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Protein

Caspase-12

Gene

Casp12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei250By similarity1
Active sitei298By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis

Protein family/group databases

MEROPSiC14.013

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-12 (EC:3.4.22.-)
Short name:
CASP-12
Gene namesi
Name:Casp12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1312922 Casp12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000004648? – 419Caspase-12
PropeptideiPRO_00000046471 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei85PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein, Zymogen

Proteomic databases

MaxQBiO08736
PaxDbiO08736
PRIDEiO08736

PTM databases

iPTMnetiO08736
PhosphoSitePlusiO08736

Expressioni

Tissue specificityi

Mainly expressed in skeletal muscle and lung.

Gene expression databases

BgeeiENSMUSG00000025887
CleanExiMM_CASP12
ExpressionAtlasiO08736 baseline and differential
GenevisibleiO08736 MM

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by two subunits (Potential). Interacts with TRAF2 under resting conditions; this interaction is reduced in ER stress conditions.Curated1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF2Q129336EBI-6140033,EBI-355744From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198494, 3 interactors
IntActiO08736, 1 interactor
STRINGi10090.ENSMUSP00000027009

Structurei

3D structure databases

ProteinModelPortaliO08736
SMRiO08736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92CARDPROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00910000144131
HOGENOMiHOG000234399
HOVERGENiHBG076981
InParanoidiO08736
KOiK04741
OMAiSWSHHLE
OrthoDBiEOG091G07NO
PhylomeDBiO08736
TreeFamiTF102023

Family and domain databases

CDDicd00032 CASc, 1 hit
InterProiView protein in InterPro
IPR001315 CARD
IPR029030 Caspase-like_dom_sf
IPR035713 Caspase_12
IPR033139 Caspase_cys_AS
IPR016129 Caspase_his_AS
IPR011029 DEATH-like_dom_sf
IPR002138 Pept_C14_p10
IPR001309 Pept_C14_p20
IPR015917 Pept_C14A
PANTHERiPTHR10454:SF134 PTHR10454:SF134, 1 hit
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PRINTSiPR00376 IL1BCENZYME
SMARTiView protein in SMART
SM00115 CASc, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
SSF52129 SSF52129, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS01122 CASPASE_CYS, 1 hit
PS01121 CASPASE_HIS, 1 hit
PS50207 CASPASE_P10, 1 hit
PS50208 CASPASE_P20, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRTHERD PIYKIKGLAK DMLDGVFDDL VEKNVLNGDE LLKIGESASF
60 70 80 90 100
ILNKAENLVE NFLEKTDMAG KIFAGHIANS QEQLSLQFSN DEDDGPQKIC
110 120 130 140 150
TPSSPSESKR KVEDDEMEVN AGLAHESHLM LTAPHGLQSS EVQDTLKLCP
160 170 180 190 200
RDQFCKIKTE RAKEIYPVME KEGRTRLALI ICNKKFDYLF DRDNADTDIL
210 220 230 240 250
NMQELLENLG YSVVLKENLT AQEMETELMQ FAGRPEHQSS DSTFLVFMSH
260 270 280 290 300
GILEGICGVK HRNKKPDVLH DDTIFKIFNN SNCRSLRNKP KILIMQACRG
310 320 330 340 350
RYNGTIWVST NKGIATADTD EERVLSCKWN NSITKAHVET DFIAFKSSTP
360 370 380 390 400
HNISWKVGKT GSLFISKLID CFKKYCWCYH LEEIFRKVQH SFEVPGELTQ
410
MPTIERVSMT RYFYLFPGN
Length:419
Mass (Da):47,854
Last modified:July 1, 1997 - v1
Checksum:iB94B0FED16B1CB40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y13090 mRNA Translation: CAA73532.1
AK077256 mRNA Translation: BAC36712.1
AK161525 mRNA Translation: BAE36443.1
BC028979 mRNA Translation: AAH28979.1
CCDSiCCDS22800.1
RefSeqiNP_033938.3, NM_009808.4
UniGeneiMm.42163

Genome annotation databases

EnsembliENSMUST00000027009; ENSMUSP00000027009; ENSMUSG00000025887
GeneIDi12364
KEGGimmu:12364
UCSCiuc009obw.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCASPC_MOUSE
AccessioniPrimary (citable) accession number: O08736
Secondary accession number(s): Q3TT82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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