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O08641

- SH3Y1_MOUSE

UniProt

O08641 - SH3Y1_MOUSE

Protein

SH3 domain-containing YSC84-like protein 1

Gene

Sh3yl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jul 1997)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphatase binding Source: MGI
    2. phosphatidylinositol binding Source: Ensembl
    3. protein binding Source: IntAct

    GO - Biological processi

    1. phosphatidylinositol biosynthetic process Source: MGI
    2. regulation of ruffle assembly Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SH3 domain-containing YSC84-like protein 1
    Gene namesi
    Name:Sh3yl1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1346118. Sh3yl1.

    Subcellular locationi

    GO - Cellular componenti

    1. ruffle membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340SH3 domain-containing YSC84-like protein 1PRO_0000341561Add
    BLAST

    Proteomic databases

    PRIDEiO08641.

    Expressioni

    Tissue specificityi

    Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle.1 Publication

    Developmental stagei

    In skin, expression follows hair-growth cycle, increasing significantly during mid and late anagen phases, and decreases during catagen, telogen and early anagen phases.1 Publication

    Gene expression databases

    BgeeiO08641.
    GenevestigatoriO08641.

    Interactioni

    Subunit structurei

    Interacts with SH3D19.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Sh3d19Q91X433EBI-2024519,EBI-2024543

    Protein-protein interaction databases

    IntActiO08641. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO08641.
    SMRiO08641. Positions 271-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini281 – 34060SH3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SH3YL1 family.Curated
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiCOG2930.
    GeneTreeiENSGT00510000048137.
    HOGENOMiHOG000215564.
    HOVERGENiHBG108487.
    InParanoidiO08641.
    OMAiYCQDVRA.
    OrthoDBiEOG7MPRFM.
    PhylomeDBiO08641.
    TreeFamiTF331022.

    Family and domain databases

    InterProiIPR001452. SH3_domain.
    IPR007461. Ysc84_actin-binding.
    [Graphical view]
    PfamiPF04366. DUF500. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00452. SH3DOMAIN.
    SMARTiSM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    PROSITEiPS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: O08641-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL    50
    SVIKAGFLVT ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD 100
    LVIILNYDRA VEAFAKGGNL TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF 150
    TYCKSRGLFA GISLEGSCLI ERKETNRKFY CQDIRAYDIL FGDVPQPAQA 200
    EDLYEILNSF TEKYETEGQR INLKKVAREQ RKAKELPPKP SSRPQPAHPP 250
    VQLNAGSQGN RNEYKLYPEL SSYHEKTGNL NQPIEVTALY SFEGQQPGDL 300
    NFQAGDRIIV ISKTDSNFDW WEGKLRGQTG IFPANYVTMN 340
    Length:340
    Mass (Da):37,028
    Last modified:July 1, 1997 - v1
    Checksum:i3FE12C0A8530C74E
    GO
    Isoform 2 (identifier: O08641-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         38-76: AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK → E

    Note: No experimental confirmation available.

    Show »
    Length:302
    Mass (Da):33,320
    Checksum:iF3D2AA03ACC883CD
    GO
    Isoform 3 (identifier: O08641-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         233-340: AKELPPKPSS...IFPANYVTMN → VLWPGFTSLSVNMRGSVLAQL

    Note: No experimental confirmation available.

    Show »
    Length:253
    Mass (Da):27,215
    Checksum:i9B545B95D3E011ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti200 – 2001A → T in AAH61488. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei38 – 7639AHVIA…LPDGK → E in isoform 2. 1 PublicationVSP_034336Add
    BLAST
    Alternative sequencei233 – 340108AKELP…YVTMN → VLWPGFTSLSVNMRGSVLAQ L in isoform 3. CuratedVSP_034337Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85926 mRNA. Translation: BAA19679.1.
    AK141199 mRNA. Translation: BAE24582.1.
    BC010296 mRNA. Translation: AAH10296.1.
    BC058557 mRNA. Translation: AAH58557.1.
    BC061488 mRNA. Translation: AAH61488.1.
    BC110043 mRNA. Translation: AAI10044.1.
    CCDSiCCDS25859.1. [O08641-1]
    RefSeqiNP_001276409.1. NM_001289480.1. [O08641-2]
    NP_038737.1. NM_013709.5. [O08641-1]
    UniGeneiMm.218624.

    Genome annotation databases

    EnsembliENSMUST00000020997; ENSMUSP00000020997; ENSMUSG00000020669. [O08641-1]
    ENSMUST00000110880; ENSMUSP00000106504; ENSMUSG00000020669. [O08641-2]
    GeneIDi24057.
    KEGGimmu:24057.
    UCSCiuc007ngz.1. mouse. [O08641-1]
    uc011ylg.1. mouse. [O08641-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D85926 mRNA. Translation: BAA19679.1 .
    AK141199 mRNA. Translation: BAE24582.1 .
    BC010296 mRNA. Translation: AAH10296.1 .
    BC058557 mRNA. Translation: AAH58557.1 .
    BC061488 mRNA. Translation: AAH61488.1 .
    BC110043 mRNA. Translation: AAI10044.1 .
    CCDSi CCDS25859.1. [O08641-1 ]
    RefSeqi NP_001276409.1. NM_001289480.1. [O08641-2 ]
    NP_038737.1. NM_013709.5. [O08641-1 ]
    UniGenei Mm.218624.

    3D structure databases

    ProteinModelPortali O08641.
    SMRi O08641. Positions 271-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O08641. 2 interactions.

    Proteomic databases

    PRIDEi O08641.

    Protocols and materials databases

    DNASUi 24057.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020997 ; ENSMUSP00000020997 ; ENSMUSG00000020669 . [O08641-1 ]
    ENSMUST00000110880 ; ENSMUSP00000106504 ; ENSMUSG00000020669 . [O08641-2 ]
    GeneIDi 24057.
    KEGGi mmu:24057.
    UCSCi uc007ngz.1. mouse. [O08641-1 ]
    uc011ylg.1. mouse. [O08641-2 ]

    Organism-specific databases

    CTDi 26751.
    MGIi MGI:1346118. Sh3yl1.

    Phylogenomic databases

    eggNOGi COG2930.
    GeneTreei ENSGT00510000048137.
    HOGENOMi HOG000215564.
    HOVERGENi HBG108487.
    InParanoidi O08641.
    OMAi YCQDVRA.
    OrthoDBi EOG7MPRFM.
    PhylomeDBi O08641.
    TreeFami TF331022.

    Miscellaneous databases

    NextBioi 304009.
    PROi O08641.
    SOURCEi Search...

    Gene expression databases

    Bgeei O08641.
    Genevestigatori O08641.

    Family and domain databases

    InterProi IPR001452. SH3_domain.
    IPR007461. Ysc84_actin-binding.
    [Graphical view ]
    Pfami PF04366. DUF500. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00452. SH3DOMAIN.
    SMARTi SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    PROSITEi PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle."
      Aoki N., Ito K., Ito M.
      J. Invest. Dermatol. 114:1050-1056(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: C57BL/6.
      Tissue: Skin.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: 129 and FVB/N.
      Tissue: Mammary tumor and Olfactory epithelium.
    4. "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles."
      Shimomura Y., Aoki N., Ito K., Ito M.
      J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SH3D19.

    Entry informationi

    Entry nameiSH3Y1_MOUSE
    AccessioniPrimary (citable) accession number: O08641
    Secondary accession number(s): Q6P7V3, Q6PDR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: July 1, 1997
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3