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O08641 (SH3Y1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SH3 domain-containing YSC84-like protein 1
Gene names
Name:Sh3yl1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with SH3D19. Ref.4

Tissue specificity

Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle. Ref.1

Developmental stage

In skin, expression follows hair-growth cycle, increasing significantly during mid and late anagen phases, and decreases during catagen, telogen and early anagen phases. Ref.1

Sequence similarities

Belongs to the SH3YL1 family.

Contains 1 SH3 domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sh3d19Q91X433EBI-2024519,EBI-2024543

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: O08641-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: O08641-2)

The sequence of this isoform differs from the canonical sequence as follows:
     38-76: AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK → E
Note: No experimental confirmation available.
Isoform 3 (identifier: O08641-3)

The sequence of this isoform differs from the canonical sequence as follows:
     233-340: AKELPPKPSS...IFPANYVTMN → VLWPGFTSLSVNMRGSVLAQL
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340SH3 domain-containing YSC84-like protein 1
PRO_0000341561

Regions

Domain281 – 34060SH3

Natural variations

Alternative sequence38 – 7639AHVIA…LPDGK → E in isoform 2.
VSP_034336
Alternative sequence233 – 340108AKELP…YVTMN → VLWPGFTSLSVNMRGSVLAQ L in isoform 3.
VSP_034337

Experimental info

Sequence conflict2001A → T in AAH61488. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 1, 1997. Version 1.
Checksum: 3FE12C0A8530C74E

FASTA34037,028
        10         20         30         40         50         60 
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL SVIKAGFLVT 

        70         80         90        100        110        120 
ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD LVIILNYDRA VEAFAKGGNL 

       130        140        150        160        170        180 
TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF TYCKSRGLFA GISLEGSCLI ERKETNRKFY 

       190        200        210        220        230        240 
CQDIRAYDIL FGDVPQPAQA EDLYEILNSF TEKYETEGQR INLKKVAREQ RKAKELPPKP 

       250        260        270        280        290        300 
SSRPQPAHPP VQLNAGSQGN RNEYKLYPEL SSYHEKTGNL NQPIEVTALY SFEGQQPGDL 

       310        320        330        340 
NFQAGDRIIV ISKTDSNFDW WEGKLRGQTG IFPANYVTMN 

« Hide

Isoform 2 [UniParc].

Checksum: F3D2AA03ACC883CD
Show »

FASTA30233,320
Isoform 3 [UniParc].

Checksum: 9B545B95D3E011ED
Show »

FASTA25327,215

References

« Hide 'large scale' references
[1]"A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle."
Aoki N., Ito K., Ito M.
J. Invest. Dermatol. 114:1050-1056(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: C57BL/6.
Tissue: Skin.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: 129 and FVB/N.
Tissue: Mammary tumor and Olfactory epithelium.
[4]"Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles."
Shimomura Y., Aoki N., Ito K., Ito M.
J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SH3D19.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D85926 mRNA. Translation: BAA19679.1.
AK141199 mRNA. Translation: BAE24582.1.
BC010296 mRNA. Translation: AAH10296.1.
BC058557 mRNA. Translation: AAH58557.1.
BC061488 mRNA. Translation: AAH61488.1.
BC110043 mRNA. Translation: AAI10044.1.
RefSeqNP_038737.1. NM_013709.5.
UniGeneMm.218624.

3D structure databases

ProteinModelPortalO08641.
SMRO08641. Positions 271-340.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActO08641. 2 interactions.

Proteomic databases

PRIDEO08641.

Protocols and materials databases

DNASU24057.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020997; ENSMUSP00000020997; ENSMUSG00000020669. [O08641-1]
ENSMUST00000110880; ENSMUSP00000106504; ENSMUSG00000020669. [O08641-2]
GeneID24057.
KEGGmmu:24057.
UCSCuc007ngz.1. mouse. [O08641-1]
uc011ylg.1. mouse. [O08641-2]

Organism-specific databases

CTD26751.
MGIMGI:1346118. Sh3yl1.

Phylogenomic databases

eggNOGCOG2930.
GeneTreeENSGT00510000048137.
HOGENOMHOG000215564.
HOVERGENHBG108487.
InParanoidO08641.
OMALFGDIPR.
OrthoDBEOG7MPRFM.
PhylomeDBO08641.
TreeFamTF331022.

Gene expression databases

BgeeO08641.
GenevestigatorO08641.

Family and domain databases

InterProIPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamPF04366. DUF500. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00452. SH3DOMAIN.
SMARTSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
PROSITEPS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304009.
PROO08641.
SOURCESearch...

Entry information

Entry nameSH3Y1_MOUSE
AccessionPrimary (citable) accession number: O08641
Secondary accession number(s): Q6P7V3, Q6PDR3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 1, 1997
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot