAAdd to Basket

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    MTETDGFYKS REVFDPAEQY KMDHKRRGVA LIFNHERFFW HLTLPERRGT    50
    NADRDNLTRR FSDLGFEVKC FNDLRAEELL LKIHEVSTSS HIDADCFICV 100
    FLSHGEGNHV YAYDAKIEIQ TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ 150
    HDVPVVPLDM VDHQTDKLDN VTQVDAASVY TLPAGADFLM CYSVAEGYYS 200
    HRETVNGSWY IQDLCEMLAR YGSSLEFTEL LTLVNRKVSQ RRVDFCKDPD 250
    AIGKKQVPCF ASMLTKKLHF CPKPSK 276
    Length:276
    Mass (Da):31,595
    Last modified:July 1, 1997 - v1
    Checksum:i5965DE9321126B6C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13087 mRNA. Translation: CAA73529.1.
    CCDSiCCDS17838.1.
    RefSeqiNP_033941.3. NM_009811.3.
    UniGeneiMm.281379.

    Genome annotation databases

    EnsembliENSMUST00000029626; ENSMUSP00000029626; ENSMUSG00000027997.
    GeneIDi12368.
    KEGGimmu:12368.
    UCSCiuc008riq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13087 mRNA. Translation: CAA73529.1 .
    CCDSi CCDS17838.1.
    RefSeqi NP_033941.3. NM_009811.3.
    UniGenei Mm.281379.

    3D structure databases

    ProteinModelPortali O08738.
    SMRi O08738. Positions 7-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198498. 2 interactions.

    Protein family/group databases

    MEROPSi C14.005.

    PTM databases

    PhosphoSitei O08738.

    Proteomic databases

    MaxQBi O08738.
    PaxDbi O08738.
    PRIDEi O08738.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029626 ; ENSMUSP00000029626 ; ENSMUSG00000027997 .
    GeneIDi 12368.
    KEGGi mmu:12368.
    UCSCi uc008riq.2. mouse.

    Organism-specific databases

    CTDi 839.
    MGIi MGI:1312921. Casp6.

    Phylogenomic databases

    eggNOGi NOG278720.
    HOGENOMi HOG000231878.
    HOVERGENi HBG050802.
    InParanoidi O08738.
    KOi K04396.
    OMAi DFCKDPS.
    OrthoDBi EOG7TTQ7K.
    PhylomeDBi O08738.
    TreeFami TF102023.

    Enzyme and pathway databases

    BRENDAi 3.4.22.59. 3474.
    Reactomei REACT_209025. Breakdown of the nuclear lamina.
    REACT_210562. Caspase-mediated cleavage of cytoskeletal proteins.
    REACT_224460. Apoptotic cleavage of cellular proteins.

    Miscellaneous databases

    ChiTaRSi CASP6. mouse.
    NextBioi 281056.
    PROi O08738.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08738.
    Bgeei O08738.
    CleanExi MM_CASP6.
    Genevestigatori O08738.

    Family and domain databases

    Gene3Di 3.40.50.1460. 1 hit.
    InterProi IPR029030. Caspase-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00115. CASc. 1 hit.
    [Graphical view ]
    PROSITEi PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H/An.

    Entry informationi

    Entry nameiCASP6_MOUSE
    AccessioniPrimary (citable) accession number: O08738
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3