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Protein

Homeobox protein Hox-A1

Gene

Hoxa1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi227 – 286HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A1
Gene namesi
Name:Hoxa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi11414885 Hoxa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000321 – 333Homeobox protein Hox-A1Add BLAST333

Proteomic databases

PaxDbiO08656
PRIDEiO08656

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065040

Structurei

3D structure databases

ProteinModelPortaliO08656
SMRiO08656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi203 – 208Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi65 – 73Poly-His9
Compositional biasi141 – 145Poly-His5
Compositional biasi312 – 317Poly-Ser6

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
HOGENOMiHOG000247020
HOVERGENiHBG006089
InParanoidiO08656
PhylomeDBiO08656

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O08656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNARLNSFL EYPILGSGDS GTCSARVYSS DHGITTFQSC AVSANSCGGD
60 70 80 90 100
DRFLGGRGVQ ITSPHHHHHH HHHPQPATYQ TSGNLGVSYS HSSCGPSYGA
110 120 130 140 150
QNFSAPYGPY GLNQEADVSG GYPPCAPAVY SGNLSSPMVQ HHHHHQGYAG
160 170 180 190 200
GTVGSPQYIH HSYGQEHQSL ALATYNNSLS PLHASHQEAC RSPASETSSP
210 220 230 240 250
AQTFDWMKVK RNPPKTGKVG EYGYVGQPNA VRTNFTTKQL TELEKEFHFN
260 270 280 290 300
KYLTRARSEI AASLQLNETQ VKIWFQNRRM KQKKREKEGL LPMSPATPPG
310 320 330
SDEKTEESSE KSSSSPSAPS PASSTSDTLT TSH
Length:333
Mass (Da):36,124
Last modified:July 1, 1997 - v1
Checksum:i54BB793C378E22E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93092 mRNA Translation: AAB51399.1
UniGeneiRn.228589
Rn.9780

Genome annotation databases

UCSCiRGD:2812 rat

Similar proteinsi

Entry informationi

Entry nameiHXA1_RAT
AccessioniPrimary (citable) accession number: O08656
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health