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O08619

- F13A_RAT

UniProt

O08619 - F13A_RAT

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Protein
Coagulation factor XIII A chain
Gene
F13a1, F13a
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin By similarity.

Catalytic activityi

Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH3.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei38 – 392Cleavage; by thrombin; to produce active factor XIII-A By similarity
Active sitei315 – 3151 By similarity
Active sitei374 – 3741 By similarity
Active sitei397 – 3971 By similarity
Metal bindingi437 – 4371Calcium By similarity
Metal bindingi439 – 4391Calcium By similarity
Metal bindingi486 – 4861Calcium By similarity
Metal bindingi491 – 4911Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein-glutamine gamma-glutamyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. blood coagulation Source: RGD
  2. peptide cross-linking Source: InterPro
  3. wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13a1
Synonyms:F13a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621495. F13a1.

Subcellular locationi

Cytoplasm By similarity. Secreted By similarity
Note: Cytoplasmic in most tissues, but also secreted in the blood plasma By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Propeptidei2 – 3837Activation peptide By similarity
PRO_0000033650Add
BLAST
Chaini39 – 732694Coagulation factor XIII A chain
PRO_0000033651Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Glycosylationi614 – 6141N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The activation peptide is released by thrombin By similarity.

Keywords - PTMi

Acetylation, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO08619.
PRIDEiO08619.

Expressioni

Gene expression databases

GenevestigatoriO08619.

Interactioni

Subunit structurei

Tetramer of two A chains and two B chains By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021568.

Structurei

3D structure databases

ProteinModelPortaliO08619.
SMRiO08619. Positions 7-729.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG80379.
HOGENOMiHOG000231695.
HOVERGENiHBG004342.
InParanoidiO08619.
KOiK03917.
PhylomeDBiO08619.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProiIPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view]
PANTHERiPTHR11590. PTHR11590. 1 hit.
PfamiPF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000459. TGM_EBP42. 1 hit.
SMARTiSM00460. TGc. 1 hit.
[Graphical view]
SUPFAMiSSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEiPS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08619-1 [UniParc]FASTAAdd to Basket

« Hide

MSDTPATTFG GRGAIPPNNS NAAGVDLPTE DLQGLVPRGV SLKDYLNVTA    50
VHLFKERWDS NKIVHHTDKF DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF 100
RVEYVIGRYP QENKGTYIPV PVVTELQSGK WGAKVIMNED RSVRLSVQSS 150
PECIVGKFRM YVAVWTPYGI LRTQRDPETD TYILFNPWCE EDAVYLDDEK 200
EREEYVLNDI GGIFHGDFND IKSRSWSYGQ FEDGILDACL FVMDKAEMDL 250
SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL 300
LEYRSSETPV RYGQCWVLAG VFNTFLRCLG IPARVITNYS SAHDNDANLQ 350
MDIFLEEDGS VSFKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP 400
QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVLGEVNSDL VYITAKKDGT 450
HVVENVDATH IGKLIVTKEI GGDGMQDITD TYKFQEGQEE ERLALETALM 500
YGAKKTLNTE GMVKSSSDVD MNFDVENAVL GKDFRVTITF QNNSSNLYTI 550
LAYLSGNITF YTGVSKKEFK TESFEVTLDP LSLEKKEVLI RAGEYMSYLL 600
EQGLLHFFVT ARINETRVVL AKQKAIVLTI PKVTIKVRGT AMVGSDMVVT 650
VEFTNPLKET LKNVWLHLEG PGVMRPKRKM FREIRPNATV QWEEVCQPWV 700
SGHRKLNASM TSDSLRHVYG ELDLQIRRRP TV 732
Length:732
Mass (Da):82,659
Last modified:January 23, 2007 - v3
Checksum:i22B052D3A73721ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12502 mRNA. Translation: CAA73104.1.
RefSeqiNP_067730.2. NM_021698.2.
UniGeneiRn.42925.

Genome annotation databases

GeneIDi60327.
KEGGirno:60327.
UCSCiRGD:621495. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12502 mRNA. Translation: CAA73104.1 .
RefSeqi NP_067730.2. NM_021698.2.
UniGenei Rn.42925.

3D structure databases

ProteinModelPortali O08619.
SMRi O08619. Positions 7-729.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021568.

Proteomic databases

PaxDbi O08619.
PRIDEi O08619.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 60327.
KEGGi rno:60327.
UCSCi RGD:621495. rat.

Organism-specific databases

CTDi 2162.
RGDi 621495. F13a1.

Phylogenomic databases

eggNOGi NOG80379.
HOGENOMi HOG000231695.
HOVERGENi HBG004342.
InParanoidi O08619.
KOi K03917.
PhylomeDBi O08619.

Miscellaneous databases

NextBioi 611953.
PROi O08619.

Gene expression databases

Genevestigatori O08619.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
3.90.260.10. 1 hit.
InterProi IPR023608. Gln_gamma-glutamylTfrase_euk.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002931. Transglutaminase-like.
IPR008958. Transglutaminase_C.
IPR013808. Transglutaminase_CS.
IPR001102. Transglutaminase_N.
[Graphical view ]
PANTHERi PTHR11590. PTHR11590. 1 hit.
Pfami PF00927. Transglut_C. 2 hits.
PF01841. Transglut_core. 1 hit.
PF00868. Transglut_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000459. TGM_EBP42. 1 hit.
SMARTi SM00460. TGc. 1 hit.
[Graphical view ]
SUPFAMi SSF49309. SSF49309. 2 hits.
SSF81296. SSF81296. 1 hit.
PROSITEi PS00547. TRANSGLUTAMINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning for rat factor XIIIa."
    Diepholz D., Grundmann U., Zettlmeissl G.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiF13A_RAT
AccessioniPrimary (citable) accession number: O08619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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