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O08691

- ARGI2_MOUSE

UniProt

O08691 - ARGI2_MOUSE

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Protein
Arginase-2, mitochondrial
Gene
Arg2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis By similarity.

Catalytic activityi

L-arginine + H2O = L-ornithine + urea.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi120 – 1201Manganese 1 By similarity
Metal bindingi143 – 1431Manganese 1 By similarity
Metal bindingi143 – 1431Manganese 2 By similarity
Metal bindingi145 – 1451Manganese 2 By similarity
Metal bindingi147 – 1471Manganese 1 By similarity
Binding sitei202 – 2021Substrate By similarity
Metal bindingi251 – 2511Manganese 1 By similarity
Metal bindingi251 – 2511Manganese 2 By similarity
Metal bindingi253 – 2531Manganese 2 By similarity
Binding sitei296 – 2961Substrate By similarity

GO - Molecular functioni

  1. arginase activity Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine metabolic process Source: UniProtKB-KW
  2. striated muscle contraction Source: MGI
  3. urea cycle Source: UniProtKB-UniPathway
  4. ureteric bud development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arginine metabolism, Urea cycle

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00158; UER00270.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginase-2, mitochondrial (EC:3.5.3.1)
Alternative name(s):
Kidney-type arginase
Non-hepatic arginase
Type II arginase
Gene namesi
Name:Arg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1330806. Arg2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2222Mitochondrion Reviewed prediction
Add
BLAST
Chaini23 – 354332Arginase-2, mitochondrial
PRO_0000002085Add
BLAST

Proteomic databases

MaxQBiO08691.
PaxDbiO08691.
PRIDEiO08691.

2D gel databases

REPRODUCTION-2DPAGEO08691.

PTM databases

PhosphoSiteiO08691.

Expressioni

Gene expression databases

BgeeiO08691.
CleanExiMM_ARG2.
GenevestigatoriO08691.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

IntActiO08691. 1 interaction.
MINTiMINT-4088250.
STRINGi10090.ENSMUSP00000021550.

Structurei

3D structure databases

ProteinModelPortaliO08691.
SMRiO08691. Positions 24-329.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni145 – 1495Substrate binding By similarity
Regioni156 – 1583Substrate binding By similarity

Sequence similaritiesi

Belongs to the arginase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0010.
GeneTreeiENSGT00530000063082.
HOGENOMiHOG000204319.
HOVERGENiHBG003030.
InParanoidiO08691.
KOiK01476.
OMAiRNMKNPR.
OrthoDBiEOG747PJ5.
PhylomeDBiO08691.
TreeFamiTF300034.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
InterProiIPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
PRINTSiPR00116. ARGINASE.
TIGRFAMsiTIGR01229. rocF_arginase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08691-1 [UniParc]FASTAAdd to Basket

« Hide

MFLRSSASRL LHGQIPCVLT RSVHSVAIVG APFSRGQKKL GVEYGPAAIR    50
EAGLLKRLSR LGCHLKDFGD LSFTNVPQDD PYNNLVVYPR SVGLANQELA 100
EVVSRAVSGG YSCVTMGGDH SLAIGTIIGH ARHRPDLCVI WVDAHADINT 150
PLTTVSGNIH GQPLSFLIKE LQDKVPQLPG FSWIKPCLSP PNIVYIGLRD 200
VEPPEHFILK NYDIQYFSMR EIDRLGIQKV MEQTFDRLIG KRQRPIHLSF 250
DIDAFDPKLA PATGTPVVGG LTYREGVYIT EEIHNTGLLS ALDLVEVNPH 300
LATSEEEAKA TARLAVDVIA SSFGQTREGG HIVYDHLPTP SSPHESENEE 350
CVRI 354
Length:354
Mass (Da):38,878
Last modified:July 1, 1997 - v1
Checksum:iB372DF68A19473F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90886 mRNA. Translation: AAC22548.1.
AF032466 mRNA. Translation: AAB86959.1.
AF045965
, AF044680, AF045959, AF045960, AF045961, AF045962, AF045963, AF045964 Genomic DNA. Translation: AAC78460.1.
CCDSiCCDS26007.1.
RefSeqiNP_033835.1. NM_009705.3.
UniGeneiMm.3506.

Genome annotation databases

EnsembliENSMUST00000021550; ENSMUSP00000021550; ENSMUSG00000021125.
GeneIDi11847.
KEGGimmu:11847.
UCSCiuc007nzv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U90886 mRNA. Translation: AAC22548.1 .
AF032466 mRNA. Translation: AAB86959.1 .
AF045965
, AF044680 , AF045959 , AF045960 , AF045961 , AF045962 , AF045963 , AF045964 Genomic DNA. Translation: AAC78460.1 .
CCDSi CCDS26007.1.
RefSeqi NP_033835.1. NM_009705.3.
UniGenei Mm.3506.

3D structure databases

ProteinModelPortali O08691.
SMRi O08691. Positions 24-329.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O08691. 1 interaction.
MINTi MINT-4088250.
STRINGi 10090.ENSMUSP00000021550.

PTM databases

PhosphoSitei O08691.

2D gel databases

REPRODUCTION-2DPAGE O08691.

Proteomic databases

MaxQBi O08691.
PaxDbi O08691.
PRIDEi O08691.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021550 ; ENSMUSP00000021550 ; ENSMUSG00000021125 .
GeneIDi 11847.
KEGGi mmu:11847.
UCSCi uc007nzv.2. mouse.

Organism-specific databases

CTDi 384.
MGIi MGI:1330806. Arg2.

Phylogenomic databases

eggNOGi COG0010.
GeneTreei ENSGT00530000063082.
HOGENOMi HOG000204319.
HOVERGENi HBG003030.
InParanoidi O08691.
KOi K01476.
OMAi RNMKNPR.
OrthoDBi EOG747PJ5.
PhylomeDBi O08691.
TreeFami TF300034.

Enzyme and pathway databases

UniPathwayi UPA00158 ; UER00270 .

Miscellaneous databases

NextBioi 279811.
PROi O08691.
SOURCEi Search...

Gene expression databases

Bgeei O08691.
CleanExi MM_ARG2.
Genevestigatori O08691.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
InterProi IPR014033. Arginase.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
PRINTSi PR00116. ARGINASE.
TIGRFAMsi TIGR01229. rocF_arginase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the mouse and rat type II arginase genes."
    Iyer R.K., Bando J.M., Jenkinson C.P., Vockley J.G., Kim P.S., Kern R.M., Cederbaum S.D., Grody W.W.
    Mol. Genet. Metab. 63:168-175(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Kidney.
  2. "Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells."
    Morris S.M. Jr., Kepka-Lenhart D., Chen L.C.
    Am. J. Physiol. 275:E740-E747(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 51-57, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiARGI2_MOUSE
AccessioniPrimary (citable) accession number: O08691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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