Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O08696

- FOXM1_MOUSE

UniProt

O08696 - FOXM1_MOUSE

Protein

Forkhead box protein M1

Gene

Foxm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi233 – 32593Fork-headPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
    2. DNA repair Source: UniProtKB-KW
    3. G2/M transition of mitotic cell cycle Source: UniProtKB
    4. liver development Source: MGI
    5. positive regulation of cell proliferation Source: MGI
    6. positive regulation of double-strand break repair Source: UniProtKB
    7. positive regulation of transcription, DNA-templated Source: UniProtKB
    8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    9. regulation of cell proliferation Source: MGI
    10. transcription, DNA-templated Source: UniProtKB-KW
    11. vasculogenesis Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Forkhead box protein M1
    Alternative name(s):
    Forkhead homolog 16
    Winged-helix transcription factor Trident
    Gene namesi
    Name:Foxm1
    Synonyms:Fkh16
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1347487. Foxm1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760Forkhead box protein M1PRO_0000091864Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei329 – 3291PhosphoserineBy similarity
    Modified residuei374 – 3741Phosphoserine; by CHEK2By similarity
    Modified residuei608 – 6081Phosphothreonine; by CDK1By similarity
    Modified residuei624 – 6241PhosphothreonineBy similarity
    Modified residuei727 – 7271Phosphoserine; by PLK1By similarity
    Modified residuei736 – 7361Phosphoserine; by PLK1By similarity

    Post-translational modificationi

    Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiO08696.

    PTM databases

    PhosphoSiteiO08696.

    Expressioni

    Tissue specificityi

    Expressed in fetal heart, brain, liver, lung, kidney and limb, but only in adult thymus. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors.

    Developmental stagei

    Expressed at E14 day in the embryo.

    Gene expression databases

    CleanExiMM_FOXM1.
    GenevestigatoriO08696.

    Interactioni

    Protein-protein interaction databases

    IntActiO08696. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO08696.
    SMRiO08696. Positions 230-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi479 – 51234Glu/Pro/Ser/Thr-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5025.
    HOGENOMiHOG000112633.
    HOVERGENiHBG051652.
    InParanoidiO08696.
    PhylomeDBiO08696.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00250. Fork_head. 1 hit.
    [Graphical view]
    PRINTSiPR00053. FORKHEAD.
    SMARTiSM00339. FH. 1 hit.
    [Graphical view]
    PROSITEiPS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08696-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTSPRRPLI LKRRRLPLPV QNAPSETSEE EAKRSPAQPE PAPAQASQEV    50
    AESSSCKFPA GIKIINHPTT PNTQVVAIPS NADIQSIITA LTAKGKESGT 100
    SGPNRFILIS SGGPSSHPSQ PQAHSSRDSK RAEVITETLG PKPAAKGVPV 150
    PKPPGAPPRQ RQESYAGGEA AGCTLDNSLT NIQWLGKMSS DGLGPCSVKQ 200
    ELEEKENCHL EQNRVKVEEP SGVSTSWQDS VSERPPYSYM AMIQFAINST 250
    ERKRMTLKDI YTWIEDHFPY FKHIAKPGWK NSIRHNLSLH DMFVRETSAN 300
    GKVSFWTIHP SANRHLTLDQ VFKPLEPGSP QSPEHLESQQ KRPNPELHRN 350
    VTIKTEIPLG ARRKMKPLLP RVSSYLEPIQ FPVNQSLVLQ PSVKVPFRLA 400
    ASLMSSELAR HSKRVRIAPK VLLSSEGIAP LPATEPPKEE KPLLGGEGLL 450
    PLLPIQSIKE EEMQPEEDIA HLERPIKVES PPLEEWPSPC ASLKEELSNS 500
    WEDSSCSPTP KPKKSYCGLK SPTRCVSEML VTKRREKREV SRSRRKQHLQ 550
    PPCLDEPDLF FPEDSSTFRP AVELLAESSE PAPHLSCPQE EGGPFKTPIK 600
    ETLPVSSTPS KSVLSRDPES WRLTPPAKVG GLDFSPVRTP QGAFGLLPDS 650
    LGLMELNTTP LKSGPLFDSP RELLNSEPFD LASDPFGSPP PPHVEGPKPG 700
    SPELQIPSLS ANRSLTEGLV LDTMNDSLSK ILLDISFPGL EEDPLGPDNI 750
    NWSQFIPELR 760
    Length:760
    Mass (Da):83,694
    Last modified:December 1, 2000 - v2
    Checksum:iAA614CB940EE7492
    GO

    Sequence cautioni

    The sequence CAA72115.1 differs from that shown. Reason: Erroneous termination at position 758. Translated as Glu.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11245 mRNA. Translation: CAA72115.1. Sequence problems.
    UniGeneiMm.42148.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y11245 mRNA. Translation: CAA72115.1 . Sequence problems.
    UniGenei Mm.42148.

    3D structure databases

    ProteinModelPortali O08696.
    SMRi O08696. Positions 230-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O08696. 2 interactions.

    PTM databases

    PhosphoSitei O08696.

    Proteomic databases

    PRIDEi O08696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1347487. Foxm1.

    Phylogenomic databases

    eggNOGi COG5025.
    HOGENOMi HOG000112633.
    HOVERGENi HBG051652.
    InParanoidi O08696.
    PhylomeDBi O08696.

    Miscellaneous databases

    ChiTaRSi FOXM1. mouse.
    PROi O08696.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_FOXM1.
    Genevestigatori O08696.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR001766. TF_fork_head.
    IPR018122. TF_fork_head_CS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00250. Fork_head. 1 hit.
    [Graphical view ]
    PRINTSi PR00053. FORKHEAD.
    SMARTi SM00339. FH. 1 hit.
    [Graphical view ]
    PROSITEi PS00657. FORK_HEAD_1. 1 hit.
    PS00658. FORK_HEAD_2. 1 hit.
    PS50039. FORK_HEAD_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The winged-helix transcription factor Trident is expressed in cycling cells."
      Korver W., Roose J., Clevers H.
      Nucleic Acids Res. 25:1715-1719(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Thymus.
    2. "Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."
      Tan Y., Raychaudhuri P., Costa R.H.
      Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN DNA REPAIR.

    Entry informationi

    Entry nameiFOXM1_MOUSE
    AccessioniPrimary (citable) accession number: O08696
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3