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Protein

Vacuolar protein sorting-associated protein 45

Gene

Vps45

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network.

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 45
Short name:
rVps45
Gene namesi
Name:Vps45
Synonyms:Vps45a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi621267 Vps45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002063141 – 570Vacuolar protein sorting-associated protein 45Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei307PhosphoserineBy similarity1
Modified residuei441PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO08700
PRIDEiO08700

PTM databases

iPTMnetiO08700
PhosphoSitePlusiO08700

Expressioni

Tissue specificityi

Ubiquitous; expression was highest in testis and in brain. Detected in every part of the brain.

Gene expression databases

BgeeiENSRNOG00000021173
GenevisibleiO08700 RN

Interactioni

Subunit structurei

Interacts with STX6 and ZFYVE20.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Stx16Q8BVI56EBI-7849203,EBI-3871057From Mus musculus.

Protein-protein interaction databases

BioGridi249101, 2 interactors
IntActiO08700, 2 interactors
MINTiO08700
STRINGi10116.ENSRNOP00000028751

Structurei

3D structure databases

ProteinModelPortaliO08700
SMRiO08700
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiKOG1299 Eukaryota
COG5158 LUCA
GeneTreeiENSGT00550000075028
HOGENOMiHOG000200803
HOVERGENiHBG059810
InParanoidiO08700
KOiK12479
OMAiIADMKNF
OrthoDBiEOG091G05OR
PhylomeDBiO08700
TreeFamiTF300407

Family and domain databases

Gene3Di3.40.50.1910, 2 hits
InterProiView protein in InterPro
IPR027482 Sec-1-like_dom2
IPR001619 Sec1-like
IPR036045 Sec1-like_sf
PANTHERiPTHR11679 PTHR11679, 1 hit
PfamiView protein in Pfam
PF00995 Sec1, 1 hit
PIRSFiPIRSF005715 VPS45_Sec1, 1 hit
SUPFAMiSSF56815 SSF56815, 1 hit

Sequencei

Sequence statusi: Complete.

O08700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVVFAVKQY ISKMIEDSGP GMKVLLMDKE TTGIVSMVYT QSEILQKEVY
60 70 80 90 100
LFERIDSQNR EIMKHLKAIC FLRPTKENVD SLIQELRRPK YSIYFIYFSN
110 120 130 140 150
VISKSDVKSL AEADEQEVVA EVQEFYGDYI AVNPHLFSLN ILGCCQGRNW
160 170 180 190 200
DPAQLSRTTQ GLTALLLSLK KCPMIRYQLS SEAAKRLGEC VKQVISKEYE
210 220 230 240 250
LFEFRRTEVP PLLLILDRCD DAITPLLNQW TYQAMVHELL GINNNRIDLS
260 270 280 290 300
RVPGISKDLR EVVLSAENDE FYANNMYLNF AEIGSNIKNL MEDFQKKRPK
310 320 330 340 350
EQQKLESIAD MKAFVENYPQ FKKMSGTVSK HVTVVGELSR LVSERNLLEV
360 370 380 390 400
SEVEQELACQ NDHSSALQNV KRLLQNPKVT EFDAVRLVML YALHYERHSS
410 420 430 440 450
NSLPGLIVDL RSKGVAEKYR KLVSAVVEYG GKRVRGSDLF SPKDAVAITK
460 470 480 490 500
QFLKGLKGVE NVYTQHQPFL HETLDHLIKG KLKENLYPYL GPSTLRDRPQ
510 520 530 540 550
DIIVFVIGGA TYEEALTVYN LNRTTPGVRI VLGGTTIHNT KSFLEEVLAS
560 570
GLHSRSRESS QATSRSASRR
Length:570
Mass (Da):64,894
Last modified:July 1, 1997 - v1
Checksum:i0FF5E2D8E7E7E571
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U81160 mRNA Translation: AAB53041.1
BC081705 mRNA Translation: AAH81705.1
RefSeqiNP_742069.1, NM_172072.2
UniGeneiRn.9316

Genome annotation databases

EnsembliENSRNOT00000028751; ENSRNOP00000028751; ENSRNOG00000021173
GeneIDi64516
KEGGirno:64516
UCSCiRGD:621267 rat

Similar proteinsi

Entry informationi

Entry nameiVPS45_RAT
AccessioniPrimary (citable) accession number: O08700
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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