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O08726

- GALR2_RAT

UniProt

O08726 - GALR2_RAT

Protein

Galanin receptor type 2

Gene

Galr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

    GO - Molecular functioni

    1. galanin receptor activity Source: RGD
    2. neuropeptide binding Source: RGD
    3. peptide hormone binding Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
    2. G-protein coupled receptor signaling pathway Source: RGD
    3. inositol phosphate metabolic process Source: RGD
    4. negative regulation of adenylate cyclase activity Source: InterPro
    5. neuropeptide signaling pathway Source: GOC
    6. phosphatidylinositol metabolic process Source: RGD
    7. positive regulation of cytosolic calcium ion concentration Source: RGD
    8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galanin receptor type 2
    Short name:
    GAL2-R
    Short name:
    GALR-2
    Gene namesi
    Name:Galr2
    Synonyms:Galnr2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi2657. Galr2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Galanin receptor type 2PRO_0000069468Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO08726.

    PTM databases

    PhosphoSiteiO08726.

    Expressioni

    Gene expression databases

    GenevestigatoriO08726.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012523.

    Structurei

    3D structure databases

    ProteinModelPortaliO08726.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini82 – 9918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini122 – 14120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 18725ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 23729CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 2602ExtracellularSequence Analysis
    Topological domaini282 – 37291CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320953.
    GeneTreeiENSGT00620000087530.
    HOGENOMiHOG000230487.
    HOVERGENiHBG101447.
    InParanoidiO08726.
    KOiK04231.
    OMAiFRKICAG.
    OrthoDBiEOG7327PK.
    PhylomeDBiO08726.
    TreeFamiTF315737.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR003907. GAL2_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01419. GALANIN2R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08726-1 [UniParc]FASTAAdd to Basket

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    MNGSGSQGAE NTSQEGGSGG WQPEAVLVPL FFALIFLVGT VGNALVLAVL    50
    LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDD WVFGSLLCKA 100
    VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW 150
    GLALLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDLC TFVFSYLLPV 200
    LVLSLTYART LRYLWRTVDP VTAGSGSQRA KRKVTRMIII VAVLFCLCWM 250
    PHHALILCVW FGRFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR 300
    KGFRKICAGL LRPAPRRASG RVSILAPGNH SGSMLEQEST DLTQVSEAAG 350
    PLVPPPALPN CTASSRTLDP AC 372
    Length:372
    Mass (Da):40,676
    Last modified:July 1, 1997 - v1
    Checksum:i5E7B67B35A54AB6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94322 mRNA. Translation: AAB53220.1.
    AF010318 mRNA. Translation: AAC53358.1.
    Y15248 mRNA. Translation: CAA75532.1.
    AF008548 mRNA. Translation: AAB62573.1.
    RefSeqiNP_062045.1. NM_019172.4.
    XP_003751012.1. XM_003750964.2.
    UniGeneiRn.9789.

    Genome annotation databases

    EnsembliENSRNOT00000012523; ENSRNOP00000012523; ENSRNOG00000009407.
    ENSRNOT00000075548; ENSRNOP00000067445; ENSRNOG00000050358.
    GeneIDi100910349.
    29234.
    KEGGirno:100910349.
    rno:29234.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U94322 mRNA. Translation: AAB53220.1 .
    AF010318 mRNA. Translation: AAC53358.1 .
    Y15248 mRNA. Translation: CAA75532.1 .
    AF008548 mRNA. Translation: AAB62573.1 .
    RefSeqi NP_062045.1. NM_019172.4.
    XP_003751012.1. XM_003750964.2.
    UniGenei Rn.9789.

    3D structure databases

    ProteinModelPortali O08726.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012523.

    Chemistry

    BindingDBi O08726.
    ChEMBLi CHEMBL5577.
    GuidetoPHARMACOLOGYi 244.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei O08726.

    Proteomic databases

    PaxDbi O08726.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000012523 ; ENSRNOP00000012523 ; ENSRNOG00000009407 .
    ENSRNOT00000075548 ; ENSRNOP00000067445 ; ENSRNOG00000050358 .
    GeneIDi 100910349.
    29234.
    KEGGi rno:100910349.
    rno:29234.

    Organism-specific databases

    CTDi 8811.
    RGDi 2657. Galr2.

    Phylogenomic databases

    eggNOGi NOG320953.
    GeneTreei ENSGT00620000087530.
    HOGENOMi HOG000230487.
    HOVERGENi HBG101447.
    InParanoidi O08726.
    KOi K04231.
    OMAi FRKICAG.
    OrthoDBi EOG7327PK.
    PhylomeDBi O08726.
    TreeFami TF315737.

    Miscellaneous databases

    NextBioi 608490.
    PROi O08726.

    Gene expression databases

    Genevestigatori O08726.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR003907. GAL2_rcpt.
    IPR000405. Galanin_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01419. GALANIN2R.
    PR00663. GALANINR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.
    2. "Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover."
      Smith K.E., Forray C., Walker M.W., Jones K.A., Tamm J.A., Bard J., Branchek T.A., Linemeyer D.L., Gerald C.
      J. Biol. Chem. 272:24612-24616(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Molecular cloning and pharmacological characterization of a new galanin receptor subtype."
      Wang S., Hashemi T., He C., Strader C., Bayne M.
      Mol. Pharmacol. 52:337-343(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.
    4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGALR2_RAT
    AccessioniPrimary (citable) accession number: O08726
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3