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Protein
Submitted name:

Insulin receptor substrate-3

Gene

Irs3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin receptor binding Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin receptor substrate-3Imported
Gene namesi
Name:Irs3Imported
Synonyms:IRS-3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi69317. Irs3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
  • plasma membrane Source: RGD
Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiO08724.

Expressioni

Gene expression databases

GenevisibleiO08724. RN.

Interactioni

GO - Molecular functioni

  • insulin receptor binding Source: RGD

Protein-protein interaction databases

IntActiO08724. 2 interactors.
MINTiMINT-2880583.
STRINGi10116.ENSRNOP00000001874.

Structurei

3D structure databases

ProteinModelPortaliO08724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 133PHInterPro annotationAdd BLAST102
Domaini159 – 274IRS-type PTBInterPro annotationAdd BLAST116

Phylogenomic databases

eggNOGiENOG410JAM1. Eukaryota.
ENOG4111ATJ. LUCA.
HOVERGENiHBG052760.
KOiK17445.
PhylomeDBiO08724.

Family and domain databases

CDDicd01204. PTB_IRS. 1 hit.
Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
PRINTSiPR00628. INSULINRSI.
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPAGTGPTV SSGGESTDVS LGPPFPWPCP PDVRLCGHLR KQKSQRRRFF
60 70 80 90 100
VLRADPPRLE CYESEKKFLA SGCRPPRPRR TVSLEGACTI SKRADARQRH
110 120 130 140 150
LIVIYTSDSS LGVAAASEAE QQTWYSALLE VRATAAAAAA TAMGFSPQEA
160 170 180 190 200
PESWIFAPFQ DVWPVTLRSK GLGRAPGLSS GSYRLCLGSG ALSLLRKPGS
210 220 230 240 250
KGSRDSRATP PPVLRLSLLS VRRCGHADSF FFLELGRSAP IGPGELWLQA
260 270 280 290 300
PDAVVAQSIH ETVLAAMKRL GSSAASGKAE APLGDSPKGA SAVPAPAPYE
310 320 330 340 350
IPALALAAQA RSPGERAKQD YVNPLERMGS APSYRGPDLG GDYIAMGMRN
360 370 380 390 400
DYVHMGGKAA EYMWMAPPGL PPPTPPRVDP RKEPEDCEST EYMPMNRFLP
410 420 430 440 450
GPLYYEFKAR EPEHGHSSAQ CSIRDRWRPM VAQPRSSQGS ELSGDYMYIP
460 470 480 490
DYPSARLGSL DSCLNYVDLD LVPPLEVPGA APGNSPHSYA SIKF
Length:494
Mass (Da):53,246
Last modified:July 1, 1997 - v1
Checksum:i0BE7229B93B8B80C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93880 mRNA. Translation: AAC53161.1.
RefSeqiNP_114463.1. NM_032074.1.
UniGeneiRn.9791.

Genome annotation databases

GeneIDi84021.
KEGGirno:84021.
UCSCiRGD:69317. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93880 mRNA. Translation: AAC53161.1.
RefSeqiNP_114463.1. NM_032074.1.
UniGeneiRn.9791.

3D structure databases

ProteinModelPortaliO08724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO08724. 2 interactors.
MINTiMINT-2880583.
STRINGi10116.ENSRNOP00000001874.

Proteomic databases

PaxDbiO08724.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84021.
KEGGirno:84021.
UCSCiRGD:69317. rat.

Organism-specific databases

CTDi16369.
RGDi69317. Irs3.

Phylogenomic databases

eggNOGiENOG410JAM1. Eukaryota.
ENOG4111ATJ. LUCA.
HOVERGENiHBG052760.
KOiK17445.
PhylomeDBiO08724.

Gene expression databases

GenevisibleiO08724. RN.

Family and domain databases

CDDicd01204. PTB_IRS. 1 hit.
Gene3Di2.30.29.30. 2 hits.
InterProiIPR002404. IRS_PTB.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PfamiPF02174. IRS. 1 hit.
[Graphical view]
PRINTSiPR00628. INSULINRSI.
SMARTiSM00233. PH. 1 hit.
SM00310. PTBI. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 2 hits.
PROSITEiPS51064. IRS_PTB. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO08724_RAT
AccessioniPrimary (citable) accession number: O08724
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: October 5, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.