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O08705

- NTCP_MOUSE

UniProt

O08705 - NTCP_MOUSE

Protein

Sodium/bile acid cotransporter

Gene

Slc10a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

    GO - Molecular functioni

    1. bile acid:sodium symporter activity Source: InterPro

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/bile acid cotransporter
    Alternative name(s):
    Na(+)/bile acid cotransporter
    Na(+)/taurocholate transport protein
    Sodium/taurocholate cotransporting polypeptide
    Solute carrier family 10 member 1
    Gene namesi
    Name:Slc10a1
    Synonyms:Ntcp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:97379. Slc10a1.

    Subcellular locationi

    GO - Cellular componenti

    1. basolateral plasma membrane Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Sodium/bile acid cotransporterPRO_0000052336Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
    Modified residuei330 – 3301Phosphothreonine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiO08705.
    PaxDbiO08705.
    PRIDEiO08705.

    PTM databases

    PhosphoSiteiO08705.

    Expressioni

    Gene expression databases

    BgeeiO08705.
    GenevestigatoriO08705.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000093229.

    Structurei

    3D structure databases

    ProteinModelPortaliO08705.
    SMRiO08705. Positions 23-306.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4522HelicalSequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 9817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei190 – 21122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei228 – 24417HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30622HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    GeneTreeiENSGT00550000074505.
    HOGENOMiHOG000234524.
    HOVERGENiHBG101123.
    InParanoidiO08705.
    KOiK14341.
    OMAiVGKSIMF.
    OrthoDBiEOG7XWPNW.
    PhylomeDBiO08705.
    TreeFamiTF315811.

    Family and domain databases

    InterProiIPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view]
    PANTHERiPTHR10361. PTHR10361. 1 hit.
    PfamiPF01758. SBF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00841. bass. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O08705-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK    50
    IKAHFWKPKG VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP 100
    GGNLSNLFTL AMKGDMNLSI VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL 150
    KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR PHYVPYVLKA GMIITFSLSV 200
    AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL SALFRLNPSC 250
    RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF 300
    IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL 350
    SPNGLNSGQM AN 362
    Length:362
    Mass (Da):39,413
    Last modified:July 1, 1997 - v1
    Checksum:i7A70493E1804280F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003303 mRNA. Translation: BAA19846.1.
    U95131 mRNA. Translation: AAB81023.1.
    BC021154 mRNA. Translation: AAH21154.1.
    BC094023 mRNA. Translation: AAH94023.1.
    CCDSiCCDS49101.1.
    RefSeqiNP_001171032.1. NM_001177561.1.
    XP_006515696.1. XM_006515633.1.
    UniGeneiMm.486361.

    Genome annotation databases

    EnsembliENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135.
    GeneIDi20493.
    KEGGimmu:20493.
    UCSCiuc007obr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB003303 mRNA. Translation: BAA19846.1 .
    U95131 mRNA. Translation: AAB81023.1 .
    BC021154 mRNA. Translation: AAH21154.1 .
    BC094023 mRNA. Translation: AAH94023.1 .
    CCDSi CCDS49101.1.
    RefSeqi NP_001171032.1. NM_001177561.1.
    XP_006515696.1. XM_006515633.1.
    UniGenei Mm.486361.

    3D structure databases

    ProteinModelPortali O08705.
    SMRi O08705. Positions 23-306.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000093229.

    Chemistry

    ChEMBLi CHEMBL2073713.

    PTM databases

    PhosphoSitei O08705.

    Proteomic databases

    MaxQBi O08705.
    PaxDbi O08705.
    PRIDEi O08705.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095572 ; ENSMUSP00000093229 ; ENSMUSG00000021135 .
    GeneIDi 20493.
    KEGGi mmu:20493.
    UCSCi uc007obr.2. mouse.

    Organism-specific databases

    CTDi 6554.
    MGIi MGI:97379. Slc10a1.

    Phylogenomic databases

    eggNOGi COG0385.
    GeneTreei ENSGT00550000074505.
    HOGENOMi HOG000234524.
    HOVERGENi HBG101123.
    InParanoidi O08705.
    KOi K14341.
    OMAi VGKSIMF.
    OrthoDBi EOG7XWPNW.
    PhylomeDBi O08705.
    TreeFami TF315811.

    Miscellaneous databases

    ChiTaRSi SLC10A1. mouse.
    NextBioi 298637.
    PROi O08705.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08705.
    Genevestigatori O08705.

    Family and domain databases

    InterProi IPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view ]
    PANTHERi PTHR10361. PTHR10361. 1 hit.
    Pfami PF01758. SBF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00841. bass. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Saeki T.
      Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Liver.
    2. Hagenbuch B.
      Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiNTCP_MOUSE
    AccessioniPrimary (citable) accession number: O08705
    Secondary accession number(s): Q52L86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3