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Protein

Synaptotagmin-10

Gene

Syt10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ca2+ sensor specifically required for the Ca2+-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca2+-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca2+ and phospholipid binding to the C2 domain: Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (PubMed:18508778).By similarity1 Publication

Cofactori

Ca2+1 PublicationNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi262Calcium 1By similarity1
Metal bindingi262Calcium 2By similarity1
Metal bindingi268Calcium 1By similarity1
Metal bindingi320Calcium 1By similarity1
Metal bindingi320Calcium 2By similarity1
Metal bindingi321Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi322Calcium 1By similarity1
Metal bindingi322Calcium 2By similarity1
Metal bindingi322Calcium 3By similarity1
Metal bindingi325Calcium 3By similarity1
Metal bindingi328Calcium 2By similarity1
Metal bindingi328Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-10
Alternative name(s):
Synaptotagmin X
Short name:
SytX
Gene namesi
Name:Syt10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi62041 Syt10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55VesicularSequence analysisAdd BLAST55
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 523CytoplasmicSequence analysisAdd BLAST447

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839681 – 523Synaptotagmin-10Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei136PhosphothreonineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO08625
PRIDEiO08625

Expressioni

Gene expression databases

BgeeiENSRNOG00000014296
GenevisibleiO08625 RN

Interactioni

Subunit structurei

Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT9.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019406

Structurei

3D structure databases

ProteinModelPortaliO08625
SMRiO08625
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 334C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini365 – 468C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni13 – 35Cysteine motifBy similarityAdd BLAST23

Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity
The first C2 domain mediates Ca2+-dependent phospholipid binding.1 Publication

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XQZ9 LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232128
HOVERGENiHBG005010
InParanoidiO08625
KOiK19910
OMAiWKDIHCA
OrthoDBiEOG091G0XMQ
PhylomeDBiO08625
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028677 SYT10
PANTHERiPTHR10024:SF46 PTHR10024:SF46, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequencei

Sequence statusi: Complete.

O08625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFRKEDGVS SLCQKALHII TELCFAGQVE WDKCSGIFPA DRSGQGGGGT
60 70 80 90 100
DISVSLLAVV VSFCGLALLV VSLFVFWKLC WPCWKSKLVA PNVSTLPQSI
110 120 130 140 150
SSAPTEVFET EEKKEVEENE KPAPKAIEPA IKISHTSPDI PAEVQTALKE
160 170 180 190 200
HLIKHARVQR QTTDPTSSSR HNSFRRHLPR QMNVSSVDFS MGTEPVLQRG
210 220 230 240 250
ETRTSIGRIK PELYKQKSVD SEGNRKDDVK TCGKLNFALQ YDYENELLVV
260 270 280 290 300
KIIKALDLPA KDFTGTSDPY VKIYLLPDRK KKFQTRVHRK TLNPLFDELF
310 320 330 340 350
QFPVVYDQLS NRKLHFSIYD FDRFSRHDMI GEVILDNLFE VSDLSREATV
360 370 380 390 400
WKDIHCATTE SIDLGEIMFS LCYLPTAGRM TLTVIKCRNL KAMDITGSSD
410 420 430 440 450
PYVKVSLMCE GRRLKKRKTT TKKNTLNPVY NEAIIFDIPP ENVDQVSLCI
460 470 480 490 500
AVMDYDRVGH NEVIGVCRTG LDAEGLGRDH WNEMLAYHRK PITHWHPLLE
510 520
LPGRATSFDS QGSCSSPRPP STP
Length:523
Mass (Da):59,011
Last modified:July 11, 2003 - v2
Checksum:i48F42A2D19517A3B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263F → S in AAB51686 (PubMed:9122248).Curated1
Sequence conflicti362I → M in AAB51686 (PubMed:9122248).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF375463 mRNA Translation: AAK56958.1
U85513 mRNA Translation: AAB51686.1
PIRiPC6300
RefSeqiNP_113854.1, NM_031666.1
UniGeneiRn.212261

Genome annotation databases

EnsembliENSRNOT00000019406; ENSRNOP00000019406; ENSRNOG00000014296
GeneIDi60567
KEGGirno:60567

Similar proteinsi

Entry informationi

Entry nameiSYT10_RAT
AccessioniPrimary (citable) accession number: O08625
Secondary accession number(s): Q925B8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 11, 2003
Last modified: May 23, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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