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Protein

Calpain-5

Gene

Capn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81By similarity1
Active sitei252By similarity1
Active sitei284By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B25. 3474.

Protein family/group databases

MEROPSiC02.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-5 (EC:3.4.22.-)
Alternative name(s):
New calpain 3
Short name:
nCL-3
Gene namesi
Name:Capn5
Synonyms:Ncl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1100859. Capn5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077141 – 640Calpain-5Add BLAST640

Proteomic databases

EPDiO08688.
PaxDbiO08688.
PeptideAtlasiO08688.
PRIDEiO08688.

PTM databases

iPTMnetiO08688.
PhosphoSitePlusiO08688.
SwissPalmiO08688.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035547.
CleanExiMM_CAPN5.
ExpressionAtlasiO08688. baseline and differential.
GenevisibleiO08688. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048183.

Structurei

3D structure databases

ProteinModelPortaliO08688.
SMRiO08688.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 343Calpain catalyticPROSITE-ProRule annotationAdd BLAST318
Domaini518 – 619C2Add BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 496Domain IIIAdd BLAST153

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 C2 domain.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiO08688.
KOiK08574.
OMAiCEGQKVR.
OrthoDBiEOG091G030A.
PhylomeDBiO08688.
TreeFamiTF314748.

Family and domain databases

CDDicd04046. C2_Calpain. 1 hit.
cd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR033884. C2_Calpain.
IPR000008. C2_dom.
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSCAKAYED QNYSALKRAC LRKKVLFEDP LFPATDDSLY YKGTPGPTVR
60 70 80 90 100
WKRPKDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV
110 120 130 140 150
IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVIVDDRL PTVNNQLIYC
160 170 180 190 200
HSNSKNEFWC ALVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT
210 220 230 240 250
EGDLATDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM EARLACGLVK
260 270 280 290 300
GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WTGPWSDTSE
310 320 330 340 350
EWQKVSKSER EKMGVTVQDD GEFWMTFEDM CRYFTDIIKC RLINTSYLSI
360 370 380 390 400
HKTWEEARLH GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY VFEVKKPEDE
410 420 430 440 450
VLISIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI
460 470 480 490 500
YINSRSVFLR TELPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL
510 520 530 540 550
DEPPRTCWSS LCGYPQQVAQ VHVLGAAGLK DSPTGANSYV IIKCEGEKVR
560 570 580 590 600
SAVQRGTSTP EYNVKGIFYR KKLAQPITVQ VWNHRVLKDE FLGQVHLKTA
610 620 630 640
PDDLQDLHTL HLQDRSSRQP SDLPGIVAVR VLCSASLTAV
Length:640
Mass (Da):72,955
Last modified:July 1, 1997 - v1
Checksum:i7F1DA3E299FEC02D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti427D → N.2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10656 mRNA. Translation: CAA71666.1.
U85020 mRNA. Translation: AAD00559.1.
BC014767 mRNA. Translation: AAH14767.1.
CCDSiCCDS21465.1.
RefSeqiNP_001288179.1. NM_001301250.1.
NP_031628.1. NM_007602.4.
UniGeneiMm.326847.

Genome annotation databases

EnsembliENSMUST00000040971; ENSMUSP00000048183; ENSMUSG00000035547.
ENSMUST00000107112; ENSMUSP00000102729; ENSMUSG00000035547.
GeneIDi12337.
KEGGimmu:12337.
UCSCiuc009ikc.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10656 mRNA. Translation: CAA71666.1.
U85020 mRNA. Translation: AAD00559.1.
BC014767 mRNA. Translation: AAH14767.1.
CCDSiCCDS21465.1.
RefSeqiNP_001288179.1. NM_001301250.1.
NP_031628.1. NM_007602.4.
UniGeneiMm.326847.

3D structure databases

ProteinModelPortaliO08688.
SMRiO08688.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048183.

Protein family/group databases

MEROPSiC02.011.

PTM databases

iPTMnetiO08688.
PhosphoSitePlusiO08688.
SwissPalmiO08688.

Proteomic databases

EPDiO08688.
PaxDbiO08688.
PeptideAtlasiO08688.
PRIDEiO08688.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040971; ENSMUSP00000048183; ENSMUSG00000035547.
ENSMUST00000107112; ENSMUSP00000102729; ENSMUSG00000035547.
GeneIDi12337.
KEGGimmu:12337.
UCSCiuc009ikc.2. mouse.

Organism-specific databases

CTDi726.
MGIiMGI:1100859. Capn5.

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
GeneTreeiENSGT00760000118971.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiO08688.
KOiK08574.
OMAiCEGQKVR.
OrthoDBiEOG091G030A.
PhylomeDBiO08688.
TreeFamiTF314748.

Enzyme and pathway databases

BRENDAi3.4.22.B25. 3474.

Miscellaneous databases

ChiTaRSiCapn5. mouse.
PROiO08688.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035547.
CleanExiMM_CAPN5.
ExpressionAtlasiO08688. baseline and differential.
GenevisibleiO08688. MM.

Family and domain databases

CDDicd04046. C2_Calpain. 1 hit.
cd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
Gene3Di2.60.40.150. 1 hit.
InterProiIPR033884. C2_Calpain.
IPR000008. C2_dom.
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAN5_MOUSE
AccessioniPrimary (citable) accession number: O08688
Secondary accession number(s): Q91YU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.