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Protein

Calpain-5

Gene

Capn5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calcium-regulated non-lysosomal thiol-protease.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei81By similarity1
Active sitei252By similarity1
Active sitei284By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.22.B25 3474
ReactomeiR-MMU-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.011

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-5 (EC:3.4.22.-)
Alternative name(s):
New calpain 3
Short name:
nCL-3
Gene namesi
Name:Capn5
Synonyms:Ncl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1100859 Capn5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002077141 – 640Calpain-5Add BLAST640

Proteomic databases

EPDiO08688
PaxDbiO08688
PeptideAtlasiO08688
PRIDEiO08688

PTM databases

iPTMnetiO08688
PhosphoSitePlusiO08688
SwissPalmiO08688

Expressioni

Gene expression databases

BgeeiENSMUSG00000035547
CleanExiMM_CAPN5
ExpressionAtlasiO08688 baseline and differential
GenevisibleiO08688 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048183

Structurei

3D structure databases

ProteinModelPortaliO08688
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 343Calpain catalyticPROSITE-ProRule annotationAdd BLAST318
Domaini518 – 619C2Add BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni344 – 496Domain IIIAdd BLAST153

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Phylogenomic databases

eggNOGiKOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232036
HOVERGENiHBG001095
InParanoidiO08688
KOiK08574
OMAiRPKDICE
OrthoDBiEOG091G030A
PhylomeDBiO08688
TreeFamiTF314748

Family and domain databases

CDDicd04046 C2_Calpain, 1 hit
cd00214 Calpain_III, 1 hit
cd00044 CysPc, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR033884 C2_Calpain
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR033883 C2_III
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF49758 SSF49758, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

O08688-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSCAKAYED QNYSALKRAC LRKKVLFEDP LFPATDDSLY YKGTPGPTVR
60 70 80 90 100
WKRPKDICDD PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV
110 120 130 140 150
IPDWKEQEWN PEKPDSYAGI FHFNFWRFGE WVDVIVDDRL PTVNNQLIYC
160 170 180 190 200
HSNSKNEFWC ALVEKAYAKL AGCYQALDGG NTADALVDFT GGVSEPIDLT
210 220 230 240 250
EGDLATDEAK RNQLFERVLK VHSRGGLISA SIKAVTAADM EARLACGLVK
260 270 280 290 300
GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WTGPWSDTSE
310 320 330 340 350
EWQKVSKSER EKMGVTVQDD GEFWMTFEDM CRYFTDIIKC RLINTSYLSI
360 370 380 390 400
HKTWEEARLH GAWTRHEDPQ QNRSGGCINH KDTFFQNPQY VFEVKKPEDE
410 420 430 440 450
VLISIQQRPK RSTRREGKGE NLAIGFDIYK VEENRQYRMH SLQHKAASSI
460 470 480 490 500
YINSRSVFLR TELPEGRYVI IPTTFEPGHT GEFLLRVFTD VPSNCRELRL
510 520 530 540 550
DEPPRTCWSS LCGYPQQVAQ VHVLGAAGLK DSPTGANSYV IIKCEGEKVR
560 570 580 590 600
SAVQRGTSTP EYNVKGIFYR KKLAQPITVQ VWNHRVLKDE FLGQVHLKTA
610 620 630 640
PDDLQDLHTL HLQDRSSRQP SDLPGIVAVR VLCSASLTAV
Length:640
Mass (Da):72,955
Last modified:July 1, 1997 - v1
Checksum:i7F1DA3E299FEC02D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti427D → N2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10656 mRNA Translation: CAA71666.1
U85020 mRNA Translation: AAD00559.1
BC014767 mRNA Translation: AAH14767.1
CCDSiCCDS21465.1
RefSeqiNP_001288179.1, NM_001301250.1
NP_031628.1, NM_007602.4
UniGeneiMm.326847

Genome annotation databases

EnsembliENSMUST00000040971; ENSMUSP00000048183; ENSMUSG00000035547
ENSMUST00000107112; ENSMUSP00000102729; ENSMUSG00000035547
GeneIDi12337
KEGGimmu:12337
UCSCiuc009ikc.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCAN5_MOUSE
AccessioniPrimary (citable) accession number: O08688
Secondary accession number(s): Q91YU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: July 1, 1997
Last modified: April 25, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health