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Protein

Telomerase protein component 1

Gene

Tep1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults particle, a multi-subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle. Binds to TERC (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1181 – 1188ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • RNA-dependent DNA biosynthetic process Source: BHF-UCL
  • telomere maintenance via recombination Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Telomerase protein component 1
Short name:
rTLP1
Alternative name(s):
Telomerase-associated protein 1
Short name:
Telomerase protein 1
p230
p240
p80 telomerase homolog
Gene namesi
Name:Tep1
Synonyms:Tlp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3869. Tep1.

Subcellular locationi

GO - Cellular componenti

  • chromosome, telomeric region Source: UniProtKB-SubCell
  • intracellular ribonucleoprotein complex Source: RGD
  • nuclear matrix Source: GO_Central
  • telomerase holoenzyme complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509841 – 2629Telomerase protein component 1Add BLAST2629

Proteomic databases

PaxDbiO08653.
PRIDEiO08653.

PTM databases

iPTMnetiO08653.
PhosphoSitePlusiO08653.

Interactioni

Subunit structurei

Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Component of the vault ribonucleoprotein particle, at least composed of MVP, PARP4 and one or more vault RNAs (vRNAs). Binds to VAULTRC1, VAULTRC2 and VAULTRC4/hvg4 vRNAs (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012235.

Structurei

3D structure databases

ProteinModelPortaliO08653.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 30TEP1 N-terminal 1PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati31 – 60TEP1 N-terminal 2PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati61 – 90TEP1 N-terminal 3PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati91 – 120TEP1 N-terminal 4PROSITE-ProRule annotation1 PublicationAdd BLAST30
Domaini231 – 689TROVEPROSITE-ProRule annotationAdd BLAST459
Domaini1175 – 1582NACHTPROSITE-ProRule annotationAdd BLAST408
Repeati1424 – 1461WD 1PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati1685 – 1724WD 2PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1727 – 1765WD 3PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati1768 – 1807WD 4PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1809 – 1848WD 5PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1851 – 1890WD 6PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1893 – 1934WD 7PROSITE-ProRule annotation1 PublicationAdd BLAST42
Repeati1936 – 1975WD 8PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati1978 – 2016WD 9PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati2019 – 2058WD 10PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati2070 – 2109WD 11PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati2116 – 2154WD 12PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati2157 – 2194WD 13PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati2200 – 2244WD 14PROSITE-ProRule annotation1 PublicationAdd BLAST45
Repeati2247 – 2285WD 15PROSITE-ProRule annotation1 PublicationAdd BLAST39
Repeati2288 – 2327WD 16PROSITE-ProRule annotation1 PublicationAdd BLAST40
Repeati2329 – 2365WD 17PROSITE-ProRule annotation1 PublicationAdd BLAST37
Repeati2378 – 2427WD 18PROSITE-ProRule annotation1 PublicationAdd BLAST50
Repeati2470 – 2510WD 19PROSITE-ProRule annotation1 PublicationAdd BLAST41
Repeati2555 – 2592WD 20PROSITE-ProRule annotation1 PublicationAdd BLAST38
Repeati2594 – 2628WD 21PROSITE-ProRule annotation1 PublicationAdd BLAST35

