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Protein
Submitted name:

Calpain Lp82

Gene

Capn3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain Lp82Imported
Submitted name:
Calpain-3Imported
Gene namesi
Name:Capn3Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2269. Capn3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiO08702. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliO08702.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 349Calpain catalyticInterPro annotationAdd BLAST300
Domaini537 – 571EF-handInterPro annotationAdd BLAST35
Domaini580 – 606EF-handInterPro annotationAdd BLAST27
Domaini610 – 645EF-handInterPro annotationAdd BLAST36
Domaini675 – 709EF-handInterPro annotationAdd BLAST35

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118971.
HOVERGENiHBG012645.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029531. CAPN3.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF320. PTHR10183:SF320. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYLLPGFFC DRVIRERDRR NGEGTVSQPL KFEGQDFVVL KQRCLAQKCL
60 70 80 90 100
FEDRVFPAGT QALGSHELSQ KAKMKAITWK RPKEICENPR FIIGGANRTD
110 120 130 140 150
ICQGDLGDCW FLAAIACLTL NERLLFRVIP HDQSFTENYA GIFHFQFWRY
160 170 180 190 200
GDWVDVVIDD CLPTYNNQLV FTKSNHRNEF WSALLEKAYA KLHGSYEALK
210 220 230 240 250
GGNTTEAMED FTGGVTEFFE IKDAPSDMYK IMRKAIERGS LMGCSIDTIV
260 270 280 290 300
PVQYETRMAC GLVKGHAYSV TGLEEALFKG EKVKLVRLRN PWGQVEWNGS
310 320 330 340 350
WSDGWKDWSF VDKDEKARLQ HQVTEDGEFW MSYDDFVYHF TKLEICNLTA
360 370 380 390 400
DALESDKLQT WTVSVNEGRW VRGCSAGGCR NFPDTFWTNP QYRLKLLEED
410 420 430 440 450
DDPDDSEVIC SFLVALMQKN RRKDRKLGAN LFTIGFAIYE VPKEMHGNKQ
460 470 480 490 500
HLQKDFFLYN ASKARSKTYI NMREVSQRFR LPPSEYVIVP STYEPHQEGE
510 520 530 540 550
FILRVFSEKR NLSEEAENTI SVDRPVPRPG HTDQESEEQQ QFRNIFRQIA
560 570 580 590 600
GDDMEICADE LKNVLNTVVN KHKDLKTQGF TLESCRSMIA LMDTDGSGRL
610 620 630 640 650
NLQEFHHLWK KIKAWQKIFK HYDTDHSGTI NSYEMRNAVN DAGFHLNSQL
660 670 680 690 700
YDIITMRYAD KHMNIDFDSF ICCFVRLEGM FRAFHAFDKD GDGIIKLNVL

EWLQLTMYA
Length:709
Mass (Da):82,259
Last modified:January 1, 1998 - v2
Checksum:iDE267BA46F27058C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053513 Genomic DNA. No translation available.
U96367 mRNA. Translation: AAC04848.1.
UniGeneiRn.9726.

Genome annotation databases

EnsembliENSRNOT00000080533; ENSRNOP00000071494; ENSRNOG00000008609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07053513 Genomic DNA. No translation available.
U96367 mRNA. Translation: AAC04848.1.
UniGeneiRn.9726.

3D structure databases

ProteinModelPortaliO08702.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080533; ENSRNOP00000071494; ENSRNOG00000008609.

Organism-specific databases

RGDi2269. Capn3.

Phylogenomic databases

GeneTreeiENSGT00760000118971.
HOVERGENiHBG012645.

Gene expression databases

ExpressionAtlasiO08702. baseline and differential.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
cd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029531. CAPN3.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF320. PTHR10183:SF320. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF13202. EF-hand_5. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 4 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO08702_RAT
AccessioniPrimary (citable) accession number: O08702
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.