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Protein
Submitted name:

Granzyme M

Gene

Gzmm

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • endopeptidase activity Source: MGI
  • serine-type endopeptidase activity Source: MGI

GO - Biological processi

  • cell death Source: MGI
  • cytolysis Source: MGI

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Enzyme and pathway databases

BRENDAi3.4.21.B2 3474
ReactomeiR-MMU-173736 Alternative complement activation

Protein family/group databases

MEROPSiS01.139

Names & Taxonomyi

Protein namesi
Submitted name:
Granzyme MImported
Submitted name:
Granzyme M (Lymphocyte met-ase 1), isoform CRA_bImported
Submitted name:
Granzyme M (lymphocyte met-ase 1)Imported
Submitted name:
Granzyme Met-ase-1 precurserImported
Gene namesi
Name:GzmmImported
Synonyms:LMet-1Imported, MMET-1Imported
ORF Names:mCG_13391Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:99549 Gzmm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501458565419 – 264Sequence analysisAdd BLAST246

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000054206

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020549

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 256Peptidase S1InterPro annotationAdd BLAST230

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
OMAiCNNSRFW
OrthoDBiEOG091G0HUQ
TreeFamiTF335738

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR033040 GZMM
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PANTHERiPTHR43890:SF18 PTHR43890:SF18, 1 hit
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

O08643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVCWSLLLL LALKTLWAAG NRFETQIIGG REAVPHSRPY MASLQKAKSH
60 70 80 90 100
VCGGVLVHRK WVLTAAHCLS EPLQNLKLVL GLHNLHDLQD PGLTFYIREA
110 120 130 140 150
IKHPGYNHKY ENDLALLKLD RRVQPSKNVK PLALPRKPRS KPAEGTWCST
160 170 180 190 200
AGWGMTHQGG PRARALQELD LRVLDTQMCN NSRFWNGVLI DSMLCLKAGS
210 220 230 240 250
KSQAPCKGDS GGPLVCGKGQ VDGILSFSSK TCTDIFKPPV ATAVAPYSSW
260
IRKVIGRWSP QSLV
Length:264
Mass (Da):29,122
Last modified:July 1, 1997 - v1
Checksum:i496E644D2630CD14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151828 Genomic DNA No translation available.
L76741 mRNA Translation: AAB51606.1
BC139217 mRNA Translation: AAI39218.1
BC139218 mRNA Translation: AAI39219.1
AB015728 mRNA Translation: BAA78336.1
CH466553 Genomic DNA Translation: EDL31677.1
RefSeqiNP_032530.1, NM_008504.3
UniGeneiMm.378960

Genome annotation databases

EnsembliENSMUST00000020549; ENSMUSP00000020549; ENSMUSG00000054206
GeneIDi16904
UCSCiuc007fzj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiO08643_MOUSE
AccessioniPrimary (citable) accession number: O08643
Entry historyiIntegrated into UniProtKB/TrEMBL: July 1, 1997
Last sequence update: July 1, 1997
Last modified: May 23, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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