Sequence similaritiesi

Contains 1 NACHT domain.PROSITE-ProRule annotation
Contains 4 TEP1 N-terminal repeats.PROSITE-ProRule annotation
Contains 1 TROVE domain.PROSITE-ProRule annotation
Contains 21 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG3602. Eukaryota.
KOG4155. Eukaryota.
ENOG410ZWBB. LUCA.
HOGENOMiHOG000154545.
HOVERGENiHBG059633.
InParanoidiO08653.
KOiK11127.
PhylomeDBiO08653.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR025139. DUF4062.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
IPR008850. TEP1_N.
IPR008858. TROVE_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13271. DUF4062. 1 hit.
PF05386. TEP1_N. 4 hits.
PF05731. TROVE. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 16 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
PS51226. TEP1_N. 4 hits.
PS50988. TROVE. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08653-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLCGYVPV HPDILSLKNR CLTMLSDIQP LEKIHGQRSV NPDILSLENR
60 70 80 90 100
CLTLLPDLQP MEKIHGQRSV HPDILSSENR CLTLLPDLQS LEKLCGHMSS
110 120 130 140 150
HPDVLSLENR CLATLPTVKR TVSSGPLLQC LHRSHTAQAD LRDPNFRNCL
160 170 180 190 200
FPEPPTIEAP CFLKELDLPT GPRALKSMSA TARVQEVALG QRCVSEGKEL
210 220 230 240 250
QEEKESAEVP MPLYSLSLGG EEEEVVGAPV LKLTSGDSDS HPETTDQILQ
260 270 280 290 300
EKKMALLTLL CSAMASSVNV KDASDPTRAS IHEVCSALAP LEPEFILKAS
310 320 330 340 350
LYARQQLNLR DIANIVLAVA ALLPACRPHV RRYYSAIVHL PSDWIQVAEF
360 370 380 390 400
YQSLAEGDEK KLVPLPACLR AAMTDKFAQF DEYQLAKYNP RKHRSKTRSR
410 420 430 440 450
QPPRPQRTKP PFSESGKCFP KSVWPLKNEQ ISFEAAYNAV SEKKRLPRFT
460 470 480 490 500
LKKLVEQLHI HEPAQHVQAL LGYRYPSTLE LFSRSHLPGP WDSSRAGQRM
510 520 530 540 550
KLQRPETWER ELSLRGNRAS VWEELIDNGK LPFMAMLRNL CNLLRTGISA
560 570 580 590 600
HHHELVLQRL QHEKSVIHSR QFPFRFLNAH DSLDRLEAQL RSKASPFPSN
610 620 630 640 650
TTLMKRIMIR NSKKIKRPAN PRYLCTLTQR QLRAAMAIPV MYEHLKREKL
660 670 680 690 700
RLHKARQWTC DLELLERYRQ ALETAVNISV KHNLPPLPGR TLLVYLTDAN
710 720 730 740 750
ANRLCPKSHL QGPPLNYVLL LIGMMMARAE QTTVWLCGTG TVKTPVLTAD
760 770 780 790 800
EGILKTAIKL QAQVQELEEN DEWPLETFEK YLLSLAVRRT PIDRVILFGQ
810 820 830 840 850
RMDTELLNVA KQIIWQHVNS KCLFVSVLLR KMQYMSPNLN PNDVTLSGCT
860 870 880 890 900
DGILKFIAEH GASRLLEHVG QLDKIFKIPP PPGKTKVSPL RPLEENNPGP
910 920 930 940 950
FVPISQHGWR NIRLFISSTF RDMHGERDLL MRSVLPALQA RAFPHRISLH
960 970 980 990 1000
AIDLRWGITE EETRRNRQLE VCLGEVENSQ LFVGILGSRY GYTPPSYDLP
1010 1020 1030 1040 1050
DHPHFHWTQR YPSGRSVTEM EVMQFLNRGQ RSEPSDQALI YFRDPGFLSS
1060 1070 1080 1090 1100
VPDVWKPDFI SESEEAAHRV SELKRFLQEQ KEVTCRRYSC EWGGVAAGRP
1110 1120 1130 1140 1150
YTGGLEEFGQ LVLQDVWSVI QKRYLQPGAQ LEQPGSISEE DLIQASFQQL
1160 1170 1180 1190 1200
KSPPSPARPR LLQDTVQQLM LPHGRLSLVI GQAGQGKTAF LASLVSALKV
1210 1220 1230 1240 1250
PDQPNVAPFV FFHFSAARPD QCLAFNLLRR LCTHLHQKLG EPSALPSTYR
1260 1270 1280 1290 1300
GLVWELQQKL LLKSAQWLQP GQTLVLIIDG ADKLVDHNGQ LISDWIPKSL
1310 1320 1330 1340 1350
PRRVHLVLSV SSDSGLGETL QQSQSAYVVA LGSLVPSSRA QLVREELALY
1360 1370 1380 1390 1400
GKRLEESPFN NQMRLLLAKQ GSSLPLYLHL VTDYLRLFTL YEQVSERLRT
1410 1420 1430 1440 1450
LPATLPLLLQ HILSTLEQEH GHNVLPQALT ALEVTHSGLT VDQLHAVLST
1460 1470 1480 1490 1500
WLTLPKETKS WEEAVAASHS GNLYPLAPFA YLVQSLRSLL GEGPVERPGA
1510 1520 1530 1540 1550
RLCLSDGPLR TAVKRRYGKR LGLEKTAHVL IAAHLWKMCD PDASGTFRSC
1560 1570 1580 1590 1600
PPEALKDLPY HLLQSGNHGL LAKFLTNLHV VAAYLEVGLV PDLLEAYELY
1610 1620 1630 1640 1650
ASSKPEVNQK LPEADVAVFH NFLKQQASLL TQYPLLLLQQ AASQPEESPV
1660 1670 1680 1690 1700
CCQAPLLTQR WHNQCILKWI NKPQTLKGQQ SLSLPISSSP TAVAFSPNGQ
1710 1720 1730 1740 1750
RAAVGTAGGT IYLLNLRTWQ EEKALVSGCD GISSFAFLSD TALFLTTFDG
1760 1770 1780 1790 1800
LLELWDLQHG CWVFQTKAHQ YQITGCCLSP DRRLLATVCL GGYVKLWDTV
1810 1820 1830 1840 1850
QGQLAFQYTH PKSLNCITFH PEGQVVATGN WSGIVTFFQA DGLKVTKELG
1860 1870 1880 1890 1900
GPGPSVRTLA FSAPGKVVAL GRIDGTVELW AWQEGTRLAA FPAQCGGVST
1910 1920 1930 1940 1950
VLFLHAGGRF LTAGEDGKAQ LWSGFLGRPR GCLGSLYLSP ALSVALNPDG
1960 1970 1980 1990 2000
DQVAVGYRGD GIKIYRISSG PQEAQCQELN VAVSALVWLS PSVLVSGAED
2010 2020 2030 2040 2050
GSLHGWMLRR NSLQSLWLSS VCQKPVLGLA ASQEFLASAS EDFTVRLWPR
2060 2070 2080 2090 2100
QLLTQPHAVE ELPCAAELRG HEGPVCCCSF SPDGRILATA GRDRNLLCWD
2110 2120 2130 2140 2150
VKVAQAPLLI HTFSSCHRDW ITGCTWTKDN ILISCSSDGS VGLWNPEAGQ
2160 2170 2180 2190 2200
QLGQFPGHQS AVSAVVAVEE HIVSVSRDGT LKVWDRQGVE LTSIPAHSGP
2210 2220 2230 2240 2250
ISQCAAALEP RPAGQPGSEL MVVTVGLDGA TKLWHPLLVC QIHTLQGHSG
2260 2270 2280 2290 2300
PVTAAAASEA SGLLLTSDNS SVRLWQIPKE ADDTCKPRSS AVITAVAWAP
2310 2320 2330 2340 2350
DGSLVVSGNE AGELTLWQKA QAVATARAPG RVSDLIWCSA NAFFVLSANE
2360 2370 2380 2390 2400
NVSEWQVELR KGSTCTNFRL YLKRVLQEDL GVLTGMALAP DGQSLILMKE
2410 2420 2430 2440 2450
DVELLQMKPG STPSSICRRY AVHSSILCTS KDYGLFYLQQ GNSGSLSILE
2460 2470 2480 2490 2500
QEESGKFEKT LDFNLNLNNP NGSPVSITQA EPESGSSLLC ATSDGMLWNL
2510 2520 2530 2540 2550
SECTPEGEWV VDNIWQKKSR NPKSRTPGTD SSPGLFCMDS WVEPTHLKAR
2560 2570 2580 2590 2600
QCKKIHLGSV TALHVLPGLL VTASEDRDVK LWERPSMQLL GLFRCEGPVS
2610 2620
CLEPWMEPSS PLQLAVGDAQ GNLYFLSWE
Length:2,629
Mass (Da):291,708
Last modified:July 1, 1997 - v1
Checksum:iB90C3F72E5D4B6BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89282 mRNA. Translation: AAB51690.1.
PIRiT32735.
RefSeqiNP_072113.1. NM_022591.2.
UniGeneiRn.5890.

