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Protein

Homeobox protein BarH-like 2

Gene

Barx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi139 – 198HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • cartilage condensation Source: MGI
  • myotube differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein BarH-like 2
Gene namesi
Name:Barx2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:109617. Barx2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488391 – 283Homeobox protein BarH-like 2Add BLAST283

Proteomic databases

PaxDbiO08686.
PRIDEiO08686.

PTM databases

iPTMnetiO08686.
PhosphoSitePlusiO08686.

Expressioni

Tissue specificityi

Nervous system, particularly in the telencephalon, spinal cord, and dorsal root ganglia.

Developmental stagei

Highly expressed in small groups of cells undergoing tissue remodeling, such as ectodermal cells within indentations surrounding the eye and maxillo-nasal groove and in the first branchial pouch, lung buds, precartilagenous condensations, and mesenchyme of the limb. At E9.5, expressed only to head, prominent in the region of telencephalon and mesencephalon, and concentrated in cells along the dorsal midline. At E10.5, expression is moderated in the most rostral regions of the head, but particularly prominent in a lateral band of cells in the periocular region. At E11.5, detected in the telencephalon, frontonasal region and limbs. At E12.5, expressed in the telencephalon and hindbrain.

Gene expression databases

BgeeiENSMUSG00000032033.
CleanExiMM_BARX2.
GenevisibleiO08686. MM.

Interactioni

Protein-protein interaction databases

BioGridi198303. 7 interactors.
IntActiO08686. 3 interactors.
STRINGi10090.ENSMUSP00000112314.

Structurei

3D structure databases

ProteinModelPortaliO08686.
SMRiO08686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi103 – 112Poly-Ala10

Sequence similaritiesi

Belongs to the BAR homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00890000139333.
HOGENOMiHOG000231924.
HOVERGENiHBG050665.
InParanoidiO08686.
KOiK09361.
OMAiGQPQELP.
OrthoDBiEOG091G10IN.
PhylomeDBiO08686.
TreeFamiTF350735.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like_sf.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O08686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHCHAELRLS SPGQLKAARR RYKTFMIDEI LSKETCDYFE KLSLYSVCPS
60 70 80 90 100
LVVRPKPLHS CTGSPSLRAY PLLSVITRQP TVISHLVPTG SGLTPVLTRH
110 120 130 140 150
PVAAAEAAAA AAETPGGEAL ASSESETEQP TPRQKKPRRS RTIFTELQLM
160 170 180 190 200
GLEKKFQKQK YLSTPDRLDL AQSLGLTQLQ VKTWYQNRRM KWKKMVLKGG
210 220 230 240 250
QEAPTKPKGR PKKNSIPTSE EIEAEEKMNS QAQSQELLES SERQEEPCDT
260 270 280
QEPKACLVPL EVAEPIHQPQ ELSEASSEPP PLS
Length:283
Mass (Da):31,534
Last modified:July 28, 2009 - v2
Checksum:iBCD8CC756B820953
GO

Sequence cautioni

The sequence AAB53146 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH12684 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73L → P in AAB53146 (PubMed:9122247).Curated1
Sequence conflicti105A → S in AAH12684 (PubMed:15489334).Curated1
Sequence conflicti106E → EA in AAH12684 (PubMed:15489334).Curated1
Sequence conflicti244 – 273Missing in AAB53146 (PubMed:9122247).CuratedAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT030724 Genomic DNA. No translation available.
BC012684 mRNA. Translation: AAH12684.1. Different initiation.
AY188085 Genomic DNA. Translation: AAO25649.1.
L77900 mRNA. Translation: AAB53146.1. Different initiation.
CCDSiCCDS52750.1.
PIRiJC6307.
RefSeqiNP_038828.2. NM_013800.2.
UniGeneiMm.261044.

Genome annotation databases

EnsembliENSMUST00000116615; ENSMUSP00000112314; ENSMUSG00000032033.
GeneIDi12023.
KEGGimmu:12023.
UCSCiuc009oru.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiBARX2_MOUSE
AccessioniPrimary (citable) accession number: O08686
Secondary accession number(s): Q80ZF9, Q921G1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 28, 2009
Last modified: November 22, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families