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O08675

- PAR3_MOUSE

UniProt

O08675 - PAR3_MOUSE

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Protein

Proteinase-activated receptor 3

Gene

F2rl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei37 – 382Cleavage; by thrombinBy similarity

GO - Molecular functioni

  1. thrombin receptor activity Source: InterPro

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).

Names & Taxonomyi

Protein namesi
Recommended name:
Proteinase-activated receptor 3
Short name:
PAR-3
Alternative name(s):
Coagulation factor II receptor-like 2
Thrombin receptor-like 2
Gene namesi
Name:F2rl2
Synonyms:Par3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1298208. F2rl2.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Propeptidei20 – 3718Removed for receptor activationBy similarityPRO_0000012758Add
BLAST
Chaini38 – 369332Proteinase-activated receptor 3PRO_0000012759Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi165 ↔ 244PROSITE-ProRule annotation

Post-translational modificationi

A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiO08675.

PTM databases

PhosphoSiteiO08675.

Expressioni

Gene expression databases

BgeeiO08675.
CleanExiMM_F2RL2.
GenevestigatoriO08675.

Interactioni

Subunit structurei

Interacts with INSC/inscuteable and GPSM2.1 Publication

Protein-protein interaction databases

DIPiDIP-41474N.
MINTiMINT-261941.

Structurei

Secondary structure

1
369
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi52 – 543Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2PUXX-ray2.00C44-56[»]
ProteinModelPortaliO08675.
SMRiO08675. Positions 85-361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO08675.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini38 – 9356ExtracellularSequence AnalysisAdd
BLAST
Topological domaini120 – 1278CytoplasmicSequence Analysis
Topological domaini148 – 16619ExtracellularSequence AnalysisAdd
BLAST
Topological domaini189 – 20517CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini230 – 25930ExtracellularSequence AnalysisAdd
BLAST
Topological domaini280 – 29617CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini322 – 33514ExtracellularSequence AnalysisAdd
BLAST
Topological domaini361 – 3699CytoplasmicSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei94 – 11926Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei128 – 14720Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei167 – 18822Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei206 – 22924Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei260 – 27920Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei297 – 32125Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei336 – 36025Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146611.
GeneTreeiENSGT00760000119001.
HOGENOMiHOG000116291.
HOVERGENiHBG105658.
InParanoidiO08675.
KOiK04235.
OMAiCPEDSIS.
OrthoDBiEOG7QC7WD.
TreeFamiTF330775.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003943. Prot_act_rcpt_3.
IPR003912. Protea_act_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR01429. PROTEASEAR3.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08675-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILILVAAG LLFLPVTVCQ SGINVSDNSA KPTLTIKSFN GGPQNTFEEF
60 70 80 90 100
PLSDIEGWTG ATTTIKAECP EDSISTLHVN NATIGYLRSS LSTQVIPAIY
110 120 130 140 150
ILLFVVGVPA NIVTLWKLSL RTKSISLVIF HTNLAIADLL FCVTLPFKIA
160 170 180 190 200
YHLNGNNWVF GEVTCRITTV VFYGNMYCAI LILTCMGINR YLATAHPFTY
210 220 230 240 250
QKLPKRSFSM LMCGMVWVMV FLYMLPFVIL KQEYHLVHSE ITTCHDVVDA
260 270 280 290 300
CESPSSFRFY YFVSLAFFGF LIPFVIIIFC YTTLIHKLKS KDRIWLGYIK
310 320 330 340 350
AVLLILVIFT ICFAPTNIIL VIHHANYYYH NTDSLYFMYL IALCLGSLNS
360
CLDPFLYFVM SKVVDQLNP
Length:369
Mass (Da):41,697
Last modified:July 27, 2011 - v2
Checksum:iC8E6B0097F0BF90F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti110 – 1101A → S in AAC53137. (PubMed:9087410)Curated
Sequence conflicti110 – 1101A → S in AAI40986. (PubMed:15489334)Curated
Sequence conflicti164 – 1641T → M in AAC53137. (PubMed:9087410)Curated
Sequence conflicti164 – 1641T → M in AAI40986. (PubMed:15489334)Curated
Sequence conflicti210 – 2101M → L in AAC53137. (PubMed:9087410)Curated
Sequence conflicti210 – 2101M → L in AAI40986. (PubMed:15489334)Curated
Sequence conflicti215 – 2151M → I in AAC53137. (PubMed:9087410)Curated
Sequence conflicti215 – 2151M → I in AAI40986. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92972 mRNA. Translation: AAC53137.1.
AK135212 mRNA. Translation: BAE22460.1.
BC140985 mRNA. Translation: AAI40986.1.
CCDSiCCDS26702.1.
RefSeqiNP_034300.3. NM_010170.4.
UniGeneiMm.440952.

Genome annotation databases

EnsembliENSMUST00000022182; ENSMUSP00000022182; ENSMUSG00000021675.
GeneIDi14064.
KEGGimmu:14064.
UCSCiuc007rmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U92972 mRNA. Translation: AAC53137.1 .
AK135212 mRNA. Translation: BAE22460.1 .
BC140985 mRNA. Translation: AAI40986.1 .
CCDSi CCDS26702.1.
RefSeqi NP_034300.3. NM_010170.4.
UniGenei Mm.440952.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2PUX X-ray 2.00 C 44-56 [» ]
ProteinModelPortali O08675.
SMRi O08675. Positions 85-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-41474N.
MINTi MINT-261941.

Chemistry

GuidetoPHARMACOLOGYi 349.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei O08675.

Proteomic databases

PRIDEi O08675.

Protocols and materials databases

DNASUi 14064.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022182 ; ENSMUSP00000022182 ; ENSMUSG00000021675 .
GeneIDi 14064.
KEGGi mmu:14064.
UCSCi uc007rmq.1. mouse.

Organism-specific databases

CTDi 2151.
MGIi MGI:1298208. F2rl2.

Phylogenomic databases

eggNOGi NOG146611.
GeneTreei ENSGT00760000119001.
HOGENOMi HOG000116291.
HOVERGENi HBG105658.
InParanoidi O08675.
KOi K04235.
OMAi CPEDSIS.
OrthoDBi EOG7QC7WD.
TreeFami TF330775.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_220322. Thrombin signalling through proteinase activated receptors (PARs).

Miscellaneous databases

EvolutionaryTracei O08675.
NextBioi 285040.
PROi O08675.
SOURCEi Search...

Gene expression databases

Bgeei O08675.
CleanExi MM_F2RL2.
Genevestigatori O08675.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003943. Prot_act_rcpt_3.
IPR003912. Protea_act_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01428. PROTEASEAR.
PR01429. PROTEASEAR3.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Protease-activated receptor 3 is a second thrombin receptor in humans."
    Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.-W., Timmons C., Tram T., Coughlin S.R.
    Nature 386:502-506(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Wolffian duct.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin."
    Lechler T., Fuchs E.
    Nature 437:275-280(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INSC AND GPSM2.
    Strain: CD-1.
    Tissue: Epidermis.

Entry informationi

Entry nameiPAR3_MOUSE
AccessioniPrimary (citable) accession number: O08675
Secondary accession number(s): B9EIT2, Q3UXV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3