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O08619

- F13A_RAT

UniProt

O08619 - F13A_RAT

Protein

Coagulation factor XIII A chain

Gene

F13a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin By similarity.By similarity

    Catalytic activityi

    Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei38 – 392Cleavage; by thrombin; to produce active factor XIII-ABy similarity
    Active sitei315 – 3151PROSITE-ProRule annotation
    Active sitei374 – 3741PROSITE-ProRule annotation
    Active sitei397 – 3971PROSITE-ProRule annotation
    Metal bindingi437 – 4371CalciumBy similarity
    Metal bindingi439 – 4391CalciumBy similarity
    Metal bindingi486 – 4861CalciumBy similarity
    Metal bindingi491 – 4911CalciumBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. blood coagulation Source: RGD
    2. peptide cross-linking Source: InterPro
    3. wound healing Source: RGD

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Blood coagulation, Hemostasis

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coagulation factor XIII A chain (EC:2.3.2.13)
    Short name:
    Coagulation factor XIIIa
    Alternative name(s):
    Protein-glutamine gamma-glutamyltransferase A chain
    Transglutaminase A chain
    Gene namesi
    Name:F13a1
    Synonyms:F13a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621495. F13a1.

    Subcellular locationi

    Cytoplasm By similarity. Secreted By similarity
    Note: Cytoplasmic in most tissues, but also secreted in the blood plasma.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Propeptidei2 – 3837Activation peptideBy similarityPRO_0000033650Add
    BLAST
    Chaini39 – 732694Coagulation factor XIII A chainPRO_0000033651Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The activation peptide is released by thrombin.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiO08619.
    PRIDEiO08619.

    Expressioni

    Gene expression databases

    GenevestigatoriO08619.

    Interactioni

    Subunit structurei

    Tetramer of two A chains and two B chains.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021568.

    Structurei

    3D structure databases

    ProteinModelPortaliO08619.
    SMRiO08619. Positions 7-729.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG80379.
    HOGENOMiHOG000231695.
    HOVERGENiHBG004342.
    InParanoidiO08619.
    KOiK03917.
    PhylomeDBiO08619.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view]
    PANTHERiPTHR11590. PTHR11590. 1 hit.
    PfamiPF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
    SMARTiSM00460. TGc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O08619-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDTPATTFG GRGAIPPNNS NAAGVDLPTE DLQGLVPRGV SLKDYLNVTA    50
    VHLFKERWDS NKIVHHTDKF DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF 100
    RVEYVIGRYP QENKGTYIPV PVVTELQSGK WGAKVIMNED RSVRLSVQSS 150
    PECIVGKFRM YVAVWTPYGI LRTQRDPETD TYILFNPWCE EDAVYLDDEK 200
    EREEYVLNDI GGIFHGDFND IKSRSWSYGQ FEDGILDACL FVMDKAEMDL 250
    SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL 300
    LEYRSSETPV RYGQCWVLAG VFNTFLRCLG IPARVITNYS SAHDNDANLQ 350
    MDIFLEEDGS VSFKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP 400
    QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVLGEVNSDL VYITAKKDGT 450
    HVVENVDATH IGKLIVTKEI GGDGMQDITD TYKFQEGQEE ERLALETALM 500
    YGAKKTLNTE GMVKSSSDVD MNFDVENAVL GKDFRVTITF QNNSSNLYTI 550
    LAYLSGNITF YTGVSKKEFK TESFEVTLDP LSLEKKEVLI RAGEYMSYLL 600
    EQGLLHFFVT ARINETRVVL AKQKAIVLTI PKVTIKVRGT AMVGSDMVVT 650
    VEFTNPLKET LKNVWLHLEG PGVMRPKRKM FREIRPNATV QWEEVCQPWV 700
    SGHRKLNASM TSDSLRHVYG ELDLQIRRRP TV 732
    Length:732
    Mass (Da):82,659
    Last modified:January 23, 2007 - v3
    Checksum:i22B052D3A73721ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12502 mRNA. Translation: CAA73104.1.
    RefSeqiNP_067730.2. NM_021698.2.
    UniGeneiRn.42925.

    Genome annotation databases

    GeneIDi60327.
    KEGGirno:60327.
    UCSCiRGD:621495. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12502 mRNA. Translation: CAA73104.1 .
    RefSeqi NP_067730.2. NM_021698.2.
    UniGenei Rn.42925.

    3D structure databases

    ProteinModelPortali O08619.
    SMRi O08619. Positions 7-729.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021568.

    Proteomic databases

    PaxDbi O08619.
    PRIDEi O08619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 60327.
    KEGGi rno:60327.
    UCSCi RGD:621495. rat.

    Organism-specific databases

    CTDi 2162.
    RGDi 621495. F13a1.

    Phylogenomic databases

    eggNOGi NOG80379.
    HOGENOMi HOG000231695.
    HOVERGENi HBG004342.
    InParanoidi O08619.
    KOi K03917.
    PhylomeDBi O08619.

    Miscellaneous databases

    NextBioi 611953.
    PROi O08619.

    Gene expression databases

    Genevestigatori O08619.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    3.90.260.10. 1 hit.
    InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
    IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002931. Transglutaminase-like.
    IPR008958. Transglutaminase_C.
    IPR013808. Transglutaminase_CS.
    IPR001102. Transglutaminase_N.
    [Graphical view ]
    PANTHERi PTHR11590. PTHR11590. 1 hit.
    Pfami PF00927. Transglut_C. 2 hits.
    PF01841. Transglut_core. 1 hit.
    PF00868. Transglut_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
    SMARTi SM00460. TGc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49309. SSF49309. 2 hits.
    SSF81296. SSF81296. 1 hit.
    PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning for rat factor XIIIa."
      Diepholz D., Grundmann U., Zettlmeissl G.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiF13A_RAT
    AccessioniPrimary (citable) accession number: O08619
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3