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O08705

- NTCP_MOUSE

UniProt

O08705 - NTCP_MOUSE

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Protein

Sodium/bile acid cotransporter

Gene
Slc10a1, Ntcp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene namesi
Name:Slc10a1
Synonyms:Ntcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:97379. Slc10a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4522Helical; Reviewed predictionAdd
BLAST
Transmembranei60 – 8021Helical; Reviewed predictionAdd
BLAST
Transmembranei82 – 9817Helical; Reviewed predictionAdd
BLAST
Transmembranei158 – 17821Helical; Reviewed predictionAdd
BLAST
Transmembranei190 – 21122Helical; Reviewed predictionAdd
BLAST
Transmembranei228 – 24417Helical; Reviewed predictionAdd
BLAST
Transmembranei285 – 30622Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Sodium/bile acid cotransporterPRO_0000052336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi11 – 111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi103 – 1031N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi271 – 2711N-linked (GlcNAc...) Reviewed prediction
Modified residuei330 – 3301Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO08705.
PaxDbiO08705.
PRIDEiO08705.

PTM databases

PhosphoSiteiO08705.

Expressioni

Gene expression databases

BgeeiO08705.
GenevestigatoriO08705.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093229.

Structurei

3D structure databases

ProteinModelPortaliO08705.
SMRiO08705. Positions 23-306.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiO08705.
KOiK14341.
OMAiVGKSIMF.
OrthoDBiEOG7XWPNW.
PhylomeDBiO08705.
TreeFamiTF315811.

Family and domain databases

InterProiIPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

O08705-1 [UniParc]FASTAAdd to Basket

« Hide

MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK    50
IKAHFWKPKG VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP 100
GGNLSNLFTL AMKGDMNLSI VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL 150
KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR PHYVPYVLKA GMIITFSLSV 200
AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL SALFRLNPSC 250
RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF 300
IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL 350
SPNGLNSGQM AN 362
Length:362
Mass (Da):39,413
Last modified:July 1, 1997 - v1
Checksum:i7A70493E1804280F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003303 mRNA. Translation: BAA19846.1.
U95131 mRNA. Translation: AAB81023.1.
BC021154 mRNA. Translation: AAH21154.1.
BC094023 mRNA. Translation: AAH94023.1.
CCDSiCCDS49101.1.
RefSeqiNP_001171032.1. NM_001177561.1.
XP_006515696.1. XM_006515633.1.
UniGeneiMm.486361.

Genome annotation databases

EnsembliENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135.
GeneIDi20493.
KEGGimmu:20493.
UCSCiuc007obr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB003303 mRNA. Translation: BAA19846.1 .
U95131 mRNA. Translation: AAB81023.1 .
BC021154 mRNA. Translation: AAH21154.1 .
BC094023 mRNA. Translation: AAH94023.1 .
CCDSi CCDS49101.1.
RefSeqi NP_001171032.1. NM_001177561.1.
XP_006515696.1. XM_006515633.1.
UniGenei Mm.486361.

3D structure databases

ProteinModelPortali O08705.
SMRi O08705. Positions 23-306.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000093229.

Chemistry

ChEMBLi CHEMBL2073713.

PTM databases

PhosphoSitei O08705.

Proteomic databases

MaxQBi O08705.
PaxDbi O08705.
PRIDEi O08705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000095572 ; ENSMUSP00000093229 ; ENSMUSG00000021135 .
GeneIDi 20493.
KEGGi mmu:20493.
UCSCi uc007obr.2. mouse.

Organism-specific databases

CTDi 6554.
MGIi MGI:97379. Slc10a1.

Phylogenomic databases

eggNOGi COG0385.
GeneTreei ENSGT00550000074505.
HOGENOMi HOG000234524.
HOVERGENi HBG101123.
InParanoidi O08705.
KOi K14341.
OMAi VGKSIMF.
OrthoDBi EOG7XWPNW.
PhylomeDBi O08705.
TreeFami TF315811.

Miscellaneous databases

ChiTaRSi SLC10A1. mouse.
NextBioi 298637.
PROi O08705.
SOURCEi Search...

Gene expression databases

Bgeei O08705.
Genevestigatori O08705.

Family and domain databases

InterProi IPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view ]
PANTHERi PTHR10361. PTHR10361. 1 hit.
Pfami PF01758. SBF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00841. bass. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Saeki T.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. Hagenbuch B.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNTCP_MOUSE
AccessioniPrimary (citable) accession number: O08705
Secondary accession number(s): Q52L86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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