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Protein

B-cell CLL/lymphoma 7 protein family member C

Gene

Bcl7c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play an anti-apoptotic role.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member C
Alternative name(s):
B-cell chronic lymphocytic leukemia/lymphoma 7C protein
Gene namesi
Name:Bcl7c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1332237. Bcl7c.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398341 – 217B-cell CLL/lymphoma 7 protein family member CAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei100PhosphoserineCombined sources1
Modified residuei103PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei118PhosphothreonineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO08664.
MaxQBiO08664.
PaxDbiO08664.
PeptideAtlasiO08664.
PRIDEiO08664.

PTM databases

iPTMnetiO08664.
PhosphoSitePlusiO08664.

Expressioni

Inductioni

Down-regulated by IL-10 in a malignant cell line derived from a murine model for chronic lymphocytic leukemia.1 Publication

Gene expression databases

BgeeiENSMUSG00000030814.
CleanExiMM_BCL7C.
ExpressionAtlasiO08664. baseline and differential.
GenevisibleiO08664. MM.

Interactioni

Protein-protein interaction databases

BioGridi198329. 20 interactors.
IntActiO08664. 20 interactors.
MINTiMINT-4104557.
STRINGi10090.ENSMUSP00000057937.

Structurei

3D structure databases

ProteinModelPortaliO08664.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi113 – 217Pro-richAdd BLAST105

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiO08664.
OMAiKRICPDA.
OrthoDBiEOG091G0T7O.
PhylomeDBiO08664.
TreeFamiTF317441.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08664-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRTVRAET RSRAKDDIKK VMATIEKVRR WEKRWVTVGD TSLRIFKWVP
60 70 80 90 100
VVDPQEEERR RAGGGAERSR GRERRGRGTS PRGGGPLILL DLNDENSNQS
110 120 130 140 150
FHSEGSLQKG AEPSPGGTPQ PSRPGSPTGP PEVITEDTQP PQLGQERDPG
160 170 180 190 200
GTPAGGTDEP PKLTKEEPVP ELLEAEAPEA YPVFEPVPSV PEAAQGDTED
210
SEGAPPLKRI CPNAPDP
Length:217
Mass (Da):23,445
Last modified:July 1, 1997 - v1
Checksum:i478660AE7C9E8592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11905 mRNA. Translation: CAA72656.1.
AK131935 mRNA. Translation: BAE20884.1.
BC002252 mRNA. Translation: AAH02252.1.
BC005673 mRNA. Translation: AAH05673.1.
BC058530 mRNA. Translation: AAH58530.1.
CCDSiCCDS21874.1.
RefSeqiNP_033876.1. NM_009746.2.
UniGeneiMm.89667.

Genome annotation databases

EnsembliENSMUST00000061468; ENSMUSP00000057937; ENSMUSG00000030814.
GeneIDi12055.
KEGGimmu:12055.
UCSCiuc009jwl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y11905 mRNA. Translation: CAA72656.1.
AK131935 mRNA. Translation: BAE20884.1.
BC002252 mRNA. Translation: AAH02252.1.
BC005673 mRNA. Translation: AAH05673.1.
BC058530 mRNA. Translation: AAH58530.1.
CCDSiCCDS21874.1.
RefSeqiNP_033876.1. NM_009746.2.
UniGeneiMm.89667.

3D structure databases

ProteinModelPortaliO08664.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198329. 20 interactors.
IntActiO08664. 20 interactors.
MINTiMINT-4104557.
STRINGi10090.ENSMUSP00000057937.

PTM databases

iPTMnetiO08664.
PhosphoSitePlusiO08664.

Proteomic databases

EPDiO08664.
MaxQBiO08664.
PaxDbiO08664.
PeptideAtlasiO08664.
PRIDEiO08664.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061468; ENSMUSP00000057937; ENSMUSG00000030814.
GeneIDi12055.
KEGGimmu:12055.
UCSCiuc009jwl.1. mouse.

Organism-specific databases

CTDi9274.
MGIiMGI:1332237. Bcl7c.

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiO08664.
OMAiKRICPDA.
OrthoDBiEOG091G0T7O.
PhylomeDBiO08664.
TreeFamiTF317441.

Miscellaneous databases

ChiTaRSiBcl7c. mouse.
PROiO08664.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030814.
CleanExiMM_BCL7C.
ExpressionAtlasiO08664. baseline and differential.
GenevisibleiO08664. MM.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCL7C_MOUSE
AccessioniPrimary (citable) accession number: O08664
Secondary accession number(s): Q99LS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.