Genome annotation databases

GeneIDi64523.
KEGGirno:64523.
UCSCiRGD:3869. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U89282 mRNA. Translation: AAB51690.1.
PIRiT32735.
RefSeqiNP_072113.1. NM_022591.2.
UniGeneiRn.5890.

3D structure databases

ProteinModelPortaliO08653.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012235.

PTM databases

iPTMnetiO08653.
PhosphoSitePlusiO08653.

Proteomic databases

PaxDbiO08653.
PRIDEiO08653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64523.
KEGGirno:64523.
UCSCiRGD:3869. rat.

Organism-specific databases

CTDi7011.
RGDi3869. Tep1.

Phylogenomic databases

eggNOGiKOG3602. Eukaryota.
KOG4155. Eukaryota.
ENOG410ZWBB. LUCA.
HOGENOMiHOG000154545.
HOVERGENiHBG059633.
InParanoidiO08653.
KOiK11127.
PhylomeDBiO08653.

Miscellaneous databases

PROiO08653.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR025139. DUF4062.
IPR007111. NACHT_NTPase.
IPR027417. P-loop_NTPase.
IPR008850. TEP1_N.
IPR008858. TROVE_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13271. DUF4062. 1 hit.
PF05386. TEP1_N. 4 hits.
PF05731. TROVE. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTiSM00320. WD40. 16 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 6 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50837. NACHT. 1 hit.
PS51226. TEP1_N. 4 hits.
PS50988. TROVE. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTEP1_RAT
AccessioniPrimary (citable) accession number: O08653
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: July 1, 1997
Last modified: November 2, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.