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Protein

Coagulation factor XIII A chain

Gene

F13a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.By similarity

Catalytic activityi

A protein-L-glutamine + a protein-L-lysine = a protein with an N6-(gamma-glutamyl)-L-lysine cross-link + NH3.By similarity

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei315PROSITE-ProRule annotation1
Active sitei374PROSITE-ProRule annotation1
Active sitei397PROSITE-ProRule annotation1
Metal bindingi437CalciumBy similarity1
Metal bindingi439CalciumBy similarity1
Metal bindingi486CalciumBy similarity1
Metal bindingi491CalciumBy similarity1

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: RGD
  • blood coagulation, fibrin clot formation Source: UniProtKB
  • peptide cross-linking Source: UniProtKB
  • wound healing Source: RGD

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processBlood coagulation, Hemostasis
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XIII A chain (EC:2.3.2.13By similarity)
Short name:
Coagulation factor XIIIa
Alternative name(s):
Protein-glutamine gamma-glutamyltransferase A chain
Transglutaminase A chain
Gene namesi
Name:F13a1
Synonyms:F13a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621495 F13a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
PropeptideiPRO_00000336502 – 38Activation peptideBy similarityAdd BLAST37
ChainiPRO_000003365139 – 732Coagulation factor XIII A chainAdd BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Glycosylationi614N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The activation peptide is released by thrombin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei38 – 39Cleavage; by thrombin; to produce active factor XIII-ABy similarity2

Keywords - PTMi

Acetylation, Glycoprotein, Zymogen

Proteomic databases

PaxDbiO08619
PRIDEiO08619

PTM databases

iPTMnetiO08619
PhosphoSitePlusiO08619

Interactioni

Subunit structurei

Tetramer of two A chains (F13A1) and two B (F13B) chains.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021568

Structurei

3D structure databases

ProteinModelPortaliO08619
SMRiO08619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFMV Eukaryota
ENOG410XQEZ LUCA
HOGENOMiHOG000231695
HOVERGENiHBG004342
InParanoidiO08619
KOiK03917
PhylomeDBiO08619

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.90.260.10, 1 hit
InterProiView protein in InterPro
IPR034810 Factor_XIII_A
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002931 Transglutaminase-like
IPR036985 Transglutaminase-like_sf
IPR023608 Transglutaminase_animal
IPR013808 Transglutaminase_AS
IPR008958 Transglutaminase_C
IPR036238 Transglutaminase_C_sf
IPR001102 Transglutaminase_N
PANTHERiPTHR11590:SF42 PTHR11590:SF42, 1 hit
PfamiView protein in Pfam
PF00927 Transglut_C, 2 hits
PF01841 Transglut_core, 1 hit
PF00868 Transglut_N, 1 hit
PIRSFiPIRSF000459 TGM_EBP42, 1 hit
SMARTiView protein in SMART
SM00460 TGc, 1 hit
SUPFAMiSSF49309 SSF49309, 2 hits
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00547 TRANSGLUTAMINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O08619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTPATTFG GRGAIPPNNS NAAGVDLPTE DLQGLVPRGV SLKDYLNVTA
60 70 80 90 100
VHLFKERWDS NKIVHHTDKF DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF
110 120 130 140 150
RVEYVIGRYP QENKGTYIPV PVVTELQSGK WGAKVIMNED RSVRLSVQSS
160 170 180 190 200
PECIVGKFRM YVAVWTPYGI LRTQRDPETD TYILFNPWCE EDAVYLDDEK
210 220 230 240 250
EREEYVLNDI GGIFHGDFND IKSRSWSYGQ FEDGILDACL FVMDKAEMDL
260 270 280 290 300
SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL
310 320 330 340 350
LEYRSSETPV RYGQCWVLAG VFNTFLRCLG IPARVITNYS SAHDNDANLQ
360 370 380 390 400
MDIFLEEDGS VSFKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP
410 420 430 440 450
QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVLGEVNSDL VYITAKKDGT
460 470 480 490 500
HVVENVDATH IGKLIVTKEI GGDGMQDITD TYKFQEGQEE ERLALETALM
510 520 530 540 550
YGAKKTLNTE GMVKSSSDVD MNFDVENAVL GKDFRVTITF QNNSSNLYTI
560 570 580 590 600
LAYLSGNITF YTGVSKKEFK TESFEVTLDP LSLEKKEVLI RAGEYMSYLL
610 620 630 640 650
EQGLLHFFVT ARINETRVVL AKQKAIVLTI PKVTIKVRGT AMVGSDMVVT
660 670 680 690 700
VEFTNPLKET LKNVWLHLEG PGVMRPKRKM FREIRPNATV QWEEVCQPWV
710 720 730
SGHRKLNASM TSDSLRHVYG ELDLQIRRRP TV
Length:732
Mass (Da):82,659
Last modified:January 23, 2007 - v3
Checksum:i22B052D3A73721ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12502 mRNA Translation: CAA73104.1
RefSeqiNP_067730.2, NM_021698.2
UniGeneiRn.42925

Genome annotation databases

GeneIDi60327
KEGGirno:60327
UCSCiRGD:621495 rat

Similar proteinsi

Entry informationi

Entry nameiF13A_RAT
AccessioniPrimary (citable) accession number: O08619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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