ID   SH3Y1_MOUSE             Reviewed;         340 AA.
AC   O08641; Q6P7V3; Q6PDR3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   24-JAN-2024, entry version 150.
DE   RecName: Full=SH3 domain-containing YSC84-like protein 1;
GN   Name=Sh3yl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=C57BL/6J; TISSUE=Skin;
RX   PubMed=10771491; DOI=10.1046/j.1523-1747.2000.00971.x;
RA   Aoki N., Ito K., Ito M.;
RT   "A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle.";
RL   J. Invest. Dermatol. 114:1050-1056(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=129, and FVB/N; TISSUE=Mammary tumor, and Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INTERACTION WITH SH3D19.
RX   PubMed=12615363; DOI=10.1016/s0923-1811(02)00140-8;
RA   Shimomura Y., Aoki N., Ito K., Ito M.;
RT   "Gene expression of Sh3d19, a novel adaptor protein with five Src homology
RT   3 domains, in anagen mouse hair follicles.";
RL   J. Dermatol. Sci. 31:43-51(2003).
CC   -!- SUBUNIT: Interacts with SH3D19. {ECO:0000269|PubMed:12615363}.
CC   -!- INTERACTION:
CC       O08641; Q91X43: Sh3d19; NbExp=3; IntAct=EBI-2024519, EBI-2024543;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=O08641-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O08641-2; Sequence=VSP_034336;
CC       Name=3;
CC         IsoId=O08641-3; Sequence=VSP_034337;
CC   -!- TISSUE SPECIFICITY: Expressed in skin, kidney, stomach, small intestine
CC       and colon. Highly expressed in the anagen hair follicle. In hair, it is
CC       expressed predominantly in the hair bulb, the hair shaft, inner root
CC       sheath, and outer root sheath in the lower half of the follicle.
CC       {ECO:0000269|PubMed:10771491}.
CC   -!- DEVELOPMENTAL STAGE: In skin, expression follows hair-growth cycle,
CC       increasing significantly during mid and late anagen phases, and
CC       decreases during catagen, telogen and early anagen phases.
CC       {ECO:0000269|PubMed:10771491}.
CC   -!- SIMILARITY: Belongs to the SH3YL1 family. {ECO:0000305}.
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DR   EMBL; D85926; BAA19679.1; -; mRNA.
DR   EMBL; AK141199; BAE24582.1; -; mRNA.
DR   EMBL; BC010296; AAH10296.1; -; mRNA.
DR   EMBL; BC058557; AAH58557.1; -; mRNA.
DR   EMBL; BC061488; AAH61488.1; -; mRNA.
DR   EMBL; BC110043; AAI10044.1; -; mRNA.
DR   CCDS; CCDS25859.1; -. [O08641-1]
DR   CCDS; CCDS79110.1; -. [O08641-2]
DR   RefSeq; NP_001276409.1; NM_001289480.1. [O08641-2]
DR   RefSeq; NP_038737.1; NM_013709.5. [O08641-1]
DR   AlphaFoldDB; O08641; -.
DR   SMR; O08641; -.
DR   IntAct; O08641; 2.
DR   STRING; 10090.ENSMUSP00000020997; -.
DR   PhosphoSitePlus; O08641; -.
DR   PaxDb; 10090-ENSMUSP00000020997; -.
DR   PeptideAtlas; O08641; -.
DR   ProteomicsDB; 257146; -. [O08641-1]
DR   ProteomicsDB; 257147; -. [O08641-2]
DR   ProteomicsDB; 257148; -. [O08641-3]
DR   Antibodypedia; 49866; 46 antibodies from 14 providers.
DR   DNASU; 24057; -.
DR   Ensembl; ENSMUST00000020997.15; ENSMUSP00000020997.9; ENSMUSG00000020669.16. [O08641-1]
DR   Ensembl; ENSMUST00000110880.3; ENSMUSP00000106504.3; ENSMUSG00000020669.16. [O08641-2]
DR   GeneID; 24057; -.
