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Protein

Tumor necrosis factor receptor superfamily member 11B

Gene

Tnfrsf11b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei400Involved in dimerizationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11B
Alternative name(s):
Osteoclastogenesis inhibitory factor
Osteoprotegerin
Gene namesi
Name:Tnfrsf11b
Synonyms:Ocif, Opg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:109587 Tnfrsf11b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000003458822 – 401Tumor necrosis factor receptor superfamily member 11BAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 54PROSITE-ProRule annotation1 Publication
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation1 Publication
Disulfide bondi65 ↔ 80PROSITE-ProRule annotation1 Publication
Disulfide bondi83 ↔ 97PROSITE-ProRule annotation1 Publication
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation1 Publication
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation1 Publication
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation1 Publication
Disulfide bondi145 ↔ 160PROSITE-ProRule annotation1 Publication
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO08712
PRIDEiO08712

PTM databases

PhosphoSitePlusiO08712

Expressioni

Tissue specificityi

Highly expressed in liver, lung, stomach, intestines and calvaria. Highly expressed in decidua and placenta, and in embryo.

Developmental stagei

Detected in embryo at high levels on day 7, whereas expression decreases at day 11 and increases from day 15 to 17. On day 15 found in developing bone primordia, brachiocephalic artery and ductus arteriosus, left main bronchus, abdominal aorta and midgut.

Inductioni

Up-regulated by TGF-beta and estrogens. Down-regulated by 1,25-dihdroxyvitamin D3 and parathyroid hormone.

Gene expression databases

BgeeiENSMUSG00000063727
ExpressionAtlasiO08712 baseline and differential
GenevisibleiO08712 MM

Interactioni

Subunit structurei

Homodimer. Interacts with TNFSF10 and TNFSF11.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Tnfsf11O35235-14EBI-16015871,EBI-15890886

Protein-protein interaction databases

DIPiDIP-59980N
IntActiO08712, 1 interactor
STRINGi10090.ENSMUSP00000078705

Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 37Combined sources3
Beta strandi48 – 52Combined sources5
Beta strandi56 – 58Combined sources3
Beta strandi61 – 64Combined sources4
Beta strandi91 – 95Combined sources5
Beta strandi99 – 101Combined sources3
Beta strandi104 – 107Combined sources4
Beta strandi111 – 114Combined sources4
Beta strandi117 – 120Combined sources4
Beta strandi128 – 132Combined sources5
Beta strandi141 – 144Combined sources4
Beta strandi155 – 157Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E4DX-ray2.70R22-197[»]
ProteinModelPortaliO08712
SMRiO08712
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 62TNFR-Cys 1Add BLAST39
Repeati65 – 105TNFR-Cys 2Add BLAST41
Repeati107 – 142TNFR-Cys 3Add BLAST36
Repeati145 – 185TNFR-Cys 4Add BLAST41
Domaini198 – 269Death 1PROSITE-ProRule annotationAdd BLAST72
Domaini283 – 365Death 2PROSITE-ProRule annotationAdd BLAST83

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFEM Eukaryota
ENOG4111PUQ LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000273896
HOVERGENiHBG061495
InParanoidiO08712
KOiK05148
OMAiSRQLMCD
OrthoDBiEOG091G03XW
PhylomeDBiO08712
TreeFamiTF331157

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR017371 TNFR_11B
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PIRSFiPIRSF038065 TNFR_11B, 1 hit
PRINTSiPR01961 TNFACTORR11
PR01975 TNFACTORR11B
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKWLCCALL VLLDIIEWTT QETLPPKYLH YDPETGHQLL CDKCAPGTYL
60 70 80 90 100
KQHCTVRRKT LCVPCPDHSY TDSWHTSDEC VYCSPVCKEL QSVKQECNRT
110 120 130 140 150
HNRVCECEEG RYLEIEFCLK HRSCPPGSGV VQAGTPERNT VCKKCPDGFF
160 170 180 190 200
SGETSSKAPC IKHTNCSTFG LLLIQKGNAT HDNVCSGNRE ATQKCGIDVT
210 220 230 240 250
LCEEAFFRFA VPTKIIPNWL SVLVDSLPGT KVNAESVERI KRRHSSQEQT
260 270 280 290 300
FQLLKLWKHQ NRDQEMVKKI IQDIDLCESS VQRHLGHSNL TTEQLLALME
310 320 330 340 350
SLPGKKISPE EIERTRKTCK SSEQLLKLLS LWRIKNGDQD TLKGLMYALK
360 370 380 390 400
HLKTSHFPKT VTHSLRKTMR FLHSFTMYRL YQKLFLEMIG NQVQSVKISC

L
Length:401
Mass (Da):45,923
Last modified:July 1, 1997 - v1
Checksum:iCAA6102D3B312470
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti138R → P in strain: 129/Ola and NIH Swiss. 1 Publication1
Natural varianti161I → R in strain: 129/Ola and NIH Swiss. 1 Publication1
Natural varianti165N → D in strain: 129/Ola and NIH Swiss. 1 Publication1
Natural varianti288S → A in strain: 129/Ola and NIH Swiss. 1 Publication1
Natural varianti296L → R in strain: 129/Ola and NIH Swiss. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94331 mRNA Translation: AAB53708.1
AB013898 mRNA Translation: BAA28269.1
AB013903 Genomic DNA Translation: BAA33388.1
CCDSiCCDS27468.1
RefSeqiNP_032790.3, NM_008764.3
UniGeneiMm.15383

Genome annotation databases

EnsembliENSMUST00000079772; ENSMUSP00000078705; ENSMUSG00000063727
GeneIDi18383
KEGGimmu:18383
UCSCiuc007vrk.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTR11B_MOUSE
AccessioniPrimary (citable) accession number: O08712
Secondary accession number(s): O70202
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health