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O08736

- CASPC_MOUSE

UniProt

O08736 - CASPC_MOUSE

Protein

Caspase-12

Gene

Casp12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Involved in the activation cascade of caspases responsible for apoptosis execution.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei250 – 2501By similarity
    Active sitei298 – 2981By similarity

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome
    2. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: MGI
    2. endoplasmic reticulum unfolded protein response Source: MGI
    3. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: UniProtKB
    4. regulation of apoptotic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    MEROPSiC14.013.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase-12 (EC:3.4.22.-)
    Short name:
    CASP-12
    Gene namesi
    Name:Casp12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1312922. Casp12.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. endoplasmic reticulum Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 419Caspase-12PRO_0000004648
    Propeptidei1 – ?Sequence AnalysisPRO_0000004647

    Keywords - PTMi

    Zymogen

    Proteomic databases

    MaxQBiO08736.
    PRIDEiO08736.

    Expressioni

    Tissue specificityi

    Mainly expressed in skeletal muscle and lung.

    Gene expression databases

    ArrayExpressiO08736.
    BgeeiO08736.
    CleanExiMM_CASP12.
    GenevestigatoriO08736.

    Interactioni

    Subunit structurei

    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits Potential. Interacts with TRAF2 under resting conditions; this interaction is reduced in ER stress conditions.1 PublicationCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TRAF2Q129336EBI-6140033,EBI-355744From a different organism.

    Protein-protein interaction databases

    BioGridi198494. 3 interactions.
    IntActiO08736. 1 interaction.
    MINTiMINT-204464.

    Structurei

    3D structure databases

    ProteinModelPortaliO08736.
    SMRiO08736. Positions 139-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 9292CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated
    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG257064.
    GeneTreeiENSGT00700000104134.
    HOGENOMiHOG000234399.
    HOVERGENiHBG076981.
    InParanoidiO08736.
    KOiK04741.
    OMAiYFKEYSW.
    OrthoDBiEOG7FXZZ6.
    PhylomeDBiO08736.
    TreeFamiTF102023.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08736-1 [UniParc]FASTAAdd to Basket

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    MAARRTHERD PIYKIKGLAK DMLDGVFDDL VEKNVLNGDE LLKIGESASF    50
    ILNKAENLVE NFLEKTDMAG KIFAGHIANS QEQLSLQFSN DEDDGPQKIC 100
    TPSSPSESKR KVEDDEMEVN AGLAHESHLM LTAPHGLQSS EVQDTLKLCP 150
    RDQFCKIKTE RAKEIYPVME KEGRTRLALI ICNKKFDYLF DRDNADTDIL 200
    NMQELLENLG YSVVLKENLT AQEMETELMQ FAGRPEHQSS DSTFLVFMSH 250
    GILEGICGVK HRNKKPDVLH DDTIFKIFNN SNCRSLRNKP KILIMQACRG 300
    RYNGTIWVST NKGIATADTD EERVLSCKWN NSITKAHVET DFIAFKSSTP 350
    HNISWKVGKT GSLFISKLID CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ 400
    MPTIERVSMT RYFYLFPGN 419
    Length:419
    Mass (Da):47,854
    Last modified:July 1, 1997 - v1
    Checksum:iB94B0FED16B1CB40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13090 mRNA. Translation: CAA73532.1.
    AK077256 mRNA. Translation: BAC36712.1.
    AK161525 mRNA. Translation: BAE36443.1.
    BC028979 mRNA. Translation: AAH28979.1.
    CCDSiCCDS22800.1.
    RefSeqiNP_033938.3. NM_009808.4.
    UniGeneiMm.42163.

    Genome annotation databases

    EnsembliENSMUST00000027009; ENSMUSP00000027009; ENSMUSG00000025887.
    GeneIDi12364.
    KEGGimmu:12364.
    UCSCiuc009obx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13090 mRNA. Translation: CAA73532.1 .
    AK077256 mRNA. Translation: BAC36712.1 .
    AK161525 mRNA. Translation: BAE36443.1 .
    BC028979 mRNA. Translation: AAH28979.1 .
    CCDSi CCDS22800.1.
    RefSeqi NP_033938.3. NM_009808.4.
    UniGenei Mm.42163.

    3D structure databases

    ProteinModelPortali O08736.
    SMRi O08736. Positions 139-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198494. 3 interactions.
    IntActi O08736. 1 interaction.
    MINTi MINT-204464.

    Protein family/group databases

    MEROPSi C14.013.

    Proteomic databases

    MaxQBi O08736.
    PRIDEi O08736.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027009 ; ENSMUSP00000027009 ; ENSMUSG00000025887 .
    GeneIDi 12364.
    KEGGi mmu:12364.
    UCSCi uc009obx.2. mouse.

    Organism-specific databases

    CTDi 100506742.
    MGIi MGI:1312922. Casp12.

    Phylogenomic databases

    eggNOGi NOG257064.
    GeneTreei ENSGT00700000104134.
    HOGENOMi HOG000234399.
    HOVERGENi HBG076981.
    InParanoidi O08736.
    KOi K04741.
    OMAi YFKEYSW.
    OrthoDBi EOG7FXZZ6.
    PhylomeDBi O08736.
    TreeFami TF102023.

    Miscellaneous databases

    NextBioi 281040.
    PROi O08736.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08736.
    Bgeei O08736.
    CleanExi MM_CASP12.
    Genevestigatori O08736.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C3H/An.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Ovary and Uterus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N-3.
      Tissue: Mammary gland.
    4. "Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress."
      Yoneda T., Imaizumi K., Oono K., Yui D., Gomi F., Katayama T., Tohyama M.
      J. Biol. Chem. 276:13935-13940(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TRAF2.

    Entry informationi

    Entry nameiCASPC_MOUSE
    AccessioniPrimary (citable) accession number: O08736
    Secondary accession number(s): Q3TT82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3