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O08726 (GALR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galanin receptor type 2

Short name=GAL2-R
Short name=GALR-2
Gene names
Name:Galr2
Synonyms:Galnr2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Galanin receptor type 2
PRO_0000069468

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 4921Helical; Name=1; Potential
Topological domain50 – 6011Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 9918Extracellular Potential
Transmembrane100 – 12122Helical; Name=3; Potential
Topological domain122 – 14120Cytoplasmic Potential
Transmembrane142 – 16221Helical; Name=4; Potential
Topological domain163 – 18725Extracellular Potential
Transmembrane188 – 20821Helical; Name=5; Potential
Topological domain209 – 23729Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 2602Extracellular Potential
Transmembrane261 – 28121Helical; Name=7; Potential
Topological domain282 – 37291Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 175 By similarity

Sequences

Sequence LengthMass (Da)Tools
O08726 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 5E7B67B35A54AB6E

FASTA37240,676
        10         20         30         40         50         60 
MNGSGSQGAE NTSQEGGSGG WQPEAVLVPL FFALIFLVGT VGNALVLAVL LRGGQAVSTT 

        70         80         90        100        110        120 
NLFILNLGVA DLCFILCCVP FQATIYTLDD WVFGSLLCKA VHFLIFLTMH ASSFTLAAVS 

       130        140        150        160        170        180 
LDRYLAIRYP LHSRELRTPR NALAAIGLIW GLALLFSGPY LSYYRQSQLA NLTVCHPAWS 

       190        200        210        220        230        240 
APRRRAMDLC TFVFSYLLPV LVLSLTYART LRYLWRTVDP VTAGSGSQRA KRKVTRMIII 

       250        260        270        280        290        300 
VAVLFCLCWM PHHALILCVW FGRFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR 

       310        320        330        340        350        360 
KGFRKICAGL LRPAPRRASG RVSILAPGNH SGSMLEQEST DLTQVSEAAG PLVPPPALPN 

       370 
CTASSRTLDP AC 

« Hide

References

[1]"Molecular cloning and characterization of a new receptor for galanin."
Howard A.D., Tan C., Shiao L.L., Palyha O.C., McKee K.K., Weinberg D.H., Feighner S.D., Cascieri M.A., Smith R.G., van der Ploeg L.H.T., Sullivan K.A.
FEBS Lett. 405:285-290(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hypothalamus.
[2]"Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover."
Smith K.E., Forray C., Walker M.W., Jones K.A., Tamm J.A., Bard J., Branchek T.A., Linemeyer D.L., Gerald C.
J. Biol. Chem. 272:24612-24616(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Molecular cloning and pharmacological characterization of a new galanin receptor subtype."
Wang S., Hashemi T., He C., Strader C., Bayne M.
Mol. Pharmacol. 52:337-343(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hypothalamus.
[4]"Cloning, pharmacological characterization and distribution of a novel galanin receptor."
Fathi Z., Cunningham A.M., Iben L.G., Battaglino P.B., Ward S.A., Nichol K.A., Pine K.A., Wang J., Goldstein M.E., Iismaa T.P., Zimanyi I.A.
Brain Res. Mol. Brain Res. 51:49-59(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[5]Erratum
Fathi Z., Cunningham A.M., Iben L.G., Battaglino P.B., Ward S.A., Nichol K.A., Pine K.A., Wang J., Goldstein M.E., Iismaa T.P., Zimanyi I.A.
Brain Res. Mol. Brain Res. 53:348-348(1998) [PubMed] [Europe PMC] [Abstract]
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U94322 mRNA. Translation: AAB53220.1.
AF010318 mRNA. Translation: AAC53358.1.
Y15248 mRNA. Translation: CAA75532.1.
AF008548 mRNA. Translation: AAB62573.1.
RefSeqNP_062045.1. NM_019172.4.
XP_003751012.1. XM_003750964.2.
UniGeneRn.9789.

3D structure databases

ProteinModelPortalO08726.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012523.

Chemistry

BindingDBO08726.
ChEMBLCHEMBL5577.
GuidetoPHARMACOLOGY244.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO08726.

Proteomic databases

PaxDbO08726.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000012523; ENSRNOP00000012523; ENSRNOG00000009407.
ENSRNOT00000075548; ENSRNOP00000067445; ENSRNOG00000050358.
GeneID100910349.
29234.
KEGGrno:100910349.
rno:29234.

Organism-specific databases

CTD8811.
RGD2657. Galr2.

Phylogenomic databases

eggNOGNOG320953.
GeneTreeENSGT00620000087530.
HOGENOMHOG000230487.
HOVERGENHBG101447.
InParanoidO08726.
KOK04231.
OMAFRKICAG.
OrthoDBEOG7327PK.
PhylomeDBO08726.
TreeFamTF315737.

Gene expression databases

GenevestigatorO08726.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR003907. GAL2_rcpt.
IPR000405. Galanin_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01419. GALANIN2R.
PR00663. GALANINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608490.
PROO08726.

Entry information

Entry nameGALR2_RAT
AccessionPrimary (citable) accession number: O08726
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries