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Protein

Procollagen C-endopeptidase enhancer 1

Gene

Pcolce

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1650814. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Procollagen C-endopeptidase enhancer 1
Alternative name(s):
Procollagen COOH-terminal proteinase enhancer 1
Short name:
PCPE-1
Short name:
Procollagen C-proteinase enhancer 1
Type 1 procollagen C-proteinase enhancer protein
Type I procollagen COOH-terminal proteinase enhancer
Gene namesi
Name:Pcolce
Synonyms:Pcpe1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi3270. Pcolce.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000002202525 – 468Procollagen C-endopeptidase enhancer 1Add BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi36 ↔ 62PROSITE-ProRule annotation
Modified residuei41PhosphothreonineCombined sources1
Modified residuei49PhosphoserineCombined sources1
Disulfide bondi89 ↔ 111PROSITE-ProRule annotation
Disulfide bondi158 ↔ 185PROSITE-ProRule annotation
Disulfide bondi212 ↔ 235PROSITE-ProRule annotation
Disulfide bondi341 ↔ 409By similarity
Disulfide bondi356 ↔ 460By similarity
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO08628.

PTM databases

iPTMnetiO08628.
PhosphoSitePlusiO08628.

Expressioni

Tissue specificityi

Expressed at highest levels in collagen-rich tissues, especially tendon. Also expressed in cornea and sterna.1 Publication

Gene expression databases

BgeeiENSRNOG00000025001.
ExpressionAtlasiO08628. baseline and differential.
GenevisibleiO08628. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001887.

Structurei

3D structure databases

ProteinModelPortaliO08628.
SMRiO08628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 148CUB 1PROSITE-ProRule annotationAdd BLAST113
Domaini158 – 272CUB 2PROSITE-ProRule annotationAdd BLAST115
Domaini341 – 460NTRPROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IPS8. Eukaryota.
ENOG410Y9AW. LUCA.
GeneTreeiENSGT00760000119018.
HOGENOMiHOG000059592.
HOVERGENiHBG053528.
InParanoidiO08628.

Family and domain databases

CDDicd00041. CUB. 2 hits.
cd03576. NTR_PCOLCE. 1 hit.
Gene3Di2.60.120.290. 2 hits.
InterProiView protein in InterPro
IPR000859. CUB_dom.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR035814. NTR_PCOLCE.
IPR028870. PCOLCE.
IPR035914. Sperma_CUB_dom_sf.
IPR008993. TIMP-like_OB-fold.
PANTHERiPTHR44264:SF2. PTHR44264:SF2. 1 hit.
PfamiView protein in Pfam
PF00431. CUB. 2 hits.
PF01759. NTR. 1 hit.
SMARTiView protein in SMART
SM00643. C345C. 1 hit.
SM00042. CUB. 2 hits.
SUPFAMiSSF49854. SSF49854. 2 hits.
SSF50242. SSF50242. 1 hit.
PROSITEiView protein in PROSITE
PS01180. CUB. 2 hits.
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPAALTSLL GPFLLAWVLP LARGQTPNYT RPVFLCGGDV TGESGYVASE
60 70 80 90 100
GFPNLYPPNK KCIWTITVPE GQTVSLSFRV FDMELHPSCR YDALEVFAGS
110 120 130 140 150
GTSGQRLGRF CGTFRPAPVV APGNQVTLRM TTDEGTGGRG FLLWYSGRAT
160 170 180 190 200
SGTEHQFCGG RMEKAQGTLT TPNWPESDYP PGISCSWHII APSNQVIMLT
210 220 230 240 250
FGKFDVEPDT YCRYDSVSVF NGAVSDDSKR LGKFCGDKAP SPISSEGNEL
260 270 280 290 300
LVQFVSDLSV TADGFSASYR TLPRDAVEKE SAPSPGEDAQ HGPQSRSDPK
310 320 330 340 350
TGTGPKVKPP SKPKVQPVEK PEGSPATQAT PVAPDAPSIT CPKQYKRSGT
360 370 380 390 400
LQSNFCSSSL VVTGTVKAMV RGPGEGLTVT VSLLGVYKTG DLDLPSPASG
410 420 430 440 450
TSLKFYVPCK QMPPMKKGAS YLLMGQVEEN RGPILPPESF VVLYRPNQDQ
460
ILSNLSKRKC PSQPRPDA
Length:468
Mass (Da):50,185
Last modified:July 1, 1997 - v1
Checksum:iB4AA1C151323969B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94710 mRNA. Translation: AAB93478.1.
AB008534 mRNA. Translation: BAA23217.1.
AF016503 mRNA. Translation: AAD01592.1.
AF016506 Genomic DNA. Translation: AAD01598.1.
RefSeqiNP_062110.1. NM_019237.1.
UniGeneiRn.2910.

Genome annotation databases

EnsembliENSRNOT00000001894; ENSRNOP00000001887; ENSRNOG00000025001.
GeneIDi29569.
KEGGirno:29569.
UCSCiRGD:3270. rat.

Similar proteinsi

Entry informationi

Entry nameiPCOC1_RAT
AccessioniPrimary (citable) accession number: O08628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: December 20, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome