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O08688

- CAN5_MOUSE

UniProt

O08688 - CAN5_MOUSE

Protein

Calpain-5

Gene

Capn5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Broad endopeptidase specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei81 – 811By similarity
    Active sitei252 – 2521By similarity
    Active sitei284 – 2841By similarity

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. proteolysis Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC02.011.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-5 (EC:3.4.22.-)
    Alternative name(s):
    New calpain 3
    Short name:
    nCL-3
    Gene namesi
    Name:Capn5
    Synonyms:Ncl3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1100859. Capn5.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. cytoplasm Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 640640Calpain-5PRO_0000207714Add
    BLAST

    Proteomic databases

    MaxQBiO08688.
    PaxDbiO08688.
    PRIDEiO08688.

    PTM databases

    PhosphoSiteiO08688.

    Expressioni

    Gene expression databases

    ArrayExpressiO08688.
    BgeeiO08688.
    CleanExiMM_CAPN5.
    GenevestigatoriO08688.

    Structurei

    3D structure databases

    ProteinModelPortaliO08688.
    SMRiO08688. Positions 5-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 343318Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST
    Domaini518 – 619102C2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni344 – 496153Domain IIIAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 C2 domain.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG258770.
    HOGENOMiHOG000232036.
    HOVERGENiHBG001095.
    InParanoidiO08688.
    KOiK08574.
    OMAiPGPTVRW.
    OrthoDBiEOG75J0MJ.
    PhylomeDBiO08688.
    TreeFamiTF314748.

    Family and domain databases

    Gene3Di2.60.40.150. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PfamiPF00168. C2. 1 hit.
    PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00239. C2. 1 hit.
    SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF49758. SSF49758. 1 hit.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O08688-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSCAKAYED QNYSALKRAC LRKKVLFEDP LFPATDDSLY YKGTPGPTVR    50
    WKRPKDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV 100
    IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVIVDDRL PTVNNQLIYC 150
    HSNSKNEFWC ALVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT 200
    EGDLATDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM EARLACGLVK 250
    GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WTGPWSDTSE 300
    EWQKVSKSER EKMGVTVQDD GEFWMTFEDM CRYFTDIIKC RLINTSYLSI 350
    HKTWEEARLH GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY VFEVKKPEDE 400
    VLISIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI 450
    YINSRSVFLR TELPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL 500
    DEPPRTCWSS LCGYPQQVAQ VHVLGAAGLK DSPTGANSYV IIKCEGEKVR 550
    SAVQRGTSTP EYNVKGIFYR KKLAQPITVQ VWNHRVLKDE FLGQVHLKTA 600
    PDDLQDLHTL HLQDRSSRQP SDLPGIVAVR VLCSASLTAV 640
    Length:640
    Mass (Da):72,955
    Last modified:July 1, 1997 - v1
    Checksum:i7F1DA3E299FEC02D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti427 – 4271D → N.2 Publications

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10656 mRNA. Translation: CAA71666.1.
    U85020 mRNA. Translation: AAD00559.1.
    BC014767 mRNA. Translation: AAH14767.1.
    CCDSiCCDS21465.1.
    RefSeqiNP_031628.1. NM_007602.3.
    XP_006507339.1. XM_006507276.1.
    UniGeneiMm.326847.

    Genome annotation databases

    EnsembliENSMUST00000040971; ENSMUSP00000048183; ENSMUSG00000035547.
    ENSMUST00000107112; ENSMUSP00000102729; ENSMUSG00000035547.
    GeneIDi12337.
    KEGGimmu:12337.
    UCSCiuc009ikc.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y10656 mRNA. Translation: CAA71666.1 .
    U85020 mRNA. Translation: AAD00559.1 .
    BC014767 mRNA. Translation: AAH14767.1 .
    CCDSi CCDS21465.1.
    RefSeqi NP_031628.1. NM_007602.3.
    XP_006507339.1. XM_006507276.1.
    UniGenei Mm.326847.

    3D structure databases

    ProteinModelPortali O08688.
    SMRi O08688. Positions 5-490.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C02.011.

    PTM databases

    PhosphoSitei O08688.

    Proteomic databases

    MaxQBi O08688.
    PaxDbi O08688.
    PRIDEi O08688.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040971 ; ENSMUSP00000048183 ; ENSMUSG00000035547 .
    ENSMUST00000107112 ; ENSMUSP00000102729 ; ENSMUSG00000035547 .
    GeneIDi 12337.
    KEGGi mmu:12337.
    UCSCi uc009ikc.1. mouse.

    Organism-specific databases

    CTDi 726.
    MGIi MGI:1100859. Capn5.

    Phylogenomic databases

    eggNOGi NOG258770.
    HOGENOMi HOG000232036.
    HOVERGENi HBG001095.
    InParanoidi O08688.
    KOi K08574.
    OMAi PGPTVRW.
    OrthoDBi EOG75J0MJ.
    PhylomeDBi O08688.
    TreeFami TF314748.

    Miscellaneous databases

    NextBioi 280956.
    PROi O08688.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi O08688.
    Bgeei O08688.
    CleanExi MM_CAPN5.
    Genevestigatori O08688.

    Family and domain databases

    Gene3Di 2.60.40.150. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    Pfami PF00168. C2. 1 hit.
    PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00239. C2. 1 hit.
    SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF49758. SSF49758. 1 hit.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution."
      Dear T.N., Matena K., Vingron M., Boehm T.
      Genomics 45:175-184(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily."
      Matena K., Boehm T., Dear N.T.
      Genomics 48:117-120(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-427.
    3. Algate P.A.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-427.

    Entry informationi

    Entry nameiCAN5_MOUSE
    AccessioniPrimary (citable) accession number: O08688
    Secondary accession number(s): Q91YU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3