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Protein
Submitted name:

Insulin receptor substrate-3

Gene

Irs3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • insulin receptor binding Source: RGD

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin receptor substrate-3Imported
Gene namesi
Name:Irs3Imported
Synonyms:IRS-3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi69317 Irs3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

GenevisibleiO08724 RN

Interactioni

GO - Molecular functioni

  • insulin receptor binding Source: RGD

Protein-protein interaction databases

IntActiO08724, 2 interactors
MINTiO08724

Structurei

3D structure databases

ProteinModelPortaliO08724
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 133PHInterPro annotationAdd BLAST102
Domaini159 – 274IRS-type PTBInterPro annotationAdd BLAST116

Phylogenomic databases

eggNOGiENOG410JAM1 Eukaryota
ENOG4111ATJ LUCA
HOVERGENiHBG052760
KOiK17445
PhylomeDBiO08724

Family and domain databases

CDDicd01204 PTB_IRS, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
PRINTSiPR00628 INSULINRSI
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

O08724-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPAGTGPTV SSGGESTDVS LGPPFPWPCP PDVRLCGHLR KQKSQRRRFF
60 70 80 90 100
VLRADPPRLE CYESEKKFLA SGCRPPRPRR TVSLEGACTI SKRADARQRH
110 120 130 140 150
LIVIYTSDSS LGVAAASEAE QQTWYSALLE VRATAAAAAA TAMGFSPQEA
160 170 180 190 200
PESWIFAPFQ DVWPVTLRSK GLGRAPGLSS GSYRLCLGSG ALSLLRKPGS
210 220 230 240 250
KGSRDSRATP PPVLRLSLLS VRRCGHADSF FFLELGRSAP IGPGELWLQA
260 270 280 290 300
PDAVVAQSIH ETVLAAMKRL GSSAASGKAE APLGDSPKGA SAVPAPAPYE
310 320 330 340 350
IPALALAAQA RSPGERAKQD YVNPLERMGS APSYRGPDLG GDYIAMGMRN
360 370 380 390 400
DYVHMGGKAA EYMWMAPPGL PPPTPPRVDP RKEPEDCEST EYMPMNRFLP
410 420 430 440 450
GPLYYEFKAR EPEHGHSSAQ CSIRDRWRPM VAQPRSSQGS ELSGDYMYIP
460 470 480 490
DYPSARLGSL DSCLNYVDLD LVPPLEVPGA APGNSPHSYA SIKF
Length:494
Mass (Da):53,246
Last modified:July 1, 1997 - v1
Checksum:i0BE7229B93B8B80C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93880 mRNA Translation: AAC53161.1
RefSeqiNP_114463.1, NM_032074.1
UniGeneiRn.9791

Genome annotation databases

GeneIDi84021
KEGGirno:84021
UCSCiRGD:69317 rat

Similar proteinsi

Entry informationi

Entry nameiO08724_RAT
AccessioniPrimary (citable) accession number: O08724
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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