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Protein
Submitted name:

Calpain Lp82

Gene

Capn3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei109PROSITE-ProRule annotation1
Active sitei266PROSITE-ProRule annotation1
Active sitei290PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi593 – 604PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi623 – 634PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-RNO-1474228 Degradation of the extracellular matrix

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain Lp82Imported
Submitted name:
Calpain-3Imported
Gene namesi
Name:Capn3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2269 Capn3

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSRNOG00000008609

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 349Calpain catalyticInterPro annotationAdd BLAST300
Domaini537 – 571EF-handInterPro annotationAdd BLAST35
Domaini580 – 606EF-handInterPro annotationAdd BLAST27
Domaini610 – 645EF-handInterPro annotationAdd BLAST36
Domaini675 – 709EF-handInterPro annotationAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili558 – 578Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000118971
HOVERGENiHBG012645

Family and domain databases

CDDicd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR029531 CAPN3
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF329 PTHR10183:SF329, 3 hits
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF13202 EF-hand_5, 1 hit
PF13833 EF-hand_8, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SM00054 EFh, 3 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49758 SSF49758, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

O08702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLLPGFFC DRVIRERDRR NGEGTVSQPL KFEGQDFVVL KQRCLAQKCL
60 70 80 90 100
FEDRVFPAGT QALGSHELSQ KAKMKAITWK RPKEICENPR FIIGGANRTD
110 120 130 140 150
ICQGDLGDCW FLAAIACLTL NERLLFRVIP HDQSFTENYA GIFHFQFWRY
160 170 180 190 200
GDWVDVVIDD CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK
210 220 230 240 250
GGNTTEAMED FTGGVTEFFE IKDAPSDMYK IMRKAIERGS LMGCSIDTIV
260 270 280 290 300
PVQYETRMAC GLVKGHAYSV TGLEEALFKG EKVKLVRLRN PWGQVEWNGS
310 320 330 340 350
WSDGWKDWSF VDKDEKARLQ HQVTEDGEFW MSYDDFVYHF TKLEICNLTA
360 370 380 390 400
DALESDKLQT WTVSVNEGRW VRGCSAGGCR NFPDTFWTNP QYRLKLLEED
410 420 430 440 450
DDPDDSEVIC SFLVALMQKN RRKDRKLGAN LFTIGFAIYE VPKEMHGNKQ
460 470 480 490 500
HLQKDFFLYN ASKARSKTYI NMREVSQRFR LPPSEYVIVP STYEPHQEGE
510 520 530 540 550
FILRVFSEKR NLSEEAENTI SVDRPVPRPG HTDQESEEQQ QFRNIFRQIA
560 570 580 590 600
GDDMEICADE LKNVLNTVVN KHKDLKTQGF TLESCRSMIA LMDTDGSGRL
610 620 630 640 650
NLQEFHHLWK KIKAWQKIFK HYDTDHSGTI NSYEMRNAVN DAGFHLNSQL
660 670 680 690 700
YDIITMRYAD KHMNIDFDSF ICCFVRLEGM FRAFHAFDKD GDGIIKLNVL

EWLQLTMYA
Length:709
Mass (Da):82,259
Last modified:January 1, 1998 - v2
Checksum:iDE267BA46F27058C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053513 Genomic DNA No translation available.
U96367 mRNA Translation: AAC04848.1
UniGeneiRn.9726

Genome annotation databases

EnsembliENSRNOT00000080533; ENSRNOP00000071494; ENSRNOG00000008609

Similar proteinsi

Entry informationi

Entry nameiO08702_RAT
AccessioniPrimary (citable) accession number: O08702
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported