O08717 (INHBE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inhibin beta E chain

Alternative name(s):
Activin beta-E chain

Gene names

Name:

Inhbe

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Subunit structure	Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only By similarity.
Subcellular location	Secreted By similarity.
Developmental stage	First expression in embryonic liver is detected at day E17.5.
Sequence similarities	Belongs to the TGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor Hormone
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW hormone activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Propeptide	22 – 236	215	Potential		PRO_0000033738
	Chain	237 – 350	114	Inhibin beta E chain		PRO_0000033739
Amino acid modifications
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	240 ↔ 248		By similarity
	Disulfide bond	247 ↔ 315		By similarity
	Disulfide bond	276 ↔ 347		By similarity
	Disulfide bond	280 ↔ 349		By similarity
	Disulfide bond	314		Interchain By similarity
Experimental info
	Sequence conflict	22	1	T → R in AAB53801. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O08717 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 9B7EA8AFFAC389FA	FASTA	350	39,002
	10 20 30 40 50 60 MKLPKAQLWL ILLWALVWVQ STRSACPSCG GPTLAPQGER ALVLELAKQQ ILEGLHLTSR 70 80 90 100 110 120 PRITRPLPQA ALTRALRRLQ PKSMVPGNRE KVISFATIID KSTSTYRSML TFQLSPLWSH 130 140 150 160 170 180 HLYHARLWLH VPPSFPGTLY LRIFRCGTTR CRGFRTFLAE HQTTSSGWHA LTLPSSGLRS 190 200 210 220 230 240 EDSGVVKLQL EFRPLDLNST AAGLPRLLLD TAGQQRPFLE LKIRANEPGA GRARRRTPTC 250 260 270 280 290 300 EPETPLCCRR DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS 310 320 330 340 350 LLKANNPWPA GSSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of the mouse activin beta E subunit gene." Fang J., Yin W., Smiley E., Wang S.Q., Bonadio J. Biochem. Biophys. Res. Commun. 228:669-674(1996) [PubMed: 8941337] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues." Fang J., Wang S.Q., Smiley E., Bonadio J. Biochem. Biophys. Res. Commun. 231:655-661(1997) [PubMed: 9070865] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U96386 mRNA. Translation: AAB53801.1. CH466578 Genomic DNA. Translation: EDL24502.1. BC010404 mRNA. Translation: AAH10404.1.
IPI	IPI00115510.
PIR	JC5241.
RefSeq	NP_032408.2. NM_008382.2.
UniGene	Mm.3510.
3D structure databases
HSSP	HSSP built from PDB template 1NYU based on UniProtKB P08476.
ProteinModelPortal	O08717.
SMR	O08717. Positions 238-350.
ModBase	Search...
Protein-protein interaction databases
STRING	O08717.
Proteomic databases
PRIDE	O08717.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000059718; ENSMUSP00000053977; ENSMUSG00000047492.
GeneID	16326.
KEGG	mmu:16326.
Organism-specific databases
CTD	83729.
MGI	MGI:109269. Inhbe.
Phylogenomic databases
eggNOG	roNOG14527.
GeneTree	ENSGT00560000076548.
HOGENOM	HBG446695.
HOVERGEN	HBG105613.
InParanoid	O08717.
OrthoDB	EOG47D9GF.
Gene expression databases
ArrayExpress	O08717.
Bgee	O08717.
CleanEx	MM_INHBE.
Genevestigator	O08717.
GermOnline	ENSMUSG00000047492. Mus musculus.
Family and domain databases
InterPro	IPR001318. Inhibin_betaC. IPR001839. TGF-b_C. IPR015615. TGF-beta-rel. IPR017948. TGFb_CS. [Graphical view]
KO	K04667.
PANTHER	PTHR11848. TGFbeta. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. [Graphical view]
PRINTS	PR00672. INHIBINBC.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	289402.
SOURCE	Search...

Entry information

Entry name

INHBE_MOUSE

Accession

Primary (citable) accession number: O08717
Secondary accession number(s): Q91XH3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program