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O08701

- ARGI2_RAT

UniProt

O08701 - ARGI2_RAT

Protein

Arginase-2, mitochondrial

Gene

Arg2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.By similarity

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.

    Cofactori

    Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Manganese 1PROSITE-ProRule annotation
    Metal bindingi143 – 1431Manganese 1PROSITE-ProRule annotation
    Metal bindingi143 – 1431Manganese 2PROSITE-ProRule annotation
    Metal bindingi145 – 1451Manganese 2PROSITE-ProRule annotation
    Metal bindingi147 – 1471Manganese 1PROSITE-ProRule annotation
    Binding sitei202 – 2021SubstrateBy similarity
    Metal bindingi251 – 2511Manganese 1PROSITE-ProRule annotation
    Metal bindingi251 – 2511Manganese 2PROSITE-ProRule annotation
    Metal bindingi253 – 2531Manganese 2PROSITE-ProRule annotation
    Binding sitei296 – 2961SubstrateBy similarity

    GO - Molecular functioni

    1. arginase activity Source: MGI
    2. metal ion binding Source: UniProtKB-KW
    3. nitric-oxide synthase binding Source: RGD
    4. protein binding Source: RGD

    GO - Biological processi

    1. apoptotic process Source: RGD
    2. arginine catabolic process to ornithine Source: RGD
    3. arginine metabolic process Source: RGD
    4. cellular response to dexamethasone stimulus Source: RGD
    5. cellular response to interferon-gamma Source: RGD
    6. cellular response to interleukin-4 Source: RGD
    7. cellular response to lipopolysaccharide Source: RGD
    8. lung development Source: RGD
    9. maternal process involved in female pregnancy Source: RGD
    10. midgut development Source: RGD
    11. negative regulation of nitric-oxide synthase activity Source: RGD
    12. negative regulation of striated muscle contraction Source: RGD
    13. regulation of L-arginine import Source: RGD
    14. regulation of nitric oxide biosynthetic process Source: RGD
    15. response to amine Source: RGD
    16. response to amino acid Source: RGD
    17. response to axon injury Source: RGD
    18. response to cadmium ion Source: RGD
    19. response to drug Source: RGD
    20. response to glucose Source: RGD
    21. response to herbicide Source: RGD
    22. response to hormone Source: RGD
    23. response to hypoxia Source: RGD
    24. response to mercury ion Source: RGD
    25. response to nutrient Source: RGD
    26. response to selenium ion Source: RGD
    27. response to vitamin E Source: RGD
    28. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism, Urea cycle

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    SABIO-RKO08701.
    UniPathwayiUPA00158; UER00270.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginase-2, mitochondrial (EC:3.5.3.1)
    Alternative name(s):
    Kidney-type arginase
    Non-hepatic arginase
    Type II arginase
    Gene namesi
    Name:Arg2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2151. Arg2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
    BLAST
    Chaini23 – 354332Arginase-2, mitochondrialPRO_0000002086Add
    BLAST

    Proteomic databases

    PaxDbiO08701.
    PRIDEiO08701.

    Expressioni

    Gene expression databases

    GenevestigatoriO08701.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO08701.
    SMRiO08701. Positions 24-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni145 – 1495Substrate bindingBy similarity
    Regioni156 – 1583Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the arginase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0010.
    HOGENOMiHOG000204319.
    HOVERGENiHBG003030.
    InParanoidiO08701.
    KOiK01476.
    PhylomeDBiO08701.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08701-1 [UniParc]FASTAAdd to Basket

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    MFLRSSVSRL LHGQIPCALT RSVHSVAVVG APFSRGQKKK GVEYGPAAIR    50
    EAGLLKRLSM LGCHIKDFGD LSFTNVPKDD PYNNLVVYPR SVGIANQELA 100
    EVVSRAVSGG YSCVTLGGDH SLAIGTISGH ARHHPDLCVI WVDAHADINT 150
    PLTTVSGNIH GQPLSFLIRE LQDKVPQLPG FSWIKPCLSP PNLVYIGLRD 200
    VEPAEHFILK SFDIQYFSMR DIDRLGIQKV MEQTFDRLIG KRKRPIHLSF 250
    DIDAFDPKLA PATGTPVVGG LTYREGLYIT EEIHSTGLLS ALDLVEVNPH 300
    LATSEEEAKA TASLAVDVIA SSFGQTREGG HIAYDHLPTP SSPHESEKEE 350
    CVRI 354
    Length:354
    Mass (Da):38,640
    Last modified:July 1, 1997 - v1
    Checksum:iBC03E6BC99B29B8C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti88 – 881Y → N in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti90 – 901R → P in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti100 – 1001A → S in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti116 – 1161L → M in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti119 – 1191D → Y in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti128 – 1281S → I in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti143 – 1431D → Y in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti164 – 1641L → V in BAA13183. (PubMed:8898077)Curated
    Sequence conflicti168 – 1681I → L in BAA13183. (PubMed:8898077)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90887 mRNA. Translation: AAC22580.1.
    D86928 mRNA. Translation: BAA13183.1.
    RefSeqiNP_062041.1. NM_019168.1.
    UniGeneiRn.11055.

    Genome annotation databases

    GeneIDi29215.
    KEGGirno:29215.
    UCSCiRGD:2151. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90887 mRNA. Translation: AAC22580.1 .
    D86928 mRNA. Translation: BAA13183.1 .
    RefSeqi NP_062041.1. NM_019168.1.
    UniGenei Rn.11055.

    3D structure databases

    ProteinModelPortali O08701.
    SMRi O08701. Positions 24-329.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi O08701.
    PRIDEi O08701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 29215.
    KEGGi rno:29215.
    UCSCi RGD:2151. rat.

    Organism-specific databases

    CTDi 384.
    RGDi 2151. Arg2.

    Phylogenomic databases

    eggNOGi COG0010.
    HOGENOMi HOG000204319.
    HOVERGENi HBG003030.
    InParanoidi O08701.
    KOi K01476.
    PhylomeDBi O08701.

    Enzyme and pathway databases

    UniPathwayi UPA00158 ; UER00270 .
    SABIO-RK O08701.

    Miscellaneous databases

    NextBioi 608397.
    PROi O08701.

    Gene expression databases

    Genevestigatori O08701.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the mouse and rat type II arginase genes."
      Iyer R.K., Bando J.M., Jenkinson C.P., Vockley J.G., Kim P.S., Kern R.M., Cederbaum S.D., Grody W.W.
      Mol. Genet. Metab. 63:168-175(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Kidney.
    2. "Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line."
      Gotoh T., Sonoki T., Nagasaki A., Terada K., Takiguchi M., Mori M.
      FEBS Lett. 395:119-122(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 87-168.
      Strain: Wistar.
      Tissue: Small intestine.

    Entry informationi

    Entry nameiARGI2_RAT
    AccessioniPrimary (citable) accession number: O08701
    Secondary accession number(s): P97539
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3