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O08619

- F13A_RAT

UniProt

O08619 - F13A_RAT

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Protein

Coagulation factor XIII A chain

Gene

F13a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin By similarity.By similarity

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.PROSITE-ProRule annotation

Cofactori

Binds 1 calcium ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei38 – 392Cleavage; by thrombin; to produce active factor XIII-ABy similarity
Active sitei315 – 3151PROSITE-ProRule annotation
Active sitei374 – 3741PROSITE-ProRule annotation
Active sitei397 – 3971PROSITE-ProRule annotation
Metal bindingi437 – 4371CalciumBy similarity
Metal bindingi439 – 4391CalciumBy similarity
Metal bindingi486 – 4861CalciumBy similarity
Metal bindingi491 – 4911CalciumBy similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. blood coagulation Source: RGD
  2. peptide cross-linking Source: InterPro
  3. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13a1
Synonyms:F13a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621495. F13a1.

Subcellular locationi

Cytoplasm By similarity. Secreted By similarity
Note: Cytoplasmic in most tissues, but also secreted in the blood plasma.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Propeptidei2 – 3837Activation peptideBy similarityPRO_0000033650Add
BLAST
Chaini39 – 732694Coagulation factor XIII A chainPRO_0000033651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Glycosylationi614 – 6141N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The activation peptide is released by thrombin.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO08619.
PRIDEiO08619.

Expressioni

Gene expression databases

GenevestigatoriO08619.

Interactioni

Subunit structurei

Tetramer of two A chains and two B chains.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021568.

Structurei

3D structure databases

ProteinModelPortaliO08619.
SMRiO08619. Positions 7-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiO08619.
KOiK03917.
PhylomeDBiO08619.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08619-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDTPATTFG GRGAIPPNNS NAAGVDLPTE DLQGLVPRGV SLKDYLNVTA
60 70 80 90 100
VHLFKERWDS NKIVHHTDKF DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF
110 120 130 140 150
RVEYVIGRYP QENKGTYIPV PVVTELQSGK WGAKVIMNED RSVRLSVQSS
160 170 180 190 200
PECIVGKFRM YVAVWTPYGI LRTQRDPETD TYILFNPWCE EDAVYLDDEK
210 220 230 240 250
EREEYVLNDI GGIFHGDFND IKSRSWSYGQ FEDGILDACL FVMDKAEMDL
260 270 280 290 300
SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL
310 320 330 340 350
LEYRSSETPV RYGQCWVLAG VFNTFLRCLG IPARVITNYS SAHDNDANLQ
360 370 380 390 400
MDIFLEEDGS VSFKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP
410 420 430 440 450
QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVLGEVNSDL VYITAKKDGT
460 470 480 490 500
HVVENVDATH IGKLIVTKEI GGDGMQDITD TYKFQEGQEE ERLALETALM
510 520 530 540 550
YGAKKTLNTE GMVKSSSDVD MNFDVENAVL GKDFRVTITF QNNSSNLYTI
560 570 580 590 600
LAYLSGNITF YTGVSKKEFK TESFEVTLDP LSLEKKEVLI RAGEYMSYLL
610 620 630 640 650
EQGLLHFFVT ARINETRVVL AKQKAIVLTI PKVTIKVRGT AMVGSDMVVT
660 670 680 690 700
VEFTNPLKET LKNVWLHLEG PGVMRPKRKM FREIRPNATV QWEEVCQPWV
710 720 730
SGHRKLNASM TSDSLRHVYG ELDLQIRRRP TV
Length:732
Mass (Da):82,659
Last modified:January 23, 2007 - v3
Checksum:i22B052D3A73721ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12502 mRNA. Translation: CAA73104.1.
RefSeqiNP_067730.2. NM_021698.2.
UniGeneiRn.42925.

Genome annotation databases

GeneIDi60327.
KEGGirno:60327.
UCSCiRGD:621495. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12502 mRNA. Translation: CAA73104.1 .
RefSeqi NP_067730.2. NM_021698.2.
UniGenei Rn.42925.

3D structure databases

ProteinModelPortali O08619.
SMRi O08619. Positions 7-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021568.

Proteomic databases

PaxDbi O08619.
PRIDEi O08619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 60327.
KEGGi rno:60327.
UCSCi RGD:621495. rat.

Organism-specific databases

CTDi 2162.
RGDi 621495. F13a1.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi O08619.
KOi K03917.
PhylomeDBi O08619.

Miscellaneous databases

NextBioi 611953.
PROi O08619.

Gene expression databases

Genevestigatori O08619.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning for rat factor XIIIa."
    Diepholz D., Grundmann U., Zettlmeissl G.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiF13A_RAT
AccessioniPrimary (citable) accession number: O08619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3