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O08707 (CCBP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chemokine-binding protein 2
Alternative name(s):
C-C chemokine receptor D6
Chemokine-binding protein D6
Gene names
Name:Ccbp2
Synonyms:D6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for C-C type chemokines including SCY3/MIP1-alpha and SCYA4/MIP-1-beta.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Chemokine-binding protein 2
PRO_0000069220

Regions

Topological domain1 – 4949Extracellular Potential
Transmembrane50 – 7021Helical; Name=1; Potential
Topological domain71 – 9121Cytoplasmic Potential
Transmembrane92 – 11221Helical; Name=2; Potential
Topological domain113 – 1175Extracellular Potential
Transmembrane118 – 13922Helical; Name=3; Potential
Topological domain140 – 16122Cytoplasmic Potential
Transmembrane162 – 18221Helical; Name=4; Potential
Topological domain183 – 21634Extracellular Potential
Transmembrane217 – 23721Helical; Name=5; Potential
Topological domain238 – 24912Cytoplasmic Potential
Transmembrane250 – 27021Helical; Name=6; Potential
Topological domain271 – 29222Extracellular Potential
Transmembrane293 – 31321Helical; Name=7; Potential
Topological domain314 – 37865Cytoplasmic Potential

Amino acid modifications

Glycosylation171N-linked (GlcNAc...) Potential
Disulfide bond116 ↔ 194 By similarity

Experimental info

Sequence conflict2661N → Y in CAA73379. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O08707 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 1436D49E71698172

FASTA37843,207
        10         20         30         40         50         60 
MPTVASPLPL TTVGSENSSS IYDYDYLDDM TILVCRKDEV LSFGRVFLPV VYSLIFVLGL 

        70         80         90        100        110        120 
AGNLLLLVVL LHSAPRRRTM ELYLLNLAVS NLLFVVTMPF WAISVAWHWV FGSFLCKVIS 

       130        140        150        160        170        180 
TLYSINFYCG IFFITCMSLD KYLEIVHAQP LHRPKAQFRN LLLIVMVWIT SLAISVPEMV 

       190        200        210        220        230        240 
FVQIHQTLDG VWHCYADFGG HATIWKLYLR FQLNLLGFLL PLLAMIFFYS RIGCVLVRLR 

       250        260        270        280        290        300 
PPGQGRALRM AAALVIVFFM LWFPYNLTLF LHSLLDLHVF GNCEISHRLD YTLQVTESLA 

       310        320        330        340        350        360 
FSHCCFTPVL YAFCSHRFRR YLKAFLSVML RWHQAPGTPS SNHSESSRVT AQEDVVSMND 

       370 
LGERQSEDSL NKGEMGNT

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel murine beta chemokine receptor, D6. Comparison to three other related macrophage inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5."
Nibbs R.J., Wylie S.M., Pragnell I.B., Graham G.J.
J. Biol. Chem. 272:12495-12504(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C3H.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J and NOD.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y12879 mRNA. Translation: CAA73379.1.
AK028281 mRNA. Translation: BAC25855.1.
AK145960 mRNA. Translation: BAE26786.1.
AK147166 mRNA. Translation: BAE27731.1.
AK157140 mRNA. Translation: BAE33976.1.
CH466587 Genomic DNA. Translation: EDL09123.1.
BC113146 mRNA. Translation: AAI13147.1.
IPIIPI00318618.
RefSeqNP_001263648.1. NM_001276719.1.
NP_067622.2. NM_021609.4.
UniGeneMm.258105.

3D structure databases

ProteinModelPortalO08707.
SMRO08707. Positions 39-319.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteO08707.

Proteomic databases

PRIDEO08707.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050327; ENSMUSP00000050119; ENSMUSG00000044534.
GeneID59289.
KEGGmmu:59289.

Organism-specific databases

CTD1238.
MGIMGI:1891697. Ccbp2.

Phylogenomic databases

eggNOGNOG297330.
GeneTreeENSGT00640000091250.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ8CEG1.
KOK04187.
OMAHWVFGSF.
OrthoDBEOG4KWJT9.

Gene expression databases

ArrayExpressO08707.
BgeeO08707.
CleanExMM_CCBP2.
GenevestigatorO08707.
GermOnlineENSMUSG00000044534. Mus musculus.

Family and domain databases

InterProIPR001277. Chemokine_CXCR4.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR00645. CXCCHMKINER4.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio314792.
SOURCESearch...

Entry information

Entry nameCCBP2_MOUSE
AccessionPrimary (citable) accession number: O08707
Secondary accession number(s): Q8CEG1
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 27, 2011
Last modified: May 1, 2013
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents