Galanin receptor type 2 - Rattus norvegicus (Rat)

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O08726 (GALR2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Galanin receptor type 2
Short name=GAL2-R
Short name=GALR-2

Gene names

Name:	Galr2
Synonyms:	Galnr2

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adenylate cyclase-activating G-protein coupled receptor signaling pathway Inferred from mutant phenotype PubMed 17143559. Source: RGD elevation of cytosolic calcium ion concentration Inferred from direct assay PubMed 15471987. Source: RGD inositol phosphate metabolic process Inferred from direct assay Ref.4. Source: RGD phosphatidylinositol metabolic process Inferred from direct assay Ref.2. Source: RGD
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay PubMed 15471987 Ref.2 PubMed 9578554. Source: RGD
Molecular_function	galanin receptor activity Inferred from direct assay Ref.2 Ref.4 PubMed 9578554. Source: RGD neuropeptide binding Inferred from direct assay Ref.2 Ref.4 PubMed 9578554. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 372

372

Galanin receptor type 2

PRO_0000069468

Regions

Topological domain

1 – 28

Extracellular Potential

Transmembrane

29 – 49

Helical; Name=1; Potential

Topological domain

50 – 60

Cytoplasmic Potential

Transmembrane

61 – 81

Helical; Name=2; Potential

Topological domain

82 – 99

Extracellular Potential

Transmembrane

100 – 121

Helical; Name=3; Potential

Topological domain

122 – 141

Cytoplasmic Potential

Transmembrane

142 – 162

Helical; Name=4; Potential

Topological domain

163 – 187

Extracellular Potential

Transmembrane

188 – 208

Helical; Name=5; Potential

Topological domain

209 – 237

Cytoplasmic Potential

Transmembrane

238 – 258

Helical; Name=6; Potential

Topological domain

259 – 260

Extracellular Potential

Transmembrane

261 – 281

Helical; Name=7; Potential

Topological domain

282 – 372

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

98 ↔ 175

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

O08726 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 5E7B67B35A54AB6E
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FASTA

372

40,676

        10         20         30         40         50         60 
MNGSGSQGAE NTSQEGGSGG WQPEAVLVPL FFALIFLVGT VGNALVLAVL LRGGQAVSTT 

        70         80         90        100        110        120 
NLFILNLGVA DLCFILCCVP FQATIYTLDD WVFGSLLCKA VHFLIFLTMH ASSFTLAAVS 

       130        140        150        160        170        180 
LDRYLAIRYP LHSRELRTPR NALAAIGLIW GLALLFSGPY LSYYRQSQLA NLTVCHPAWS 

       190        200        210        220        230        240 
APRRRAMDLC TFVFSYLLPV LVLSLTYART LRYLWRTVDP VTAGSGSQRA KRKVTRMIII 

       250        260        270        280        290        300 
VAVLFCLCWM PHHALILCVW FGRFPLTRAT YALRILSHLV SYANSCVNPI VYALVSKHFR 

       310        320        330        340        350        360 
KGFRKICAGL LRPAPRRASG RVSILAPGNH SGSMLEQEST DLTQVSEAAG PLVPPPALPN 

       370 
CTASSRTLDP AC

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References

[1]	"Molecular cloning and characterization of a new receptor for galanin." Howard A.D., Tan C., Shiao L.L., Palyha O.C., McKee K.K., Weinberg D.H., Feighner S.D., Cascieri M.A., Smith R.G., van der Ploeg L.H.T., Sullivan K.A. FEBS Lett. 405:285-290(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hypothalamus.
[2]	"Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover." Smith K.E., Forray C., Walker M.W., Jones K.A., Tamm J.A., Bard J., Branchek T.A., Linemeyer D.L., Gerald C. J. Biol. Chem. 272:24612-24616(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Molecular cloning and pharmacological characterization of a new galanin receptor subtype." Wang S., Hashemi T., He C., Strader C., Bayne M. Mol. Pharmacol. 52:337-343(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hypothalamus.
[4]	"Cloning, pharmacological characterization and distribution of a novel galanin receptor." Fathi Z., Cunningham A.M., Iben L.G., Battaglino P.B., Ward S.A., Nichol K.A., Pine K.A., Wang J., Goldstein M.E., Iismaa T.P., Zimanyi I.A. Brain Res. Mol. Brain Res. 51:49-59(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[5]	Erratum Fathi Z., Cunningham A.M., Iben L.G., Battaglino P.B., Ward S.A., Nichol K.A., Pine K.A., Wang J., Goldstein M.E., Iismaa T.P., Zimanyi I.A. Brain Res. Mol. Brain Res. 53:348-348(1998) [PubMed] [Europe PMC] [Abstract]
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U94322 mRNA. Translation: AAB53220.1. AF010318 mRNA. Translation: AAC53358.1. Y15248 mRNA. Translation: CAA75532.1. AF008548 mRNA. Translation: AAB62573.1.
IPI	IPI00195513.
RefSeq	NP_062045.1. NM_019172.4. XP_003751012.1. XM_003750964.1.
UniGene	Rn.9789.
3D structure databases
ProteinModelPortal	O08726.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000012523.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	O08726.
Proteomic databases
PaxDb	O08726.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000012523; ENSRNOP00000012523; ENSRNOG00000009407. ENSRNOT00000075548; ENSRNOP00000067445; ENSRNOG00000050358.
GeneID	100910349. 29234.
KEGG	rno:100910349. rno:29234.
Organism-specific databases
CTD	8811.
RGD	2657. Galr2.
Phylogenomic databases
eggNOG	NOG320953.
GeneTree	ENSGT00620000087530.
HOGENOM	HOG000230487.
HOVERGEN	HBG101447.
InParanoid	O08726.
KO	K04231.
OMA	FRKICAG.
OrthoDB	EOG4K9BCJ.
Gene expression databases
Genevestigator	O08726.
GermOnline	ENSRNOG00000009407. Rattus norvegicus.
Family and domain databases
InterPro	IPR000405. Galanin_rcpt. IPR003907. Galnin_2_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01419. GALANIN2R. PR00663. GALANINR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	O08726.
ChEMBL	CHEMBL5577.
NextBio	608490.

Entry information

Entry name

GALR2_RAT

Accession

Primary (citable) accession number: O08726

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents