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O08738 (CASP6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caspase-6

Short name=CASP-6
EC=3.4.22.59
Alternative name(s):
Apoptotic protease Mch-2

Cleaved into the following 2 chains:

  1. Caspase-6 subunit p18
  2. Caspase-6 subunit p11
Gene names
Name:Casp6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death By similarity.

Catalytic activity

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.

Enzyme regulation

Activation is suppressed by phosphorylation at Ser-239 By similarity.

Subunit structure

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit By similarity. Interacts with BIRC6/bruce By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Highly expressed in lung, liver, kidney, testis, and heart. Lower levels in spleen, skeletal muscle and brain.

Post-translational modification

Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits By similarity.

Sequence similarities

Belongs to the peptidase C14A family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 55 By similarity
PRO_0000004612
Chain6 – 162157Caspase-6 subunit p18 By similarity
PRO_0000004613
Propeptide163 – 17614 By similarity
PRO_0000004614
Chain177 – 276100Caspase-6 subunit p11 By similarity
PRO_0000004615

Sites

Active site1041 By similarity
Active site1461 By similarity

Amino acid modifications

Modified residue2391Phosphoserine; by NUAK1 By similarity

Sequences

Sequence LengthMass (Da)Tools
O08738 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 5965DE9321126B6C

FASTA27631,595
        10         20         30         40         50         60 
MTETDGFYKS REVFDPAEQY KMDHKRRGVA LIFNHERFFW HLTLPERRGT NADRDNLTRR 

        70         80         90        100        110        120 
FSDLGFEVKC FNDLRAEELL LKIHEVSTSS HIDADCFICV FLSHGEGNHV YAYDAKIEIQ 

       130        140        150        160        170        180 
TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ HDVPVVPLDM VDHQTDKLDN VTQVDAASVY 

       190        200        210        220        230        240 
TLPAGADFLM CYSVAEGYYS HRETVNGSWY IQDLCEMLAR YGSSLEFTEL LTLVNRKVSQ 

       250        260        270 
RRVDFCKDPD AIGKKQVPCF ASMLTKKLHF CPKPSK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y13087 mRNA. Translation: CAA73529.1.
CCDSCCDS17838.1.
RefSeqNP_033941.3. NM_009811.3.
UniGeneMm.281379.

3D structure databases

ProteinModelPortalO08738.
SMRO08738. Positions 7-273.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198498. 2 interactions.

Protein family/group databases

MEROPSC14.005.

PTM databases

PhosphoSiteO08738.

Proteomic databases

MaxQBO08738.
PaxDbO08738.
PRIDEO08738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029626; ENSMUSP00000029626; ENSMUSG00000027997.
GeneID12368.
KEGGmmu:12368.
UCSCuc008riq.2. mouse.

Organism-specific databases

CTD839.
MGIMGI:1312921. Casp6.

Phylogenomic databases

eggNOGNOG278720.
HOGENOMHOG000231878.
HOVERGENHBG050802.
InParanoidO08738.
KOK04396.
OMADFCKDPS.
OrthoDBEOG7TTQ7K.
PhylomeDBO08738.
TreeFamTF102023.

Enzyme and pathway databases

BRENDA3.4.22.59. 3474.

Gene expression databases

ArrayExpressO08738.
BgeeO08738.
CleanExMM_CASP6.
GenevestigatorO08738.

Family and domain databases

Gene3D3.40.50.1460. 1 hit.
InterProIPR029030. Caspase-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PRINTSPR00376. IL1BCENZYME.
SMARTSM00115. CASc. 1 hit.
[Graphical view]
PROSITEPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCASP6. mouse.
NextBio281056.
PROO08738.
SOURCESearch...

Entry information

Entry nameCASP6_MOUSE
AccessionPrimary (citable) accession number: O08738
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot