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Protein

Nuclear pore complex protein Nup88

Gene

Nup88

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of nuclear pore complex.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-191859. snRNP Assembly.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear pore complex protein Nup88
Alternative name(s):
88 kDa nucleoporin
Nucleoporin Nup84
Nucleoporin Nup88
Gene namesi
Name:Nup88
Synonyms:Nup84
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620182. Nup88.

Subcellular locationi

GO - Cellular componenti

  • nuclear pore Source: RGD
  • nucleoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002048892 – 742Nuclear pore complex protein Nup88Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei35PhosphoserineBy similarity1
Modified residuei380PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei518PhosphoserineCombined sources1
Modified residuei541PhosphoserineBy similarity1
Modified residuei699PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO08658.
PRIDEiO08658.

PTM databases

iPTMnetiO08658.
PhosphoSitePlusiO08658.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006126.
GenevisibleiO08658. RN.

Interactioni

Subunit structurei

Interacts with NUP214/CAN.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009015.

Structurei

3D structure databases

ProteinModelPortaliO08658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili597 – 652Sequence analysisAdd BLAST56

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4460. Eukaryota.
ENOG410YC30. LUCA.
GeneTreeiENSGT00390000015063.
HOGENOMiHOG000234330.
HOVERGENiHBG052700.
InParanoidiO08658.
KOiK14318.
OMAiAWYPSEI.
OrthoDBiEOG091G0O97.
PhylomeDBiO08658.

Family and domain databases

InterProiIPR019321. Nucleoporin_Nup88.
[Graphical view]
PfamiPF10168. Nup88. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAGPVGD GELWQSWLPN HVVFLRLREG LKNQSPAEAD KPATSTSPSC
60 70 80 90 100
PPLPPHLPTR NLVFGLGGEL FLWDAEGSAF LVVRLRGPSG GSVEPPLSQY
110 120 130 140 150
QRLLCINPPL FEIHQVLLSP TQHHVALIGT KGLMALELPQ RWGKDSEFEG
160 170 180 190 200
GKATVNCSTI PIAERFFTSS TSLTLKHAAW YPSEMLDPHI VLLTSDNVIR
210 220 230 240 250
IYSLREPQTP TKVIVLSEAE EESLILNKGR AYTASLGETA VAFDFGPLVT
260 270 280 290 300
VSKNMFEQKD REAVAYPLYI LYENGETFLT YVSLLHSPGN IGKLLGPLPM
310 320 330 340 350
HPAAEDNYGY DACAILCLPC VPNILVIATE SGMLYHCVVL EGEEDDDQTL
360 370 380 390 400
EKSWDPRADL IPSLYVFECV ELELALKLAS AEDDPFASDF SCPIKLHRDP
410 420 430 440 450
KCPSRYHCSH EAGVHSVGLT WIHKLHKFLG SDEEDKDSLQ ELTAEQKCFV
460 470 480 490 500
EHILCTKPLP CRQPAPIRGF WIVPDILGPT MICITSTYEC LIRPLLSTVH
510 520 530 540 550
PASPPLLCTR EDAGVAESPL RILAEAPDSF EKHIKRILQR SAANPALLKS
560 570 580 590 600
SEKDLAPPPE ECLQLISRAT QVFREQYILK QDLAKEEIQR RVKLLCDQKR
610 620 630 640 650
KQLEDLNYCR EERKSLREMA ERLADKYEEA KEKQEDIMNR MKKVLHSFHT
660 670 680 690 700
QLPVLSDSER DMKKELQLIP DQLRHLGNAI KQVTMKKDYQ QRKMEKVLSP
710 720 730 740
QKPTITLSAY QRKCIQSILK EEGEHIREMV KQINDIRNHV NF
Length:742
Mass (Da):83,585
Last modified:July 1, 1997 - v1
Checksum:iE2C38D0DCEFFB3D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93692 mRNA. Translation: AAB52419.1.
BC072524 mRNA. Translation: AAH72524.1.
RefSeqiNP_446068.1. NM_053616.1.
UniGeneiRn.11042.

Genome annotation databases

EnsembliENSRNOT00000009015; ENSRNOP00000009015; ENSRNOG00000006126.
GeneIDi113929.
KEGGirno:113929.
UCSCiRGD:620182. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93692 mRNA. Translation: AAB52419.1.
BC072524 mRNA. Translation: AAH72524.1.
RefSeqiNP_446068.1. NM_053616.1.
UniGeneiRn.11042.

3D structure databases

ProteinModelPortaliO08658.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009015.

PTM databases

iPTMnetiO08658.
PhosphoSitePlusiO08658.

Proteomic databases

PaxDbiO08658.
PRIDEiO08658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009015; ENSRNOP00000009015; ENSRNOG00000006126.
GeneIDi113929.
KEGGirno:113929.
UCSCiRGD:620182. rat.

Organism-specific databases

CTDi4927.
RGDi620182. Nup88.

Phylogenomic databases

eggNOGiKOG4460. Eukaryota.
ENOG410YC30. LUCA.
GeneTreeiENSGT00390000015063.
HOGENOMiHOG000234330.
HOVERGENiHBG052700.
InParanoidiO08658.
KOiK14318.
OMAiAWYPSEI.
OrthoDBiEOG091G0O97.
PhylomeDBiO08658.

Enzyme and pathway databases

ReactomeiR-RNO-159236. Transport of Mature mRNA derived from an Intron-Containing Transcript.
R-RNO-170822. Regulation of Glucokinase by Glucokinase Regulatory Protein.
R-RNO-191859. snRNP Assembly.
R-RNO-3108214. SUMOylation of DNA damage response and repair proteins.
R-RNO-3301854. Nuclear Pore Complex (NPC) Disassembly.
R-RNO-3371453. Regulation of HSF1-mediated heat shock response.
R-RNO-4570464. SUMOylation of RNA binding proteins.
R-RNO-4615885. SUMOylation of DNA replication proteins.
R-RNO-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiO08658.

Gene expression databases

BgeeiENSRNOG00000006126.
GenevisibleiO08658. RN.

Family and domain databases

InterProiIPR019321. Nucleoporin_Nup88.
[Graphical view]
PfamiPF10168. Nup88. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNUP88_RAT
AccessioniPrimary (citable) accession number: O08658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: July 1, 1997
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.