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Reviewed, UniProtKB/Swiss-Prot O08680 (EPHA3_RAT)

Last modified October 13, 2009. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ephrin type-A receptor 3
    EC=2.7.10.1
Alternative name(s):
    Tyrosine-protein kinase receptor REK4
    Tyrosine-protein kinase TYRO4
Gene names
Name: Epha3
Synonyms: Rek4, Tyro4
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Most abundant in the heart, brain and lung.

Induction

Down-regulated by IL1-beta in neonatal cardiac myocytes.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.

Contains 2 fibronectin type-III domains.

Contains 1 protein kinase domain.

Contains 1 SAM (sterile alpha motif) domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 984964Ephrin type-A receptor 3
PRO_0000016804

Regions

Topological domain21 – 541521Extracellular Potential
Transmembrane542 – 56524 Potential
Topological domain566 – 984419Cytoplasmic Potential
Domain325 – 429105Fibronectin type-III 1
Domain437 – 52791Fibronectin type-III 2
Domain622 – 883262Protein kinase
Domain912 – 97665SAM
Nucleotide binding628 – 6369ATP By similarity
Motif982 – 9843PDZ-binding Potential
Compositional bias189 – 322134Cys-rich

Sites

Active site7471Proton acceptor By similarity
Binding site6541ATP By similarity

Amino acid modifications

Modified residue5971Phosphotyrosine; by autocatalysis Potential
Modified residue6031Phosphotyrosine; by autocatalysis Potential
Modified residue7801Phosphotyrosine; by autocatalysis By similarity
Modified residue9381Phosphotyrosine By similarity
Glycosylation2321N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation3911N-linked (GlcNAc...) Potential
Glycosylation4041N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Potential

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Sequences

Sequence LengthMass (Da)Tools
O08680-1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: F170C49312F7A0AB

FASTA984110,228
        10         20         30         40         50         60 
MDCHLSILIL FGCCVLSCSR ELSPQPSNEV NLLDSKTIQG ELGWISYPSH GWEEISGVDE 

        70         80         90        100        110        120 
HYTPIRTYQV CNVMDHSQNN WLRTNWVPRN SAQKIYVELK FTLRDCNSIP LVLGTCKETF 

       130        140        150        160        170        180 
NLYYMESDDD HGVKFLEHQF TKIDTIAADE SFTQMDLGDR ILKLNTEIRE VGPVNKKGFY 

       190        200        210        220        230        240 
LAFQDVGACV ALVSVRVYFK KCPFTVKNLA MFPDTVPMDS QSLVEVRGSC VNNSKEEDPP 

       250        260        270        280        290        300 
RMYCSTEGEW LVPIGKCTCN AGYEERGFIC QACRPGFYKA LDGVAKCTKC PPHSSTQEDG 

       310        320        330        340        350        360 
SMNCRCENNY FRAEKDPPSM ACTRPPSAPR NVISNINETS VILDWSWPLD TGGRKDITFN 

       370        380        390        400        410        420 
IICKKCGWNV RQCEPCSPNV RFLPRQLGLT NTTVTVTDLL AHTNYTFEID AINGVSELSS 

       430        440        450        460        470        480 
PPRQFAAVSI TTNQAAPSPV MTIKKDRTSR NSISLSWQEP EHPNGIILDY EVKYYEKQEQ 

       490        500        510        520        530        540 
ETSYTILRAR GTNVTISSLK PDTTYVFQIR ARTAAGYGTN SRKFEFENSP DSFSISGENS 

       550        560        570        580        590        600 
HVVMIAISAA VAIIVLTVVT YVLVGRFCGY HKSKHSSDEK RLHFGNGHLR LPGLRTYVDP 

       610        620        630        640        650        660 
HTYEDPTQAV HEFAKELDAT NIAIDKVVGA GEFGEVCSGR LKLPSKKEIS VAIKTLKVGY 

       670        680        690        700        710        720 
TEKQRRDFLG EASIMGQFDH PNIIRLEGVV TKSKPVMIVT EYMENGSLDS FLRKHDAQFT 

       730        740        750        760        770        780 
VIQLVGMLRG IASGMKYLSD MGYVHRDLAA RNILINSNLV CKVSDFGLSR VLEDDPEAAY 

       790        800        810        820        830        840 
TTRGGKIPVR WTSPEATAYR KFTSASDVWS YGIVLWEVMS YGERPYWEMS NQDVIKAVDE 

       850        860        870        880        890        900 
GYRLPLPMDC PAALYQLMLD CWQKDRNNRP KFEQIVSILD KLIRNPGSLK IITSAAARPS 

       910        920        930        940        950        960 
NLLLDQSNVD IATFHTTGDW LNGMRTAHCK EIFTGVEYSS CDTIAKISTD DMKKVGVTVV 

       970        980 
GPQKKIISSI KALETQSKNG PVPV

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References

[1]"IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes."
Li Y.Y., McTiernan C.F., Feldman A.M.
Am. J. Physiol. 274:H331-H341(1998) [PubMed: 9458884] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U69278 mRNA. Translation: AAC06273.1.
IPIIPI00194806.
PIRPT0186.
RefSeqNP_113752.1.
UniGeneRn.10713

3D structure databases

HSSPHSSP built from PDB template 1JPA based on UniProtKB P54763.
SMRO08680. Positions 602-900.
ModBaseSearch...

Protein-protein interaction databases

STRINGO08680.

PTM databases

PhosphoSiteO08680.

Genome annotation databases

EnsemblENSRNOT00000040065; ENSRNOP00000043263; ENSRNOG00000030285; Rattus norvegicus. [Genome view]
GeneID29210.
KEGGrno:29210.
UCSCNM_031564. rat.

Organism-specific databases

CTD29210.
RGD68389. Epha3.

Phylogenomic databases

HOVERGENO08680.

Enzyme and pathway databases

BRENDA2.7.10.1. 248.

Gene expression databases

ArrayExpressO08680.
GenevestigatorO08680.
GermOnlineENSRNOG00000030285. Rattus norvegicus.

Family and domain databases

InterProIPR013032. EGF-like_reg_CS.
IPR001090. Ephrin_rcpt_lig-bd.
IPR008957. Fibronectin_typ-III-like_fold.
IPR003961. FN_III.
IPR003962. FnIII_subd.
IPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR001660. SAM.
IPR011510. SAM_2.
IPR013761. SAM_type.
IPR001245. Tyr_pkinase.
IPR008266. Tyr_pkinase_AS.
IPR016257. TyrPK_ephrin_receptor.
IPR001426. YKase_receptorV_CS.
[Graphical view]
Gene3DG3DSA:2.60.40.30. FN_III-like. 2 hits.
G3DSA:1.10.150.50. SAM_type. 1 hit.
PfamPF01404. Ephrin_lbd. 1 hit.
PF00041. fn3. 2 hits.
PF07714. Pkinase_Tyr. 1 hit.
PF07647. SAM_2. 1 hit.
[Graphical view]
PIRSFPIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTSPR00014. FNTYPEIII.
PR00109. TYRKINASE.
ProDomPD001495. Ephrin_receptor. 1 hit.
PD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00615. EPH_lbd. 1 hit.
SM00060. FN3. 2 hits.
SM00454. SAM. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
PROSITEPS01186. EGF_2. 1 hit. Uncertain.
PS50853. FN3. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit.
PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio608380.

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Entry information

Entry nameEPHA3_RAT
AccessionPrimary (citable) accession number: O08680
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: October 13, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents