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Protein

Homeobox protein Hox-A1

Gene

Hoxa1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi227 – 28660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A1
Gene namesi
Name:Hoxa1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2812. Hoxa1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 333333Homeobox protein Hox-A1PRO_0000200032Add
BLAST

Proteomic databases

PaxDbiO08656.
PRIDEiO08656.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065040.

Structurei

3D structure databases

ProteinModelPortaliO08656.
SMRiO08656. Positions 201-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi203 – 2086Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi65 – 739Poly-His
Compositional biasi141 – 1455Poly-His
Compositional biasi312 – 3176Poly-Ser

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiO08656.
PhylomeDBiO08656.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08656-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNARLNSFL EYPILGSGDS GTCSARVYSS DHGITTFQSC AVSANSCGGD
60 70 80 90 100
DRFLGGRGVQ ITSPHHHHHH HHHPQPATYQ TSGNLGVSYS HSSCGPSYGA
110 120 130 140 150
QNFSAPYGPY GLNQEADVSG GYPPCAPAVY SGNLSSPMVQ HHHHHQGYAG
160 170 180 190 200
GTVGSPQYIH HSYGQEHQSL ALATYNNSLS PLHASHQEAC RSPASETSSP
210 220 230 240 250
AQTFDWMKVK RNPPKTGKVG EYGYVGQPNA VRTNFTTKQL TELEKEFHFN
260 270 280 290 300
KYLTRARSEI AASLQLNETQ VKIWFQNRRM KQKKREKEGL LPMSPATPPG
310 320 330
SDEKTEESSE KSSSSPSAPS PASSTSDTLT TSH
Length:333
Mass (Da):36,124
Last modified:July 1, 1997 - v1
Checksum:i54BB793C378E22E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93092 mRNA. Translation: AAB51399.1.
UniGeneiRn.228589.
Rn.9780.

Genome annotation databases

UCSCiRGD:2812. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93092 mRNA. Translation: AAB51399.1.
UniGeneiRn.228589.
Rn.9780.

3D structure databases

ProteinModelPortaliO08656.
SMRiO08656. Positions 201-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065040.

Proteomic databases

PaxDbiO08656.
PRIDEiO08656.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2812. rat.

Organism-specific databases

RGDi2812. Hoxa1.

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiO08656.
PhylomeDBiO08656.

Miscellaneous databases

PROiO08656.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXA1_RAT
AccessioniPrimary (citable) accession number: O08656
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: July 1, 1997
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.