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Protein

Inhibin beta E chain

Gene

Inhbe

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Keywords - Molecular functioni

Growth factor, Hormone

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibin beta E chain
Alternative name(s):
Activin beta-E chain
Gene namesi
Name:Inhbe
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109269. Inhbe.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Propeptidei22 – 236215Sequence analysisPRO_0000033738Add
BLAST
Chaini237 – 350114Inhibin beta E chainPRO_0000033739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence analysis
Disulfide bondi240 ↔ 248By similarity
Disulfide bondi247 ↔ 315By similarity
Disulfide bondi276 ↔ 347By similarity
Disulfide bondi280 ↔ 349By similarity
Disulfide bondi314 – 314InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiO08717.
PaxDbiO08717.
PRIDEiO08717.

Expressioni

Developmental stagei

First expression in embryonic liver is detected at day E17.5.

Gene expression databases

BgeeiO08717.
CleanExiMM_INHBE.
GenevisibleiO08717. MM.

Interactioni

Subunit structurei

Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053977.

Structurei

3D structure databases

ProteinModelPortaliO08717.
SMRiO08717. Positions 213-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiO08717.
KOiK04667.
OMAiGYQLNYC.
OrthoDBiEOG741Z2G.
TreeFamiTF318514.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08717-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPKAQLWL ILLWALVWVQ STRSACPSCG GPTLAPQGER ALVLELAKQQ
60 70 80 90 100
ILEGLHLTSR PRITRPLPQA ALTRALRRLQ PKSMVPGNRE KVISFATIID
110 120 130 140 150
KSTSTYRSML TFQLSPLWSH HLYHARLWLH VPPSFPGTLY LRIFRCGTTR
160 170 180 190 200
CRGFRTFLAE HQTTSSGWHA LTLPSSGLRS EDSGVVKLQL EFRPLDLNST
210 220 230 240 250
AAGLPRLLLD TAGQQRPFLE LKIRANEPGA GRARRRTPTC EPETPLCCRR
260 270 280 290 300
DHYVDFQELG WRDWILQPEG YQLNYCSGQC PPHLAGSPGI AASFHSAVFS
310 320 330 340 350
LLKANNPWPA GSSCCVPTAR RPLSLLYLDH NGNVVKTDVP DMVVEACGCS
Length:350
Mass (Da):39,002
Last modified:July 27, 2011 - v2
Checksum:i9B7EA8AFFAC389FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti22 – 221T → R in AAB53801 (PubMed:8941337).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96386 mRNA. Translation: AAB53801.1.
CH466578 Genomic DNA. Translation: EDL24502.1.
BC010404 mRNA. Translation: AAH10404.1.
CCDSiCCDS24239.1.
PIRiJC5241.
RefSeqiNP_032408.2. NM_008382.2.
UniGeneiMm.3510.

Genome annotation databases

EnsembliENSMUST00000059718; ENSMUSP00000053977; ENSMUSG00000047492.
GeneIDi16326.
KEGGimmu:16326.
UCSCiuc011xps.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96386 mRNA. Translation: AAB53801.1.
CH466578 Genomic DNA. Translation: EDL24502.1.
BC010404 mRNA. Translation: AAH10404.1.
CCDSiCCDS24239.1.
PIRiJC5241.
RefSeqiNP_032408.2. NM_008382.2.
UniGeneiMm.3510.

3D structure databases

ProteinModelPortaliO08717.
SMRiO08717. Positions 213-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053977.

Proteomic databases

MaxQBiO08717.
PaxDbiO08717.
PRIDEiO08717.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059718; ENSMUSP00000053977; ENSMUSG00000047492.
GeneIDi16326.
KEGGimmu:16326.
UCSCiuc011xps.1. mouse.

Organism-specific databases

CTDi83729.
MGIiMGI:109269. Inhbe.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000119112.
HOGENOMiHOG000220890.
HOVERGENiHBG105613.
InParanoidiO08717.
KOiK04667.
OMAiGYQLNYC.
OrthoDBiEOG741Z2G.
TreeFamiTF318514.

Enzyme and pathway databases

ReactomeiR-MMU-209822. Glycoprotein hormones.

Miscellaneous databases

NextBioi289402.
PROiO08717.
SOURCEiSearch...

Gene expression databases

BgeeiO08717.
CleanExiMM_INHBE.
GenevisibleiO08717. MM.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001318. Inhibin_betaC.
IPR001839. TGF-b_C.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
[Graphical view]
PRINTSiPR00672. INHIBINBC.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the mouse activin beta E subunit gene."
    Fang J., Yin W., Smiley E., Wang S.Q., Bonadio J.
    Biochem. Biophys. Res. Commun. 228:669-674(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Genes coding for mouse activin beta C and beta E are closely linked and exhibit a liver-specific expression pattern in adult tissues."
    Fang J., Wang S.Q., Smiley E., Bonadio J.
    Biochem. Biophys. Res. Commun. 231:655-661(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiINHBE_MOUSE
AccessioniPrimary (citable) accession number: O08717
Secondary accession number(s): Q91XH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.