O08684 (PLD1_CRIGR) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 81.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Phospholipase D1 Short name=PLD 1 EC=3.1.4.4 Alternative name(s): Choline phosphatase 1 Phosphatidylcholine-hydrolyzing phospholipase D1 | ||
| Gene names |
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| Organism | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) | ||
| Taxonomic identifier | 10029 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Cricetidae › Cricetinae › Cricetulus |
Protein attributes
| Sequence length | 1036 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic By similarity. |
| Catalytic activity | A phosphatidylcholine + H2O = choline + a phosphatidate. |
| Enzyme regulation | Stimulated by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42 By similarity. |
| Subunit structure | Interacts with PIP5K1B By similarity. |
| Subcellular location | Cytoplasm › perinuclear region By similarity. Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side By similarity. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side By similarity. Late endosome membrane; Lipid-anchor; Cytoplasmic side By similarity. |
| Sequence similarities | Belongs to the phospholipase D family. Contains 1 PH domain. Contains 2 PLD phosphodiesterase domains. Contains 1 PX (phox homology) domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1036 | 1036 | Phospholipase D1 | PRO_0000218801 | |||||
Regions | |||||||||
| Domain | 81 – 212 | 132 | PX | ||||||
| Domain | 219 – 328 | 110 | PH | ||||||
| Domain | 459 – 486 | 28 | PLD phosphodiesterase 1 | ||||||
| Domain | 853 – 880 | 28 | PLD phosphodiesterase 2 | ||||||
| Region | 463 – 890 | 428 | Catalytic | ||||||
Amino acid modifications | |||||||||
| Modified residue | 591 | 1 | Phosphoserine By similarity | ||||||
| Lipidation | 240 | 1 | S-palmitoyl cysteine By similarity | ||||||
| Lipidation | 241 | 1 | S-palmitoyl cysteine By similarity | ||||||
Sequences
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References
| [1] | Klaus J.R., Baldassare J.J., Raben D.M. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U94995 mRNA. Translation: AAB53631.1. |
| PIR | T18530. |
| RefSeq | NP_001233757.1. NM_001246828.1. |
3D structure databases | |
| ProteinModelPortal | O08684. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 100689404. |
Phylogenomic databases | |
| HOVERGEN | HBG006650. |
Family and domain databases | |
| InterPro | IPR011993. PH_type. IPR001683. Phox. IPR001849. Pleckstrin_homology. IPR015679. PLipase_D. IPR001736. PLipase_D/transphosphatidylase. IPR016555. PLipase_D_euk. [Graphical view] |
| Gene3D | G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:3.30.1520.10. PX. 1 hit. |
| PANTHER | PTHR18896. Phospholipase_D. 1 hit. |
| Pfam | PF00169. PH. 1 hit. PF00614. PLDc. 1 hit. PF00787. PX. 1 hit. [Graphical view] |
| PIRSF | PIRSF009376. Phospholipase_D_euk. 1 hit. |
| SMART | SM00233. PH. 1 hit. SM00155. PLDc. 2 hits. SM00312. PX. 1 hit. [Graphical view] |
| SUPFAM | SSF64268. PX. 1 hit. |
| PROSITE | PS50003. PH_DOMAIN. False negative. PS50035. PLD. 2 hits. PS50195. PX. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PLD1_CRIGR | ||||||||
| Accession | Primary (citable) accession number: O08684 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with