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Protein
Submitted name:

Granzyme M

Gene

Gzmm

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • endopeptidase activity Source: MGI
  • serine-type endopeptidase activity Source: MGI

GO - Biological processi

  • cell death Source: MGI
  • cytolysis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi3.4.21.B2. 3474.

Protein family/group databases

MEROPSiS01.139.

Names & Taxonomyi

Protein namesi
Submitted name:
Granzyme MImported
Submitted name:
Granzyme M (Lymphocyte met-ase 1)Imported
Submitted name:
Granzyme M (Lymphocyte met-ase 1), isoform CRA_bImported
Submitted name:
Granzyme Met-ase-1 precurserImported
Submitted name:
Protein GzmmImported
Gene namesi
Name:GzmmImported
Synonyms:LMet-1Imported, MMET-1Imported
ORF Names:mCG_13391Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:99549. Gzmm.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 264246Sequence analysisPRO_5007921750Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

PTM databases

PhosphoSiteiO08643.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054206.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 256230Peptidase S1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation
Contains 1 peptidase S1 domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
OMAiPYSSWIR.
OrthoDBiEOG091G0HUQ.
TreeFamiTF335738.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR033040. GZMM.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24256:SF132. PTHR24256:SF132. 1 hit.
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O08643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVCWSLLLL LALKTLWAAG NRFETQIIGG REAVPHSRPY MASLQKAKSH
60 70 80 90 100
VCGGVLVHRK WVLTAAHCLS EPLQNLKLVL GLHNLHDLQD PGLTFYIREA
110 120 130 140 150
IKHPGYNHKY ENDLALLKLD RRVQPSKNVK PLALPRKPRS KPAEGTWCST
160 170 180 190 200
AGWGMTHQGG PRARALQELD LRVLDTQMCN NSRFWNGVLI DSMLCLKAGS
210 220 230 240 250
KSQAPCKGDS GGPLVCGKGQ VDGILSFSSK TCTDIFKPPV ATAVAPYSSW
260
IRKVIGRWSP QSLV
Length:264
Mass (Da):29,122
Last modified:July 1, 1997 - v1
Checksum:i496E644D2630CD14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151828 Genomic DNA. No translation available.
L76741 mRNA. Translation: AAB51606.1.
BC139217 mRNA. Translation: AAI39218.1.
BC139218 mRNA. Translation: AAI39219.1.
AB015728 mRNA. Translation: BAA78336.1.
CH466553 Genomic DNA. Translation: EDL31677.1.
RefSeqiNP_032530.1. NM_008504.3.
UniGeneiMm.378960.

Genome annotation databases

EnsembliENSMUST00000020549; ENSMUSP00000020549; ENSMUSG00000054206.
GeneIDi16904.
UCSCiuc007fzj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151828 Genomic DNA. No translation available.
L76741 mRNA. Translation: AAB51606.1.
BC139217 mRNA. Translation: AAI39218.1.
BC139218 mRNA. Translation: AAI39219.1.
AB015728 mRNA. Translation: BAA78336.1.
CH466553 Genomic DNA. Translation: EDL31677.1.
RefSeqiNP_032530.1. NM_008504.3.
UniGeneiMm.378960.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020549.

Protein family/group databases

MEROPSiS01.139.

PTM databases

PhosphoSiteiO08643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020549; ENSMUSP00000020549; ENSMUSG00000054206.
GeneIDi16904.
UCSCiuc007fzj.2. mouse.

Organism-specific databases

CTDi3004.
MGIiMGI:99549. Gzmm.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
OMAiPYSSWIR.
OrthoDBiEOG091G0HUQ.
TreeFamiTF335738.

Enzyme and pathway databases

BRENDAi3.4.21.B2. 3474.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054206.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR033040. GZMM.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PANTHERiPTHR24256:SF132. PTHR24256:SF132. 1 hit.
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO08643_MOUSE
AccessioniPrimary (citable) accession number: O08643
Entry historyi
Integrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.