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Protein

Kinesin-like protein KIFC2

Gene

Kifc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi486 – 4938ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIFC2
Gene namesi
Name:Kifc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109187. Kifc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 792792Kinesin-like protein KIFC2PRO_0000125430Add
BLAST

Proteomic databases

PaxDbiO08672.
PRIDEiO08672.

PTM databases

iPTMnetiO08672.
PhosphoSiteiO08672.

Expressioni

Tissue specificityi

Present in axons and dendrites of neurons in the central and peripheral nervous systems.

Gene expression databases

CleanExiMM_KIFC2.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004294.

Structurei

3D structure databases

ProteinModelPortaliO08672.
SMRiO08672. Positions 409-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini409 – 732324Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili186 – 347162Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi280 – 33253Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000113226.
HOVERGENiHBG052258.
InParanoidiO08672.
PhylomeDBiO08672.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAFYSLLIY IFYSLFRRDG GAAAVSDPGD PTQKSGGQPR GRRRPDQFTS
60 70 80 90 100
ELWSELNSLA GCSESEDGQK GAEGGAAEVS LEEALMRLAE FLSVQLGAEE
110 120 130 140 150
SCGTTPDLGK PGEVPPLLTV TSQLLALLAW TRSPRGRQAL LQGTQPTCPV
160 170 180 190 200
QPSTLDGSLS QEESSSQPTP ILDEVPRDET QEHQPLQLEE EQRVWQRLEQ
210 220 230 240 250
LILGQLEELR QQLEQQEEEL SRLRLGVGVT DSEKRVQHLT LENEALKQSL
260 270 280 290 300
SLTRDLLLHW GPGPLPRLSQ EEAGALLELQ GQLQEAQDTT EALRVQLGAQ
310 320 330 340 350
ELQLQGLRGA LRQLQQETEQ NCRQELQQVH GQLAGLRARM ASLRQGCGDL
360 370 380 390 400
RGLVSTFTQS CQGSLSEAQG QVSWALGALS AGKAKTQLSE GNQAPPTGCS
410 420 430 440 450
GRLLELKGNI RVLCRLRPAE GQPSSLVSVE PGQGGTITTC YRGRQHCFRL
460 470 480 490 500
DWVFPQDASQ EEVFRQLEPA VLSCLQGYSV CIFTYGQTGT GKTYSMEGPP
510 520 530 540 550
EDPGIAPRAL QLLFREMGTG GHHHVTLSMV EIYNEAVRDL LATGPPERLV
560 570 580 590 600
VRQGPAGQGG IQVAGLTHWD VPNLETLHQM LSLGRSNRAT AATVMNQHSS
610 620 630 640 650
RSHALVTLTL RAASPPRPQG ITGTLHLVDL AGSERVWKAG VASPVQRDPN
660 670 680 690 700
GARRLREAQA INRSLLALGG VMAALRARRP HVPFRDSQLT RLLQPALWAG
710 720 730 740 750
TTAVLLLQIS TRAEDLGETI CSLKFAERVG QVELGPARRR RAPRSGTPSS
760 770 780 790
LSTDTPLTGT SCTPTPSPGS PPSTSPNSCS GLTLEPPGDP PP
Length:792
Mass (Da):85,686
Last modified:July 1, 1997 - v1
Checksum:iF8616F929B1613B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti447 – 4471C → R in AAB51397 (PubMed:9115737).Curated
Sequence conflicti618 – 6181P → A in AAB51397 (PubMed:9115737).Curated
Sequence conflicti698 – 6981W → C in AAB51397 (PubMed:9115737).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49545 mRNA. Translation: BAA19677.1.
U92949 mRNA. Translation: AAB51397.1.
CCDSiCCDS27583.1.
UniGeneiMm.378950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49545 mRNA. Translation: BAA19677.1.
U92949 mRNA. Translation: AAB51397.1.
CCDSiCCDS27583.1.
UniGeneiMm.378950.

3D structure databases

ProteinModelPortaliO08672.
SMRiO08672. Positions 409-729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004294.

PTM databases

iPTMnetiO08672.
PhosphoSiteiO08672.

Proteomic databases

PaxDbiO08672.
PRIDEiO08672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109187. Kifc2.

Phylogenomic databases

eggNOGiKOG0239. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000113226.
HOVERGENiHBG052258.
InParanoidiO08672.
PhylomeDBiO08672.

Miscellaneous databases

PROiO08672.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KIFC2.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 3 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles."
    Saito N., Okada Y., Noda Y., Kinoshita Y., Kondo S., Hirokawa N.
    Neuron 18:425-438(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Brain.
  2. "Characterization of KIFC2, a neuronal kinesin superfamily member in mouse."
    Hanlon D.W., Yang Z., Goldstein L.S.
    Neuron 18:439-451(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiKIFC2_MOUSE
AccessioniPrimary (citable) accession number: O08672
Secondary accession number(s): O08613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: July 1, 1997
Last modified: July 6, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.