O08656 (HXA1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A1

Gene names

Name:

Hoxa1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Labial subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Homeobox protein Hox-A1		PRO_0000200032
Regions
	DNA binding	227 – 286	60	Homeobox
	Motif	203 – 208	6	Antp-type hexapeptide
	Compositional bias	65 – 73	9	Poly-His
	Compositional bias	141 – 145	5	Poly-His
	Compositional bias	312 – 317	6	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	O08656 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 54BB793C378E22E1	FASTA	333	36,124
	10 20 30 40 50 60 MDNARLNSFL EYPILGSGDS GTCSARVYSS DHGITTFQSC AVSANSCGGD DRFLGGRGVQ 70 80 90 100 110 120 ITSPHHHHHH HHHPQPATYQ TSGNLGVSYS HSSCGPSYGA QNFSAPYGPY GLNQEADVSG 130 140 150 160 170 180 GYPPCAPAVY SGNLSSPMVQ HHHHHQGYAG GTVGSPQYIH HSYGQEHQSL ALATYNNSLS 190 200 210 220 230 240 PLHASHQEAC RSPASETSSP AQTFDWMKVK RNPPKTGKVG EYGYVGQPNA VRTNFTTKQL 250 260 270 280 290 300 TELEKEFHFN KYLTRARSEI AASLQLNETQ VKIWFQNRRM KQKKREKEGL LPMSPATPPG 310 320 330 SDEKTEESSE KSSSSPSAPS PASSTSDTLT TSH

References

[1]	Cook T., Urrutia R. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U93092 mRNA. Translation: AAB51399.1.
IPI	IPI00324676.
RefSeq	NP_037207.1. NM_013075.1.
UniGene	Rn.9780.
3D structure databases
ProteinModelPortal	O08656.
SMR	O08656. Positions 201-288.
ModBase	Search...
Protein-protein interaction databases
STRING	O08656.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	25607.
KEGG	rno:25607.
UCSC	NM_013075. rat.
Organism-specific databases
CTD	3198.
RGD	2812. Hoxa1.
Phylogenomic databases
eggNOG	roNOG13691.
GeneTree	ENSGT00600000084339.
HOVERGEN	HBG006089.
InParanoid	O08656.
OrthoDB	EOG47H5QN.
Gene expression databases
ArrayExpress	O08656.
Genevestigator	O08656.
GermOnline	ENSRNOG00000005628. Rattus norvegicus.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09301.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. False negative. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607335.

Entry information

Entry name

HXA1_RAT

Accession

Primary (citable) accession number: O08656

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	July 1, 1997
Last modified:	December 14, 2011
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program