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O08675

- PAR3_MOUSE

UniProt

O08675 - PAR3_MOUSE

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Protein
Proteinase-activated receptor 3
Gene
F2rl2, Par3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei37 – 382Cleavage; by thrombin By similarity

GO - Molecular functioni

  1. thrombin receptor activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase-activated receptor 3
Short name:
PAR-3
Alternative name(s):
Coagulation factor II receptor-like 2
Thrombin receptor-like 2
Gene namesi
Name:F2rl2
Synonyms:Par3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1298208. F2rl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 9356Extracellular Reviewed prediction
Add
BLAST
Transmembranei94 – 11926Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini120 – 1278Cytoplasmic Reviewed prediction
Transmembranei128 – 14720Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini148 – 16619Extracellular Reviewed prediction
Add
BLAST
Transmembranei167 – 18822Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini189 – 20517Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei206 – 22924Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini230 – 25930Extracellular Reviewed prediction
Add
BLAST
Transmembranei260 – 27920Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini280 – 29617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei297 – 32125Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini322 – 33514Extracellular Reviewed prediction
Add
BLAST
Transmembranei336 – 36025Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini361 – 3699Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Propeptidei20 – 3718Removed for receptor activation By similarity
PRO_0000012758Add
BLAST
Chaini38 – 369332Proteinase-activated receptor 3
PRO_0000012759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi81 – 811N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi165 ↔ 244 By similarity

Post-translational modificationi

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO08675.

PTM databases

PhosphoSiteiO08675.

Expressioni

Gene expression databases

BgeeiO08675.
CleanExiMM_F2RL2.
GenevestigatoriO08675.

Interactioni

Subunit structurei

Interacts with INSC/inscuteable and GPSM2.1 Publication

Protein-protein interaction databases

MINTiMINT-261941.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 543

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PUXX-ray2.00C44-56[»]
ProteinModelPortaliO08675.
SMRiO08675. Positions 85-361.

Miscellaneous databases

EvolutionaryTraceiO08675.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146611.
GeneTreeiENSGT00660000095329.
HOGENOMiHOG000116291.
HOVERGENiHBG105658.
InParanoidiQ3UXV3.
KOiK04235.
OMAiCPEDSIS.
OrthoDBiEOG7QC7WD.
TreeFamiTF330775.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003943. Prot_act_rcpt_3.
IPR003912. Protea_act_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR01429. PROTEASEAR3.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08675-1 [UniParc]FASTAAdd to Basket

« Hide

MKILILVAAG LLFLPVTVCQ SGINVSDNSA KPTLTIKSFN GGPQNTFEEF    50
PLSDIEGWTG ATTTIKAECP EDSISTLHVN NATIGYLRSS LSTQVIPAIY 100
ILLFVVGVPA NIVTLWKLSL RTKSISLVIF HTNLAIADLL FCVTLPFKIA 150
YHLNGNNWVF GEVTCRITTV VFYGNMYCAI LILTCMGINR YLATAHPFTY 200
QKLPKRSFSM LMCGMVWVMV FLYMLPFVIL KQEYHLVHSE ITTCHDVVDA 250
CESPSSFRFY YFVSLAFFGF LIPFVIIIFC YTTLIHKLKS KDRIWLGYIK 300
AVLLILVIFT ICFAPTNIIL VIHHANYYYH NTDSLYFMYL IALCLGSLNS 350
CLDPFLYFVM SKVVDQLNP 369
Length:369
Mass (Da):41,697
Last modified:July 27, 2011 - v2
Checksum:iC8E6B0097F0BF90F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101A → S in AAC53137. 1 Publication
Sequence conflicti110 – 1101A → S in AAI40986. 1 Publication
Sequence conflicti164 – 1641T → M in AAC53137. 1 Publication
Sequence conflicti164 – 1641T → M in AAI40986. 1 Publication
Sequence conflicti210 – 2101M → L in AAC53137. 1 Publication
Sequence conflicti210 – 2101M → L in AAI40986. 1 Publication
Sequence conflicti215 – 2151M → I in AAC53137. 1 Publication
Sequence conflicti215 – 2151M → I in AAI40986. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92972 mRNA. Translation: AAC53137.1.
AK135212 mRNA. Translation: BAE22460.1.
BC140985 mRNA. Translation: AAI40986.1.
CCDSiCCDS26702.1.
RefSeqiNP_034300.3. NM_010170.4.
UniGeneiMm.440952.

Genome annotation databases

EnsembliENSMUST00000022182; ENSMUSP00000022182; ENSMUSG00000021675.
GeneIDi14064.
KEGGimmu:14064.
UCSCiuc007rmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92972 mRNA. Translation: AAC53137.1 .
AK135212 mRNA. Translation: BAE22460.1 .
BC140985 mRNA. Translation: AAI40986.1 .
CCDSi CCDS26702.1.
RefSeqi NP_034300.3. NM_010170.4.
UniGenei Mm.440952.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PUX X-ray 2.00 C 44-56 [» ]
ProteinModelPortali O08675.
SMRi O08675. Positions 85-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-261941.

Chemistry

GuidetoPHARMACOLOGYi 349.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O08675.

Proteomic databases

PRIDEi O08675.

Protocols and materials databases

DNASUi 14064.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022182 ; ENSMUSP00000022182 ; ENSMUSG00000021675 .
GeneIDi 14064.
KEGGi mmu:14064.
UCSCi uc007rmq.1. mouse.

Organism-specific databases

CTDi 2151.
MGIi MGI:1298208. F2rl2.

Phylogenomic databases

eggNOGi NOG146611.
GeneTreei ENSGT00660000095329.
HOGENOMi HOG000116291.
HOVERGENi HBG105658.
InParanoidi Q3UXV3.
KOi K04235.
OMAi CPEDSIS.
OrthoDBi EOG7QC7WD.
TreeFami TF330775.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).

Miscellaneous databases

EvolutionaryTracei O08675.
NextBioi 285040.
PROi O08675.
SOURCEi Search...

Gene expression databases

Bgeei O08675.
CleanExi MM_F2RL2.
Genevestigatori O08675.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003943. Prot_act_rcpt_3.
IPR003912. Protea_act_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR01429. PROTEASEAR3.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protease-activated receptor 3 is a second thrombin receptor in humans."
    Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.-W., Timmons C., Tram T., Coughlin S.R.
    Nature 386:502-506(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Wolffian duct.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin."
    Lechler T., Fuchs E.
    Nature 437:275-280(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INSC AND GPSM2.
    Strain: CD-1.
    Tissue: Epidermis.

Entry informationi

Entry nameiPAR3_MOUSE
AccessioniPrimary (citable) accession number: O08675
Secondary accession number(s): B9EIT2, Q3UXV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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