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O08656 (HXA1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A1
Gene names
Name:Hoxa1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family. Labial subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Homeobox protein Hox-A1
PRO_0000200032

Regions

DNA binding227 – 28660Homeobox
Motif203 – 2086Antp-type hexapeptide
Compositional bias65 – 739Poly-His
Compositional bias141 – 1455Poly-His
Compositional bias312 – 3176Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
O08656 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 54BB793C378E22E1

FASTA33336,124
        10         20         30         40         50         60 
MDNARLNSFL EYPILGSGDS GTCSARVYSS DHGITTFQSC AVSANSCGGD DRFLGGRGVQ 

        70         80         90        100        110        120 
ITSPHHHHHH HHHPQPATYQ TSGNLGVSYS HSSCGPSYGA QNFSAPYGPY GLNQEADVSG 

       130        140        150        160        170        180 
GYPPCAPAVY SGNLSSPMVQ HHHHHQGYAG GTVGSPQYIH HSYGQEHQSL ALATYNNSLS 

       190        200        210        220        230        240 
PLHASHQEAC RSPASETSSP AQTFDWMKVK RNPPKTGKVG EYGYVGQPNA VRTNFTTKQL 

       250        260        270        280        290        300 
TELEKEFHFN KYLTRARSEI AASLQLNETQ VKIWFQNRRM KQKKREKEGL LPMSPATPPG 

       310        320        330 
SDEKTEESSE KSSSSPSAPS PASSTSDTLT TSH 

« Hide

References

[1]Cook T., Urrutia R.
Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U93092 mRNA. Translation: AAB51399.1.
RefSeqNP_037207.1. NM_013075.1.
UniGeneRn.228589.
Rn.9780.

3D structure databases

ProteinModelPortalO08656.
SMRO08656. Positions 201-288.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007807.

Proteomic databases

PaxDbO08656.
PRIDEO08656.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25607.
KEGGrno:25607.
UCSCRGD:2812. rat.

Organism-specific databases

CTD3198.
RGD2812. Hoxa1.

Phylogenomic databases

eggNOGNOG236971.
HOGENOMHOG000247020.
HOVERGENHBG006089.
InParanoidO08656.
KOK09301.
PhylomeDBO08656.

Gene expression databases

GenevestigatorO08656.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607335.

Entry information

Entry nameHXA1_RAT
AccessionPrimary (citable) accession number: O08656
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries