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O08738

- CASP6_MOUSE

UniProt

O08738 - CASP6_MOUSE

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Protein

Caspase-6

Gene

Casp6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity).By similarity

Catalytic activityi

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.

Enzyme regulationi

Activation is suppressed by phosphorylation at Ser-239.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041By similarity
Active sitei146 – 1461By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. apoptotic process Source: RefGenome
  2. epithelial cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.59. 3474.
ReactomeiREACT_209025. Breakdown of the nuclear lamina.
REACT_210562. Caspase-mediated cleavage of cytoskeletal proteins.
REACT_224460. Apoptotic cleavage of cellular proteins.

Protein family/group databases

MEROPSiC14.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-6 (EC:3.4.22.59)
Short name:
CASP-6
Alternative name(s):
Apoptotic protease Mch-2
Cleaved into the following 2 chains:
Gene namesi
Name:Casp6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1312921. Casp6.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. cytosol Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55By similarityPRO_0000004612
Chaini6 – 162157Caspase-6 subunit p18By similarityPRO_0000004613Add
BLAST
Propeptidei163 – 17614By similarityPRO_0000004614Add
BLAST
Chaini177 – 276100Caspase-6 subunit p11By similarityPRO_0000004615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei239 – 2391Phosphoserine; by NUAK1By similarity

Post-translational modificationi

Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.By similarity

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

MaxQBiO08738.
PaxDbiO08738.
PRIDEiO08738.

PTM databases

PhosphoSiteiO08738.

Expressioni

Tissue specificityi

Highly expressed in lung, liver, kidney, testis, and heart. Lower levels in spleen, skeletal muscle and brain.

Gene expression databases

BgeeiO08738.
CleanExiMM_CASP6.
ExpressionAtlasiO08738. baseline and differential.
GenevestigatoriO08738.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce.By similarity

Protein-protein interaction databases

BioGridi198498. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO08738.
SMRiO08738. Positions 7-273.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiNOG278720.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
InParanoidiO08738.
KOiK04396.
OMAiDFCKDPS.
OrthoDBiEOG7TTQ7K.
PhylomeDBiO08738.
TreeFamiTF102023.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08738-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTETDGFYKS REVFDPAEQY KMDHKRRGVA LIFNHERFFW HLTLPERRGT
60 70 80 90 100
NADRDNLTRR FSDLGFEVKC FNDLRAEELL LKIHEVSTSS HIDADCFICV
110 120 130 140 150
FLSHGEGNHV YAYDAKIEIQ TLTGLFKGDK CQSLVGKPKI FIIQACRGSQ
160 170 180 190 200
HDVPVVPLDM VDHQTDKLDN VTQVDAASVY TLPAGADFLM CYSVAEGYYS
210 220 230 240 250
HRETVNGSWY IQDLCEMLAR YGSSLEFTEL LTLVNRKVSQ RRVDFCKDPD
260 270
AIGKKQVPCF ASMLTKKLHF CPKPSK
Length:276
Mass (Da):31,595
Last modified:July 1, 1997 - v1
Checksum:i5965DE9321126B6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13087 mRNA. Translation: CAA73529.1.
CCDSiCCDS17838.1.
RefSeqiNP_033941.3. NM_009811.3.
UniGeneiMm.281379.

Genome annotation databases

EnsembliENSMUST00000029626; ENSMUSP00000029626; ENSMUSG00000027997.
GeneIDi12368.
KEGGimmu:12368.
UCSCiuc008riq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13087 mRNA. Translation: CAA73529.1 .
CCDSi CCDS17838.1.
RefSeqi NP_033941.3. NM_009811.3.
UniGenei Mm.281379.

3D structure databases

ProteinModelPortali O08738.
SMRi O08738. Positions 7-273.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198498. 2 interactions.

Protein family/group databases

MEROPSi C14.005.

PTM databases

PhosphoSitei O08738.

Proteomic databases

MaxQBi O08738.
PaxDbi O08738.
PRIDEi O08738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029626 ; ENSMUSP00000029626 ; ENSMUSG00000027997 .
GeneIDi 12368.
KEGGi mmu:12368.
UCSCi uc008riq.2. mouse.

Organism-specific databases

CTDi 839.
MGIi MGI:1312921. Casp6.

Phylogenomic databases

eggNOGi NOG278720.
HOGENOMi HOG000231878.
HOVERGENi HBG050802.
InParanoidi O08738.
KOi K04396.
OMAi DFCKDPS.
OrthoDBi EOG7TTQ7K.
PhylomeDBi O08738.
TreeFami TF102023.

Enzyme and pathway databases

BRENDAi 3.4.22.59. 3474.
Reactomei REACT_209025. Breakdown of the nuclear lamina.
REACT_210562. Caspase-mediated cleavage of cytoskeletal proteins.
REACT_224460. Apoptotic cleavage of cellular proteins.

Miscellaneous databases

ChiTaRSi Casp6. mouse.
NextBioi 281056.
PROi O08738.
SOURCEi Search...

Gene expression databases

Bgeei O08738.
CleanExi MM_CASP6.
ExpressionAtlasi O08738. baseline and differential.
Genevestigatori O08738.

Family and domain databases

Gene3Di 3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00115. CASc. 1 hit.
[Graphical view ]
PROSITEi PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C3H/An.

Entry informationi

Entry nameiCASP6_MOUSE
AccessioniPrimary (citable) accession number: O08738
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3