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O08696

- FOXM1_MOUSE

UniProt

O08696 - FOXM1_MOUSE

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Protein

Forkhead box protein M1

Gene

Foxm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi233 – 32593Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: UniProtKB
  2. DNA repair Source: UniProtKB-KW
  3. G2/M transition of mitotic cell cycle Source: UniProtKB
  4. liver development Source: MGI
  5. positive regulation of cell proliferation Source: MGI
  6. positive regulation of double-strand break repair Source: UniProtKB
  7. positive regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  9. regulation of cell proliferation Source: MGI
  10. transcription, DNA-templated Source: UniProtKB-KW
  11. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein M1
Alternative name(s):
Forkhead homolog 16
Winged-helix transcription factor Trident
Gene namesi
Name:Foxm1
Synonyms:Fkh16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1347487. Foxm1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760Forkhead box protein M1PRO_0000091864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei329 – 3291PhosphoserineBy similarity
Modified residuei374 – 3741Phosphoserine; by CHEK2By similarity
Modified residuei608 – 6081Phosphothreonine; by CDK1By similarity
Modified residuei624 – 6241PhosphothreonineBy similarity
Modified residuei727 – 7271Phosphoserine; by PLK1By similarity
Modified residuei736 – 7361Phosphoserine; by PLK1By similarity

Post-translational modificationi

Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiO08696.
PRIDEiO08696.

PTM databases

PhosphoSiteiO08696.

Expressioni

Tissue specificityi

Expressed in fetal heart, brain, liver, lung, kidney and limb, but only in adult thymus. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors.

Developmental stagei

Expressed at E14 day in the embryo.

Gene expression databases

CleanExiMM_FOXM1.
GenevestigatoriO08696.

Interactioni

Protein-protein interaction databases

IntActiO08696. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO08696.
SMRiO08696. Positions 230-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi479 – 51234Glu/Pro/Ser/Thr-richAdd
BLAST

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5025.
HOGENOMiHOG000112633.
HOVERGENiHBG051652.
InParanoidiO08696.
PhylomeDBiO08696.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Fork_head. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08696-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTSPRRPLI LKRRRLPLPV QNAPSETSEE EAKRSPAQPE PAPAQASQEV
60 70 80 90 100
AESSSCKFPA GIKIINHPTT PNTQVVAIPS NADIQSIITA LTAKGKESGT
110 120 130 140 150
SGPNRFILIS SGGPSSHPSQ PQAHSSRDSK RAEVITETLG PKPAAKGVPV
160 170 180 190 200
PKPPGAPPRQ RQESYAGGEA AGCTLDNSLT NIQWLGKMSS DGLGPCSVKQ
210 220 230 240 250
ELEEKENCHL EQNRVKVEEP SGVSTSWQDS VSERPPYSYM AMIQFAINST
260 270 280 290 300
ERKRMTLKDI YTWIEDHFPY FKHIAKPGWK NSIRHNLSLH DMFVRETSAN
310 320 330 340 350
GKVSFWTIHP SANRHLTLDQ VFKPLEPGSP QSPEHLESQQ KRPNPELHRN
360 370 380 390 400
VTIKTEIPLG ARRKMKPLLP RVSSYLEPIQ FPVNQSLVLQ PSVKVPFRLA
410 420 430 440 450
ASLMSSELAR HSKRVRIAPK VLLSSEGIAP LPATEPPKEE KPLLGGEGLL
460 470 480 490 500
PLLPIQSIKE EEMQPEEDIA HLERPIKVES PPLEEWPSPC ASLKEELSNS
510 520 530 540 550
WEDSSCSPTP KPKKSYCGLK SPTRCVSEML VTKRREKREV SRSRRKQHLQ
560 570 580 590 600
PPCLDEPDLF FPEDSSTFRP AVELLAESSE PAPHLSCPQE EGGPFKTPIK
610 620 630 640 650
ETLPVSSTPS KSVLSRDPES WRLTPPAKVG GLDFSPVRTP QGAFGLLPDS
660 670 680 690 700
LGLMELNTTP LKSGPLFDSP RELLNSEPFD LASDPFGSPP PPHVEGPKPG
710 720 730 740 750
SPELQIPSLS ANRSLTEGLV LDTMNDSLSK ILLDISFPGL EEDPLGPDNI
760
NWSQFIPELR
Length:760
Mass (Da):83,694
Last modified:December 1, 2000 - v2
Checksum:iAA614CB940EE7492
GO

Sequence cautioni

The sequence CAA72115.1 differs from that shown. Reason: Erroneous termination at position 758. Translated as Glu.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11245 mRNA. Translation: CAA72115.1. Sequence problems.
UniGeneiMm.42148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11245 mRNA. Translation: CAA72115.1 . Sequence problems.
UniGenei Mm.42148.

3D structure databases

ProteinModelPortali O08696.
SMRi O08696. Positions 230-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O08696. 2 interactions.

PTM databases

PhosphoSitei O08696.

Proteomic databases

MaxQBi O08696.
PRIDEi O08696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1347487. Foxm1.

Phylogenomic databases

eggNOGi COG5025.
HOGENOMi HOG000112633.
HOVERGENi HBG051652.
InParanoidi O08696.
PhylomeDBi O08696.

Miscellaneous databases

ChiTaRSi Foxm1. mouse.
PROi O08696.
SOURCEi Search...

Gene expression databases

CleanExi MM_FOXM1.
Genevestigatori O08696.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR001766. TF_fork_head.
IPR018122. TF_fork_head_CS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00250. Fork_head. 1 hit.
[Graphical view ]
PRINTSi PR00053. FORKHEAD.
SMARTi SM00339. FH. 1 hit.
[Graphical view ]
PROSITEi PS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The winged-helix transcription factor Trident is expressed in cycling cells."
    Korver W., Roose J., Clevers H.
    Nucleic Acids Res. 25:1715-1719(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Thymus.
  2. "Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes."
    Tan Y., Raychaudhuri P., Costa R.H.
    Mol. Cell. Biol. 27:1007-1016(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN DNA REPAIR.

Entry informationi

Entry nameiFOXM1_MOUSE
AccessioniPrimary (citable) accession number: O08696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 26, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3