O08641 (SH3Y1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
SH3 domain-containing YSC84-like protein 1

Gene names

Name:

Sh3yl1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with SH3D19. Ref.4
Tissue specificity	Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle. Ref.1
Developmental stage	In skin, expression follows hair-growth cycle, increasing significantly during mid and late anagen phases, and decreases during catagen, telogen and early anagen phases. Ref.1
Sequence similarities	Belongs to the SH3YL1 family. Contains 1 SH3 domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	SH3 domain
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylinositol biosynthetic process Inferred from mutant phenotype PubMed 21624956. Source: MGI regulation of ruffle assembly Inferred from mutant phenotype PubMed 21624956. Source: MGI
Cellular_component	ruffle membrane Inferred from electronic annotation. Source: Compara
Molecular_function	phosphatase binding Inferred from sequence orthology PubMed 21624956. Source: MGI phosphatidylinositol binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Sh3d19	Q91X43	3	EBI-2024519,EBI-2024543

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: O08641-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: O08641-2)

The sequence of this isoform differs from the canonical sequence as follows:
     38-76: AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK → E

Note: No experimental confirmation available.

Isoform 3 (identifier: O08641-3)

The sequence of this isoform differs from the canonical sequence as follows:
     233-340: AKELPPKPSS...IFPANYVTMN → VLWPGFTSLSVNMRGSVLAQL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	SH3 domain-containing YSC84-like protein 1		PRO_0000341561
Regions
	Domain	281 – 340	60	SH3
Natural variations
	Alternative sequence	38 – 76	39	AHVIA…LPDGK → E in isoform 2.		VSP_034336
	Alternative sequence	233 – 340	108	AKELP…YVTMN → VLWPGFTSLSVNMRGSVLAQ L in isoform 3.		VSP_034337
Experimental info
	Sequence conflict	200	1	A → T in AAH61488. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 1, 1997. Version 1. Checksum: 3FE12C0A8530C74E	FASTA	340	37,028
	10 20 30 40 50 60 MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL SVIKAGFLVT 70 80 90 100 110 120 ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL 130 140 150 160 170 180 TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF TYCKSRGLFA GISLEGSCLI ERKETNRKFY 190 200 210 220 230 240 CQDIRAYDIL FGDVPQPAQA EDLYEILNSF TEKYETEGQR INLKKVAREQ RKAKELPPKP 250 260 270 280 290 300 SSRPQPAHPP VQLNAGSQGN RNEYKLYPEL SSYHEKTGNL NQPIEVTALY SFEGQQPGDL 310 320 330 340 NFQAGDRIIV ISKTDSNFDW WEGKLRGQTG IFPANYVTMN
	Isoform 2 [UniParc]. Checksum: F3D2AA03ACC883CD	FASTA	302	33,320
	10 20 30 40 50 60 MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPEWS APSAIGIAGL GGGFEIGIEV 70 80 90 100 110 120 SDLVIILNYD RAVEAFAKGG NLTLGGNFTV AVGPLGRNLE GNVSLRSSAA VFTYCKSRGL 130 140 150 160 170 180 FAGISLEGSC LIERKETNRK FYCQDIRAYD ILFGDVPQPA QAEDLYEILN SFTEKYETEG 190 200 210 220 230 240 QRINLKKVAR EQRKAKELPP KPSSRPQPAH PPVQLNAGSQ GNRNEYKLYP ELSSYHEKTG 250 260 270 280 290 300 NLNQPIEVTA LYSFEGQQPG DLNFQAGDRI IVISKTDSNF DWWEGKLRGQ TGIFPANYVT MN
	Isoform 3 [UniParc]. Checksum: 9B545B95D3E011ED	FASTA	253	27,215
	10 20 30 40 50 60 MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL SVIKAGFLVT 70 80 90 100 110 120 ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL 130 140 150 160 170 180 TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF TYCKSRGLFA GISLEGSCLI ERKETNRKFY 190 200 210 220 230 240 CQDIRAYDIL FGDVPQPAQA EDLYEILNSF TEKYETEGQR INLKKVAREQ RKVLWPGFTS 250 LSVNMRGSVL AQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle." Aoki N., Ito K., Ito M. J. Invest. Dermatol. 114:1050-1056(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: C57BL/6. Tissue: Skin.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: 129 and FVB/N. Tissue: Mammary tumor and Olfactory epithelium.
[4]	"Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles." Shimomura Y., Aoki N., Ito K., Ito M. J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SH3D19.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D85926 mRNA. Translation: BAA19679.1. AK141199 mRNA. Translation: BAE24582.1. BC010296 mRNA. Translation: AAH10296.1. BC058557 mRNA. Translation: AAH58557.1. BC061488 mRNA. Translation: AAH61488.1. BC110043 mRNA. Translation: AAI10044.1.
IPI	IPI00114903. IPI00756442. IPI00896036.
RefSeq	NP_038737.1. NM_013709.4.
UniGene	Mm.218624.
3D structure databases
HSSP	HSSP built from PDB template 1OOT based on UniProtKB P43603.
ProteinModelPortal	O08641.
SMR	O08641. Positions 271-340.
ModBase	Search...
Protein-protein interaction databases
IntAct	O08641. 2 interactions.
Proteomic databases
PRIDE	O08641.
Protocols and materials databases
DNASU	24057.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020997; ENSMUSP00000020997; ENSMUSG00000020669. ENSMUST00000110880; ENSMUSP00000106504; ENSMUSG00000020669.
GeneID	24057.
KEGG	mmu:24057.
UCSC	uc007ngz.1. mouse. uc011ylg.1. mouse.
Organism-specific databases
CTD	26751.
MGI	MGI:1346118. Sh3yl1.
Phylogenomic databases
eggNOG	COG2930.
GeneTree	ENSGT00510000048137.
HOGENOM	HOG000215564.
HOVERGEN	HBG108487.
InParanoid	O08641.
OMA	ELSSYHE.
OrthoDB	EOG4BRWMF.
Gene expression databases
Bgee	O08641.
Genevestigator	O08641.
Family and domain databases
InterPro	IPR001452. SH3_domain. IPR007461. Ysc84_actin-binding. [Graphical view]
Pfam	PF04366. DUF500. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN.
SMART	SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF50044. SH3. 1 hit.
PROSITE	PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	304009.
SOURCE	Search...

Entry information

Entry name

SH3Y1_MOUSE

Accession

Primary (citable) accession number: O08641
Secondary accession number(s): Q6P7V3, Q6PDR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	July 1, 1997
Last modified:	April 3, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program