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O08688

- CAN5_MOUSE

UniProt

O08688 - CAN5_MOUSE

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Protein

Calpain-5

Gene

Capn5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Broad endopeptidase specificity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei81 – 811By similarity
Active sitei252 – 2521By similarity
Active sitei284 – 2841By similarity

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. proteolysis Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC02.011.

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-5 (EC:3.4.22.-)
Alternative name(s):
New calpain 3
Short name:
nCL-3
Gene namesi
Name:Capn5
Synonyms:Ncl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1100859. Capn5.

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytoplasm Source: RefGenome
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Calpain-5PRO_0000207714Add
BLAST

Proteomic databases

MaxQBiO08688.
PaxDbiO08688.
PRIDEiO08688.

PTM databases

PhosphoSiteiO08688.

Expressioni

Gene expression databases

BgeeiO08688.
CleanExiMM_CAPN5.
ExpressionAtlasiO08688. baseline and differential.
GenevestigatoriO08688.

Structurei

3D structure databases

ProteinModelPortaliO08688.
SMRiO08688. Positions 5-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 343318Calpain catalyticPROSITE-ProRule annotationAdd
BLAST
Domaini518 – 619102C2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni344 – 496153Domain IIIAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated
Contains 1 C2 domain.Curated
Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG258770.
HOGENOMiHOG000232036.
HOVERGENiHBG001095.
InParanoidiO08688.
KOiK08574.
OMAiPGPTVRW.
OrthoDBiEOG75J0MJ.
PhylomeDBiO08688.
TreeFamiTF314748.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08688-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSCAKAYED QNYSALKRAC LRKKVLFEDP LFPATDDSLY YKGTPGPTVR
60 70 80 90 100
WKRPKDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV
110 120 130 140 150
IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVIVDDRL PTVNNQLIYC
160 170 180 190 200
HSNSKNEFWC ALVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT
210 220 230 240 250
EGDLATDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM EARLACGLVK
260 270 280 290 300
GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WTGPWSDTSE
310 320 330 340 350
EWQKVSKSER EKMGVTVQDD GEFWMTFEDM CRYFTDIIKC RLINTSYLSI
360 370 380 390 400
HKTWEEARLH GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY VFEVKKPEDE
410 420 430 440 450
VLISIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI
460 470 480 490 500
YINSRSVFLR TELPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL
510 520 530 540 550
DEPPRTCWSS LCGYPQQVAQ VHVLGAAGLK DSPTGANSYV IIKCEGEKVR
560 570 580 590 600
SAVQRGTSTP EYNVKGIFYR KKLAQPITVQ VWNHRVLKDE FLGQVHLKTA
610 620 630 640
PDDLQDLHTL HLQDRSSRQP SDLPGIVAVR VLCSASLTAV
Length:640
Mass (Da):72,955
Last modified:July 1, 1997 - v1
Checksum:i7F1DA3E299FEC02D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti427 – 4271D → N.2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10656 mRNA. Translation: CAA71666.1.
U85020 mRNA. Translation: AAD00559.1.
BC014767 mRNA. Translation: AAH14767.1.
CCDSiCCDS21465.1.
RefSeqiNP_001288179.1. NM_001301250.1.
NP_031628.1. NM_007602.4.
UniGeneiMm.326847.

Genome annotation databases

EnsembliENSMUST00000040971; ENSMUSP00000048183; ENSMUSG00000035547.
ENSMUST00000107112; ENSMUSP00000102729; ENSMUSG00000035547.
GeneIDi12337.
KEGGimmu:12337.
UCSCiuc009ikc.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10656 mRNA. Translation: CAA71666.1 .
U85020 mRNA. Translation: AAD00559.1 .
BC014767 mRNA. Translation: AAH14767.1 .
CCDSi CCDS21465.1.
RefSeqi NP_001288179.1. NM_001301250.1.
NP_031628.1. NM_007602.4.
UniGenei Mm.326847.

3D structure databases

ProteinModelPortali O08688.
SMRi O08688. Positions 5-490.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C02.011.

PTM databases

PhosphoSitei O08688.

Proteomic databases

MaxQBi O08688.
PaxDbi O08688.
PRIDEi O08688.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040971 ; ENSMUSP00000048183 ; ENSMUSG00000035547 .
ENSMUST00000107112 ; ENSMUSP00000102729 ; ENSMUSG00000035547 .
GeneIDi 12337.
KEGGi mmu:12337.
UCSCi uc009ikc.1. mouse.

Organism-specific databases

CTDi 726.
MGIi MGI:1100859. Capn5.

Phylogenomic databases

eggNOGi NOG258770.
HOGENOMi HOG000232036.
HOVERGENi HBG001095.
InParanoidi O08688.
KOi K08574.
OMAi PGPTVRW.
OrthoDBi EOG75J0MJ.
PhylomeDBi O08688.
TreeFami TF314748.

Miscellaneous databases

ChiTaRSi Capn5. mouse.
NextBioi 280956.
PROi O08688.
SOURCEi Search...

Gene expression databases

Bgeei O08688.
CleanExi MM_CAPN5.
ExpressionAtlasi O08688. baseline and differential.
Genevestigatori O08688.

Family and domain databases

Gene3Di 2.60.40.150. 1 hit.
InterProi IPR000008. C2_dom.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
Pfami PF00168. C2. 1 hit.
PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00239. C2. 1 hit.
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution."
    Dear T.N., Matena K., Vingron M., Boehm T.
    Genomics 45:175-184(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily."
    Matena K., Boehm T., Dear N.T.
    Genomics 48:117-120(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASN-427.
  3. Algate P.A.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASN-427.

Entry informationi

Entry nameiCAN5_MOUSE
AccessioniPrimary (citable) accession number: O08688
Secondary accession number(s): Q91YU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: July 1, 1997
Last modified: November 26, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3