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O08641

- SH3Y1_MOUSE

UniProt

O08641 - SH3Y1_MOUSE

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Protein

SH3 domain-containing YSC84-like protein 1

Gene

Sh3yl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. phosphatase binding Source: MGI
  2. phosphatidylinositol binding Source: Ensembl

GO - Biological processi

  1. phosphatidylinositol biosynthetic process Source: MGI
  2. regulation of ruffle assembly Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-containing YSC84-like protein 1
Gene namesi
Name:Sh3yl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1346118. Sh3yl1.

Subcellular locationi

GO - Cellular componenti

  1. ruffle membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340SH3 domain-containing YSC84-like protein 1PRO_0000341561Add
BLAST

Proteomic databases

PRIDEiO08641.

Expressioni

Tissue specificityi

Expressed in skin, kidney, stomach, small intestine and colon. Highly expressed in the anagen hair follicle. In hair, it is expressed predominantly in the hair bulb, the hair shaft, inner root sheath, and outer root sheath in the lower half of the follicle.1 Publication

Developmental stagei

In skin, expression follows hair-growth cycle, increasing significantly during mid and late anagen phases, and decreases during catagen, telogen and early anagen phases.1 Publication

Gene expression databases

BgeeiO08641.
GenevestigatoriO08641.

Interactioni

Subunit structurei

Interacts with SH3D19.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Sh3d19Q91X433EBI-2024519,EBI-2024543

Protein-protein interaction databases

IntActiO08641. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO08641.
SMRiO08641. Positions 271-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini281 – 34060SH3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SH3YL1 family.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiCOG2930.
GeneTreeiENSGT00510000048137.
HOGENOMiHOG000215564.
HOVERGENiHBG108487.
InParanoidiO08641.
OMAiYCQDVRA.
OrthoDBiEOG7MPRFM.
PhylomeDBiO08641.
TreeFamiTF331022.

Family and domain databases

InterProiIPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view]
PfamiPF04366. DUF500. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: O08641-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNNPIPSNLK SEAKKAAKIL REFTEITSRN GPDKIIPAHV IAKAKGLAVL
60 70 80 90 100
SVIKAGFLVT ARGGSGIVLA RLPDGKWSAP SAIGIAGLGG GFEIGIEVSD
110 120 130 140 150
LVIILNYDRA VEAFAKGGNL TLGGNFTVAV GPLGRNLEGN VSLRSSAAVF
160 170 180 190 200
TYCKSRGLFA GISLEGSCLI ERKETNRKFY CQDIRAYDIL FGDVPQPAQA
210 220 230 240 250
EDLYEILNSF TEKYETEGQR INLKKVAREQ RKAKELPPKP SSRPQPAHPP
260 270 280 290 300
VQLNAGSQGN RNEYKLYPEL SSYHEKTGNL NQPIEVTALY SFEGQQPGDL
310 320 330 340
NFQAGDRIIV ISKTDSNFDW WEGKLRGQTG IFPANYVTMN
Length:340
Mass (Da):37,028
Last modified:July 1, 1997 - v1
Checksum:i3FE12C0A8530C74E
GO
Isoform 2 (identifier: O08641-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-76: AHVIAKAKGLAVLSVIKAGFLVTARGGSGIVLARLPDGK → E

Note: No experimental confirmation available.

Show »
Length:302
Mass (Da):33,320
Checksum:iF3D2AA03ACC883CD
GO
Isoform 3 (identifier: O08641-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-340: AKELPPKPSS...IFPANYVTMN → VLWPGFTSLSVNMRGSVLAQL

Note: No experimental confirmation available.

Show »
Length:253
Mass (Da):27,215
Checksum:i9B545B95D3E011ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001A → T in AAH61488. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei38 – 7639AHVIA…LPDGK → E in isoform 2. 1 PublicationVSP_034336Add
BLAST
Alternative sequencei233 – 340108AKELP…YVTMN → VLWPGFTSLSVNMRGSVLAQ L in isoform 3. CuratedVSP_034337Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85926 mRNA. Translation: BAA19679.1.
AK141199 mRNA. Translation: BAE24582.1.
BC010296 mRNA. Translation: AAH10296.1.
BC058557 mRNA. Translation: AAH58557.1.
BC061488 mRNA. Translation: AAH61488.1.
BC110043 mRNA. Translation: AAI10044.1.
CCDSiCCDS25859.1. [O08641-1]
RefSeqiNP_001276409.1. NM_001289480.1. [O08641-2]
NP_038737.1. NM_013709.5. [O08641-1]
UniGeneiMm.218624.

Genome annotation databases

EnsembliENSMUST00000020997; ENSMUSP00000020997; ENSMUSG00000020669. [O08641-1]
ENSMUST00000110880; ENSMUSP00000106504; ENSMUSG00000020669. [O08641-2]
GeneIDi24057.
KEGGimmu:24057.
UCSCiuc007ngz.1. mouse. [O08641-1]
uc011ylg.1. mouse. [O08641-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85926 mRNA. Translation: BAA19679.1 .
AK141199 mRNA. Translation: BAE24582.1 .
BC010296 mRNA. Translation: AAH10296.1 .
BC058557 mRNA. Translation: AAH58557.1 .
BC061488 mRNA. Translation: AAH61488.1 .
BC110043 mRNA. Translation: AAI10044.1 .
CCDSi CCDS25859.1. [O08641-1 ]
RefSeqi NP_001276409.1. NM_001289480.1. [O08641-2 ]
NP_038737.1. NM_013709.5. [O08641-1 ]
UniGenei Mm.218624.

3D structure databases

ProteinModelPortali O08641.
SMRi O08641. Positions 271-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi O08641. 2 interactions.

Proteomic databases

PRIDEi O08641.

Protocols and materials databases

DNASUi 24057.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020997 ; ENSMUSP00000020997 ; ENSMUSG00000020669 . [O08641-1 ]
ENSMUST00000110880 ; ENSMUSP00000106504 ; ENSMUSG00000020669 . [O08641-2 ]
GeneIDi 24057.
KEGGi mmu:24057.
UCSCi uc007ngz.1. mouse. [O08641-1 ]
uc011ylg.1. mouse. [O08641-2 ]

Organism-specific databases

CTDi 26751.
MGIi MGI:1346118. Sh3yl1.

Phylogenomic databases

eggNOGi COG2930.
GeneTreei ENSGT00510000048137.
HOGENOMi HOG000215564.
HOVERGENi HBG108487.
InParanoidi O08641.
OMAi YCQDVRA.
OrthoDBi EOG7MPRFM.
PhylomeDBi O08641.
TreeFami TF331022.

Miscellaneous databases

NextBioi 304009.
PROi O08641.
SOURCEi Search...

Gene expression databases

Bgeei O08641.
Genevestigatori O08641.

Family and domain databases

InterProi IPR001452. SH3_domain.
IPR007461. Ysc84_actin-binding.
[Graphical view ]
Pfami PF04366. DUF500. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00452. SH3DOMAIN.
SMARTi SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
PROSITEi PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle."
    Aoki N., Ito K., Ito M.
    J. Invest. Dermatol. 114:1050-1056(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6.
    Tissue: Skin.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: 129 and FVB/N.
    Tissue: Mammary tumor and Olfactory epithelium.
  4. "Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles."
    Shimomura Y., Aoki N., Ito K., Ito M.
    J. Dermatol. Sci. 31:43-51(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SH3D19.

Entry informationi

Entry nameiSH3Y1_MOUSE
AccessioniPrimary (citable) accession number: O08641
Secondary accession number(s): Q6P7V3, Q6PDR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 1, 1997
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3