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Protein

Sodium/bile acid cotransporter

Gene

Slc10a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: GO_Central

GO - Biological processi

  1. bile acid and bile salt transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_300927. Recycling of bile acids and salts.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene namesi
Name:Slc10a1
Synonyms:Ntcp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:97379. Slc10a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4522HelicalSequence AnalysisAdd
BLAST
Transmembranei60 – 8021HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 9817HelicalSequence AnalysisAdd
BLAST
Transmembranei158 – 17821HelicalSequence AnalysisAdd
BLAST
Transmembranei190 – 21122HelicalSequence AnalysisAdd
BLAST
Transmembranei228 – 24417HelicalSequence AnalysisAdd
BLAST
Transmembranei285 – 30622HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: Ensembl
  2. integral component of plasma membrane Source: GO_Central
  3. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Sodium/bile acid cotransporterPRO_0000052336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi271 – 2711N-linked (GlcNAc...)Sequence Analysis
Modified residuei330 – 3301Phosphothreonine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiO08705.
PaxDbiO08705.
PRIDEiO08705.

PTM databases

PhosphoSiteiO08705.

Expressioni

Gene expression databases

BgeeiO08705.
GenevestigatoriO08705.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093229.

Structurei

3D structure databases

ProteinModelPortaliO08705.
SMRiO08705. Positions 34-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiO08705.
KOiK14341.
OMAiVGKSIMF.
OrthoDBiEOG7XWPNW.
PhylomeDBiO08705.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF18. PTHR10361:SF18. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

O08705-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK
60 70 80 90 100
IKAHFWKPKG VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP
110 120 130 140 150
GGNLSNLFTL AMKGDMNLSI VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL
160 170 180 190 200
KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR PHYVPYVLKA GMIITFSLSV
210 220 230 240 250
AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL SALFRLNPSC
260 270 280 290 300
RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF
310 320 330 340 350
IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL
360
SPNGLNSGQM AN
Length:362
Mass (Da):39,413
Last modified:July 1, 1997 - v1
Checksum:i7A70493E1804280F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003303 mRNA. Translation: BAA19846.1.
U95131 mRNA. Translation: AAB81023.1.
BC021154 mRNA. Translation: AAH21154.1.
BC094023 mRNA. Translation: AAH94023.1.
CCDSiCCDS49101.1.
RefSeqiNP_001171032.1. NM_001177561.1.
XP_006515696.1. XM_006515633.2.
UniGeneiMm.486361.

Genome annotation databases

EnsembliENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135.
GeneIDi20493.
KEGGimmu:20493.
UCSCiuc007obr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003303 mRNA. Translation: BAA19846.1.
U95131 mRNA. Translation: AAB81023.1.
BC021154 mRNA. Translation: AAH21154.1.
BC094023 mRNA. Translation: AAH94023.1.
CCDSiCCDS49101.1.
RefSeqiNP_001171032.1. NM_001177561.1.
XP_006515696.1. XM_006515633.2.
UniGeneiMm.486361.

3D structure databases

ProteinModelPortaliO08705.
SMRiO08705. Positions 34-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093229.

Chemistry

ChEMBLiCHEMBL2073713.

PTM databases

PhosphoSiteiO08705.

Proteomic databases

MaxQBiO08705.
PaxDbiO08705.
PRIDEiO08705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135.
GeneIDi20493.
KEGGimmu:20493.
UCSCiuc007obr.2. mouse.

Organism-specific databases

CTDi6554.
MGIiMGI:97379. Slc10a1.

Phylogenomic databases

eggNOGiCOG0385.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG101123.
InParanoidiO08705.
KOiK14341.
OMAiVGKSIMF.
OrthoDBiEOG7XWPNW.
PhylomeDBiO08705.
TreeFamiTF315811.

Enzyme and pathway databases

ReactomeiREACT_300927. Recycling of bile acids and salts.

Miscellaneous databases

ChiTaRSiSlc10a1. mouse.
NextBioi298637.
PROiO08705.
SOURCEiSearch...

Gene expression databases

BgeeiO08705.
GenevestigatoriO08705.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030208. SLC10A1.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF18. PTHR10361:SF18. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Saeki T.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Liver.
  2. Hagenbuch B.
    Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNTCP_MOUSE
AccessioniPrimary (citable) accession number: O08705
Secondary accession number(s): Q52L86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 1, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.