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O08705 (NTCP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/bile acid cotransporter
Alternative name(s):
Na(+)/bile acid cotransporter
Na(+)/taurocholate transport protein
Sodium/taurocholate cotransporting polypeptide
Solute carrier family 10 member 1
Gene names
Name:Slc10a1
Synonyms:Ntcp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Sodium/bile acid cotransporter
PRO_0000052336

Regions

Transmembrane24 – 4522Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane82 – 9817Helical; Potential
Transmembrane158 – 17821Helical; Potential
Transmembrane190 – 21122Helical; Potential
Transmembrane228 – 24417Helical; Potential
Transmembrane285 – 30622Helical; Potential

Amino acid modifications

Modified residue3301Phosphothreonine Ref.4
Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation2711N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O08705 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 7A70493E1804280F

FASTA36239,413
        10         20         30         40         50         60 
MEAHNVSAPF NFSLPPGFGH RATDTALSVI LVVMLLLIML SLGCTMEFSK IKAHFWKPKG 

        70         80         90        100        110        120 
VIIAIVAQYG IMPLSAFLLG KVFHLTSIEA LAILICGCSP GGNLSNLFTL AMKGDMNLSI 

       130        140        150        160        170        180 
VMTTCSSFTA LGMMPLLLYI YSKGIYDGDL KDKVPYKGIM LSLVMVLIPC AIGIFLKSKR 

       190        200        210        220        230        240 
PHYVPYVLKA GMIITFSLSV AVTVLSVINV GNSIMFVMTP HLLATSSLMP FTGFLMGYIL 

       250        260        270        280        290        300 
SALFRLNPSC RRTISMETGF QNVQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLF 

       310        320        330        340        350        360 
IIIFRCYLKI KPQKDQTKIT YKAAATEDAT PAALEKGTHN GNNPPTQPGL SPNGLNSGQM 


AN 

« Hide

References

« Hide 'large scale' references
[1]Saeki T.
Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Liver.
[2]Hagenbuch B.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-330, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB003303 mRNA. Translation: BAA19846.1.
U95131 mRNA. Translation: AAB81023.1.
BC021154 mRNA. Translation: AAH21154.1.
BC094023 mRNA. Translation: AAH94023.1.
RefSeqNP_001171032.1. NM_001177561.1.
XP_006515696.1. XM_006515633.1.
UniGeneMm.486361.

3D structure databases

ProteinModelPortalO08705.
SMRO08705. Positions 22-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000093229.

Chemistry

ChEMBLCHEMBL2073713.

PTM databases

PhosphoSiteO08705.

Proteomic databases

PaxDbO08705.
PRIDEO08705.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095572; ENSMUSP00000093229; ENSMUSG00000021135.
GeneID20493.
KEGGmmu:20493.
UCSCuc007obr.2. mouse.

Organism-specific databases

CTD6554.
MGIMGI:97379. Slc10a1.

Phylogenomic databases

eggNOGCOG0385.
GeneTreeENSGT00550000074505.
HOGENOMHOG000234524.
HOVERGENHBG101123.
InParanoidO08705.
KOK14341.
OMALANIMPL.
OrthoDBEOG7XWPNW.
PhylomeDBO08705.
TreeFamTF315811.

Gene expression databases

BgeeO08705.
GenevestigatorO08705.

Family and domain databases

InterProIPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERPTHR10361. PTHR10361. 1 hit.
PfamPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00841. bass. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC10A1. mouse.
NextBio298637.
PROO08705.
SOURCESearch...

Entry information

Entry nameNTCP_MOUSE
AccessionPrimary (citable) accession number: O08705
Secondary accession number(s): Q52L86
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot