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O08688

- CAN5_MOUSE

UniProt

O08688 - CAN5_MOUSE

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Protein
Calpain-5
Gene
Capn5, Ncl3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811 By similarity
Active sitei252 – 2521 By similarity
Active sitei284 – 2841 By similarity

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-5 (EC:3.4.22.-)
Alternative name(s):
New calpain 3
Short name:
nCL-3
Gene namesi
Name:Capn5
Synonyms:Ncl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1100859. Capn5.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: RefGenome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Calpain-5
PRO_0000207714Add
BLAST

Proteomic databases

MaxQBiO08688.
PaxDbiO08688.
PRIDEiO08688.

PTM databases

PhosphoSiteiO08688.

Expressioni

Gene expression databases

ArrayExpressiO08688.
BgeeiO08688.
CleanExiMM_CAPN5.
GenevestigatoriO08688.

Structurei

3D structure databases

ProteinModelPortaliO08688.
SMRiO08688. Positions 5-490.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 343318Calpain catalytic
Add
BLAST
Domaini518 – 619102C2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 496153Domain III
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.
Contains 1 C2 domain.

Phylogenomic databases

eggNOGiNOG258770.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiO08688.
KOiK08574.
OMAiPGPTVRW.
OrthoDBiEOG75J0MJ.
PhylomeDBiO08688.
TreeFamiTF314748.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08688-1 [UniParc]FASTAAdd to Basket

« Hide

MFSCAKAYED QNYSALKRAC LRKKVLFEDP LFPATDDSLY YKGTPGPTVR    50
WKRPKDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV 100
IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVIVDDRL PTVNNQLIYC 150
HSNSKNEFWC ALVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT 200
EGDLATDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM EARLACGLVK 250
GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WTGPWSDTSE 300
EWQKVSKSER EKMGVTVQDD GEFWMTFEDM CRYFTDIIKC RLINTSYLSI 350
HKTWEEARLH GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY VFEVKKPEDE 400
VLISIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI 450
YINSRSVFLR TELPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL 500
DEPPRTCWSS LCGYPQQVAQ VHVLGAAGLK DSPTGANSYV IIKCEGEKVR 550
SAVQRGTSTP EYNVKGIFYR KKLAQPITVQ VWNHRVLKDE FLGQVHLKTA 600
PDDLQDLHTL HLQDRSSRQP SDLPGIVAVR VLCSASLTAV 640
Length:640
Mass (Da):72,955
Last modified:July 1, 1997 - v1
Checksum:i7F1DA3E299FEC02D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti427 – 4271D → N.2 Publications

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10656 mRNA. Translation: CAA71666.1.
U85020 mRNA. Translation: AAD00559.1.
BC014767 mRNA. Translation: AAH14767.1.
CCDSiCCDS21465.1.
RefSeqiNP_031628.1. NM_007602.3.
XP_006507339.1. XM_006507276.1.
UniGeneiMm.326847.

Genome annotation databases

EnsembliENSMUST00000040971; ENSMUSP00000048183; ENSMUSG00000035547.
ENSMUST00000107112; ENSMUSP00000102729; ENSMUSG00000035547.
GeneIDi12337.
KEGGimmu:12337.
UCSCiuc009ikc.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10656 mRNA. Translation: CAA71666.1 .
U85020 mRNA. Translation: AAD00559.1 .
BC014767 mRNA. Translation: AAH14767.1 .
CCDSi CCDS21465.1.
RefSeqi NP_031628.1. NM_007602.3.
XP_006507339.1. XM_006507276.1.
UniGenei Mm.326847.

3D structure databases

ProteinModelPortali O08688.
SMRi O08688. Positions 5-490.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C02.011.

PTM databases

PhosphoSitei O08688.

Proteomic databases

MaxQBi O08688.
PaxDbi O08688.
PRIDEi O08688.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040971 ; ENSMUSP00000048183 ; ENSMUSG00000035547 .
ENSMUST00000107112 ; ENSMUSP00000102729 ; ENSMUSG00000035547 .
GeneIDi 12337.
KEGGi mmu:12337.
UCSCi uc009ikc.1. mouse.

Organism-specific databases

CTDi 726.
MGIi MGI:1100859. Capn5.

Phylogenomic databases

eggNOGi NOG258770.
HOGENOMi HOG000232036.
HOVERGENi HBG001095.
InParanoidi O08688.
KOi K08574.
OMAi PGPTVRW.
OrthoDBi EOG75J0MJ.
PhylomeDBi O08688.
TreeFami TF314748.

Miscellaneous databases

NextBioi 280956.
PROi O08688.
SOURCEi Search...

Gene expression databases

ArrayExpressi O08688.
Bgeei O08688.
CleanExi MM_CAPN5.
Genevestigatori O08688.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution."
    Dear T.N., Matena K., Vingron M., Boehm T.
    Genomics 45:175-184(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily."
    Matena K., Boehm T., Dear N.T.
    Genomics 48:117-120(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-427.
  3. Algate P.A.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-427.

Entry informationi

Entry nameiCAN5_MOUSE
AccessioniPrimary (citable) accession number: O08688
Secondary accession number(s): Q91YU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: July 1, 1997
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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