Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor receptor superfamily member 11B

Gene

Tnfrsf11b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei400 – 4001Involved in dimerizationBy similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic signaling pathway Source: GO_Central
  • extracellular matrix organization Source: Ensembl
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • negative regulation of bone resorption Source: RGD
  • negative regulation of odontogenesis of dentin-containing tooth Source: RGD
  • positive regulation of MAPK cascade Source: GO_Central
  • regulation of apoptotic process Source: GO_Central
  • regulation of cell proliferation Source: GO_Central
  • response to arsenic-containing substance Source: RGD
  • response to drug Source: RGD
  • response to estrogen Source: RGD
  • response to inorganic substance Source: RGD
  • response to lipopolysaccharide Source: GO_Central
  • response to magnesium ion Source: RGD
  • response to nutrient Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11B
Alternative name(s):
Osteoprotegerin
Gene namesi
Name:Tnfrsf11b
Synonyms:Opg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi619802. Tnfrsf11b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 401380Tumor necrosis factor receptor superfamily member 11BPRO_0000034589Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 54PROSITE-ProRule annotation
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 80PROSITE-ProRule annotation
Disulfide bondi83 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation
Disulfide bondi145 ↔ 160PROSITE-ProRule annotation
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi166 ↔ 185PROSITE-ProRule annotation
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO08727.
PRIDEiO08727.

Expressioni

Inductioni

Up-regulated by osteopontin.

Gene expression databases

GenevisibleiO08727. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with TNFSF10 and TNFSF11 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011344.

Structurei

3D structure databases

ProteinModelPortaliO08727.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 6239TNFR-Cys 1Add
BLAST
Repeati65 – 10541TNFR-Cys 2Add
BLAST
Repeati107 – 14236TNFR-Cys 3Add
BLAST
Repeati145 – 18541TNFR-Cys 4Add
BLAST
Domaini198 – 26972Death 1Add
BLAST
Domaini270 – 36596Death 2Add
BLAST

Sequence similaritiesi

Contains 2 death domains.Curated
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFEM. Eukaryota.
ENOG4111PUQ. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000273896.
HOVERGENiHBG061495.
InParanoidiO08727.
KOiK05148.
OMAiSRQLMCD.
OrthoDBiEOG786H2Q.
PhylomeDBiO08727.
TreeFamiTF331157.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR017371. TNFR_11B.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PIRSFiPIRSF038065. TNFR_11B. 1 hit.
PRINTSiPR01961. TNFACTORR11.
PR01975. TNFACTORR11B.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKWLCCALL VFLDIIEWTT QETFPPKYLH YDPETGRQLL CDKCAPGTYL
60 70 80 90 100
KQHCTVRRKT LCVPCPDYSY TDSWHTSDEC VYCSPVCKEL QTVKQECNRT
110 120 130 140 150
HNRVCECEEG RYLELEFCLK HRSCPPGLGV LQAGTPERNT VCKRCPDGFF
160 170 180 190 200
SGETSSKAPC RKHTNCSSLG LLLIQKGNAT HDNVCSGNRE ATQNCGIDVT
210 220 230 240 250
LCEEAFFRFA VPTKIIPNWL SVLVDSLPGT KVNAESVERI KRRHSSQEQT
260 270 280 290 300
FQLLKLWKHQ NRDQEMVKKI IQDIDLCESS VQRHIGHANL TTEQLRILME
310 320 330 340 350
SLPGKKISPD EIERTRKTCK PSEQLLKLLS LWRIKNGDQD TLKGLMYALK
360 370 380 390 400
HLKAYHFPKT VTHSLRKTIR FLHSFTMYRL YQKLFLEMIG NQVQSVKISC

L
Length:401
Mass (Da):46,192
Last modified:July 1, 1997 - v1
Checksum:iFEC6A31F1D4E573A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94330 mRNA. Translation: AAB53707.1.
BC081830 mRNA. Translation: AAH81830.1.
RefSeqiNP_037002.1. NM_012870.2.
UniGeneiRn.202973.

Genome annotation databases

EnsembliENSRNOT00000011344; ENSRNOP00000011344; ENSRNOG00000008336.
GeneIDi25341.
KEGGirno:25341.
UCSCiRGD:619802. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94330 mRNA. Translation: AAB53707.1.
BC081830 mRNA. Translation: AAH81830.1.
RefSeqiNP_037002.1. NM_012870.2.
UniGeneiRn.202973.

3D structure databases

ProteinModelPortaliO08727.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011344.

Proteomic databases

PaxDbiO08727.
PRIDEiO08727.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011344; ENSRNOP00000011344; ENSRNOG00000008336.
GeneIDi25341.
KEGGirno:25341.
UCSCiRGD:619802. rat.

Organism-specific databases

CTDi4982.
RGDi619802. Tnfrsf11b.

Phylogenomic databases

eggNOGiENOG410IFEM. Eukaryota.
ENOG4111PUQ. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000273896.
HOVERGENiHBG061495.
InParanoidiO08727.
KOiK05148.
OMAiSRQLMCD.
OrthoDBiEOG786H2Q.
PhylomeDBiO08727.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-RNO-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

PROiO08727.

Gene expression databases

GenevisibleiO08727. RN.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR017371. TNFR_11B.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PIRSFiPIRSF038065. TNFR_11B. 1 hit.
PRINTSiPR01961. TNFACTORR11.
PR01975. TNFACTORR11B.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiTR11B_RAT
AccessioniPrimary (citable) accession number: O08727
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.