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O08691

- ARGI2_MOUSE

UniProt

O08691 - ARGI2_MOUSE

Protein

Arginase-2, mitochondrial

Gene

Arg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis.By similarity

    Catalytic activityi

    L-arginine + H2O = L-ornithine + urea.

    Cofactori

    Binds 2 manganese ions per subunit.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi120 – 1201Manganese 1PROSITE-ProRule annotation
    Metal bindingi143 – 1431Manganese 1PROSITE-ProRule annotation
    Metal bindingi143 – 1431Manganese 2PROSITE-ProRule annotation
    Metal bindingi145 – 1451Manganese 2PROSITE-ProRule annotation
    Metal bindingi147 – 1471Manganese 1PROSITE-ProRule annotation
    Binding sitei202 – 2021SubstrateBy similarity
    Metal bindingi251 – 2511Manganese 1PROSITE-ProRule annotation
    Metal bindingi251 – 2511Manganese 2PROSITE-ProRule annotation
    Metal bindingi253 – 2531Manganese 2PROSITE-ProRule annotation
    Binding sitei296 – 2961SubstrateBy similarity

    GO - Molecular functioni

    1. arginase activity Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine metabolic process Source: UniProtKB-KW
    2. striated muscle contraction Source: MGI
    3. urea cycle Source: UniProtKB-UniPathway
    4. ureteric bud development Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Arginine metabolism, Urea cycle

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00158; UER00270.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Arginase-2, mitochondrial (EC:3.5.3.1)
    Alternative name(s):
    Kidney-type arginase
    Non-hepatic arginase
    Type II arginase
    Gene namesi
    Name:Arg2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1330806. Arg2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2222MitochondrionSequence AnalysisAdd
    BLAST
    Chaini23 – 354332Arginase-2, mitochondrialPRO_0000002085Add
    BLAST

    Proteomic databases

    MaxQBiO08691.
    PaxDbiO08691.
    PRIDEiO08691.

    2D gel databases

    REPRODUCTION-2DPAGEO08691.

    PTM databases

    PhosphoSiteiO08691.

    Expressioni

    Gene expression databases

    BgeeiO08691.
    CleanExiMM_ARG2.
    GenevestigatoriO08691.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    IntActiO08691. 1 interaction.
    MINTiMINT-4088250.
    STRINGi10090.ENSMUSP00000021550.

    Structurei

    3D structure databases

    ProteinModelPortaliO08691.
    SMRiO08691. Positions 24-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni145 – 1495Substrate bindingBy similarity
    Regioni156 – 1583Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the arginase family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0010.
    GeneTreeiENSGT00530000063082.
    HOGENOMiHOG000204319.
    HOVERGENiHBG003030.
    InParanoidiO08691.
    KOiK01476.
    OMAiRNMKNPR.
    OrthoDBiEOG747PJ5.
    PhylomeDBiO08691.
    TreeFamiTF300034.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    InterProiIPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    PRINTSiPR00116. ARGINASE.
    TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08691-1 [UniParc]FASTAAdd to Basket

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    MFLRSSASRL LHGQIPCVLT RSVHSVAIVG APFSRGQKKL GVEYGPAAIR    50
    EAGLLKRLSR LGCHLKDFGD LSFTNVPQDD PYNNLVVYPR SVGLANQELA 100
    EVVSRAVSGG YSCVTMGGDH SLAIGTIIGH ARHRPDLCVI WVDAHADINT 150
    PLTTVSGNIH GQPLSFLIKE LQDKVPQLPG FSWIKPCLSP PNIVYIGLRD 200
    VEPPEHFILK NYDIQYFSMR EIDRLGIQKV MEQTFDRLIG KRQRPIHLSF 250
    DIDAFDPKLA PATGTPVVGG LTYREGVYIT EEIHNTGLLS ALDLVEVNPH 300
    LATSEEEAKA TARLAVDVIA SSFGQTREGG HIVYDHLPTP SSPHESENEE 350
    CVRI 354
    Length:354
    Mass (Da):38,878
    Last modified:July 1, 1997 - v1
    Checksum:iB372DF68A19473F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90886 mRNA. Translation: AAC22548.1.
    AF032466 mRNA. Translation: AAB86959.1.
    AF045965
    , AF044680, AF045959, AF045960, AF045961, AF045962, AF045963, AF045964 Genomic DNA. Translation: AAC78460.1.
    CCDSiCCDS26007.1.
    RefSeqiNP_033835.1. NM_009705.3.
    UniGeneiMm.3506.

    Genome annotation databases

    EnsembliENSMUST00000021550; ENSMUSP00000021550; ENSMUSG00000021125.
    GeneIDi11847.
    KEGGimmu:11847.
    UCSCiuc007nzv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U90886 mRNA. Translation: AAC22548.1 .
    AF032466 mRNA. Translation: AAB86959.1 .
    AF045965
    , AF044680 , AF045959 , AF045960 , AF045961 , AF045962 , AF045963 , AF045964 Genomic DNA. Translation: AAC78460.1 .
    CCDSi CCDS26007.1.
    RefSeqi NP_033835.1. NM_009705.3.
    UniGenei Mm.3506.

    3D structure databases

    ProteinModelPortali O08691.
    SMRi O08691. Positions 24-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O08691. 1 interaction.
    MINTi MINT-4088250.
    STRINGi 10090.ENSMUSP00000021550.

    PTM databases

    PhosphoSitei O08691.

    2D gel databases

    REPRODUCTION-2DPAGE O08691.

    Proteomic databases

    MaxQBi O08691.
    PaxDbi O08691.
    PRIDEi O08691.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021550 ; ENSMUSP00000021550 ; ENSMUSG00000021125 .
    GeneIDi 11847.
    KEGGi mmu:11847.
    UCSCi uc007nzv.2. mouse.

    Organism-specific databases

    CTDi 384.
    MGIi MGI:1330806. Arg2.

    Phylogenomic databases

    eggNOGi COG0010.
    GeneTreei ENSGT00530000063082.
    HOGENOMi HOG000204319.
    HOVERGENi HBG003030.
    InParanoidi O08691.
    KOi K01476.
    OMAi RNMKNPR.
    OrthoDBi EOG747PJ5.
    PhylomeDBi O08691.
    TreeFami TF300034.

    Enzyme and pathway databases

    UniPathwayi UPA00158 ; UER00270 .

    Miscellaneous databases

    NextBioi 279811.
    PROi O08691.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08691.
    CleanExi MM_ARG2.
    Genevestigatori O08691.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    InterProi IPR014033. Arginase.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    PRINTSi PR00116. ARGINASE.
    TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the mouse and rat type II arginase genes."
      Iyer R.K., Bando J.M., Jenkinson C.P., Vockley J.G., Kim P.S., Kern R.M., Cederbaum S.D., Grody W.W.
      Mol. Genet. Metab. 63:168-175(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Kidney.
    2. "Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells."
      Morris S.M. Jr., Kepka-Lenhart D., Chen L.C.
      Am. J. Physiol. 275:E740-E747(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 51-57, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiARGI2_MOUSE
    AccessioniPrimary (citable) accession number: O08691
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3