Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O08726

- GALR2_RAT

UniProt

O08726 - GALR2_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Galanin receptor type 2

Gene

Galr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

GO - Molecular functioni

  1. galanin receptor activity Source: RGD
  2. neuropeptide binding Source: RGD
  3. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  2. G-protein coupled receptor signaling pathway Source: RGD
  3. inositol phosphate metabolic process Source: RGD
  4. negative regulation of adenylate cyclase activity Source: InterPro
  5. neuropeptide signaling pathway Source: GOC
  6. phosphatidylinositol metabolic process Source: RGD
  7. positive regulation of cytosolic calcium ion concentration Source: RGD
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 2
Short name:
GAL2-R
Short name:
GALR-2
Gene namesi
Name:Galr2
Synonyms:Galnr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi2657. Galr2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Galanin receptor type 2PRO_0000069468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO08726.

PTM databases

PhosphoSiteiO08726.

Expressioni

Gene expression databases

GenevestigatoriO08726.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012523.

Structurei

3D structure databases

ProteinModelPortaliO08726.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini82 – 9918ExtracellularSequence AnalysisAdd
BLAST
Topological domaini122 – 14120CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 18725ExtracellularSequence AnalysisAdd
BLAST
Topological domaini209 – 23729CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 2602ExtracellularSequence Analysis
Topological domaini282 – 37291CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei261 – 28121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO08726.
KOiK04231.
OMAiFRKICAG.
OrthoDBiEOG7327PK.
PhylomeDBiO08726.
TreeFamiTF315737.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08726-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNGSGSQGAE NTSQEGGSGG WQPEAVLVPL FFALIFLVGT VGNALVLAVL
60 70 80 90 100
LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDD WVFGSLLCKA
110 120 130 140 150
VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW
160 170 180 190 200
GLALLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDLC TFVFSYLLPV
210 220 230 240 250
LVLSLTYART LRYLWRTVDP VTAGSGSQRA KRKVTRMIII VAVLFCLCWM
260 270 280 290 300
PHHALILCVW FGRFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR
310 320 330 340 350
KGFRKICAGL LRPAPRRASG RVSILAPGNH SGSMLEQEST DLTQVSEAAG
360 370
PLVPPPALPN CTASSRTLDP AC
Length:372
Mass (Da):40,676
Last modified:July 1, 1997 - v1
Checksum:i5E7B67B35A54AB6E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U94322 mRNA. Translation: AAB53220.1.
AF010318 mRNA. Translation: AAC53358.1.
Y15248 mRNA. Translation: CAA75532.1.
AF008548 mRNA. Translation: AAB62573.1.
RefSeqiNP_062045.1. NM_019172.4.
UniGeneiRn.9789.

Genome annotation databases

EnsembliENSRNOT00000012523; ENSRNOP00000012523; ENSRNOG00000009407.
ENSRNOT00000075548; ENSRNOP00000067445; ENSRNOG00000050358.
GeneIDi29234.
KEGGirno:100910349.
rno:29234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U94322 mRNA. Translation: AAB53220.1 .
AF010318 mRNA. Translation: AAC53358.1 .
Y15248 mRNA. Translation: CAA75532.1 .
AF008548 mRNA. Translation: AAB62573.1 .
RefSeqi NP_062045.1. NM_019172.4.
UniGenei Rn.9789.

3D structure databases

ProteinModelPortali O08726.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000012523.

Chemistry

BindingDBi O08726.
ChEMBLi CHEMBL5577.
GuidetoPHARMACOLOGYi 244.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O08726.

Proteomic databases

PaxDbi O08726.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000012523 ; ENSRNOP00000012523 ; ENSRNOG00000009407 .
ENSRNOT00000075548 ; ENSRNOP00000067445 ; ENSRNOG00000050358 .
GeneIDi 29234.
KEGGi rno:100910349.
rno:29234.

Organism-specific databases

CTDi 8811.
RGDi 2657. Galr2.

Phylogenomic databases

eggNOGi NOG320953.
GeneTreei ENSGT00760000118797.
HOGENOMi HOG000230487.
HOVERGENi HBG101447.
InParanoidi O08726.
KOi K04231.
OMAi FRKICAG.
OrthoDBi EOG7327PK.
PhylomeDBi O08726.
TreeFami TF315737.

Miscellaneous databases

NextBioi 608490.
PROi O08726.

Gene expression databases

Genevestigatori O08726.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  2. "Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover."
    Smith K.E., Forray C., Walker M.W., Jones K.A., Tamm J.A., Bard J., Branchek T.A., Linemeyer D.L., Gerald C.
    J. Biol. Chem. 272:24612-24616(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and pharmacological characterization of a new galanin receptor subtype."
    Wang S., Hashemi T., He C., Strader C., Bayne M.
    Mol. Pharmacol. 52:337-343(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGALR2_RAT
AccessioniPrimary (citable) accession number: O08726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3