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Protein

Galanin receptor type 2

Gene

Galr2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the hormone galanin, GALP and spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

GO - Molecular functioni

  1. galanin receptor activity Source: RGD
  2. neuropeptide binding Source: RGD
  3. peptide hormone binding Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
  2. G-protein coupled receptor signaling pathway Source: RGD
  3. inositol phosphate metabolic process Source: RGD
  4. negative regulation of adenylate cyclase activity Source: InterPro
  5. neuropeptide signaling pathway Source: GOC
  6. phosphatidylinositol metabolic process Source: RGD
  7. positive regulation of cytosolic calcium ion concentration Source: RGD
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.
REACT_339234. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Galanin receptor type 2
Short name:
GAL2-R
Short name:
GALR-2
Gene namesi
Name:Galr2
Synonyms:Galnr2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2657. Galr2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 6011CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini82 – 9918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini122 – 14120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 18725ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 23729CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 2602ExtracellularSequence Analysis
Transmembranei261 – 28121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini282 – 37291CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Galanin receptor type 2PRO_0000069468Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO08726.

PTM databases

PhosphoSiteiO08726.

Expressioni

Gene expression databases

GenevestigatoriO08726.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012523.

Structurei

3D structure databases

ProteinModelPortaliO08726.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO08726.
KOiK04231.
OMAiFRKICAG.
OrthoDBiEOG7327PK.
PhylomeDBiO08726.
TreeFamiTF315737.

Family and domain databases

InterProiIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGSGSQGAE NTSQEGGSGG WQPEAVLVPL FFALIFLVGT VGNALVLAVL
60 70 80 90 100
LRGGQAVSTT NLFILNLGVA DLCFILCCVP FQATIYTLDD WVFGSLLCKA
110 120 130 140 150
VHFLIFLTMH ASSFTLAAVS LDRYLAIRYP LHSRELRTPR NALAAIGLIW
160 170 180 190 200
GLALLFSGPY LSYYRQSQLA NLTVCHPAWS APRRRAMDLC TFVFSYLLPV
210 220 230 240 250
LVLSLTYART LRYLWRTVDP VTAGSGSQRA KRKVTRMIII VAVLFCLCWM
260 270 280 290 300
PHHALILCVW FGRFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR
310 320 330 340 350
KGFRKICAGL LRPAPRRASG RVSILAPGNH SGSMLEQEST DLTQVSEAAG
360 370
PLVPPPALPN CTASSRTLDP AC
Length:372
Mass (Da):40,676
Last modified:July 1, 1997 - v1
Checksum:i5E7B67B35A54AB6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94322 mRNA. Translation: AAB53220.1.
AF010318 mRNA. Translation: AAC53358.1.
Y15248 mRNA. Translation: CAA75532.1.
AF008548 mRNA. Translation: AAB62573.1.
RefSeqiNP_062045.1. NM_019172.4.
XP_008766654.1. XM_008768432.1.
UniGeneiRn.9789.

Genome annotation databases

EnsembliENSRNOT00000012523; ENSRNOP00000012523; ENSRNOG00000009407.
ENSRNOT00000075548; ENSRNOP00000067445; ENSRNOG00000050358.
GeneIDi103690156.
29234.
KEGGirno:103690156.
rno:29234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94322 mRNA. Translation: AAB53220.1.
AF010318 mRNA. Translation: AAC53358.1.
Y15248 mRNA. Translation: CAA75532.1.
AF008548 mRNA. Translation: AAB62573.1.
RefSeqiNP_062045.1. NM_019172.4.
XP_008766654.1. XM_008768432.1.
UniGeneiRn.9789.

3D structure databases

ProteinModelPortaliO08726.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012523.

Chemistry

BindingDBiO08726.
ChEMBLiCHEMBL5577.
GuidetoPHARMACOLOGYi244.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiO08726.

Proteomic databases

PaxDbiO08726.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012523; ENSRNOP00000012523; ENSRNOG00000009407.
ENSRNOT00000075548; ENSRNOP00000067445; ENSRNOG00000050358.
GeneIDi103690156.
29234.
KEGGirno:103690156.
rno:29234.

Organism-specific databases

CTDi8811.
RGDi2657. Galr2.

Phylogenomic databases

eggNOGiNOG320953.
GeneTreeiENSGT00760000118797.
HOGENOMiHOG000230487.
HOVERGENiHBG101447.
InParanoidiO08726.
KOiK04231.
OMAiFRKICAG.
OrthoDBiEOG7327PK.
PhylomeDBiO08726.
TreeFamiTF315737.

Enzyme and pathway databases

ReactomeiREACT_306851. Peptide ligand-binding receptors.
REACT_339234. G alpha (i) signalling events.

Miscellaneous databases

NextBioi608490.
PROiO08726.

Gene expression databases

GenevestigatoriO08726.

Family and domain databases

InterProiIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  2. "Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover."
    Smith K.E., Forray C., Walker M.W., Jones K.A., Tamm J.A., Bard J., Branchek T.A., Linemeyer D.L., Gerald C.
    J. Biol. Chem. 272:24612-24616(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Molecular cloning and pharmacological characterization of a new galanin receptor subtype."
    Wang S., Hashemi T., He C., Strader C., Bayne M.
    Mol. Pharmacol. 52:337-343(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hypothalamus.
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGALR2_RAT
AccessioniPrimary (citable) accession number: O08726
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 1, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.