DR   KEGG; mmu:24057; -.
DR   UCSC; uc007ngz.2; mouse. [O08641-1]
DR   UCSC; uc011ylg.2; mouse. [O08641-2]
DR   AGR; MGI:1346118; -.
DR   CTD; 26751; -.
DR   MGI; MGI:1346118; Sh3yl1.
DR   VEuPathDB; HostDB:ENSMUSG00000020669; -.
DR   eggNOG; KOG1843; Eukaryota.
DR   GeneTree; ENSGT00510000048137; -.
DR   HOGENOM; CLU_015320_2_1_1; -.
DR   InParanoid; O08641; -.
DR   OMA; NDAMYND; -.
DR   OrthoDB; 37167at2759; -.
DR   PhylomeDB; O08641; -.
DR   TreeFam; TF331022; -.
DR   BioGRID-ORCS; 24057; 3 hits in 76 CRISPR screens.
DR   ChiTaRS; Sh3yl1; mouse.
DR   PRO; PR:O08641; -.
DR   Proteomes; UP000000589; Chromosome 12.
DR   RNAct; O08641; Protein.
DR   Bgee; ENSMUSG00000020669; Expressed in seminal vesicle and 230 other cell types or tissues.
DR   GO; GO:0032587; C:ruffle membrane; ISO:MGI.
DR   GO; GO:0019902; F:phosphatase binding; ISO:MGI.
DR   GO; GO:0035091; F:phosphatidylinositol binding; ISO:MGI.
DR   GO; GO:0006661; P:phosphatidylinositol biosynthetic process; IMP:MGI.
DR   GO; GO:1900027; P:regulation of ruffle assembly; IMP:MGI.
DR   CDD; cd11841; SH3_SH3YL1_like; 1.
DR   CDD; cd11525; SYLF_SH3YL1_like; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035511; SH3YL1_SH3.
DR   InterPro; IPR033643; SYLF_SH3YL1-like.
DR   InterPro; IPR007461; Ysc84_actin-binding.
DR   PANTHER; PTHR15629:SF2; SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1; 1.
DR   PANTHER; PTHR15629; SH3YL1 PROTEIN; 1.
DR   Pfam; PF14604; SH3_9; 1.
DR   Pfam; PF04366; Ysc84; 1.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50002; SH3; 1.
DR   Genevisible; O08641; MM.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; SH3 domain.
FT   CHAIN           1..340
FT                   /note="SH3 domain-containing YSC84-like protein 1"
FT                   /id="PRO_0000341561"
FT   DOMAIN          281..340
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          226..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         38..76
FT                   /note="AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK -> E (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_034336"
FT   VAR_SEQ         233..340
FT                   /note="AKELPPKPSSRPQPAHPPVQLNAGSQGNRNEYKLYPELSSYHEKTGNLNQPI
FT                   EVTALYSFEGQQPGDLNFQAGDRIIVISKTDSNFDWWEGKLRGQTGIFPANYVTMN ->
FT                   VLWPGFTSLSVNMRGSVLAQL (in isoform 3)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_034337"
FT   CONFLICT        200
FT                   /note="A -> T (in Ref. 3; AAH61488)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   340 AA;  37028 MW;  3FE12C0A8530C74E CRC64;
     MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL SVIKAGFLVT
     ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL
     TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF TYCKSRGLFA GISLEGSCLI ERKETNRKFY
     CQDIRAYDIL FGDVPQPAQA EDLYEILNSF TEKYETEGQR INLKKVAREQ RKAKELPPKP
     SSRPQPAHPP VQLNAGSQGN RNEYKLYPEL SSYHEKTGNL NQPIEVTALY SFEGQQPGDL
     NFQAGDRIIV ISKTDSNFDW WEGKLRGQTG IFPANYVTMN
//